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1.
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13 p, 4.8 MB |
Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition
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Mateo, Francesca (Institut d'Investigació Biomèdica de Bellvitge) ;
Arenas, E.J. (Institut de Recerca Biomèdica) ;
Aguilar, Helena (Institut d'Investigació Biomèdica de Bellvitge) ;
Serra-Musach, Jordi (Institut d'Investigació Biomèdica de Bellvitge) ;
Ruiz de Garibay, Gorka (Institut d'Investigació Biomèdica de Bellvitge) ;
Boni, Jacopo (Institut d'Investigació Biomèdica de Bellvitge) ;
Maicas, M. (Universidad de Navarra) ;
Du, S. (New York University School of Medicine) ;
Iorio, F. (Wellcome Trust Sanger Institute) ;
Herranz-Ors, Carmen (Institut d'Investigació Biomèdica de Bellvitge) ;
Islam, A. (University of Dhaka) ;
Prado, X. (Institut d'Investigació Biomèdica de Bellvitge) ;
Llorente, A. (Institut d'Investigació Biomèdica de Bellvitge) ;
Petit Montserrat, Anna (Hospital Universitari de Bellvitge) ;
Vidal, August (Hospital Universitari de Bellvitge) ;
Català, Isabel (Hospital Universitari de Bellvitge) ;
Soler, Teresa (Hospital Universitari de Bellvitge) ;
Venturas, G. (Hospital Universitari de Bellvitge) ;
Rojo-Sebastian, A. (MD Anderson Cancer Center) ;
Serra, H. (Institut d'Investigació Biomèdica de Bellvitge) ;
Cuadras, Daniel (Institut d'Investigació Biomèdica de Bellvitge) ;
Blanco, I. (Institut d'Investigació Biomèdica de Bellvitge) ;
Lozano, J. (Hospital Universitario Virgen de la Victoria) ;
Canals, Francesc (Hospital Universitari Vall d'Hebron) ;
Sieuwerts, A.M. (Cancer Genomics Centre) ;
De Weerd, V. (Cancer Genomics Centre) ;
Look, M.P. (Cancer Genomics Centre) ;
Puertas, Sara (Institut d'Investigació Biomèdica de Bellvitge) ;
García, N. (Institut d'Investigació Biomèdica de Bellvitge) ;
Perkins, A.S. (University of Rochester Medical Center) ;
Bonifaci, Nuria (Institut d'Investigació Biomèdica de Bellvitge) ;
Skowron, M. (Institut d'Investigació Biomèdica de Bellvitge) ;
Gómez-Baldó, Laia (Institut d'Investigació Biomèdica de Bellvitge) ;
Hernández, V. (Institut d'Investigació Biomèdica de Bellvitge) ;
Martínez-Aranda, Antonio (Institut d'Investigació Biomèdica de Bellvitge) ;
Martínez-Iniesta, Maria (Institut d'Investigació Biomèdica de Bellvitge) ;
Serrat Farran, Xènia (Institut d'Investigació Biomèdica de Bellvitge) ;
Cerón, Julián (Institut d'Investigació Biomèdica de Bellvitge) ;
Brunet, J. (Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta) ;
Barretina, M.P. (Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta) ;
Gil, Mercedes (Institut d'Investigació Biomèdica de Bellvitge) ;
Falo, Catalina (Institut d'Investigació Biomèdica de Bellvitge) ;
Fernández, A. (Institut d'Investigació Biomèdica de Bellvitge) ;
Morilla, I. (Institut d'Investigació Biomèdica de Bellvitge) ;
Pernas, Sonia (Institut d'Investigació Biomèdica de Bellvitge) ;
Plà, M.J. (Hospital Universitari de Bellvitge) ;
Andreu, Xavier (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Segui Palmer, Miquel Angel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Ballester, Rosa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Castellà Fernández, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Nellist, M. (Erasmus Medical Centre) ;
Morales, S. (Hospital Universitari Arnau de Vilanova) ;
Valls, J. (Hospital Universitari Arnau de Vilanova) ;
Velasco, A. (Hospital Universitari Arnau de Vilanova) ;
Matias-Guiu, X. (Hospital Universitari Arnau de Vilanova) ;
Figueras, Agnes (Institut d'Investigació Biomèdica de Bellvitge) ;
Sánchez-Mut, José Vicente (Institut d'Investigació Biomèdica de Bellvitge) ;
Sánchez-Céspedes, Montse (Institut d'Investigació Biomèdica de Bellvitge) ;
Cordero Casanovas, Alex (Institut d'Investigació Biomèdica de Bellvitge) ;
Gómez-Miragaya, Jorge (Institut d'Investigació Biomèdica de Bellvitge) ;
Palomero, Luis (Institut d'Investigació Biomèdica de Bellvitge) ;
Gómez, A. (Institut d'Investigació Biomèdica de Bellvitge) ;
Gajewski, T.F. (University of Chicago) ;
Cohen, E.E.W. (University of California San Diego) ;
Jesiotr, M. (Military Institute of Medicine) ;
Bodnar, L. (Military Institute of Medicine) ;
Quintela-Fandino, M. (Centro Nacional de Investigaciones Oncológicas) ;
López-Bigas, N. (Institució Catalana de Recerca i Estudis Avançats) ;
Valdés-Mas, R. (Universidad de Oviedo) ;
Puente, X.S. (Universidad de Oviedo) ;
Viñals, Francesc (Institut d'Investigació Biomèdica de Bellvitge) ;
Casanovas, O. (Institut d'Investigació Biomèdica de Bellvitge) ;
Graupera, M. (Institut d'Investigació Biomèdica de Bellvitge) ;
Hernández-Losa, Javier (Hospital Universitari Vall d'Hebron) ;
Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ;
García-Alonso, L. (European Molecular Biology Laboratory-European Bioinformatics Institute) ;
Saez-Rodriguez, J. (European Molecular Biology Laboratory-European Bioinformatics Institute) ;
Esteller, M. (Universitat de Barcelona) ;
Sierra, A. (Universitat de Vic - Universitat Central de Catalunya) ;
Martín-Martín, N. (Center for Cooperative Research in Biosciences) ;
Matheu, A. (Ikerbasque. Basque Foundation for Science) ;
Carracedo, A. (Universidad del País Vasco) ;
González-Suárez, Eva (Institut d'Investigació Biomèdica de Bellvitge) ;
Nanjundan, M. (University of South Florida) ;
Cortés, Javier (Hospital Universitari Vall d'Hebron) ;
Lázaro Garcia, Conxi (Institut d'Investigació Biomèdica de Bellvitge) ;
Odero, M.D. (Universidad de Navarra) ;
Martens, J.W.M. (Cancer Genomics Centre) ;
Moreno-Bueno, G. (Universidad Autónoma de Madrid) ;
Barcellos-Hoff, M.H. (New York University School of Medicine) ;
Villanueva, Alberto (Institut d'Investigació Biomèdica de Bellvitge) ;
Gomis, R.R. (Institució Catalana de Recerca i Estudis Avançats) ;
Genestar Pujana, Miguel Ángel (Institut d'Investigació Biomèdica de Bellvitge) ;
Universitat Autònoma de Barcelona
Inhibitors of the mechanistic target of rapamycin (mTOR) are currently used to treat advanced metastatic breast cancer. However, whether an aggressive phenotype is sustained through adaptation or resistance to mTOR inhibition remains unknown. [...]
2017 -  10.1038/onc.2016.427
Oncogene, Vol. 36 Núm. 19 (november 2017) , p. 2737-2749
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2.
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16 p, 3.4 MB |
Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolution
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Tomás Daza, Laureano (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rovirosa, Llorenç (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
López-Martí, Paula (Barcelona Supercomputing Center) ;
Nieto-Aliseda, Andrea (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Serra, François (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Planas-Riverola, Ainhoa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Molina, Oscar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
McDonald, Rebecca (Wellcome-MRC Cambridge Stem Cell Institute) ;
Ghevaert, Cedric (NHS Blood and Transplant) ;
Cuatrecasas, Esther (Hospital Sant Joan de Déu (Manresa)) ;
Costa, Dolors (Cancer Network Biomedical Research Center) ;
Camós, Mireia (Instituto de Salud Carlos III) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Menéndez, Pablo (Institució Catalana de Recerca i Estudis Avançats) ;
Valencia, Alonso (Institució Catalana de Recerca i Estudis Avançats) ;
Javierre, B. M (Institut Germans Trias i Pujol)
Long-range interactions between regulatory elements and promoters are key in gene transcriptional control; however, their study requires large amounts of starting material, which is not compatible with clinical scenarios nor the study of rare cell populations. [...]
2023 - 10.1038/s41467-023-35911-8
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 268
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3.
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27 p, 8.1 MB |
Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin
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Liang, Wen-Wei (Washington University in St. Louis) ;
Lu, Rita Jui-Hsien Lu (Washington University in St. Louis) ;
Jayasinghe, Reyka G. (Washington University in St. Louis) ;
Foltz, Steven M. (Washington University in St. Louis) ;
Porta-Pardo, Eduard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Geffen, Yifat (Massachusetts General Hospital) ;
Wendl, Michael C. (Department of Mathematics. Washington University in St. Louis) ;
Lazcano, Rossana (Departments of Pathology & Genomic Medicine. The University of Texas MD Anderson Cancer Center) ;
Kolodziejczak, Iga (Medical University of Warsaw) ;
Song, Yizhe (Washington University in St. Louis) ;
Govindan, Akshay (Washington University in St. Louis) ;
Demicco, Elisabeth G. (University of Toronto) ;
Li, Xiang (Washington University in St. Louis) ;
Li, Yize (Washington University in St. Louis) ;
Sethuraman, Sunantha (Washington University in St. Louis) ;
Payne, Samuel H. (Department of Biology. Brigham Young University) ;
Fenyö, David (Department of Biochemistry and Molecular Pharmacology. NYU Grossman School of Medicine) ;
Rodriguez, Henry (Office of Cancer Clinical Proteomics Research. National Cancer Institute) ;
Wiznerowicz, Maciej (Poznań University of Medical Sciences) ;
Shen, Hui (Van Andel Research Institute) ;
Mani, D.R. (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Rodland, Karin D. (Developmental. and Cancer Biology. Oregon Health & Science University) ;
Lazar, Alexander J. (Departments of Pathology & Genomic Medicine. The University of Texas MD Anderson Cancer Center) ;
Robles, Ana I. (Office of Cancer Clinical Proteomics Research) ;
Ding, Li (Washington University in St. Louis) ;
Universitat Autònoma de Barcelona
DNA methylation plays a critical role in establishing and maintaining cellular identity. However, it is frequently dysregulated during tumor development and is closely intertwined with other genetic alterations. [...]
2023 - 10.1016/j.ccell.2023.07.013
Cancer Cell, Vol. 41 Núm. 9 (november 2023) , p. 1567-1585.e7
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12 p, 2.5 MB |
Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell lymphoma in mice
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Galindo Campos, Miguel A. (Cancer Research Program. Hospital del Mar Medical Research Institute (IMIM)) ;
Lutfi, Nura (Cancer Research Program. Hospital del Mar Medical Research Institute (IMIM)) ;
Bonnin, Sarah (Centre de Regulació Genòmica) ;
Martínez Cáceres, Carlos (Instituto Murciano de Investigación Biosanitaria-Laboratorio de Investigación Biosanitaria-Arrixaca) ;
Velasco-Hernández, Talia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García-Hernández, Violeta (Cancer Research Program. Hospital del Mar Medical Research Institute (IMIM)) ;
Martín Caballero, Juan (Instituto Cajal. Consejo Superior de Investigaciones Científicas (CSIC)) ;
Ampurdanés, Coral (Cancer Research Program. Hospital del Mar Medical Research Institute (IMIM)) ;
Gimeno, Ramón (Laboratory of Immunology. Department of Pathology) ;
Colomo, Lluís (Hospital del Mar (Barcelona, Catalunya)) ;
Roué, Gaël (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guilbaud, Guillaume (Division of Protein and Nucleic Acid Chemistry. Medical Research Council Laboratory of Molecular Biology) ;
Dantzer, Françoise (Biotechnology and Cell Signaling. Unité Mixte de Recherche (UMR) 7242 Centre National de la Recherche Scientifique. Laboratory of Excellence Medalis. École Supérieure de Biotechnologie de Strasbourg. Strasbourg University) ;
Navarro, Pilar (Hospital del Mar Medical Research Institute. Unidad Asociada IIBB-CSIC) ;
Murga, Matilde (Genomic Instability Group. Spanish National Cancer Research Centre) ;
Fernández Capetillo, Oscar (Science for Life Laboratory. Department of Medical Biochemistry and Biophysics. Karolinska Institutet) ;
Bigas Salvans, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sale, Julian E. (Division of Protein and Nucleic Acid Chemistry. Medical Research Council Laboratory of Molecular Biology) ;
Yélamos, José (Laboratory of Immunology. Department of Pathology)
Dysregulation of the c-Myc oncogene occurs in a wide variety of hematologic malignancies, and its overexpression has been linked with aggressive tumor progression. Here, we show that poly (ADP-ribose) polymerase 1 (PARP-1) and PARP-2 exert opposing influences on progression of c-Myc-driven B-cell lymphoma. [...]
2022 - 10.1182/blood.2021012805
Blood, Vol. 139 Núm. 2 (13 2022) , p. 228-239
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5.
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11 p, 5.0 MB |
Fibroblast activation and abnormal extracellular matrix remodelling as common hallmarks in three cancer-prone genodermatoses
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Chacón-Solano, Esteban (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
León Canseco, Carlos (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
Díaz, F. (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
García-García, Francisco (Bioinformatics and Biostatistics Unit. Centro de Investigación Príncipe Felipe (CIPF)) ;
García, M. (Epithelial Biomedicine Division. CIEMAT-CIBERER (U714)) ;
Escámez Toledano, María José (Epithelial Biomedicine Division. CIEMAT-CIBERER (U714)) ;
Guerrero-Aspizua, Sara (Epithelial Biomedicine Division. CIEMAT-CIBERER (U714)) ;
Conti, C.J. (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
Mencía, None (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
Martínez-Santamaría, L. (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
Llames, S. (Tissue Engineering Unit. Centro Comunitario Sangre y Tejidos (CCST)) ;
Pévida, M. (Tissue Engineering Unit. Centro Comunitario Sangre y Tejidos (CCST)) ;
Carbonell-Caballero, J. (Department of Computational Genomics. Centro de Investigación Príncipe Felipe (CIPF)) ;
Puig-Butille, Joan Anton (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Maseda, R. (Department of Pediatric Dermatology. La Paz Hospital) ;
Puig, Susana (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
de Lucas, R. (Department of Pediatric Dermatology. La Paz Hospital) ;
Baselga Torres, Eulàlia (Institut d'Investigació Biomèdica Sant Pau) ;
Larcher, F. (Epithelial Biomedicine Division. CIEMAT-CIBERER (U714)) ;
Dopazo, J. (Bioinformatics in Rare Diseases (BiER-U715). CIBERER. FPS. Hospital Virgen del Rocío) ;
del Río, M. (Epithelial Biomedicine Division. CIEMAT-CIBERER (U714))
Background: Recessive dystrophic epidermolysis bullosa (RDEB), Kindler syndrome (KS) and xeroderma pigmentosum complementation group C (XPC) are three cancer-prone genodermatoses whose causal genetic mutations cannot fully explain, on their own, the array of associated phenotypic manifestations. [...]
2019 - 10.1111/bjd.17698
British journal of dermatology, Vol. 181 Núm. 3 (january 2019) , p. 512-522
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16 p, 1.5 MB |
Development and carotenoid synthesis in dark-grown carrot taproots require PHYTOCHROME RAPIDLY REGULATED1
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Arias, Daniela (Universidad de Chile. Centro de Biología Molecular Vegetal) ;
Ortega, Angélica (Universidad de Chile. Centro de Biología Molecular Vegetal) ;
González-Calquin, Christian (Universidad de Chile. Centro de Biología Molecular Vegetal) ;
Quiroz Iturra, Luis Felipe (Universidad de Chile. Centro de Biología Molecular Vegetal) ;
Moreno Romero, Jordi (Centre de Recerca en Agrigenòmica) ;
Martínez García, Jaime F. (Centre de Recerca en Agrigenòmica) ;
Stange, Claudia (Universidad de Chile. Centro de Biología Molecular Vegetal)
Light stimulates carotenoid synthesis in plants during photomorphogenesis through the expression of PHYTOENE SYNTHASE (PSY), a key gene in carotenoid biosynthesis. The orange carrot (Daucus carota) synthesizes and accumulates high amounts of carotenoids in the taproot that grows underground. [...]
2022 - 10.1093/plphys/kiac097
Plant physiology, Vol. 189, Issue 3 (July 2022) , p. 1450-1465
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7.
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33 p, 5.0 MB |
SAUR63 stimulates cell growth at the plasma membrane
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Nagpal, Punita (Université de Lyon. Laboratoire Reproduction et Développement des Plantes) ;
Reeves, Paul (University of North Carolina at Chapel Hill. Department of Biology) ;
Wong, Jeh Haur (University of Minnesota. Department of Plant and Microbial Biology) ;
Armengot, Laia (Centre de Recerca en Agrigenòmica) ;
Chae, Keun (University of North Carolina at Chapel Hill. Department of Biology) ;
Rieveschl, Nathaniel (University of North Carolina at Chapel Hill. Department of Biology) ;
Trinidad, Brendan (University of North Carolina at Chapel Hill. Department of Biology) ;
Davidsdottir, Vala (University of North Carolina at Chapel Hill. Department of Biology) ;
Jain, Prateek (University of North Carolina at Chapel Hill. Department of Biology) ;
Gray, William (University of Minnesota. Department of Plant and Microbial Biology) ;
Jaillais, Yvon (Université de Lyon. Laboratoire Reproduction et Développement des Plantes) ;
Reed, Jason (Université de Lyon. Laboratoire Reproduction et Développement des Plantes)
In plants, regulated cell expansion determines organ size and shape. Several members of the family of redundantly acting Small Auxin Up RNA (SAUR) proteins can stimulate plasma membrane (PM) H+-ATPase proton pumping activity by inhibiting PM-associated PP2C. [...]
2022 - 10.1371/journal.pgen.1010375
PLoS Genetics, Vol. 18, Num. 9 (September 2022) , art. e1010375
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8.
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20 p, 1.3 MB |
Early prognostic performance of miR155-5p monitoring for the risk of rejection : Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients
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Quintairos, Luis (Hospital Clínic i Provincial de Barcelona) ;
Colom, Helena (Universitat de Barcelona. Departament de Farmacologia, Toxicologia i Química Terapèutica) ;
Millan, Olga (Instituto de Salud Carlos III) ;
Fortuna, Virginia (Hospital Clínic i Provincial de Barcelona) ;
Espinosa, Cristina (Hospital Clínic i Provincial de Barcelona) ;
Guirado, Luis (Institut d'Investigació Biomèdica Sant Pau) ;
Budde, K (Charité - Universitätsmedizin Berlin) ;
Sommerer, Claudia (Heidelberg University Hospital (Alemanya)) ;
Lizana, Ana (Hospital Clínic i Provincial de Barcelona) ;
Lopez-Pua, Yolanda (Hospital Clínic i Provincial de Barcelona) ;
Brunet, Mercè (Instituto de Salud Carlos III)
Previous results from our group and others have shown that urinary pellet expression of miR155-5p and urinary CXCL-10 production could play a key role in the prognosis and diagnosis of acute rejection (AR) in kidney transplantation patients. [...]
2021 - 10.1371/journal.pone.0245880
PloS one, Vol. 16 Núm. 1 January (january 2021) , p. e0245880
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9.
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17 p, 1.3 MB |
Genome-wide association study of circulating interleukin 6 levels identifies novel loci
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Ahluwalia, Tarunveer Singh (University of Copenhagen) ;
Prins, Bram Peter (University of Groningen) ;
Abdollahi, Mohammadreza (University of Groningen) ;
Armstrong, Nicola (Murdoch University) ;
Aslibekyan, Stella (University of Alabama at Birmingham School of Public Health) ;
Bain, Lisa J (Qimr Berghofer Medical Research Institute) ;
Jefferis, Barbara (University College London) ;
Baumert, Jens (Helmholtz Zentrum München-German Research Center for Environmental Health) ;
Beekman, Marian (Leiden University Medical Center) ;
Ben-Shlomo, Yoav (University of Bristol) ;
Bis, Joshua C (University of Washington) ;
Mitchell, Braxton D. (University of Maryland School of Medicine) ;
de Geus, Eco J. C (Amsterdam UMC. University Medical Center) ;
Delgado, Graciela E. (University of Heidelberg) ;
Marek, Diana (Sib Swiss Institute of Bioinformatics) ;
Eriksson, Joel (University of Gothenburg) ;
Kajantie, Eero (Helsinki University Central Hospital and University of Helsinki) ;
Kanoni, Stavroula (Queen Mary University of London) ;
Kemp, John P. (University of Bristol) ;
Lu, Chen (Boston University School of Public Health) ;
Marioni, Riccardo E. (University of Edinburgh) ;
McLachlan, Stela (University of Edinburgh) ;
Milaneschi, Yuri (Amsterdam Umc. Vrije Universiteit) ;
Nolte, Ilja M. (University of Groningen) ;
Petrelis, Alexandros M. (Université de Lorraine) ;
Porcu, Eleonora (Consiglio Nazionale Delle Ricerche) ;
Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Naderi, Elnaz (University of Groningen) ;
Seppälä, Ilkka (Tampere University) ;
Shah, Tina (University College London) ;
Singhal, Gaurav (University of Adelaide) ;
Standl, Marie (Helmholtz Zentrum München-German Research Center for Environmental Health) ;
Teumer, Alexander (University Medicine Greifswald) ;
Thalamuthu, Anbupalam (University of New South Wales) ;
Thiering, Elisabeth (Ludwig-Maximilians-University of Munich. Dr. von Hauner Children's Hospital) ;
Trompet, Stella (Leiden University Medical Center) ;
Ballantyne, Christie M. (Baylor College of Medicine) ;
Benjamin, Emelia J. (Boston University School of Medicine) ;
Casas, Juan P. (Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC). Va Boston Healthcare System) ;
Toben, Catherine (University of Adelaide) ;
Dedoussis, George (Harokopio University) ;
Deelen, Joris (Max Planck Institute for Biology of Ageing) ;
Durda, Peter (Larner College of Medicine. University of Vermont) ;
Engmann, Jorgen (University College London) ;
Feitosa, Mary (Washington University School of Medicine) ;
Grallert, Harald (German Center for Diabetes Research (DZD)) ;
Hammarstedt, Ann (Sahlgrenska Academy at the University of Gothenburg) ;
Harris, Sarah E (University of Edinburgh) ;
Homuth, Georg (University Medicine Greifswald) ;
Hottenga, Jouke Jan (Amsterdam UMC. University Medical Center) ;
Jalkanen, Sirpa (University of Turku) ;
Jamshidi, Yalda (St George's University of London) ;
Jawahar, Magdalene C. (University of Adelaide) ;
Jess, Tine (Statens Serum Institute) ;
Kivimaki, Mika (University College London) ;
Kleber, Marcus E. (University of Heidelberg) ;
Lahti, Jari (University of Helsinki) ;
Liu, Yongmei (Wake Forest School of Medicine) ;
Marques-Vidal, Pedro (University of Lausanne) ;
Mellström, Dan (Sahlgrenska Academy at the University of Gothenburg. Centre for Bone and Arthritis Research) ;
Mooijaart, Simon P. (Leiden University Medical Center) ;
Müller-Nurasyid, Martina (Johhanes Gutenberg University) ;
Penninx, Brenda WJH (Amsterdam Umc. Vrije Universiteit) ;
Revez, Joana A. (Qimr Berghofer Medical Research Institute) ;
Rossing, Peter (University of Copenhagen) ;
Raïkkönen, Katri (University of Helsinki) ;
Sattar, Naveed (Bhf Glasgow Cardiovascular Research Centre) ;
Scharnagl, Hubert (Medical University of Graz) ;
Sennblad, Bengt (Uppsala University) ;
Silveira, Angela (Karolinska Institutet (Estocolm, Suècia)) ;
Pourcain, Beate St (Radboud University) ;
Timpson, Nicholas J. (University of Bristol) ;
Trollor, Julian (University of New South Wales) ;
Van Dongen, Jenny (Amsterdam UMC. University Medical Center) ;
Van Heemst, Diana (Baylor College of Medicine) ;
Visvikis-Siest, Sophie (Université de Lorraine. Inserm. IGE-PCV) ;
Vollenweider, Peter (University of Lausanne) ;
Völker, Uwe (University of Turku) ;
Waldenberger, Melanie (Helmholtz Zentrum München-German Research Center for Environmental Health) ;
Willemsen, Gonneke (Amsterdam UMC. University Medical Center) ;
Zabaneh, Delilah (University College London Genetics Institute) ;
Morris, Richard W. (Bristol Medical School. University of Bristol) ;
Arnett, Donna K. (University of Kentucky) ;
Baune, Bernhard T. (University of Melbourne) ;
Boomsma, Dorret I. (Amsterdam UMC. University Medical Center) ;
Chang, Yen-Pei C. (University of Maryland School of Medicine) ;
Deary, Ian J. (University of Edinburgh) ;
Deloukas, Panos (Queen Mary University of London) ;
Eriksson, Johan G. (University of Helsinki) ;
Evans, David M. (University of Bristol) ;
Ferreira, Manuel A. (Qimr Berghofer Medical Research Institute) ;
Gaunt, Tom (University of Bristol) ;
Gudnason, Vilmundur (University of Iceland) ;
Hamsten, Anders (Karolinska Institutet (Estocolm, Suècia)) ;
Heinrich, Joachim (University of Melbourne) ;
Hingorani, Aroon (University College London) ;
Humphries, Steve E. (University College London) ;
Jukema, J. Wouter (Durrer Center for Cardiogenetic Research) ;
Koenig, Wolfgang (University of Ulm) ;
Kumari, Meena (University of Essex) ;
Kutalik, Zoltan (University of Lausanne) ;
Lawlor, Deborah A. (University of Bristol) ;
Lehtimäki, Terho (Tampere University) ;
März, Winfried (Synlab Academy. Synalb Holding Deutschland GmbH) ;
Mather, Karen A (Neuroscience Research Australia) ;
Naitza, Silvia. (Consiglio Nazionale Delle Ricerche) ;
Nauck, Matthias (Dzhk (German Center for Cardiovascular Research). Partner Site Greifswald) ;
Ohlsson, Claes (University of Gothenburg) ;
Price, Jackie F. (University of Edinburgh) ;
Raitakari, Olli (Turku University Hospital (Finlàndia)) ;
Rice, Ken (University of Washington) ;
Sachdev, Perminder S. (Prince of Wales Hospital (Australia)) ;
Slagboom, Pieternella Eline (Max Planck Institute for Biology of Ageing) ;
Sørensen, Thorkild I.A. (University of Copenhagen. Department of Public Health. Section on Epidemiology) ;
Spector, Tim (King's College London. Department of Twin Research and Genetic Epidemiology) ;
Stacey, David (University of Cambridge) ;
Stathopoulou, Maria G. (Université de Lorraine. Inserm. IGE-PCV) ;
Tanaka, Toshiko (National Institute on Aging (Estats Units d'Amèrica)) ;
Wannamethee, Sasiwarang Goya (University College London) ;
Whincup, Peter (University of London) ;
Rotter, Jerome I. (The Lundquist Institute at Harbor-UCLA Medical Center) ;
Dehghan, Abbas (Erasmus Mc) ;
Boerwinkle, Eric (Baylor College of Medicine) ;
Psaty, Bruce M. (University of Washington) ;
Snieder, Harold (University Medical Center Groningen) ;
Alizadeh, Behrooz Ziad (University Medical Center Groningen)
Interleukin 6 (IL-6) is a multifunctional cytokine with both pro-A nd anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. [...]
2021 - 10.1093/hmg/ddab023
Human Molecular Genetics, Vol. 30 Núm. 5 (january 2021) , p. 393-409
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Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease
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García Gómez, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Li, Tianlu (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
de la Calle-Fabregat, Carlos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rodríguez-Ubreva, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Català-Moll, Francesc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Godoy-Tena, Gerard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martín Sánchez, Montserrat (Universidad de Salamanca) ;
San Segundo, Laura (Universidad de Salamanca) ;
Muntión, Sandra (Universidad de Salamanca) ;
Morales, Xabier (Universidad de Navarra) ;
Ortiz de Solórzano, Carlos (Universidad de Navarra) ;
Oyarzabal, Julen (Universidad de Navarra) ;
San José Enériz, Edurne (Universidad de Navarra) ;
Esteller, M (Universitat de Barcelona. Departament de Ciències Fisiològiques) ;
Agirre, Xabier (Universidad de Navarra) ;
Prosper, Felipe (Universidad de Navarra) ;
Garayoa, Mercedes (Universidad de Salamanca) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epigenetic mechanisms governing their tumor-promoting functions and prolonged osteoblast suppression. [...]
2021 - 10.1038/s41467-020-20715-x
Nature communications, Vol. 12 Núm. 1 (december 2021) , p. 421
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