|
1.
|
|
17 p, 9.6 MB |
Gene dysregulation in acute HIV-1 infection - early transcriptomic analysis reveals the crucial biological functions affected
/
Parker, Erica (University of Western Australia) ;
Judge, Melinda A. (University of Western Australia) ;
Pastor Palomo, Lucía (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fuente-Soro, Laura (Hospital Clínic i Provincial de Barcelona) ;
Jairoce, Chenjerai (Centro de Investigação em Saúde da Manhiça (CISM)) ;
Carter, Kim W. (Telethon Kids Institute) ;
Anderson, Denise (Telethon Kids Institute) ;
Mandomando, Inácio (Centro de Investigação em Saúde da Manhiça (CISM)) ;
Clifford, Holly D. (Telethon Kids Institute) ;
Naniche, Denise (Hospital Clínic i Provincial de Barcelona) ;
Le Souëf, Peter Neils (Telethon Kids Institute) ;
Universitat Autònoma de Barcelona
Transcriptomic analyses from early human immunodeficiency virus (HIV) infection have the potential to reveal how HIV causes widespread and lasting damage to biological functions, especially in the immune system. [...]
2023 -  10.3389/fcimb.2023.1074847
Frontiers in cellular and infection microbiology, Vol. 13 (april 2023)
|
|
|
2.
|
|
12 p, 3.2 MB |
Global analysis of the association between pig muscle fatty acid composition and gene expression using RNA-Seq
/
Valdés-Hernández, Jesús (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Ramayo-Caldas, Yuliaxis (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Passols, Magí (Centre de Recerca en Agrigenòmica) ;
Sebastià, Cristina (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Criado Mesas, Lourdes (Centre de Recerca en Agrigenòmica) ;
Crespo-Piazuelo, Daniel (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Esteve-Codina, Anna (Barcelona Institute of Science and Technology (BIST)) ;
Castelló Farré, Anna (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Sánchez Bonastre, Armando (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Folch, Josep M. (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Fatty acids (FAs) play an essential role as mediators of cell signaling and signal transduction, affecting metabolic homeostasis and determining meat quality in pigs. However, FAs are transformed by the action of several genes, such as those encoding desaturases and elongases of FAs in lipogenic tissues. [...]
2023 - 10.1038/s41598-022-27016-x
Scientific reports, Vol. 13 (january 2023)
|
|
|
3.
|
|
14 p, 1.9 MB |
Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma
/
Frontzek, Fabian (University Hospital of Münster (Alemanya)) ;
Staiger, Annette M. (Robert Bosch Hospital) ;
Zapukhlyak, Myroslav (University Hospital of Münster (Alemanya)) ;
Xu, Wendan (University Hospital of Münster (Alemanya)) ;
Bonzheim, Irina (University Hospital of Tübingen (Alemanya)) ;
Borgmann, Vanessa (University Hospital of Tübingen (Alemanya)) ;
Sander, Philip (University Hospital of Tübingen (Alemanya)) ;
Baptista, Maria Joao (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Heming, Jan-Niklas (University Hospital of Münster (Alemanya)) ;
Berning, Philipp (University Hospital of Münster (Alemanya)) ;
Wullenkord, Ramona (University Hospital of Münster (Alemanya)) ;
Erdmann, Tabea (University Hospital of Münster (Alemanya)) ;
Lutz, Mathias (University Hospital of Münster (Alemanya)) ;
Veratti, Pia (University Hospital Freiburg) ;
Ehrenfeld, Sophia (University of Freiburg) ;
Wienand, Kirsty (University Medical Center Göttingen) ;
Horn, Heike (Robert Bosch Hospital) ;
Goodlad, John R. (Queen Elizabeth University Hospital) ;
Wilson, Matthew R. (Beatson West of Scotland Cancer Centre (Glasgow, Regne Unit)) ;
Anagnostopoulos, Ioannis (Charité - Universitätsmedizin Berlin) ;
Lamping, Mario (Charité - Universitätsmedizin Berlin) ;
González Barca, Eva (Universitat de Barcelona) ;
Climent, Fina (Institut d'Investigació Biomèdica de Bellvitge) ;
Salar, Antonio (Hospital del Mar (Barcelona, Catalunya)) ;
Castellvi, Josep (Hospital Universitari Vall d'Hebron) ;
Abrisqueta, Pau (Hospital Universitari Vall d'Hebron) ;
Menarguez, Javier (Hospital General Universitario Gregorio Marañón) ;
Aldámiz-Echevarría, T (Hospital General Universitario Gregorio Marañón) ;
Richter, Julia (Christian-Albrechts-University) ;
Klapper, Wolfram (Christian-Albrechts-University) ;
Tzankov, Alexander (University Hospital Basel (Basilea, Suïssa)) ;
Dirnhofer, Stefan (University Hospital Basel (Basilea, Suïssa)) ;
Rosenwald, Andreas (University of Würzburg) ;
Mate Sanz, Jose Luís (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tapia, Gustavo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lenz, Peter (Department of Physics. University of Marburg) ;
Miething, C. (German Cancer Research Center) ;
Hartmann, Wolfgang (University Hospital of Münster (Alemanya)) ;
Chapuy, Björn (University Medical Center Göttingen) ;
Fend, Falko (University Hospital of Tübingen (Alemanya)) ;
Ott, Gustav (Department of Clinical Pathology. Robert Bosch Hospital) ;
Navarro, José-Tomás (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Grau, Michael (University Hospital of Münster (Alemanya)) ;
Lenz, Georg (University Hospital of Münster (Alemanya)) ;
Universitat Autònoma de Barcelona
Plasmablastic lymphoma (PBL) represents a rare and aggressive lymphoma subtype frequently associated with immunosuppression. Clinically, patients with PBL are characterized by poor outcome. The current understanding of the molecular pathogenesis is limited. [...]
2021 - 10.1038/s41467-021-25405-w
Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 5183
|
|
|
4.
|
|
31 p, 22.1 MB |
The molecular evolution of spermatogenesis across mammals
/
Murat, Florent (Heidelberg University. Center for Molecular Biology) ;
Mbengue, Noe (Heidelberg University. Center for Molecular Biology) ;
Boeg Winge, Sofia (Copenhagen University Hospital. Department of Growth and Reproduction) ;
Trefzer, Timo (University of Medicine Berlin. Berlin Institute of Health at Charité) ;
Leushkin, Evgeny (Heidelberg University. Center for Molecular Biology) ;
Sepp, Mari (Heidelberg University. Center for Molecular Biology) ;
Cardoso-Moreira, Margarida (Francis Crick Institute. Evolutionary Developmental Biology Laboratory (UK)) ;
Schmidt, Julia (Heidelberg University. Center for Molecular Biology) ;
Schneider, Celine (Heidelberg University. Center for Molecular Biology) ;
Mößinger, Katharina (Heidelberg University. Center for Molecular Biology) ;
Brüning, Thoomke (Heidelberg University. Center for Molecular Biology) ;
Lamanna, Francesco (Heidelberg University. Center for Molecular Biology) ;
Riera Belles, Meritxell (Aarhus University. Bioinformatics Research Centre) ;
Conrad, Christian (University of Medicine Berlin. Berlin Institute of Health at Charité) ;
Kondova, Ivanela (Biomedical Primate Research Center (the Netherlands)) ;
Bontrop, Ronald (Biomedical Primate Research Center (the Netherlands)) ;
Behr, Rüdiger (German Primate Center. Platform Degenerative Diseases) ;
Khaitovich, Philipp (Skolkovo Institute of Science and Technology. Center for Neurobiology and Brain Restoration (Russia)) ;
Pääbo, Svante (Max Planck Institute for Evolutionary Anthropology) ;
Marques-Bonet, Tomas 1975- (Institut Català de Paleontologia Miquel Crusafont) ;
Grutzner, Frank (University of Adelaide. The Robinson Research Institute (Australia)) ;
Almstrup, Kristian (Copenhagen University Hospital. Department of Growth and Reproduction) ;
Schierup, Mikkel Heide (Aarhus University. Bioinformatics Research Centre) ;
Kaessmann, Henrik (Heidelberg University. Center for Molecular Biology)
The testis produces gametes through spermatogenesis and evolves rapidly at both the morphological and molecular level in mammals1,2,3,4,5,6, probably owing to the evolutionary pressure on males to be reproductively successful7. [...]
2023 - 10.1038/s41586-022-05547-7
Nature, Vol. 613 (2023) , p. 308-316
|
|
|
5.
|
|
9 p, 1.9 MB |
A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood
/
Gassó, Patricia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rodríguez, Natalia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Martínez Piñeiro, Alberto (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Mezquida, Gisela (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ribeiro-Fernández, María (Instituto de Investigación Sanitaria de Navarra) ;
González-Peñas, Javier (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Zorrilla, Iñaki (Araba Unibertsitate Ospitalea) ;
Martínez-Sadurni, L. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rodriguez-Jimenez, Roberto (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
Corripio, Iluminada (Institut d'Investigació Biomèdica Sant Pau) ;
Sarró, Salvador (FIDMAG Germanes Hospitalàries Research Foundation) ;
Ibáñez, Ángela (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Usall, Judith (Institut de Recerca Sant Joan de Déu) ;
Lobo, Antonio (Instituto de Investigación Sanitaria de Aragón) ;
Moren, C. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Cuesta, Manuel J (Instituto de Investigación Sanitaria de Navarra) ;
Parellada, M. (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
González-Pinto, A. (Araba Unibertsitate Ospitalea) ;
Berrocoso, E. (Instituto de Investigación e Innovación Biomédica de Cádiz) ;
Bernardo, Miquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Mas, S. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Alonso-Solís, Anna (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Grasa, Eva (Institut d'Investigació Biomèdica Sant Pau) ;
Bergé Baquero, Daniel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Trabsa, Amira (Institut Hospital del Mar d'Investigacions Mèdiques) ;
2EPs Group
Little is known about the pathophysiological mechanisms of relapse in first-episode schizophrenia, which limits the study of potential biomarkers. To explore relapse mechanisms and identify potential biomarkers for relapse prediction, we analyzed gene expression in peripheral blood in a cohort of first-episode schizophrenia patients with less than 5 years of evolution who had been evaluated over a 3-year follow-up period. [...]
2021 - 10.1038/s41398-021-01645-8
Translational psychiatry, Vol. 11 Núm. 1 (december 2021) , p. 539
|
|
|
6.
|
|
14 p, 2.0 MB |
Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation
/
Diesch, Jeannine (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bywater, M. J. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ;
Sanij, E. (Department of Pathology. University of Melbourne) ;
Cameron, D. P. (Sir Peter MacCallum Department of Oncology. University of Melbourne) ;
Schierding, W. (Liggins Institute. The University of Auckland) ;
Brajanovski, N. (Cancer Research Division. Peter MacCallum Cancer Centre) ;
Son, J. (Sir Peter MacCallum Department of Oncology. University of Melbourne) ;
Sornkom, J. (Sir Peter MacCallum Department of Oncology. University of Melbourne) ;
Hein, N. (ACRF Department of Cancer Biology and Therapeutics. John Curtin School of Medical Research. Australian National University) ;
Evers, M. (ACRF Department of Cancer Biology and Therapeutics. John Curtin School of Medical Research. Australian National University) ;
Pearson, R. B. (Department of Biochemistry and Molecular Biology. University of Melbourne) ;
McArthur, G. A. (St Vincent's Hospital (Sydney)) ;
Ganley, A. R. D. (School of Biological Sciences. The University of Auckland) ;
O'Sullivan, J. M. (Liggins Institute. The University of Auckland) ;
Hannan, R. D. (School of Biomedical Sciences. University of Queensland) ;
Poortinga, G. (St Vincent's Hospital (Sydney)) ;
Universitat Autònoma de Barcelona
The three-dimensional organization of the genome contributes to its maintenance and regulation. While chromosomal regions associate with nucleolar ribosomal RNA genes (rDNA), the biological significance of rDNA-genome interactions and whether they are dynamically regulated during disease remain unclear. [...]
2019 - 10.1038/s42003-019-0284-y
Communications Biology, Vol. 2 Núm. 1 (january 2019) , p. 39
|
|
|
7.
|
|
13 p, 4.7 MB |
Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis
/
Agraz-Doblás, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rogers, R. B. (Department of Medicine. University of Cambridge. Cambridge Biomedical Campus) ;
Roy, A. (Department of Paediatrics. University of Oxford) ;
Schneider, P. (Princess Maxima Center for Pediatric Oncology) ;
Bardini, Michela (Università degli Studi di Milano-Bicocca) ;
Ballerini, Paola (Pediatric Hematology. A. Trousseau Hospital) ;
Cazzaniga, Giovanni (Centro Ricerca Tettamanti. Department of Pediatrics. University of Milano Bicocca. Fondazione MBBM) ;
Moreno, T. (Instituto de Biomedicina y Biotecnología de Cantabria. Universidad de Cantabria-CSIC) ;
Revilla, C. (Instituto de Biomedicina y Biotecnología de Cantabria. Universidad de Cantabria-CSIC) ;
Gut, Marta (Universitat Pompeu Fabra) ;
Valsecchi, M. G. (Interfant Trial Data Center. University of Milano-Bicocca) ;
Roberts, I. (MRC Molecular Haematology Unit. MRC Weatherall Institute of Molecular Medicine. University of Oxford) ;
Pieters, R. (Princess Maxima Center for Pediatric Oncology) ;
De Lorenzo, P. (Interfant Trial Data Center. University of Milano-Bicocca) ;
Varela, Ignacio (Instituto de Biomedicina y Biotecnología de Cantabria. Universidad de Cantabria-CSIC) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Stam, R. W. (Princess Maxima Center for Pediatric Oncology) ;
Universitat Autònoma de Barcelona
Bcell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell acute lymphoblastic leukemia remains fatal, especially in patients with t(4;11), present in ~80% of cases. The pathogenesis of t(4;11)/KMT2A-AFF1 (MLL-AF4) infant B-cell acute lymphoblastic leukemia remains difficult to model, and the pathogenic contribution in cancer of the reciprocal fusions resulting from derivative translocated-chromosomes remains obscure. [...]
2019 - 10.3324/haematol.2018.206375
Haematologica, Vol. 104 Núm. 6 (2019) , p. 1176-1188
|
|
|
8.
|
|
15 p, 2.9 MB |
MethCORR modelling of methylomes from formalin-fixed paraffin-embedded tissue enables characterization and prognostication of colorectal cancer
/
Mattesen, T. B. (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Rasmussen, M. H. (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Sandoval, J. (Instituto de Investigación Sanitaria La Fe) ;
Ongen, H. (Genetic Medicine and Development. University of Geneva Medical School-CMU) ;
Árnadóttir, S. S. (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Gladov, J. (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Martínez Cardús, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Castro de Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Madsen, A. H. (Department of Surgery. Hospitalsenheden Vest) ;
Laurberg, S. (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Dermitzakis, Emmanouil T (University of Geneva Medical School) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Andersen, Claus Lindbjerg (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Bramsen, Jesper Bertram (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Universitat Autònoma de Barcelona
Transcriptional characterization and classification has potential to resolve the inter-tumor heterogeneity of colorectal cancer and improve patient management. Yet, robust transcriptional profiling is difficult using formalin-fixed, paraffin-embedded (FFPE) samples, which complicates testing in clinical and archival material. [...]
2020 - 10.1038/s41467-020-16000-6
Nature communications, Vol. 11 Núm. 1 (january 2020) , p. 2025
|
|
|
9.
|
|
37 p, 10.2 MB |
Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals
/
Trevijano-Contador, Núria (Centro Nacional de Microbiología (Espanya)) ;
Oliveira, Haroldo César de (Universidade Estadual Paulista (UNESP). Departamento de Análises Clínicas) ;
García-Rodas, Rocío (Centro Nacional de Microbiología (Espanya)) ;
Rossi, Suélen Andreida (Centro Nacional de Microbiología (Espanya)) ;
Llorente Muñoz, Irene (Centro Nacional de Microbiología (Espanya)) ;
Zaballos, Ángel (Instituto de Salud Carlos III) ;
Janbon, Guilhem (Institut Pasteur. Département de Mycologie) ;
Ariño Carmona, Joaquín (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Zaragoza, Óscar (Centro Nacional de Microbiología (Espanya)) ;
Universitat Autònoma de Barcelona.
Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Cryptococcus neoformans is an encapsulated pathogenic yeast that can change the size of the cells during infection. In particular, this process can occur by enlarging the size of the capsule without modifying the size of the cell body, or by increasing the diameter of the cell body, which is normally accompanied by an increase of the capsule too. [...]
2018 - 10.1371/journal.ppat.1007007
PLOS pathogens, Vol. 14 issue 5 (2018) , art. e1007007
|
|
|
10.
|
|
visitante ::
identificación
alerta personal vía correo electrónico o subscríbase al 
canal RSS.
