Results overview: Found 2 records in 0.08 seconds.
Articles, 2 records found
Articles 2 records found  
1.
16 p, 1.8 MB Interleukin-10 enhances the intestinal epithelial barrier in the presence of corticosteroids through p38 MAPK activity in Caco-2 monolayers : a possible mechanism for steroid responsiveness in ulcerative colitis / Lorén Moreno, Violeta (Institut Germans Trias i Pujol) ; Cabré i Gelada, Eduard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ojanguren, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Domènech i Morral, Eugeni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Pedrosa Tapias, Elisabet (Institut Germans Trias i Pujol) ; García-Jaraquemada, Arce (Institut Germans Trias i Pujol) ; Mañosa i Ciria, Míriam (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Manyé Almero, Josep (Institut Germans Trias i Pujol)
Glucocorticosteroids are the first line therapy for moderate-severe flare-ups of ulcerative colitis. Despite that, up to 60% of patients do not respond adequately to steroid treatment. Previously, we reported that low IL-10 mRNA levels in intestine are associated with a poor response to glucocorticoids in active Crohn's disease. [...]
2015 - 10.1371/journal.pone.0130921
PloS one, Vol. 10, No 6 (June 2015) , p. e0130921  
2.
22 p, 1.4 MB Overlapping DNA methylation dynamics in mouse intestinal cell differentiation and early stages of malignant progression / Forn Bernaus, Marta (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Díez-Villanueva, Anna (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Merlos-Suárez, Anna (Institute for Research in Biomedicine (IRB Barcelona)) ; Muñoz, Mar (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Lois, Sergi (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Carrió Gaspar, Elvira (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Jordà Ramos, Mireia (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Bigas Salvans, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ; Batlle, Eduard (Institute for Research in Biomedicine (IRB Barcelona)) ; Peinado Morales, Miguel Á. (Miguel Ángel) (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
Mouse models of intestinal crypt cell differentiation and tumorigenesis have been used to characterize the molecular mechanisms underlying both processes. DNA methylation is a key epigenetic mark and plays an important role in cell identity and differentiation programs and cancer. [...]
2015 - 10.1371/journal.pone.0123263
PloS one, Vol. 10, No. 5 (May 2015) , p. e0123263  

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