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Resultats globals: 5 registres trobats en 0.03 segons.
Articles, 5 registres trobats
Articles 5 registres trobats  
1.
16 p, 4.5 MB Mapping the Interface of a GPCR Dimer : A Structural Model of the A Adenosine and D Dopamine Receptor Heteromer / Borroto-Escuela, Dasiel O. (Karolinska Institutet (Estocolm, Suècia) ; Rodriguez, David (Science for Life Laboratory, Stockholm University) ; Romero-Fernandez, Wilber (Uppsala University) ; Kapla, Jon (Uppsala University) ; Jaiteh, Mariama (Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University) ; Ranganathan, Anirudh (Stockholm University) ; Lazarova, Tzvetana (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Fuxe, Kjell (Karolinska Institutet (Estocolm, Suècia)) ; Carlsson, Jens (Uppsala University)
The A adenosine (AR) and D dopamine (DR) receptors form oligomers in the cell membrane and allosteric interactions across the AR-DR heteromer represent a target for development of drugs against central nervous system disorders. [...]
2018 - 10.3389/fphar.2018.00829
Frontiers in Pharmacology, Vol. 9 (august 2018)  
Registre complet - Creative Commons
2.
15 p, 6.7 MB The mutational landscape of human olfactory G protein-coupled receptors / Jimenez, Ramón Cierco (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Casajuana-Martin, Nil (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; García Recio, Ädrian (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Alcántara, Lidia (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Pardo Carrasco, Leonardo (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Campillo Grau, María Mercedes (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Gonzalez, Angel (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional)
Olfactory receptors (ORs) constitute a large family of sensory proteins that enable us to recognize a wide range of chemical volatiles in the environment. By contrast to the extensive information about human olfactory thresholds for thousands of odorants, studies of the genetic influence on olfaction are limited to a few examples. [...]
2021 - 10.1186/s12915-021-00962-0
BMC biology, Vol. 19 (february 2021)  
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3.
11 p, 711.6 KB Exploring the Activation Mechanism of the mGlu5 Transmembrane Domain / Lans, Isaias (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Díaz Sanzo, Óscar (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ; Dalton, James A. R.. (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències)
UDTAULÍ.
As a class C GPCR and regulator of synaptic activity, mGlu5 is an attractive drug target, potentially offering treatment for several neurologic and psychiatric disorders. As little is known about the activation mechanism of mGlu5 at a structural level, potential of mean force calculations linked to molecular dynamics simulations were performed on the mGlu5 transmembrane domain crystal structure to explore various internal mechanisms responsible for its activation. [...]
2020 - 10.3389/fmolb.2020.00038
Frontiers in Molecular Biosciences, Vol. 7 (march 2020)  
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4.
25 p, 3.0 MB Distinct dopamine D2 receptor antagonists differentially impact D2 receptor oligomerization / Wouters, Elise (Laboratory of Toxicology. Department of Bioanalysis. Faculty of Pharmaceutical Sciences. Ghent University) ; Ricarte Marín, Adrián (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Dalton, James A. R.. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Stove, Christophe. (Laboratory of Toxicology. Department of Bioanalysis. Faculty of Pharmaceutical Sciences. Ghent University)
Dopamine D receptors (DR) are known to form transient homodimer complexes, of which the increased formation has already been associated with development of schizophrenia. Pharmacological targeting and modulation of the equilibrium of these receptor homodimers might lead to a better understanding of the critical role played by these complexes in physiological and pathological conditions. [...]
2019 - 10.3390/ijms20071686
International journal of molecular sciences, Vol. 20 Núm. 7 (january 2019) , p. 1686  
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5.
17 p, 2.9 MB Analysis of Human Dopamine D Receptor Quaternary Structure / Marsango, Sara (University of Glasgow) ; Caltabiano, Gianluigi 1978- (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Pou, Chantevy (University of Glasgow) ; Varela Liste, María José (University of Glasgow) ; Milligan, Graeme (University of Glasgow)
Background: The dopamine D receptor can form dimers/oligomers, but the molecular basis for this is poorly defined. Results: Molecular modeling, mutagenesis, and analysis of inactive state receptor crystal structures allowed assessment of models of receptor organization. [...]
2015 - 10.1074/jbc.M114.630681
Journal of biological chemistry, Vol. 290 (april 2015) , p. 15146-15162  
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