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1.
12 p, 3.3 MB Spanish cohort of VEXAS syndrome : clinical manifestations, outcome of treatments and novel evidences about UBA1 mosaicism / Mascaro, Jose Manuel (Hospital Clínic i Provincial de Barcelona) ; Rodriguez-Pinto, Ignasi (Hospital Universitari MútuaTerrassa) ; Poza, Gabriela (Hospital Universitario Virgen de la Arrixaca) ; Mensa-Vilaro, Anna (Hospital Clínic i Provincial de Barcelona) ; Fernández-Martín, Julián (Hospital Álvaro Cunqueiro) ; Caminal-Montero, Luis (Instituto de Investigación Sanitaria del Principado de Asturias) ; Espinosa, Gerard (Hospital Clínic i Provincial de Barcelona) ; Hernández Rodríguez, José (Hospital Clínic i Provincial de Barcelona) ; Diaz, Marina (Hospital Clínic i Provincial de Barcelona) ; Rita-Marques, Joana (Hospital Universitari Vall d'Hebron) ; Sanmartí, Raimon (Hospital Clínic i Provincial de Barcelona) ; Castañeda, Santos (Universidad Autónoma de Madrid) ; Colunga, Dolores (Hospital Universitario Central de Asturias) ; Coto-Hernández, Rubén (Instituto de Investigación Sanitaria del Principado de Asturias) ; Fanlo, Patricia (Hospital Universitario de Navarra) ; Elejalde, Jose Ignacio (Hospital Universitario de Navarra) ; Segundo, Bujan (Hospital Universitari Vall d'Hebron) ; Figueras, Ignasi (Hospital Universitari de Bellvitge) ; Marco, Francisco Manuel (Hospital General Universitario de Alicante Dr Balmis) ; Andrés, Mariano (Universidad Miguel Hernandez de Elche) ; Suárez, Silvia (Hospital Valle del Nalón) ; Gonzalez-Garcia, Andres (Hospital Universitario Ramón y Cajal) ; Fustà-Novell, Xavier (Fundació Althaia de Manresa) ; Garcia-Belando, Clara (Hospital Universitario Virgen de la Arrixaca) ; Granados-Maturano, Ana (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ; Fernandez Figueras, Maria Teresa (Hospital Universitari General de Catalunya) ; Quilis, Neus (Hospital Universitari de Vinalopo) ; Orriols-Caba, Maria (Hospital comarcal Alt Penedès) ; Gómez de la Torre, Ricardo (Hospital Universitario Central de Asturias) ; Cid, María Cinta (Hospital Clínic i Provincial de Barcelona) ; Espígol-Frigolé, Georgina (Hospital Clínic i Provincial de Barcelona) ; Alvarez-Abella, Alba (Hospital Universitari MútuaTerrassa) ; Labrador, Eztizen (Hospital San Pedro) ; Rozman, Maria (Hospital Clínic i Provincial de Barcelona) ; Lopez-Guerra, Monica (Hospital Clínic i Provincial de Barcelona) ; Castillo, Paola (Hospital Clínic i Provincial de Barcelona) ; Alamo-Moreno, Jose R (Hospital Clínic i Provincial de Barcelona) ; Gonzalez-Roca, Eva (Hospital Clínic i Provincial de Barcelona) ; Plaza, Susana (Hospital Clínic i Provincial de Barcelona) ; Fabregat, Virginia (Hospital Clínic i Provincial de Barcelona) ; Lara, Rocio (Hospital Clínic i Provincial de Barcelona) ; Vicente-Rabaneda, Esther F (Universidad Autónoma de Madrid) ; Tejedor Vaquero, Sonia (Institut Hospital del Mar d'Investigacions Mèdiques) ; Magri, Giuliana (Institut Hospital del Mar d'Investigacions Mèdiques) ; Bonet, Nuria (Universitat Pompeu Fabra) ; Solis-Moruno, Manuel (Universitat Pompeu Fabra) ; Cerutti, Andrea (Institut Hospital del Mar d'Investigacions Mèdiques) ; Fornas, Òscar (Universitat Pompeu Fabra) ; Casals, Ferran (Universitat de Barcelona) ; Yagüe, Jordi (Hospital Clínic i Provincial de Barcelona) ; Aróstegui, Juan Ignacio (Hospital Clínic i Provincial de Barcelonaa) ; Universitat Autònoma de Barcelona
The vacuoles, E1-enzyme, X linked, autoinflammatory and somatic (VEXAS) syndrome is an adult-onset autoinflammatory disease (AID) due to postzygotic UBA1 variants. To investigate the presence of VEXAS syndrome among patients with adult-onset undiagnosed AID. [...]
2023 - 10.1136/ard-2023-224460
Annals of the rheumatic diseases, Vol. 82 (september 2023) , p. 1594-1605  
2.
10 p, 1.2 MB Association of candidate gene polymorphisms with chronic kidney disease : Results of a case-control analysis in the NEFRONA cohort / Valls, Joan (Instituto de Salud Carlos III) ; Cambray, Serafí (Instituto de Salud Carlos III) ; Pérez-Guallar, Carles (Instituto de Salud Carlos III) ; Bozic, Milica (Instituto de Salud Carlos III) ; Bermúdez-López, Marcelino (Instituto de Salud Carlos III) ; Fernández, Elvira (Instituto de Salud Carlos III) ; Betriu, Àngels (Instituto de Salud Carlos III) ; Rodríguez, Isabel (Instituto de Salud Carlos III) ; Valdivielso, José M. (Instituto de Salud Carlos III) ; Aladrén Regidor, Mª José (Hospital Comarcal Ernest Lluch) ; Almirall Daly, Jaume (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ; Ponz, Esther (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ; Arteaga Coloma, Jesús (Complejo Hospitalario de Navarra) ; Bajo Rubio, Mª Auxiliadora (Raquel Hospital la Paz) ; Díaz, Raquel (Raquel Hospital la Paz) ; Belart Rodríguez, Montserrat (Sistemes Renals) ; Gascón, Antonio (Hospital Obispo Polanco) ; Bover, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Bronsoms Artero, Josep (Clínica Girona) ; Cabezuelo Romero, Juan B. (Hospital Universitario Reina Sofía (Córdoba, Espanya)) ; Muray Cases, Salomé (Hospital Universitario Reina Sofía (Córdoba, Espanya)) ; Calviño Varela, Jesús (Hospital Universitario Lucus Augusti (Lugo)) ; Caro Acevedo, Pilar (Clínica Ruber) ; Carreras Bassa, Jordi (Diaverum Baix Llobregat) ; Cases Amenós, Aleix (Hospital Clínic i Provincial de Barcelona) ; Massó Jiménez, Elisabet (Hospital Clínic i Provincial de Barcelona) ; Moreno López, Rosario (Hospital de la Defensa) ; Cigarrán Guldris, Secundino (Hospital da Costa) ; López Prieto, Saray (Hospital da Costa) ; Comas Mongay, Lourdes (Hospital General de Vic) ; Comerma, Isabel (Hospital General de Manresa) ; Compte Jové, MªTeresa (Hospital de la Santa Creu de Jesús) ; Cuberes Izquierdo, Marta (Hospital Universitario Reina Sofía (Córdoba, Espanya)) ; De Álvaro, Fernando (Hospital Universitario Infanta Sofía (San Sebastián de los Reyes)) ; Hevia Ojanguren, Covadonga (Hospital Universitario Infanta Sofía (San Sebastián de los Reyes)) ; De Arriba De La Fuente, Gabriel (Hospital Universitario de Guadalajara) ; Del Pino Y Pino, Mª Dolores (Complejo Hospitalario Torrecardenas de Almeria) ; Diaz-Tejeiro Izquierdo, Rafael (Francisco Hospital Virgen de la Salud) ; Hormigos, Ahijado (Francisco Hospital Virgen de la Salud) ; Dotori, Marta (USP Marbella) ; Duarte, Verónica (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Estupiñan Torres, Sara (Hospital Universitario de Canarias (La Laguna)) ; Fernández Reyes, MªJosé (Hospital de Segovia) ; Fernández Rodríguez, Mª Loreto (Hospital Príncipe de Asturias) ; Fernández, Guilermina (Clínica Santa Isabel) ; Galán Serrano, Antonio (Hospital General Universitari de València) ; García Cantón, Cesar (Hospital Universitario Insular de Gran Canaria) ; García Herrera, Antonio L. (Hospital Universitario Puerto Real (Cadis)) ; García Mena, Mercedes (Hospital San Juan de Dios) ; Gil Sacaluga, Luis (Hospital Virgen Del Rocío) ; Aguilar, Maria (Hospital Virgen Del Rocío) ; Górriz, José Luis (Hospital Universitari Doctor Peset (València)) ; Huarte Loza, Emma (Hospital San Pedro de Alcántara) ; Lerma, José Luis (Hospital Universitario de Salamanca) ; Liebana Cañada, Antonio (Hospital de Jaén) ; Marín Álvarez, Jesús Pedro. (Hospital San Pedro de Alcántara) ; Martín Alemany, Nadia (Hospital Universitari de Girona Doctor Josep Trueta) ; Martín García, Jesús (Hospital Nuestra Señora de Sonsoles (Àvila)) ; Martínez Castelao, Alberto (Hospital Universitari de Bellvitge) ; Martínez Villaescusa, María (Complejo Hospitalario Universitario de Albacete) ; Martínez, Isabel (Hospital Galdakao) ; Moina Eguren, Iñigo (Hospital Basurto) ; Moreno Los Huertos, Silvia (Hospital Santa Bárbara) ; Mouzo Mirco, Ricardo (Hospital El Bierzo Ponferrada) ; Munar Vila, Antonia (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ; Muñoz Díaz, Ana Beatriz (Hospital Vithas Nisa Virgen Del Consuelo) ; Navarro González, Juan F. (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ; Nieto, Javier (Hospital General Universitario de Ciudad Real) ; Carreño, Agustín (Hospital General Universitario de Ciudad Real) ; Novoa Fernández, Enrique (Complexo Hospitalario de Ourense) ; Ortiz, Alberto (Fundacion Jimenez Diaz) ; Fernandez, Beatriz (Fundacion Jimenez Diaz) ; Paraíso, Vicente (Hospital Universitario del Henares (Madrid)) ; Pérez Fontán, Miguel (Complejo Hospitalario Universitario de A Coruña) ; Peris Domingo, Ana (Hospital Francesc de Borja) ; Piñera Haces, Celestino (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Prados Garrido, Mª Dolores (Hospital Universitario San Cecilio (Granada)) ; Prieto Velasco, Mario (Hospital Universitario de León) ; Puig Marí, Carmina (Hospital D'Igualada) ; Rivera Gorrín, Maite (Hospital Universitario Ramón y Cajal (Madrid)) ; Rubio, Esther (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ; Ruiz, Pilar (Hospital de Sant Joan Despí Moisès Broggi) ; Salgueira Lazo, Mercedes (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ; Martínez Puerto, Ana Isabel (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ; Sánchez Tomero, José Antonio (Hospital Universitario de la Princesa (Madrid)) ; Sánchez, José Emilio (Hospital Universitario Central de Asturias) ; Sans Lorman, Ramon (Hospital de Figueres) ; Saracho, Ramon (Hospital de Santiago) ; Sarrias, Maria (Hospital Universitari Vall d'Hebron) ; Seron, Daniel (Hospital Universitari Vall d'Hebron) ; Soler, María José (Hospital del Mar (Barcelona, Catalunya)) ; Barrios, Clara (Hospital del Mar (Barcelona, Catalunya)) ; Sousa, Fernando (Hospital Rio Carrión) ; Toran, Daniel (Hospital General de Jerez) ; Tornero Molina, Fernando (Hospital Universitario Del Sureste) ; Usón Carrasco, José Javier (Hospital Virgen de La Luz (Cuenca)) ; Valera Cortes, Iidefonso (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ; Vilaprinyo del Perugia, Mª Merce (Institut Catala d'Urologia i Nefrologia) ; Virto Ruiz, Rafael C. (Hospital San Jorge) ; Carratalá, Vicente Pallarés (Clinica MEDEFIS) ; Altozano, Carlos Santos (CS Azuqueca de Henares) ; Ródenas, Miguel Artigao (CS Zona III) ; Gil, Inés Gil (Área Básica Sanitaria de Arán) ; Gil, Francisco Adan (CS Alfaro) ; Criado, Emilio García (Centro de Salud Del Carpio) ; Belinchón, Rafael Durá (CS Godella) ; Ma Fernández Toro, Jose (CS Zona Centro) ; Antonio Divisón Garrote, Juan (Consultorio de Fuentealbilla) ; Universitat Autònoma de Barcelona
Chronic kidney disease (CKD) is a major risk factor for end-stage renal disease, cardiovascular disease and premature death. Despite classical clinical risk factors for CKD and some genetic risk factors have been identified, the residual risk observed in prediction models is still high. [...]
2019 - 10.3389/fgene.2019.00118
Frontiers in genetics, Vol. 10 Núm. FEB (2019) , p. 118  
3.
16 p, 1.1 MB Genetics in chronic kidney disease : conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference / Köttgen, Anna (Institute of Genetic Epidemiology. Faculty of Medicine and Medical Center. University of Freiburg) ; Cornec-Le Gall, Emilie (Univ Brest. INSERM UMR 1078. GGB. CHU Brest) ; Halbritter, Jan (Charité - Universitätsmedizin Berlin) ; Kiryluk, Krzysztof (Division of Nephrology and Center for Precision Medicine and Genomics. Department of Medicine. Columbia University Irving Medical Center) ; Mallett, Andrew (KidGen Collaborative. Australian Genomics Health Alliance) ; Parekh, Rulan (Dalla Lana School of Public Health. and Health Policy. Management and Evaluation. University of Toronto) ; Rasouly, Hila Milo (Division of Nephrology and Center for Precision Medicine and Genomics. Department of Medicine. Columbia University Irving Medical Center) ; Sampson, Matthew G. (Kidney Disease Initiative. Broad Institute of MIT and Harvard) ; Tin, Adrienne (Division of Nephrology. University of Mississippi Medical Center) ; Antignac, Corinne (Department of Genetics. Necker Hospital. APHP) ; Ars, Elisabet (Institut d'Investigació Biomèdica Sant Pau) ; Bergmann, Carsten (Department of Nephrology. Faculty of Medicine and Medical Center. University of Freiburg) ; Bleyer, Anthony J. (Section on Nephrology. Wake Forest School of Medicine) ; Bockenhauer, Detlef (Department of Renal Medicine. University College London) ; Devuyst, Olivier (Department of Physiology. Mechanisms of Inherited Kidney Disorders Group. University of Zurich) ; Florez, Jose C. (Department of Medicine. Harvard Medical School) ; Fowler, Kevin J. (The Voice of the Patient. Inc.) ; Franceschini, Nora (Department of Epidemiology. Gillings School of Global Public Health. University of North Carolina) ; Fukagawa, Masafumi (Division of Nephrology. Endocrinology and Metabolism. Tokai University School of Medicine) ; Gale, Daniel (Rare Renal Disease Registry. UK Renal Registry) ; Gbadegesin, Rasheed A. (Department of Pediatrics. Division of Nephrology. Duke University Medical Center) ; Goldstein, David B. (Department of Genetics and Development. Columbia University) ; Grams, Morgan E. (Department of Nephrology. Johns Hopkins University School of Medicine) ; Greka, Anna (Department of Medicine. Brigham and Women's Hospital. Harvard Medical School) ; Gross, Oliver (University Medical Center Göttingen) ; Guay-Woodford, Lisa M. (Center for Translational Science. Children's National Health System) ; Harris, Peter C. (Division of Nephrology and Hypertension. Mayo Clinic) ; Hoefele, Julia (Technische Universität München. Institut für Humangenetik) ; Hung, Adriana M. (VA Tennessee Valley Healthcare System. Division of Nephrology and Hypertension. Department of Medicine. Vanderbilt Center for Kidney Disease. Vanderbilt Precision Nephrology Program. Vanderbilt University Medical Center) ; Knoers, Nine V.A.M. (Department of Genetics. University Medical Center Groningen) ; Kopp, Jeffrey B. (Kidney Disease Section. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). National Institutes of Health (NIH)) ; Kretzler, Matthias (Department of Computational Medicine and Bioinformatics. University of Michigan) ; Lanktree, Matthew B. (Department of Medicine. McMaster University) ; Lipska-Ziętkiewicz, Beata S. (Rare Diseases Centre and Clinical Genetics Unit. Department of Biology and Medical Genetics. Medical University of Gdansk) ; Nicholls, Kathleen (Department of Nephrology. Royal Melbourne Hospital. University of Melbourne) ; Nozu, Kandai (Department of Pediatrics. Kobe University Graduate School of Medicine) ; Ojo, Akinlolu (University of Kansas School of Medicine) ; Parsa, Afshin (Department of Medicine. University of Maryland School of Medicine) ; Pattaro, Cristian (Eurac Research. Institute for Biomedicine (affiliated with the University of Lübeck)) ; Pei, York (Division of Nephrology. University Health Network) ; Pollak, Martin R. (Division of Nephrology. Beth Israel Deaconess Medical Center. Harvard Medical School) ; Rhee, Eugene P. (Massachusetts General Hospital) ; Sanna-Cherchi, Simone (Columbia University) ; Savige, Judy (The University of Melbourne) ; Sayer, John (NIHR Newcastle Biomedical Research Centre) ; Scolari, Francesco (Department of Medical and Surgical Specialties. University of Brescia) ; Sedor, John R. (Case Western Reserve University. Department of Physiology and Biophysics) ; Sim, Xueling (Saw Swee Hock School of Public Health. National University of Singapore and National University Health System) ; Somlo, Stefan (Yale University. Department of Genetics) ; Susztak, Katalin (University of Pennsylvania. Perelman School of Medicine) ; Tayo, Bamidele O. (Loyola University Chicago. Department of Public Health Sciences) ; Torra Balcells, Roser (Institut d'Investigació Biomèdica Sant Pau) ; van Eerde, Albertien M. (Utrecht University Medical Center. Department of Genetics) ; Weinstock, André (Alport Syndrome Foundation) ; Winkler, Cheryl A. (Frederick National Laboratory for Cancer Research. National Cancer Institute) ; Wuttke, Matthias (University of Freiburg) ; Zhang, Hong (Key Ministry of Health of China. Laboratory of Renal Disease) ; King, Jennifer M. (August Editorial) ; Cheung, Michael (KDIGO) ; Jadoul, Michel (Université Catholique de Louvain. Cliniques Universitaires Saint Luc) ; Winkelmayer, Wolfgang C. (Baylor College of Medicine. Selzman Institute for Kidney Health) ; Gharavi, Ali G. (Columbia University Irving Medical Center) ; Universitat Autònoma de Barcelona
Numerous genes for monogenic kidney diseases with classical patterns of inheritance, as well as genes for complex kidney diseases that manifest in combination with environmental factors, have been discovered. [...]
2022 - 10.1016/j.kint.2022.03.019
Kidney International, Vol. 101 Núm. 6 (june 2022) , p. 1126-1141  
4.
17 p, 1.3 MB Genome-wide association study of circulating interleukin 6 levels identifies novel loci / Ahluwalia, Tarunveer Singh (University of Copenhagen) ; Prins, Bram Peter (University of Groningen) ; Abdollahi, Mohammadreza (University of Groningen) ; Armstrong, Nicola (Murdoch University) ; Aslibekyan, Stella (University of Alabama at Birmingham School of Public Health) ; Bain, Lisa J (Qimr Berghofer Medical Research Institute) ; Jefferis, Barbara (University College London) ; Baumert, Jens (Helmholtz Zentrum München-German Research Center for Environmental Health) ; Beekman, Marian (Leiden University Medical Center) ; Ben-Shlomo, Yoav (University of Bristol) ; Bis, Joshua C (University of Washington) ; Mitchell, Braxton D. (University of Maryland School of Medicine) ; de Geus, Eco J. C (Amsterdam UMC. University Medical Center) ; Delgado, Graciela E. (University of Heidelberg) ; Marek, Diana (Sib Swiss Institute of Bioinformatics) ; Eriksson, Joel (University of Gothenburg) ; Kajantie, Eero (Helsinki University Central Hospital and University of Helsinki) ; Kanoni, Stavroula (Queen Mary University of London) ; Kemp, John P. (University of Bristol) ; Lu, Chen (Boston University School of Public Health) ; Marioni, Riccardo E. (University of Edinburgh) ; McLachlan, Stela (University of Edinburgh) ; Milaneschi, Yuri (Amsterdam Umc. Vrije Universiteit) ; Nolte, Ilja M. (University of Groningen) ; Petrelis, Alexandros M. (Université de Lorraine) ; Porcu, Eleonora (Consiglio Nazionale Delle Ricerche) ; Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau) ; Naderi, Elnaz (University of Groningen) ; Seppälä, Ilkka (Tampere University) ; Shah, Tina (University College London) ; Singhal, Gaurav (University of Adelaide) ; Standl, Marie (Helmholtz Zentrum München-German Research Center for Environmental Health) ; Teumer, Alexander (University Medicine Greifswald) ; Thalamuthu, Anbupalam (University of New South Wales) ; Thiering, Elisabeth (Ludwig-Maximilians-University of Munich. Dr. von Hauner Children's Hospital) ; Trompet, Stella (Leiden University Medical Center) ; Ballantyne, Christie M. (Baylor College of Medicine) ; Benjamin, Emelia J. (Boston University School of Medicine) ; Casas, Juan P. (Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC). Va Boston Healthcare System) ; Toben, Catherine (University of Adelaide) ; Dedoussis, George (Harokopio University) ; Deelen, Joris (Max Planck Institute for Biology of Ageing) ; Durda, Peter (Larner College of Medicine. University of Vermont) ; Engmann, Jorgen (University College London) ; Feitosa, Mary (Washington University School of Medicine) ; Grallert, Harald (German Center for Diabetes Research (DZD)) ; Hammarstedt, Ann (Sahlgrenska Academy at the University of Gothenburg) ; Harris, Sarah E (University of Edinburgh) ; Homuth, Georg (University Medicine Greifswald) ; Hottenga, Jouke Jan (Amsterdam UMC. University Medical Center) ; Jalkanen, Sirpa (University of Turku) ; Jamshidi, Yalda (St George's University of London) ; Jawahar, Magdalene C. (University of Adelaide) ; Jess, Tine (Statens Serum Institute) ; Kivimaki, Mika (University College London) ; Kleber, Marcus E. (University of Heidelberg) ; Lahti, Jari (University of Helsinki) ; Liu, Yongmei (Wake Forest School of Medicine) ; Marques-Vidal, Pedro (University of Lausanne) ; Mellström, Dan (Sahlgrenska Academy at the University of Gothenburg. Centre for Bone and Arthritis Research) ; Mooijaart, Simon P. (Leiden University Medical Center) ; Müller-Nurasyid, Martina (Johhanes Gutenberg University) ; Penninx, Brenda WJH (Amsterdam Umc. Vrije Universiteit) ; Revez, Joana A. (Qimr Berghofer Medical Research Institute) ; Rossing, Peter (University of Copenhagen) ; Raïkkönen, Katri (University of Helsinki) ; Sattar, Naveed (Bhf Glasgow Cardiovascular Research Centre) ; Scharnagl, Hubert (Medical University of Graz) ; Sennblad, Bengt (Uppsala University) ; Silveira, Angela (Karolinska Institutet (Estocolm, Suècia)) ; Pourcain, Beate St (Radboud University) ; Timpson, Nicholas J. (University of Bristol) ; Trollor, Julian (University of New South Wales) ; Van Dongen, Jenny (Amsterdam UMC. University Medical Center) ; Van Heemst, Diana (Baylor College of Medicine) ; Visvikis-Siest, Sophie (Université de Lorraine. Inserm. IGE-PCV) ; Vollenweider, Peter (University of Lausanne) ; Völker, Uwe (University of Turku) ; Waldenberger, Melanie (Helmholtz Zentrum München-German Research Center for Environmental Health) ; Willemsen, Gonneke (Amsterdam UMC. University Medical Center) ; Zabaneh, Delilah (University College London Genetics Institute) ; Morris, Richard W. (Bristol Medical School. University of Bristol) ; Arnett, Donna K. (University of Kentucky) ; Baune, Bernhard T. (University of Melbourne) ; Boomsma, Dorret I. (Amsterdam UMC. University Medical Center) ; Chang, Yen-Pei C. (University of Maryland School of Medicine) ; Deary, Ian J. (University of Edinburgh) ; Deloukas, Panos (Queen Mary University of London) ; Eriksson, Johan G. (University of Helsinki) ; Evans, David M. (University of Bristol) ; Ferreira, Manuel A. (Qimr Berghofer Medical Research Institute) ; Gaunt, Tom (University of Bristol) ; Gudnason, Vilmundur (University of Iceland) ; Hamsten, Anders (Karolinska Institutet (Estocolm, Suècia)) ; Heinrich, Joachim (University of Melbourne) ; Hingorani, Aroon (University College London) ; Humphries, Steve E. (University College London) ; Jukema, J. Wouter (Durrer Center for Cardiogenetic Research) ; Koenig, Wolfgang (University of Ulm) ; Kumari, Meena (University of Essex) ; Kutalik, Zoltan (University of Lausanne) ; Lawlor, Deborah A. (University of Bristol) ; Lehtimäki, Terho (Tampere University) ; März, Winfried (Synlab Academy. Synalb Holding Deutschland GmbH) ; Mather, Karen A (Neuroscience Research Australia) ; Naitza, Silvia. (Consiglio Nazionale Delle Ricerche) ; Nauck, Matthias (Dzhk (German Center for Cardiovascular Research). Partner Site Greifswald) ; Ohlsson, Claes (University of Gothenburg) ; Price, Jackie F. (University of Edinburgh) ; Raitakari, Olli (Turku University Hospital (Finlàndia)) ; Rice, Ken (University of Washington) ; Sachdev, Perminder S. (Prince of Wales Hospital (Australia)) ; Slagboom, Pieternella Eline (Max Planck Institute for Biology of Ageing) ; Sørensen, Thorkild I.A. (University of Copenhagen. Department of Public Health. Section on Epidemiology) ; Spector, Tim (King's College London. Department of Twin Research and Genetic Epidemiology) ; Stacey, David (University of Cambridge) ; Stathopoulou, Maria G. (Université de Lorraine. Inserm. IGE-PCV) ; Tanaka, Toshiko (National Institute on Aging (Estats Units d'Amèrica)) ; Wannamethee, Sasiwarang Goya (University College London) ; Whincup, Peter (University of London) ; Rotter, Jerome I. (The Lundquist Institute at Harbor-UCLA Medical Center) ; Dehghan, Abbas (Erasmus Mc) ; Boerwinkle, Eric (Baylor College of Medicine) ; Psaty, Bruce M. (University of Washington) ; Snieder, Harold (University Medical Center Groningen) ; Alizadeh, Behrooz Ziad (University Medical Center Groningen)
Interleukin 6 (IL-6) is a multifunctional cytokine with both pro-A nd anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. [...]
2021 - 10.1093/hmg/ddab023
Human Molecular Genetics, Vol. 30 Núm. 5 (january 2021) , p. 393-409  
5.
10 p, 1.8 MB Diversity of genotypes in a European population : Conserved and recombinant haplotypes in the coding, promoter, and 3'-untranslated regions / Asenjo, Judit (Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana) ; Moraru, Manuela (Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana) ; Al-Akioui-Sanz, Karima (Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana) ; Altadill, Mireia (Universitat Pompeu Fabra) ; Muntasell i Castellví, Aura 1972- (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Lopez-Botet, Miguel (Institut Hospital del Mar d'Investigacions Mèdiques) ; Vilches, Carlos (Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana)
NK cells monitor altered molecular patterns in tumors and infected cells through an ample array of receptors. Two families of evolutionarily distant receptors have converged to enable human NK cells to sense levels of HLA class I ligands, frequently abnormal in altered cells. [...]
2022 - 10.1111/tan.14734
Hla, Vol. 100, Issue 5 (November 2022) , p. 469-478  
6.
6 p, 1.5 MB Validation and functional characterization of GWAS-identified variants for chronic lymphocytic leukemia : a CRuCIAL study / García Martín, Paloma (Hospital Campus de la Salud (Granada)) ; Moñiz Díez, Ana (Instituto de Investigación Sanitaria de Granada) ; Sánchez Maldonado, José Manuel (Instituto de Investigación Sanitaria de Granada) ; Cabrera Serrano, Antonio José (Instituto de Investigación Sanitaria de Granada) ; ter Horst, Rob (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences) ; Benavente, Yolanda (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Landi, Stefano (Department of Biology. University of Pisa) ; Macauda, Angelica (German Cancer Research Center) ; Clay-Gilmour, Alyssa (University of South Carolina) ; Hernández-Mohedo, Francisca (Instituto de Investigación Sanitaria de Granada) ; Niazi, Yasmeen (Hopp Children's Cancer Center) ; González-Sierra, Pedro Antonio (Instituto de Investigación Sanitaria de Granada) ; Espinet, Blanca (Institut Hospital del Mar d'Investigacions Mèdiques) ; Rodriguez-Sevilla, Juan Jose (Hospital del Mar (Barcelona, Catalunya)) ; Maffei, Rossana (Department of Medical and Surgical Sciences. University of Modena and Reggio Emilia) ; Blanco, Gonzalo (Institut Hospital del Mar d'Investigacions Mèdiques) ; Giaccherini, Matteo (Department of Biology. University of Pisa) ; Puiggros, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ; Cerhan, James (Mayo Clinic) ; Marasca, Roberto (Department of Medical and Surgical Sciences. University of Modena and Reggio Emilia) ; Cañadas-Garre, Marisa (Instituto de Investigación Sanitaria de Granada) ; Lopez Nevot, Miguel Angel (Hospital Universitario Virgen de las Nieves (Granada)) ; Chen-Liang, Tzu (Hospital General Universitario Morales Meseguer (Múrcia)) ; Thomsen, Hauke (ProtaGene CGT GmbH (Alemanya)) ; Gámez, Irene (Hospital General Universitario Morales Meseguer (Múrcia)) ; Morros, Rosa (Institut d'Investigació Biomèdica de Bellvitge) ; Marcos-Gragera, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; García-Álvarez, María (Hospital Universitario de Salamanca) ; Llorca, Javier (Universidad de Cantabria) ; Jerez, Andrés (Hospital General Universitario Morales Meseguer (Múrcia)) ; Berndt, Sonja (National Institutes of Health (Estats Units d'Amèrica)) ; Butrym, Aleksandra (Medical University of Wrocław) ; Norman, Aaron D. (Mayo Clinic) ; Casabonne, Delphine (CCIBER Epidemiología y Salud Pública (Madrid)) ; Luppi, Mario (Department of Medical and Surgical Sciences. University of Modena and Reggio Emilia) ; Slager, Susan L. (Mayo Clinic) ; Hemminki, Kari (Charles University in Prague) ; Li, Yang (CHannover Medical School) ; Alcoceba, Miguel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Campa, Daniele (Department of Biology. University of Pisa) ; Canzian, Federico (German Cancer Research Center (Alemanya)) ; De Sanjose, Silvia (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Försti, Asta (Hopp Children's Cancer Center) ; Netea, Mihai G. (University of Bonn) ; Jurado, Manuel (Instituto de Investigación Sanitaria de Granada) ; Sainz, Juan (Universidad de Granada. Departamento de Bioquímica y Biología Molecular) ; Universitat Autònoma de Barcelona
2022 - 10.1038/s41408-022-00676-8
Blood Cancer Journal, Vol. 12 Núm. 5 (may 2022) , p. 79  
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17 p, 2.4 MB Evolution of inbreeding : a gaze into five Italian beef cattle breeds history / Rovelli, Giacomo (Centre de Recerca en Agrigenòmica) ; Luigi Sierra, Maria Gracia (Centre de Recerca en Agrigenòmica) ; Guan, Dailu (Centre de Recerca en Agrigenòmica) ; Sbarra, Fiorella (National Association of Italian Beef-Cattle Breeders) ; Quaglia, Andrea (National Association of Italian Beef-Cattle Breeders) ; Sarti, Francesca Maria (University of Perugia. Department of Agricultural, Food and Environmental Sciences) ; Amills i Eras, Marcel (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ; Lasagna, Emiliano (University of Perugia. Department of Agricultural, Food and Environmental Sciences)
In the last decades, intensive selection programs have led to sustained increases of inbreeding in dairy cattle, a feature that might have adverse consequences on the viability and phenotypic performance of their offspring. [...]
2021 - 10.7717/peerj.12049
PeerJ, Vol. 9 (september 2021)  
8.
58 p, 1.4 MB The power of genetic diversity in genome-wide association studies of lipids / Graham, Sarah E. (University of Michigan. Department of Internal Medicine) ; Chang, Kyong-Mi (Corporal Michael J. Crescenz VA Medical Center) ; Cho, Kelly (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; O'Donnell, Christopher J. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Gaziano, John M. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Wilson, Peter (Emory University School of Medicine) ; Rotimi, Charles (Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health) ; Hazelhurst, Scott (University of the Witwatersrand. School of Electrical and Information Engineering) ; Ramsay, Michele (University of the Witwatersrand) ; Trembath, Richard C. (King's College London) ; van Heel, David A (Queen Mary University of London) ; Tamiya, Gen (Tohoku Medical Megabank Organization. Tohoku University) ; Yamamoto, Masayuki (Tohoku Medical Megabank Organization. Tohoku University) ; Kim, Bong-Jo (Department of Precision Medicine. Division of Genome Science. National Institute of Health) ; Mohlke, Karen L (Department of Genetics. University of North Carolina) ; Frayling, Timothy M. (Genetics of Complex Traits. University of Exeter Medical School. University of Exeter) ; Hirschhorn, Joel N. (Departments of Pediatrics and Genetics. Harvard Medical School) ; Kathiresan, Sekar (Center for Genomic Medicine. Department of Medicine. Massachusetts General Hospital) ; Boehnke, Michael (Department of Biostatistics and Center for Statistics Genetics. University of Michigan) ; Natarajan, Pradeep (Cardiovascular Research Center and Center for Genomic Medicine. Massachusetts General Hospital) ; Peloso, Gina M (Department of Biostatistics. Boston University School of Public Health) ; Brown, Christopher D. (Department of Genetics. Perelman School of Medicine. University of Pennsylvania) ; Morris, Andrew P. (University College London. Centre for Adolescent Rheumatology Versus Arthritis) ; Assimes, Themistocles (Stanford University School of Medicine. Cardiovascular Institute) ; Deloukas, Panos (King Abdulaziz University) ; Sun, Yan V. (Atlanta VA Health Care System) ; Willer, Cristen J. (Department of Human Genetics. University of Michigan) ; Clarke, Shoa L. (Department of Medicine. Division of Cardiovascular Medicine. Stanford University School of Medicine) ; Wu, Kuan-Han H. (Department of Computational Medicine and Bioinformatics. University of Michigan) ; Kanoni, Stavroula (Queen Mary University of London) ; Zajac, Greg J. M. (University of Michigan) ; Ramdas, Shweta (University of Pennsylvania) ; Surakka, Ida (University of Michigan) ; Ntalla, Ioanna (Queen Mary University of London) ; Vedantam, Sailaja (Medical and Population Genetics. Broad Institute) ; Winkler, Thomas W. (Department of Genetic Epidemiology. University of Regensburg) ; Locke, Adam E. (McDonnell Genome Institute and Department of Medicine. Washington University) ; Marouli, Eirini (Queen Mary University of London) ; Hwang, Mi Yeong (Department of Precision Medicine. Division of Genome Science. National Institute of Health) ; Han, Sohee (Department of Precision Medicine. Division of Genome Science. National Institute of Health) ; Narita, Akira (Tohoku Medical Megabank Organization. Tohoku University) ; Choudhury, Ananyo (Sydney Brenner Institute for Molecular Bioscience. Faculty of Health Sciences. University of the Witwatersrand) ; Bentley, Amy R (Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health) ; Ekoru, Kenneth (Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health) ; Verma, Anurag (Department of Genetics. Perelman School of Medicine. University of Pennsylvania) ; Trivedi, Bhavi (Blizard Institute. Barts and the London School of Medicine and Dentistry. Queen Mary University of London) ; Martin, Hilary C. (Wellcome Trust Sanger Institute (Regne Unit)) ; Hunt, Karen A. (Blizard Institute. Barts and the London School of Medicine and Dentistry. Queen Mary University of London) ; Hui, Qin (Atlanta VA Health Care System) ; Klarin, Derek (Program in Medical and Population Genetics. Broad Institute of MIT and Harvard) ; Zhu, Xiang (Stanford University. Department of Statistics) ; Thorleifsson, Gudmar (deCODE genetics/Amgen) ; Helgadottir, Anna (deCODE genetics/Amgen) ; Gudbjartsson, Daniel F. (School of Engineering and Natural Sciences. University of Iceland) ; Holm, Hilma (deCODE genetics/Amgen) ; Olafsson, Isleifur (Department of Clinical Biochemistry. Landspitali-National University Hospital of Iceland) ; Akiyama, Masato (Kyushu University) ; Sakaue, Saori (Department of Allergy and Rheumatology. Graduate School of Medicine. The University of Tokyo) ; Terao, Chikashi (Laboratory for Statistical and Translational Genetics. RIKEN Center for Integrative Medical Sciences) ; Kanai, Masahiro (Harvard Medical School. Department of Biomedical Informatics) ; Zhou, Wei (Broad Institute of MIT and Harvard) ; Brumpton, Ben M. (St Olavs Hospital. Trondheim University Hospital) ; Rasheed, Humaira (MRC Integrative Epidemiology Unit. University of Bristol) ; Ruotsalainen, Sanni E. (University of Helsinki) ; Havulinna, Aki S. (Finnish Institute for Health and Welfare) ; Veturi, Yogasudha (University of Pennsylvania. Perelman School of Medicine) ; Feng, QiPing (Vanderbilt University Medical Center) ; Rosenthal, Elisabeth A. (University of Washington. Department of Medicine) ; Lingren, Todd (Cincinnati Children's Hospital Medical Center) ; Pacheco, Jennifer Allen (Center for Genetic Medicine. Northwestern University) ; Pendergrass, Sarah A. (Genentech) ; Haessler, Jeffrey (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences) ; Giulianini, Franco (Division of Preventive Medicine. Brigham and Women's Hospital) ; Bradford, Yuki (Department of Genetics. Institute for Biomedical Informatics. Perelman School of Medicine. University of Pennsylvania) ; Miller, Jason E. (Department of Genetics. Institute for Biomedical Informatics. Perelman School of Medicine. University of Pennsylvania) ; Campbell, Archie (University of Edinburgh) ; Lin, Kuang (University of Oxford. Nuffield Department of Population Health) ; Millwood, Iona Y. (University of Oxford. Nuffield Department of Population Health) ; Hindy, George (Qatar University College of Medicine) ; Rasheed, Asif (Center for Non-Communicable Diseases) ; Faul, Jessica D. (University of Michigan. Institute for Social Research) ; Zhao, Wei (University of Michigan. School of Public Health) ; Weir, David R (University of Michigan. Institute for Social Research) ; Turman, Constance (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ; Huang, Hongyan (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ; Graff, Mariaelisa (University of North Carolina. Department of Epidemiology) ; Mahajan, Anubha (University of Oxford. Wellcome Centre for Human Genetics) ; Brown, Michael R. (The University of Texas Health Science Center at Houston) ; Zhang, Weihua (Imperial College Healthcare NHS Trust) ; Yu, Ketian (Department of Biostatistics. Center for Statistical Genetics. University of Michigan) ; Schmidt, Ellen M. (Department of Biostatistics. Center for Statistical Genetics. University of Michigan) ; Pandit, Anita (Department of Biostatistics. Center for Statistical Genetics. University of Michigan) ; Gustafsson, Stefan (Department of Medical Sciences. Molecular Epidemiology and Science for Life Laboratory. Uppsala University) ; Yin, Xianyong (Department of Biostatistics. Center for Statistical Genetics. University of Michigan) ; Luan, Jian'an (MRC Epidemiology Unit. University of Cambridge School of Clinical Medicine) ; Zhao, Jing-Hua (Cardiovascular Epidemiology Unit. Department of Public Health and Primary Care. University of Cambridge Strangeways Research Laboratory) ; Matsuda, Fumihiko (Center for Genomic Medicine. Kyoto University Graduate School of Medicine) ; Jang, Hye-Mi (Department of Precision Medicine. Division of Genome Science. National Institute of Health) ; Yoon, Kyungheon (Department of Precision Medicine. Division of Genome Science. National Institute of Health) ; Medina-Gomez, Carolina (Department of Epidemiology. Erasmus MC. University Medical Center Rotterdam) ; Pitsillides, Achilleas (Department of Biostatistics. Boston University School of Public Health) ; Hottenga, Jouke Jan (Amsterdam Public Health. VU Medical Center Amsterdam) ; Willemsen, Gonneke (Amsterdam Public Health Research Institute. VU Medical Center Amsterdam) ; Wood, Andrew R. (Genetics of Complex Traits. University of Exeter Medical School. University of Exeter) ; Ji, Yingji (Genetics of Complex Traits. University of Exeter Medical School. University of Exeter) ; Gao, Zishan (Institute of Epidemiology. Helmholtz Zentrum München. German Research Center for Environmental Health) ; Haworth, Simon (Bristol Dental School. University of Bristol) ; Mitchell, Ruth E. (Population Health Sciences. Bristol Medical School. University of Bristol) ; Chai, Jin-Fang (Saw Swee Hock School of Public Health. National University of Singapore and National University Health System) ; Aadahl, Mette (Center for Clinical Research and Prevention. Bispebjerg and Frederiksberg Hospital) ; Yao, Jie (The Institute for Translational Genomics and Population Sciences. Department of Pediatrics. Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center) ; Manichaikul, Ani (University of Virginia. Center for Public Health Genomics) ; Warren, Helen R. (NIHR Barts Cardiovascular Biomedical Research Centre. Barts and The London School of Medicine and Dentistry. Queen Mary University of London) ; Ramírez, Julia (William Harvey Research Institute. Barts and The London School of Medicine and Dentistry. John Vane Science Centre. Queen Mary University of London) ; Bork-Jensen, Jette (University of Copenhagen) ; Kårhus, Line L. (Center for Clinical Research and Prevention. Bispebjerg and Frederiksberg Hospital) ; Goel, Anuj (University of Oxford. Radcliffe Department of Medicine) ; Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau) ; Noordam, Raymond (Leiden University Medical Center) ; Sidore, Carlo (Institute for Genetic and Biomedical Research. Italian National Council of Research (IRGB CNR)) ; Fiorillo, Edoardo (Institute for Genetic and Biomedical Research. Italian National Council of Research (IRGB CNR)) ; McDaid, Aaron F. (Swiss Institute of Bioinformatics) ; Marques-Vidal, Pedro (Lausanne University Hospital) ; Wielscher, Matthias (Department of Epidemiology and Biostatistics. MRC-PHE Centre for Environment and Health. School of Public Health. Imperial College London) ; Trompet, Stella (Leiden University Medical Center) ; Sattar, Naveed (BHF Glasgow Cardiovascular Research Centre. Faculty of Medicine) ; Møllehave, Line T. (Center for Clinical Research and Prevention. Bispebjerg and Frederiksberg Hospital) ; Thuesen, Betina H. (Center for Clinical Research and Prevention. Bispebjerg and Frederiksberg Hospital) ; Munz, Matthias (Department of Periodontology and Synoptic Dentistry. Berlin Institute of Health. Institute for Dental and Craniofacial Sciences) ; Zeng, Lingyao (Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK). Partner site Munich Heart Alliance) ; Huang, Jianfeng (Chinese Academy of Medical Sciences) ; Yang, Bin (Chinese Academy of Medical Sciences) ; Poveda, Alaitz (Lund University Diabetes Centre) ; Kurbasic, Azra (Lund University Diabetes Centre) ; Lamina, Claudia (German Chronic Kidney Disease Study) ; Forer, Lukas (German Chronic Kidney Disease Study) ; Scholz, Markus (LIFE Research Centre for Civilization Diseases. University of Leipzig) ; Galesloot, Tessel E (Radboud University Medical Center. Radboud Institute for Health Sciences) ; Bradfield, Jonathan Paul (Quantinuum Research) ; Daw, E. Warwick (Division of Statistical Genomics. Department of Genetics. Washington University School of Medicine) ; Zmuda, Joseph M (Department of Epidemiology. University of Pittsburgh) ; Mitchell, Jonathan S. (Institute for Biomedicine. Eurac Research. Affiliated Institute of the University of Lübeck) ; Fuchsberger, Christian (Institute for Biomedicine. Eurac Research. Affiliated Institute of the University of Lübeck) ; Christensen, Henry (Department of Clinical Biochemistry. Lillebaelt Hospital) ; Brody, Jennifer A. (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ; Feitosa, Mary (Division of Statistical Genomics. Department of Genetics. Washington University School of Medicine) ; Wojczynski, Mary K. (Division of Statistical Genomics. Department of Genetics. Washington University School of Medicine) ; Preuss, Michael (The Charles Bronfman Institute for Personalized Medicine. Icahn School of Medicine at Mount Sinai) ; Mangino, Massimo (NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust) ; Christofidou, Paraskevi (Department of Twin Research and Genetic Epidemiology. King's College London) ; Verweij, Niek (Department of Cardiology. University Medical Center Groningen. University of Groningen) ; Benjamins, Jan W (Department of Cardiology. University Medical Center Groningen. University of Groningen) ; Engmann, Jorgen (Department of Epidemiology and Public Health. University College London) ; Kember, Rachel L. (Department of Psychiatry. University of Pennsylvania) ; Slieker, Roderick C. (Department of Cell and Chemical Biology. Leiden University Medical Center) ; Lo, Ken S. (Montreal Heart Institute) ; Zilhao, Nuno R. (Icelandic Heart Association) ; Le, Phuong (Department of Anthropology. University of Toronto at Mississauga) ; Kleber, Marcus E. (Synlab MVZ Humangenetik Mannheim) ; Delgado, Graciela E. (University of Heidelberg. Vth Department of Medicine) ; Huo, Shsofeng (Shanghai Institute of Nutrition and Health. University of Chinese Academy of Sciences. Chinese Academy of Sciences) ; Ikeda, Daisuke D. (Biomedical Technology Research Center. Tokushima Research Institute. Otsuka Pharmaceutical) ; Iha, Hiroyuki (Biomedical Technology Research Center. Tokushima Research Institute. Otsuka Pharmaceutical) ; Yang, Jian (Department of Neurological Sciences. Rush University Medical Center) ; Liu, Jun (Genome Institute of Singapore. Agency for Science. Technology and Research) ; Leonard, Hampton L. (Data Tecnica International) ; Marten, Jonathan (MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital) ; Schmidt, Börge (Institute for Medical Informatics. Biometrie and Epidemiology. University of Duisburg-Essen) ; Arendt, Marina (Department of Computer Science. University of Applied Sciences and Arts Dortmund) ; Smyth, Laura J. (Centre for Public Health. Queen's University of Belfast) ; Cañadas-Garre, Marisa (Centre for Public Health. Queen's University of Belfast) ; Wang, Chaolong (Genome Institute of Singapore. Agency for Science. Technology and Research) ; Nakatochi, Masahiro (Public Health Informatics Unit. Department of Integrated Health Sciences. Nagoya University Graduate School of Medicine) ; Wong, Andrew (MRC Unit for Lifelong Health and Ageing at UCL) ; Hutri-Kähönen, Nina (Department of Pediatrics. Faculty of Medicine and Health Technology. Tampere University) ; Sim, Xueling (Saw Swee Hock School of Public Health. National University of Singapore and National University Health System) ; Xia, Rui (Brown Foundation Institute of Molecular Medicine. McGovern Medical School. University of Texas Health Science Center at Houston) ; Huerta-Chagoya, Alicia (Departamento de Medicina Genómica y Toxicología Ambiental. Instituto de Investigaciones Biomédicas. UNAM. Ciudad de Mexico) ; Fernandez-Lopez, Juan Carlos (Departamento de Genómica Computacional. Instituto Nacional de Medicina Genómica. Ciudad de Mexico) ; Lyssenko, Valeriya (Lund University Diabetes Center. Lund University) ; Ahmed, Meraj (Genomic Research on Complex Diseases (GRC Group). CSIR-Centre for Cellular and Molecular Biology) ; Jackson, Anne U. (Department of Biostatistics and Center for Statistics Genetics. University of Michigan) ; Irvin, Marguerite R. (Epidemiology. School of Public Health. University of Alabama at Birmingham) ; Oldmeadow, Christopher (Hunter Medical Research Institute) ; Kim, Han-Na (Department of Clinical Research Design and Evaluation. SAIHST. Sungkyunkwan University) ; Ryu, Seungho (Sungkyunkwan University School of Medicine) ; Timmers, Paul R. H. J. (Centre for Global Health Research. Usher Institute. University of Edinburgh) ; Arbeeva, Liubov (University of North Carolina. Thurston Arthritis Research Center) ; Dorajoo, Rajkumar (Genome Institute of Singapore. Agency for Science. Technology and Research) ; Lange, Leslie A. (Division of Biomedical Informatics and Personalized Medicine. Department of Medicine. Anschutz Medical Campus. University of Colorado. Denver) ; Chai, Xiaoran (Department of Ophthalmology. National University of Singapore and National University Health System) ; Prasad, Gauri (Academy of Scientific and Innovative Research. CSIR-Institute of Genomics and Integrative Biology Campus) ; Lorés-Motta, Laura (Departments of Ophthalmology and Human Genetics. Radboud University Nijmegen Medical Center) ; Pauper, Marc (Departments of Ophthalmology and Human Genetics. Radboud University Nijmegen Medical Center) ; Long, Jirong (Vanderbilt Epidemiology Center. Division of Epidemiology. Vanderbilt University Medical Center) ; Li, Xiaohui (Department of Population and Quantitative Health Sciences. Case Western Reserve University) ; Theusch, Elisabeth (Department of Pediatrics. University of California. San Francisco) ; Takeuchi, Fumihiko (National Center for Global Health and Medicine) ; Spracklen, Cassandra N. (Department of Biostatistics and Epidemiology. University of Massachusetts-Amherst) ; Loukola, Anu (Institute for Molecular Medicine Finland (FIMM). HiLIFE. University of Helsinki) ; Bollepalli, Sailalitha (Institute for Molecular Medicine Finland (FIMM). HiLIFE. University of Helsinki) ; Warner, Sophie C. (NIHR Leicester Biomedical Research Centre. Glenfield Hospital) ; Wang, Ya Xing (Beijing Tongren Eye Center. Beijing Tongren Hospital. Capital Medical University) ; Wei, Wen B. (Beijing Tongren Eye Center. Beijing Tongren Hospital. Capital Medical University) ; Nutile, Teresa (Institute of Genetics and Biophysics "Adriano Buzzati-Traverso"-CNR) ; Ruggiero, Daniela (IRCCS Neuromed. Pozzilli) ; Sung, Yun Ju (Department of Psychiatry. Washington University) ; Hung, Yi-Jen (Division of Endocrinology and Metabolism. Tri-Service General Hospital Songshan Branch) ; Chen, Shufeng (Chinese Academy of Medical Sciences) ; Liu, Fangchao (Chinese Academy of Medical Sciences) ; Yang, Jingyun (Department of Neurological Sciences. Rush University Medical Center) ; Kentistou, Katherine A. (Centre for Global Health Research. Usher Institute. University of Edinburgh) ; Gorski, Mathias (Department of Nephrology. University Hospital Regensburg) ; Brumat, Marco (Department of Medicine. Surgery and Health Sciences. University of Trieste) ; Meidtner, Karina (German Center for Diabetes Research (DZD)) ; Bielak, Lawrence F. (Department of Epidemiology. School of Public Health. University of Michigan) ; Smith, Jennifer A. (Department of Epidemiology. School of Public Health. University of Michigan) ; Hebbar, Prashantha (Dasman Diabetes Institute. Department of Genetics and Bioinformatics) ; Farmaki, Aliki-Eleni (Department of Population Science and Experimental Medicine. University College London) ; Hofer, Edith (Institute for Medical Informatics. Statistics and Documentation. Medical University of Graz) ; Lin, Maoxuan (Department of Bioinformatics and Genomics. University of North Carolina at Charlotte) ; Xue, Chao (Department of Internal Medicine. Division of Cardiology. University of Michigan) ; Zhang, Jifeng (Department of Internal Medicine. Division of Cardiology. University of Michigan) ; Concas, Maria Pina (Institute for Maternal and Child Health. IRCCS Burlo Garofolo) ; Vaccargiu, Simona (Institute of Genetic and Biomedical Research. National Research Council of Italy. UOS of Sassari) ; van der Most, Peter J (Department of Epidemiology. University Medical Center Groningen. University of Groningen) ; Pitkänen, Niina (Centre for Population Health Research. University of Turku and Turku University Hospital) ; Cade, Brian E (Division of Sleep Medicine. Harvard Medical School) ; Lee, Jiwon (Sleep Medicine and Circadian Disorders. Brigham and Women's Hospital) ; van der Laan, Sander W (University Medical Center Utrecht) ; Chitrala, Kumaraswamy Naidu (Laboratory of Epidemiology and Population Science. National Institute on Aging Intramural Research Program. NIH Biomedical Research Center. NIA) ; Weiss, Stefan (University Medicine Greifswald) ; Zimmermann, Martina E (University of Regensburg. Department of Genetic Epidemiology) ; Lee, Jong Young (Oneomics) ; Choi, Hyeok Sun (Department of Biomedical Science. Hallym University) ; Nethander, Maria (Bioinformatics Core Facility. Sahlgrenska Academy. University of Gothenburg) ; Freitag-Wolf, Sandra (Institute of Medical Informatics and Statistics. Kiel University) ; Southam, Lorraine (Wellcome Trust Sanger Institute (Regne Unit)) ; Rayner, Nigel W. (Oxford Centre for Diabetes Endocrinology and Metabolism) ; Wang, Carol A (School of Medicine and Public Health. College of Health. Medicine and Wellbeing. University of Newcastle) ; Lin, Shih Yi (School of Medicine. National Defense Medical Center) ; Wang, Jun-Sing (Department of Medicine. School of Medicine. National Yang-Ming University) ; Couture, Christian (Department of Kinesiology. Université Laval) ; Lyytikäinen, Leo-Pekka (Department of Clinical Chemistry. Finnish Cardiovascular Research Center-Tampere. Faculty of Medicine and Health Technology. Tampere University) ; Nikus, Kjell (Department of Cardiology. Finnish Cardiovascular Research Center-Tampere. Faculty of Medicine and Health Technology. Tampere University) ; Cuellar-Partida, Gabriel (University of Queensland Diamantina Institute. Translational Research Institute) ; Vestergaard, Henrik (Department of Medicine. Bornholms Hospital) ; Hildalgo, Bertha (School of Public Health. University of Alabama at Birmingham) ; Giannakopoulou, Olga (William Harvey Research Institute. Barts and the London School of Medicine and Dentistry. Queen Mary University of London) ; Cai, Qiuyin (Vanderbilt Epidemiology Center. Division of Epidemiology. Vanderbilt University Medical Center) ; Obura, Morgan O. (Amsterdam UMC. Department of Epidemiology and Biostatistics. Amsterdam Public Health Research Institute) ; van Setten, Jessica (University Medical Center Utrecht) ; Li, Xiaoyin (Department of Population and Quantitative Health Sciences. Case Western Reserve University) ; Schwander, Karen (Division of Statistical Genomics. Department of Genetics. Washington University School of Medicine) ; Terzikhan, Natalie (Department of Epidemiology. Erasmus MC. University Medical Center Rotterdam) ; Shin, Jae Hun (Department of Biomedical Science. Hallym University) ; Jackson, Rebecca D. (Division of Endocrinology. Ohio State University) ; Reiner, Alewxander P. (Department of Epidemiology. University of Washington) ; Martin, Lisa W. (School of Medicine and Health Sciences. George Washington University) ; Chen, Zhengming (Medical Research Council Population Health Research Unit. Nuffield Department of Population Health. University of Oxford) ; Li, Liming (Peking University Health Science Center) ; Highland, Heather M. (Department of Epidemiology. University of North Carolina) ; Young, Kristin L. (Department of Epidemiology. University of North Carolina) ; Kawaguchi, Takahisa (Center for Genomic Medicine. Kyoto University Graduate School of Medicine) ; Thiery, Joachim (Institute for Laboratory Medicine. University Hospital Leipzig) ; Bis, Joshua C (Cardiovascular Health Research Unit. Department of Medicine. University of Washington) ; Nadkarni, Girish N. (The Charles Bronfman Institute for Personalized Medicine. Icahn School of Medicine at Mount Sinai) ; Launer, Lenore Joy (Laboratory of Epidemiology and Population Sciences. National Institute on Aging. NIH) ; Li, Huaixing (Shanghai Institute of Nutrition and Health. University of Chinese Academy of Sciences. Chinese Academy of Sciences) ; Nalls, Mike A. (Data Tecnica International) ; Raitakari, Olli T. (Department of Clinical Physiology and Nuclear Medicine. Turku University Hospital) ; Ichihara, Sahoko (Department of Environmental and Preventive Medicine. Jichi Medical University School of Medicine) ; Wild, Sarah (Centre for Population Health Sciences. Usher Institute. University of Edinburgh) ; Nelson, Christopher P. (NIHR Leicester Biomedical Research Centre. Glenfield Hospital) ; Campbell, Harry (Centre for Global Health Research. Usher Institute. University of Edinburgh) ; Jäger, Susanne (German Center for Diabetes Research (DZD)) ; Nabika, Toru (Department of Functional Pathology. Shimane University School of Medicine) ; Al-Mulla, Fahd (Dasman Diabetes Institute. Department of Genetics and Bioinformatics) ; Niinikoski, Harri (Department of Physiology. University of Turku) ; Braund, Peter S. (NIHR Leicester Biomedical Research Centre. Glenfield Hospital) ; Kolcic, Ivana (Faculty of Medicine. University of Split) ; Kovacs, Peter (Medical Department III-Endocrinology. Nephrology. Rheumatology. University of Leipzig Medical Center) ; Giardoglou, Tota (Department of Nutrition-Dietetics. Harokopio University. Eleftheriou Venizelou) ; Katsuya, Tomohiro (Department of Geriatric and General Medicine. Osaka University Graduate School of Medicine) ; Bhatti, Konain Fatima (William Harvey Research Institute. Barts and the London School of Medicine and Dentistry. Queen Mary University of London) ; de Kleijn, Dominique (University Medical Center Utrecht) ; de Borst, Gert J. (University Medical Center Utrecht) ; Kim, Eung Kweon (Corneal Dystrophy Research Institute. Department of Ophthalmology. Yonsei University College of Medicine) ; Adams, Hieab H. H. (Department of Radiology and Nuclear Medicine. Erasmus MC. University Medical Center Rotterdam) ; Ikram, M. Arfan (Erasmus University Medical Center. Department of Epidemiology) ; Zhu, Xiaofeng (Case Western Reserve University. Department of Population and Quantitative Health Sciences) ; Asselbergs, Folkert W (University Medical Center Utrecht) ; Kraaijeveld, Adriaan O. (University Medical Center Utrecht) ; Beulens, Joline W. J. (University Medical Center Utrecht) ; Shu, Xiao-Ou (Vanderbilt Epidemiology Center. Division of Epidemiology. Vanderbilt University Medical Center) ; Rallidis, Loukianos S. (Kapodistrian University of Athens) ; Pedersen, Oluf (University of Copenhagen) ; Hansen, Torben (University of Copenhagen) ; Mitchell, Paul (University of Sydney) ; Hewitt, Alex W. (University of Melbourne) ; Kähönen, Mika (Tampere University) ; Pérusse, Louis (Institute of Nutrition and Functional Foods (INAF). Université Laval) ; Bouchard, Claude (Pennington Biomedical Research Center) ; Tönjes, Anke (Medical Department III-Endocrinology. Nephrology. Rheumatology. University of Leipzig Medical Center) ; Chen, Yii Der Ida (The Institute for Translational Genomics and Population Sciences. Department of Pediatrics. Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center) ; Pennell, Craig E. (School of Medicine and Public Health. College of Health. Medicine and Wellbeing. University of Newcastle) ; Mori, Trevor A (Medical School. Faculty of Health and Medical Sciences. University of Western Australia) ; Lieb, Wolfgang (Institute of Epidemiology. Kiel University) ; Franke, Andre (Christian-Albrechts-University of Kiel. Institute of Clinical Molecular Biology) ; Ohlsson, Claes (Department of Drug Treatment. Sahlgrenska University Hospital) ; Mellström, Dan (Geriatric Medicine. Institute of Medicine. Sahlgrenska Academy. University of Gothenburg) ; Cho, Yoon Shin (Department of Biomedical Science. Hallym University) ; Lee, Hyejin (Department of Internal Medicine. Ewha Womans University School of Medicine) ; Yuan, Jan-Min (Department of Epidemiology. Graduate School of Public Health. University of Pittsburgh) ; Koh, Woon-Puay (Singapore Institute for Clinical Sciences. Agency for Science Technology and Research (A*STAR)) ; Rhee, Sang Youl (Department of Endocrinology and Metabolism. Kyung Hee University School of Medicine) ; Woo, Jeong-Taek (Department of Endocrinology and Metabolism. Kyung Hee University School of Medicine) ; Heid, Iris M. (Department of Genetic Epidemiology. University of Regensburg) ; Stark, Klaus J. (Department of Genetic Epidemiology. University of Regensburg) ; Völzke, Henry (Institute for Community Medicine. University Medicine Greifswald) ; Homuth, Georg (Department of Functional Genomics. Interfaculty Institute for Genetics and Functional Genomics. University of Greifswald and University Medicine Greifswald) ; Evans, Michele K. (Laboratory of Epidemiology and Population Science. National Institute on Aging Intramural Research Program. NIH Biomedical Research Center) ; Zonderman, Alan B (Laboratory of Epidemiology and Population Science. National Institute on Aging Intramural Research Program. NIH Biomedical Research Center) ; Polasek, Ozren (Faculty of Medicine. University of Split) ; Pasterkamp, Gerard (University Medical Center Utrecht) ; Hoefer, Imo E. (University Medical Center Utrecht) ; Redline, Susan (Harvard Medical School) ; Pahkala, Katja (University of Turku) ; Oldehinkel, Albertine J (Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE). University of Groningen. University Medical Center Groningen) ; Snieder, Harold (Department of Epidemiology. University Medical Center Groningen. University of Groningen) ; Biino, Ginevra (National Research Council of Italy. Institute of Molecular Genetics) ; Schmidt, Reinhold (Department of Neurology. Clinical Division of Neurogeriatrics. Medical University of Graz) ; Schmidt, Helena (Medical University Graz) ; Chen, Y. Eugene (Department of Internal Medicine. Division of Cardiology. University of Michigan) ; Bandinelli, Stefania (Local Health Unit Toscana Centro) ; Dedoussis, George (Harokopio University of Athens) ; Thanaraj, Thangavel Alphonse (Dasman Diabetes Institute. Department of Genetics and Bioinformatics) ; Kardia, Sharon L. R. (Department of Epidemiology. School of Public Health. University of Michigan) ; Kato, Norihiro (National Center for Global Health and Medicine) ; Schulze, Matthias B. (Institute of Nutritional Science. University of Potsdam) ; Girotto, Giorgia (Institute for Maternal and Child Health IRCCS "Burlo Garofolo") ; Jung, Bettina (Department of Nephrology. University Hospital Regensburg) ; Böger, Carsten A. (KfH Kidney Center Traunstein) ; Joshi, Peter K. (Centre for Global Health Research. Usher Institute. University of Edinburgh) ; Bennett, David A. (Department of Neurological Sciences. Rush University Medical Center) ; De Jager, Philip L. (Program in Medical and Population Genetics. Broad Institute) ; Lu, Xiangfeng (Chinese Academy of Medical Sciences) ; Mamakou, Vasiliki (Dromokaiteio Psychiatric Hospital) ; Brown, Morris (Clinical Pharmacology. William Harvey Research Institute. Queen Mary University of London) ; Caulfield, Mark (Queen Mary University of London. William Harvey Research Institute) ; Munroe, Patricia B. (Queen Mary University of London. Barts and The London School of Medicine and Dentistry) ; Guo, Xiuqing (The Institute for Translational Genomics and Population Sciences. Department of Pediatrics. Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center) ; Ciullo, Marina (IRCCS Neuromed. Pozzilli) ; Jonas, Jost B. (Institute of Molecular and Clinical Ophthalmology Basel) ; Samani, Nilesh J. (NIHR Leicester Biomedical Research Centre. Glenfield Hospital) ; Kaprio, Jaakko (Institute for Molecular Medicine Finland (FIMM). HiLIFE. University of Helsinki) ; Pajukanta, Päivi (University of California. David Geffen School of Medicine at UCLA.) ; Adair, Linda S (Carolina Population Center. University of North Carolina) ; Bechayda, Sonny Augustin (Department of Anthropology. Sociology. and History. University of San Carlos) ; de Silva, H. Janaka (Department of Medicine. Faculty of Medicine. University of Kelaniya) ; Wickremasinghe, Ananda R. (Department of Public Health. Faculty of Medicine. University of Kelaniya) ; Krauss, Ronald M. (Departments of Pediatrics and Medicine. University of California. San Francisco) ; Wu, Jer-Yuarn (Institute of Biomedical Sciences. Academia Sinica) ; Zheng, Wei (Vanderbilt Epidemiology Center. Division of Epidemiology. Vanderbilt University Medical Center) ; den Hollander, Anneke I. (Departments of Ophthalmology and Human Genetics. Radboud University Nijmegen Medical Center) ; Bharadwaj, Dwaipayan (Systems Genomics Laboratory. School of Biotechnology. Jawaharlal Nehru University) ; Correa, Adolfo (University of Mississippi Medical Center) ; Wilson, James G. (University of Mississippi Medical Center) ; Lind, Lars (Uppsala University. Department of Medical Sciences) ; Heng, Chew-Kiat (Khoo Teck Puat-National University Children's Medical Institute. National University Health System) ; Nelson, Amanda E. (Department of Medicine. University of North Carolina) ; Golightly, Yvonne M. (Division of Physical Therapy. University of North Carolina) ; Wilson, James F. (Centre for Global Health Research. Usher Institute. University of Edinburgh) ; Penninx, Brenda WJH (Amsterdam Public Health Research Institute. VU Medical Center Amsterdam) ; Kim, Hyung-Lae (Department of Biochemistry. College of Medicine. Ewha Womans University) ; Attia, John (University of Newcastle. Faculty of Health and Medicine) ; Scott, Rodney J. (University of Newcastle. Faculty of Health and Medicine) ; Rao, D. C. (Washington University School of Medicine) ; Arnett, Donna K. (University of Kentucky. College of Public Health) ; Walker, Mark (Institute of Cellular Medicine (Diabetes). The Medical School. Newcastle University) ; Koistinen, Heikki A. (Minerva Foundation Institute for Medical Research) ; Chandak, Giriraj Ratan (Academy of Scientific and Innovative Research (AcSIR)) ; Yajnik, Chittaranjan S. (Diabetology Research Centre. KEM Hospital and Research Centre) ; Mercader, Josep M. (Diabetes Unit and Center for Genomic Medicine. Massachusetts General Hospital) ; Tusié-Luna, Teresa (Unidad de Biología Molecular y Medicina Genómica. Instituto de Investigaciones Bimédicas UNAM/ Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán) ; Aguilar-Salinas, Carlos Alberto (Dirección de Nutrición and Unidad de Estudios de Enfermedades Metabólicas. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán) ; Gonzalez Villalpando, Clicerio (Instituto Nacional de Salud Publica y Centro de Estudios en Diabetes) ; Orozco, Lorena (Instituto Nacional de Medicina Genómica) ; Fornage, Myriam (University of Texas Health Science at Houston) ; Tai, E. Shyong (Yong Loo Lin School of Medicine. National University of Singapore and National University Health System) ; van Dam, Rob M. (Yong Loo Lin School of Medicine. National University of Singapore and National University Health System) ; Lehtimäki, Terho (Department of Clinical Chemistry. Finnish Cardiovascular Research Center-Tampere. Faculty of Medicine and Health Technology. Tampere University) ; Chaturvedi, Nish (MRC Unit for Lifelong Health and Ageing at UCL) ; Yokota, Mitsuhiro (Kurume University School of Medicine) ; Liu, Jianjun (Genome Institute of Singapore. Agency for Science. Technology and Research) ; Reilly, Dermot F. (Genetics. Merck Sharp & Dohme) ; McKnight, Amy Jayne (Centre for Public Health. Queen's University of Belfast) ; Kee, Frank (Queen's University Belfast) ; Jöckel, Karl-Heinz (University of Duisburg-Essen) ; McCarthy, Mark I. (University of Oxford) ; Palmer, Colin N. A. (University of Dundee. Ninwells Hospital and Medical School) ; Vitart, Veronique (University of Edinburgh. Western General Hospital) ; Hayward, Caroline (University of Edinburgh. Western General Hospital) ; Simonsick, Eleanor (Intramural Research Program. National Institute on Aging) ; van Duijn, Cornelia M. (Nuffield Department of Population Health. University of Oxford) ; Lu, Fan (The Eye Hospital. School of Ophthalmology and Optometry. Wenzhou Medical University) ; Qu, Jia (The Eye Hospital. School of Ophthalmology and Optometry. Wenzhou Medical University) ; Hishigaki, Haretsugu (Biomedical Technology Research Center. Tokushima Research Institute. Otsuka Pharmaceutical) ; Lin, Xu (Shanghai Chinese Academy of Sciences) ; März, Winfried (Medical University of Graz) ; Parra, Esteban J. (Department of Anthropology. University of Toronto at Mississauga) ; Cruz, Miguel (Instituto Mexicano del Seguro Social) ; Gudnason, Vilmundur (Faculty of Medicine. University of Iceland) ; Tardif, Jean-Claude (Department of Medicine. Faculty of Medecine. Université de Montréal) ; Lettre, Guillaume (Department of Medicine. Faculty of Medicine. Université de Montréal) ; 't Hart, Leen M. (Department of Biomedical Data Sciences. Section Molecular Epidemiology. Leiden University Medical Center) ; Elders, Petra J. M. (Amsterdam UMC. Department of General Practice and Elderly Care. Amsterdam Public Health Research Institute) ; Damrauer, Scott M. (Corporal Michael Crescenz VA Medical Center) ; Kumari, Meena (Institute of Social and Economic Research. University of Essex) ; Kivimaki, Mika (Department of Epidemiology and Public Health. University College London) ; van der Harst, Pim (Department of Cardiology. University Medical Center Groningen. University of Groningen) ; Spector, Tim (Department of Twin Research and Genetic Epidemiology. King's College London) ; Loos, Ruth J. F. (The Mindich Child Health and Development Institute. Icahn School of Medicine at Mount Sinai) ; Province, Michael A. (Division of Statistical Genomics. Department of Genetics. Washington University School of Medicine) ; Psaty, Bruce M. (Kaiser Permanent Washington Health Research Institute) ; Brandslund, Ivan (Institute of Regional Health Research. University of Southern Denmark) ; Pramstaller, Peter P. (Institute for Biomedicine. Eurac Research. Affiliated Institute of the University of Lübeck) ; Christensen, Kaare (Danish Aging Research Center. University of Southern Denmark) ; Ripatti, Samuli (Broad Institute of MIT and Harvard) ; Widén, Elisabeth (Institute for Molecular Medicine Finland (FIMM). HiLIFE. University of Helsinki) ; Hakonarson, Hakon (Department of Pediatrics. Perelman School of Medicine. The University of Pennsylvania) ; Grant, Struan F. A. (Children's Hospital of Philadelphia (Pennsilvània)) ; Kiemeney, Lambertus A. L. M. (Radboud University Medical Center. Radboud Institute for Health Sciences) ; de Graaf, Jacqueline (Radboud University Medical Center. Radboud Institute for Health Sciences) ; Loeffler, Markus (LIFE Research Centre for Civilization Diseases. University of Leipzig) ; Kronenberg, Florian (Institute of Genetic Epidemiology. Department of Genetics and Pharmacology. Medical University of Innsbruck) ; Gu, Dongfeng (School of Medicine. Southern University of Science and Technology) ; Erdmann, Jeanette (University of Lübeck. Institute for Cardiogenetics) ; Schunkert, Heribert (Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) e.V.. Partner site Munich Heart Alliance) ; Franks, Paul W. (Lund University Diabetes Centre) ; Linneberg, Allan (University of Copenhagen. Department of Clinical Medicine) ; Jukema, J. Wouter (Netherlands Heart Institute) ; Khera, Amit V. (Department of Medicine. Harvard Medical School) ; Männikkö, Minna (University of Oulu) ; Jarvelin, Marjo-Riitta (University of Oulu. Biocenter of Oulu) ; Kutalik, Zoltan (University Center for Primary Care and Public Health) ; Cucca, Francesco (University of Sassari) ; Mook-Kanamori, Dennis O. (Department of Public Health and Primary Care. Leiden University Medical Center) ; van Dijk, Ko Willems (Department of Human Genetics. Leiden University Medical Center) ; Watkins, Hugh (Division of Cardiovascular Medicine. Radcliffe Department of Medicine. John Radcliffe Hospital. University of Oxford) ; Strachan, David P. (Population Health Research Institute. St George's University of London) ; Grarup, Niels (Novo Nordisk Foundation Center for Basic Metabolic Research. Faculty of Health and Medical Sciences. University of Copenhagen) ; Sever, Peter (National Heart and Lung Institute. Imperial College London) ; Poulter, Neil (Imperial College London) ; Rotter, Jerome I. (The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics) ; Dantoft, Thomas M. (Center for Clinical Research and Prevention. Bispebjerg and Frederiksberg Hospital) ; Karpe, Fredrik (NIHR Oxford Biomedical Research Centre. Churchill Hospital) ; Neville, Matt J. (NIHR Oxford Biomedical Research Centre. Churchill Hospital) ; Timpson, Nicholas J. (University of Bristol) ; Cheng, Ching-Yu (Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP). Duke-NUS Medical School) ; Wong, Tien-Yin (Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP). Duke-NUS Medical School) ; Khor, Chiea Chuen (Genome Institute of Singapore. Agency for Science. Technology and Research) ; Sabanayagam, Charumathi (Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP). Duke-NUS Medical School) ; Peters, Annette (DZHK (German Centre for Cardiovascular Research). Munich Heart Alliance Partner Site) ; Gieger, Christian (German Center for Diabetes Research (DZD)) ; Hattersley, Andrew T. (University of Exeter Medical School. University of Exeter) ; Pedersen, Nancy L. (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Magnusson, Patrik K. E. (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Boomsma, Dorret I. (Amsterdam Reproduction and Development Research Institute. VU Medical Center Amsterdam) ; de Geus, Eco J. C. (Amsterdam Public Health Research Institute. VU Medical Center Amsterdam) ; Cupples, L. Adrienne (Framingham Heart Study. National Heart. Lung. and Blood Institute. US National Institutes of Health) ; van Meurs, Joyce B. J. (Department of Epidemiology. Erasmus MC. University Medical Center Rotterdam) ; Ghanbari, Mohsen (Department of Genetics. School of Medicine. Mashhad University of Medical Sciences) ; Gordon-Larsen, Penny (Carolina Population Center. University of North Carolina) ; Huang, Wei (Department of Genetics. Shanghai-MOST Key Laboratory of Health and Disease Genomics. Chinese National Human Genome Center at Shanghai) ; Kim, Young Jin (Department of Precision Medicine. Division of Genome Science. National Institute of Health) ; Tabara, Yasuharu (Center for Genomic Medicine. Kyoto University Graduate School of Medicine) ; Wareham, Nicholas J. (University of Cambridge (Regne Unit). School of Clinical Medicine) ; Langenberg, Claudia (University of Cambridge (Regne Unit). School of Clinical Medicine) ; Zeggini, Eleftheria (TUM School of Medicine. Technical University of Munich (TUM) and Klinikum Rechts der Isar) ; Kuusisto, Johanna (Institute of Clinical Medicine. Internal Medicine. University of Eastern Finland and Kuopio University Hospital) ; Laakso, Markku (Institute of Clinical Medicine. Internal Medicine. University of Eastern Finland and Kuopio University Hospital) ; Ingelsson, Erik (Stanford Diabetes Research Center. Stanford University) ; Abecasis, Goncalo (Regeneron Pharmaceuticals) ; Chambers, John C. (Imperial College Healthcare NHS Trust. Imperial College London) ; Kooner, Jaspal S. (National Heart and Lung Institute. Imperial College London) ; de Vries, Paul S. (Human Genetics Center. Department of Epidemiology. Human Genetics. and Environmental Sciences. School of Public Health. The University of Texas Health Science Center at Houston) ; Morrison, Alanna (Human Genetics Center. Department of Epidemiology. Human Genetics. and Environmental Sciences. School of Public Health. The University of Texas Health Science Center at Houston) ; North, Kari E. (Department of Epidemiology. University of North Carolina) ; Daviglus, Martha (Institute for Minority Health Research. University of Illinois College of Medicine) ; Kraft, Peter (Department of Biostatistics. Harvard T. H. Chan School of Public Health) ; Martin, Nicholas G (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Whitfield, John B (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Abbas, Shahid (Faisalabad Institute of Cardiology) ; Saleheen, Danish (Department of Cardiology. Columbia University Irving Medical Center) ; Walters, Robin G. (Big Data Institute. University of Oxford) ; Holmes, Michael V (National Institute for Health Research Oxford Biomedical Research Centre. Oxford University Hospitals) ; Black, Corri (Aberdeen Centre for Health Data Science (Aberdeen, Regne Unit)) ; Smith, Blair H (Division of Population Health and Genomics. Ninewells Hospital and Medical School. University of Dundee) ; Justice, Anne E. (Biomedical and Translational Informatics. Geisinger Health) ; Baras, Aris (Regeneron Pharmaceuticals) ; Buring, Julie E. (Harvard Medical School) ; Ridker, Paul M. (Harvard Medical School) ; Chasman, Daniel I. (Harvard Medical School) ; Kooperberg, Charles (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences) ; Wei, Wei-Qi (Department of Biomedical Informatics. Vanderbilt University Medical Center) ; Jarvik, Gail P. (Departments of Medicine (Medical Genetics) and Genome Sciences. University of Washington Medical Center) ; Namjou, Bahram (Center for Autoimmune Genomics and Etiology. Cincinnati Children's Hospital Medical Center (CCHMC)) ; Hayes, M. Geoffrey (Center for Genetic Medicine. Northwestern University. Feinberg School of Medicine) ; Ritchie, Marylyn D. (Department of Genetics. Institute for Biomedical Informatics. Perelman School of Medicine. University of Pennsylvania) ; Jousilahti, Pekka (Department of Public Health and Welfare. Finnish Institute for Health and Welfare) ; Salomaa, Veikko (Department of Public Health and Welfare. Finnish Institute for Health and Welfare) ; Hveem, Kristian (Department of Medicine. Levanger Hospital. Nord-Trøndelag Hospital Trust) ; Åsvold, Bjørn Olav (Department of Endocrinology. St Olavs Hospital. Trondheim University Hospital) ; Kubo, Michiaki (RIKEN Center for Integrative Medical Sciences) ; Kamatani, Yoichiro (The University of Tokyo. Department of Computational Biology and Medical Sciences) ; Okada, Yukinori (Integrated Frontier Research for Medical Science Division. Institute for Open and Transdisciplinary Research Initiatives. Osaka University) ; Murakami, Yoshinori (The University of Tokyo. Institute of Medical Science) ; Thorsteinsdottir, Unnur (Faculty of Medicine. University of Iceland) ; Stefansson, Kari (Faculty of Medicine. University of Iceland) ; Ho, Yuk-Lam (VA Boston Healthcare System) ; Lynch, Julie A. (University of Massachusetts) ; Rader, Daniel J. (Department of Medicine. Perelman School of Medicine. University of Pennsylvania) ; Tsao, Philip S. (Cardiovascular Institute. Stanford University School of Medicine)
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use. Despite advances in prevention and treatment, in particular through reducing low-density lipoprotein cholesterol levels, heart disease remains the leading cause of death worldwide. [...]
2021 - 10.1038/s41586-021-04064-3
Nature, Vol. 600 Núm. 7890 (12 2021) , p. 675-679  
9.
3 p, 168.4 KB Multiple adverse drug reactions and genetic polymorphism testing / Arellano, Ana Lucía (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ; Martin-Subero, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Monerris, Mar (Universitat Autònoma de Barcelona. Departament de Cirurgia) ; LLerena, Adrián (CICAB Clinical Research Center, Extremadura University Hospital and Medical School) ; Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ; Montané Esteva, Eva (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Defects in drug metabolic pathways could explain why some patients have a history of multiple adverse drug reactions (ADR); therefore we aimed to analyze genetic polymorphisms in a patient with multiple ADR related to drugs with a common hepatic metabolic pathway through CYP2D6. [...]
2017 - 10.1097/MD.0000000000008505
Medicine, Vol. 96 (november 2017)  
10.
2 p, 208.5 KB Corrigendum : Influence of Polymorphisms Involved in Platelet Activation and Inflammatory Response on Aspirin-Related Upper Gastrointestinal Bleeding: A Case-Control Study / Mallah, Narmeen (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Zapata-Cachafeiro, Maruxa (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Aguirre, Carmelo (Universidad del País Vasco) ; Ibarra-García, Eguzkiñe (Hospital de Urduliz Alfredo Espinosa) ; Palacios-Zabalza, Itziar (Hospital de Galdakao (Usansolo, Biscaia)) ; Macías-García, Fernando (Complejo Hospitalario Universitario de Santiago de Compostela) ; Domínguez-Muñoz, J. Enrique (Complejo Hospitalario Universitario de Santiago de Compostela) ; Piñeiro-Lamas, María (Instituto de Investigación Sanitaria de Santiago (IDIS)) ; Ibáñez, Luisa (Hospital Universitari Vall d'Hebron) ; Vidal Guitart, Xavier (Hospital Universitari Vall d'Hebron) ; Vendrell Bosch, Lourdes (Hospital Universitari Vall d'Hebron) ; Martin-Arias, Luis (Universidad de Valladolid) ; Sáinz-Gil, María (Universidad de Valladolid) ; Velasco-González, Verónica (Universidad de Valladolid) ; Figueiras, Adolfo (Instituto de Investigación Sanitaria de Santiago (IDIS)) ; Universitat Autònoma de Barcelona
2020 - 10.3389/fphar.2020.01072
Frontiers in Pharmacology, Vol. 11 (july 2020)  

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