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8 p, 1012.2 KB |
Reduced intensity conditioning increases risk of severe cGVHD : identification of risk factors for cGVHD in a multicenter setting
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Afram, Gabriel (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Simón, Jose Antonio Pérez (Instituto de Biomedicina de Sevilla) ;
Remberger, Mats (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Caballero Velazquez, Teresa (Instituto de Biomedicina de Sevilla) ;
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau) ;
Piñana, Jose Luis (Hospital Clinico Universitario) ;
Ringden, Olle (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Esquirol, Albert (Institut d'Investigació Biomèdica Sant Pau) ;
Lopez-Corral, Lucia (Hospital Universitario de Salamanca-IBSAL) ;
Garcia Cadenas, Irene (Institut d'Investigació Biomèdica Sant Pau) ;
López-Godino, Oriana (Hospital Universitario de Salamanca-IBSAL) ;
Malouf Sierra, Jorge 1971- (Institut d'Investigació Biomèdica Sant Pau) ;
Caballero, Dolores (Hospital Universitario de Salamanca-IBSAL) ;
Ljungman, Per (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Vazquez, Lourdes (Hospital Clínico Universitario (Salamanca)) ;
Hägglund, Hans (Uppsala University Hospital) ;
Universitat Autònoma de Barcelona
Chronic graft-versus-host disease (cGVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Aim is to identify risk factors for the development of cGVHD in a multicenter setting. [...]
2018 -  10.1007/s12032-018-1127-2
Medical Oncology, Vol. 35 Núm. 6 (january 2018) , p. 79
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25 p, 635.6 KB |
CD34 + Cell Selection versus Reduced-Intensity Conditioning and Unmodified Grafts for Allogeneic Hematopoietic Cell Transplantation in Patients Age >50 Years with Acute Myelogenous Leukemia and Myelodysplastic Syndrome
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Barba, Pere (Hospital Universitari Vall d'Hebron) ;
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau) ;
Zhou, Qin (Memorial Sloan Kettering Cancer Center) ;
Cho, Christina (Weill Cornell Medical College) ;
Castro-Malaspina, Hugo (Weill Cornell Medical College) ;
Devlin, Sean M (Memorial Sloan Kettering Cancer Center) ;
Esquirol, Albert (Institut d'Investigació Biomèdica Sant Pau) ;
Giralt, Sergio (Weill Cornell Medical College) ;
Jakubowski, Ann A. (Weill Cornell Medical College) ;
Caballero, Dolores (Hospital Universitario Salamanca (CAUSA/IBSAL)) ;
Maloy, Molly (Memorial Sloan Kettering Cancer Center) ;
Papadopoulos, Esperanza B. (Weill Cornell Medical College) ;
Piñana, José Luis (Hospital Clínic Universitari (València)) ;
Fox, Maria Laura (Hospital Universitari Vall d'Hebron) ;
Márquez-Malaver, Francisco J. (Hospital Virgen del Rocío Sevilla) ;
Valcárcel, David (Hospital Universitari Vall d'Hebron) ;
Solano, Carlos (Hospital Clínic Universitari (València)) ;
López-Corral, Lucía (Hospital Universitario Salamanca (CAUSA/IBSAL)) ;
Malouf Sierra, Jorge 1971- (Institut d'Investigació Biomèdica Sant Pau) ;
Perales, Miguel-Angel (Weill Cornell Medical College) ;
Universitat Autònoma de Barcelona
Reduced-intensity conditioning (RIC) and T cell depletion (TCD) through CD34 cell selection without the use of post-transplantation immunosuppression are 2 strategies used to reduce nonrelapse mortality (NRM) in older patients after allogeneic hematopoietic cell transplantation (allo-HCT). [...]
2018 - 10.1016/j.bbmt.2017.12.804
Biology of blood and marrow transplantation, Vol. 24 Núm. 5 (may 2018) , p. 964-972
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9 p, 406.9 KB |
Impact of T Cell Dose on Outcome of T Cell-Replete HLA-Matched Allogeneic Peripheral Blood Stem Cell Transplantation
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Saad, Ayman (The Ohio State University) ;
Lamb, Lawrence (University of Alabama at Birmingham) ;
Wang, Tao (Medical College of Wisconsin) ;
Hemmer, Michael T. (Medical College of Wisconsin) ;
Spellman, Stephen (National Marrow Donor Program/Be the Match) ;
Couriel, Daniel R (Utah Blood and Marrow Transplant Program) ;
Alousi, Amin (Anderson Cancer Center) ;
Pidala, Joseph (H. Lee Moffitt Cancer Center) ;
Abdel-Azim, Hisham (University of Southern California Keck School of Medicine) ;
Agrawal, Vaibhav (Indiana University School of Medicine) ;
Aljurf, Mahmoud (King Faisal Specialist Hospital and Research Centre (Aràbia Saudita)) ;
Beitinjaneh, Amer (University of Miami) ;
Bhatt, Vijaya Raj (University of Nebraska Medical Center) ;
Buchbinder, David Kyle (Children's Hospital of Orange County) ;
Byrne, Michael (Vanderbilt University Medical Center) ;
Cahn, Jean-Yves (CHU Grenoble Alpes) ;
Cairo, Mitchell S. (New York Medical College) ;
Castillo, Paul A. (UF Health Shands Children's Hospital) ;
Chhabra, Saurabh (Medical College of Wisconsin) ;
Diaz, Miguel Angel (Hospital Infantil Universitario Nino Jesus) ;
Farhan, Shatha (Henry Ford Hospital Bone Marrow Transplant Program) ;
Floisand, Yngvar (The National Hospital) ;
Frangoul, Haydar A. (Children's Hospital at TriStar Centennial and Sarah Cannon Research Institute) ;
Gadalla, Shahinaz M. (National Cancer Institute) ;
Gajewski, James (Consultant at Lu Daopei Hospital) ;
Gale, Robert Peter (Imperial College London) ;
Gandhi, Manish (Mayo Clinic) ;
Gergis, Usama (New York Presbyterian Hospital/Weill Cornell Medical Center) ;
Hamilton, Betty (Cleveland Clinic Taussig Cancer Institute) ;
Hematti, Peiman (University of Wisconsin Hospital and Clinics) ;
Hildebrandt, Gerhard C. (University of Kentucky) ;
Kamble, Rammurti T. (Baylor College of Medicine) ;
Kanate, Abraham S. (West Virginia University) ;
Khandelwal, Pooja (Cincinnati Children's Hospital Medical Center) ;
Lazaryn, Aleksandr (H. Lee Moffitt Cancer Center) ;
MacMillan, Margaret (University of Minnesota Blood and Marrow Transplant Program) ;
Marks, David I. (University Hospitals Bristol NHS Trust) ;
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau) ;
Mehta, Parinda A. (Cincinnati Children's Hospital Medical Center) ;
Nishihori, Taiga (H. Lee Moffitt Cancer Center) ;
Olsson, Richard (Uppsala University) ;
Patel, Sagar (Cleveland Clinic Foundation) ;
Qayed, Muna (Emory University School of Medicine) ;
Rangarajan, Hemalatha G. (Nationwide Children's Hospital) ;
Reshef, R. (Columbia University Medical Center) ;
Ringden, O. (Karolinska Institutet (Estocolm, Suècia)) ;
Savani, B.N. (Vanderbilt University Medical Center) ;
Schouten, H.C. (Academische Ziekenhuis) ;
Schultz, K.R. (The University of British Columbia) ;
Seo, S. (Dokkyo Medical University) ;
Shaffer, B.C. (Memorial Sloan Kettering Cancer Center) ;
Solh, M. (Northside Hospital) ;
Teshima, T. (Hokkaido University Hospital) ;
Urbano-Ispizua, Alvaro (Hospital Clínic i Provincial de Barcelona) ;
Verdonck, L.F. (Isala Clinic) ;
Vij, R. (Washington University School of Medicine) ;
Waller, E.K. (Emory University) ;
William, B. (The Ohio State University) ;
Wirk, B. (Seattle Cancer Care Alliance) ;
Yared, J.A. (University of Maryland) ;
Yu, L.C. (Children's Hospital/Louisiana State University Medical Center) ;
Arora, M. (University of Minnesota Medical Center) ;
Hashmi, S. (Mayo Clinic) ;
Universitat Autònoma de Barcelona
Data on whether the T cell dose of allogeneic peripheral blood stem cell (PBSC) products influences transplantation outcomes are conflicting. Using the Center for International Blood and Marrow Transplant Research database, we identified 2736 adult patients who underwent first allogeneic PBSC transplantation for acute leukemia or myelodysplastic syndrome between 2008 and 2014 using an HLA-matched sibling donor (MSD) or an 8/8-matched unrelated donor (MUD). [...]
2019 - 10.1016/j.bbmt.2019.05.007
Biology of blood and marrow transplantation, Vol. 25 Núm. 9 (september 2019) , p. 1875-1883
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8 p, 316.8 KB |
Solid organ transplantation after hematopoietic stem cell transplantation in childhood : A multicentric retrospective survey
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Faraci, Maura (Istituto G Gaslini) ;
Bertaina, Alice (Stanford University) ;
Dalissier, Arnaud (European Society for Blood and Marrow Transplantation Pediatric Disease Working Party) ;
Ifversen, Marianne (Copenhagen University Hospital) ;
Schulz, Ansgar (University Medical Center) ;
Gennery, Andrew (Great North Children's Hospital) ;
Burkhardt, Birgit (University Hospital of Münster (Alemanya)) ;
Badell Serra, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Díaz de Heredia, Cristina (Vall d'Hebron Institut d'Oncologia) ;
Lanino, Edoardo (Istituto G Gaslini) ;
Lankester, Arjan C. (Leiden University Medical Center) ;
Gruhn, Bernd (Jena University Hospital (Alemania)) ;
Matthes-Martin, Susanne Medical University of Vienna ;
Kühl, Joern S. (Universitätsklinikum Leipzig) ;
Varotto, Stefania (University Hospital of Padova (Pàdua, Itàlia)) ;
Paillard, Catherine (Hôpital Hautepierre) ;
Guilmatre, Audrey (Hôpital Armand Trousseau (París, França)) ;
Sastre, Ana (Hospital Universitario La Paz (Madrid)) ;
Abecasis, Manuel (Instute Portugues Oncologia Lisboa) ;
Garwer, Birgit (University Hospital Eppendorf) ;
Sedlacek, Petr (University Hospital Motol) ;
Boelens, Jaap Jan (Memorial Sloan Kettering Cancer Center) ;
Beohou, Eric (European Society for Blood and Marrow Transplantation Pediatric Disease Working Party) ;
Bader, Peter (University Hospital of Frankfurt (Alemanya)) ;
Universitat Autònoma de Barcelona
We report data obtained from a retrospective multicenter pediatric survey on behalf of the European Society for Blood and Marrow Transplantation (EBMT). Information on solid organ transplantation (SOT) performed in pediatric recipients of either autologous or allogeneic hematopoietic stem cell transplantation (HSCT) between 1984 and 2016 was collected in 20 pediatric EBMT Centers (25. [...]
2019 - 10.1111/ajt.15240
American Journal of Transplantation, Vol. 19 Núm. 6 (june 2019) , p. 1798-1805
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11 p, 2.4 MB |
Acute Graft-vs.-Host Disease-Associated Endothelial Activation in vitro Is Prevented by Defibrotide
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Martinez-Sanchez, Julia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Hamelmann, H. (Berlin Institute of Health. Department of Hematology and Oncology) ;
Palomo, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mir, Enrique (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Moreno-Castaño, Ana Belén (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Torramade, S. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rovira, M. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Escolar, Ginès (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Cordes, Steffen (Berlin Institute of Health. Department of Hematology and Oncology) ;
Kalupa, Martina (Berlin Institute of Health. Department of Hematology and Oncology) ;
Mertlitz, S. (Berlin Institute of Health. Department of Hematology and Oncology) ;
Riesner, K. (Berlin Institute of Health. Department of Hematology and Oncology) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Penack, O. (Berlin Institute of Health. Department of Hematology and Oncology) ;
Diaz-Ricart, Maribel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Angiogenesis and endothelial activation and dysfunction have been associated with acute graft-vs. -host disease (aGVHD), pointing to the endothelium as a potential target for pharmacological intervention. [...]
2019 - 10.3389/fimmu.2019.02339
Frontiers in immunology, Vol. 10 (september 2019) , p. 2339
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14 p, 2.2 MB |
Defibrotide inhibits donor leucocyte-endothelial interactions and protects against acute graft-versus-host disease
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García-Bernal, D. (Internal Medicine Department. Medicine School. University of Murcia) ;
Palomo, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martínez, C. M. (Instituto Murciano de Investigación Biosanitaria) ;
Millán-Rivero, J. E. (Internal Medicine Department. Medicine School. University of Murcia) ;
García-Guillén, A. I. (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Blanquer, M. (Internal Medicine Department. Medicine School. University of Murcia) ;
Diaz-Ricart, Maribel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sackstein, R. (Department of Translational Medicine. and the Translational Glycobiology Institute. Herbert Wertheim College of Medicine. Florida International University) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Moraleda, J. M. (Internal Medicine Department. Medicine School. University of Murcia) ;
Universitat Autònoma de Barcelona
Allogeneic hematopoietic stem cell transplantation (allo-HCT) is an effective therapy for the treatment of high-risk haematological malignant disorders and other life-threatening haematological and genetic diseases. [...]
2020 - 10.1111/jcmm.15434
Journal of Cellular and Molecular Medicine, Vol. 24 Núm. 14 (january 2020) , p. 8031-8044
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11 p, 858.6 KB |
Unrelated cord blood transplantation for adult patients with acute myeloid leukemia: higher incidence of acute graft-versus-host disease and lower survival in male patients transplanted with female unrelated cord blood--a report from Eurocord, the Acute Leukemia Working Party, and the Cord Blood Committee of the Cellular Therapy and Immunobiology Working Party of the European Group for Blood and Marrow Transplantation
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Baron, Frederic (Université de Liège (Bèlgica)) ;
Labopin, Myriam (Hôpital Saint-Antoine (Paris, França)) ;
Ruggeri, Annalisa (Hôpital Saint-Louis (Paris, França)) ;
Mohty, Mohamad (Hôpital Saint-Antoine (Paris, França)) ;
Sanz, Guillermo (Hospital Universitari i Politècnic La Fe (València)) ;
Milpied, Noel (Hôpital Haut Léveque (Pessac, França)) ;
Bacigalupo, Andrea (Ospedale Sant Martino (Genova, Itàlia)) ;
Rambaldi, Alessandro (Azienda Ospedaliera Papa Giovanni XXIII (Bergamo, Itàlia)) ;
Bonifazi, Francesca (Policlinico Sant'Orsola-Malpighi (Bologna, Itàlia)) ;
Bosi, Alberto (Azienda Ospedaliero Universitaria Careggi (Firenze, Itàlia)) ;
Sierra, Jorge (Institut d'Investigació Biomèdica Sant Pau) ;
Yakoub-Agha, Ibrahim (Hôpital Claude Huriez (Lille, França)) ;
Ribera, Jose-Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gluckman, Eliane (Hôpital Saint-Louis (Paris, França)) ;
Nagler, Arnon (Sheba Medical Center (Ramat Gran, Israel)) ;
Universitat Autònoma de Barcelona
BACKGROUND: In the setting of allogeneic human leukocyte antigen (HLA)-matched bone marrow transplantation, transplanting male patients with grafts from female donors has been associated with a higher incidence of graft-versus-host disease (GVHD) and of nonrelapse mortality (NRM). [...]
2015 - 10.1186/s13045-015-0207-4
Journal of hematology & oncology, Vol. 8 Núm. 107 (october 2015)
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