1.
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15 p, 2.4 MB |
Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study
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Vilor-Tejedor, N. (Universitat Pompeu Fabra) ;
Operto, Gregory (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Evans, T.E. (Erasmus MC University Medical Center Rotterdam. Department of Clinical Genetics) ;
Falcon, Carles (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Crous-Bou, M. (Cancer Epidemiology Research Program. Catalan Institute of Oncology (ICO). Hospitalet de Llobregat) ;
Minguillón, Carolina Institut Hospital del Mar d'Investigacions Mèdiques ;
Cacciaglia, Raffaele Institut Hospital del Mar d'Investigacions Mèdiques ;
Milà-Alomà, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Grau-Rivera, Oriol (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Suárez-Calvet, Marc (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Garrido-Martín, D. (Centre for Genomic Regulation (CRG). The Barcelona Institute for Science and Technology) ;
Moran, Sebastian (Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Biomedical Research Institute (IDIBELL)) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Adams, H.H. (Erasmus MC University Medical Center Rotterdam. Department of Radiology) ;
Molinuevo, José Luís (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Guigó, R. (Universitat Pompeu Fabra) ;
Gispert, Juan Domingo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Background: Current evidence supports the involvement of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and the ε4 allele of APOE gene in hippocampal-dependent functions. Previous studies on the association of Val66Met with whole hippocampal volume included patients of a variety of disorders. [...]
2020 - 10.1007/s00429-020-02125-3
Brain Structure and Function, Vol. 225 Núm. 8 (january 2020) , p. 2331-2345
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2.
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14 p, 4.1 MB |
Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis
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Isidro-Hernández, M. (Institute for Biomedical Research of Salamanca (IBSAL)) ;
Mayado, A. (Servicio de Citometría. Departamento de Medicina. Biomedical Research Networking Centre on Cancer CIBER- CIBERONC (CB16/12/00400). Institute of Health Carlos III. and Instituto de Biología Molecular y Celular del Cáncer. CSIC/Universidad de Salamanca) ;
Casado-García, A. (Institute for Biomedical Research of Salamanca (IBSAL)) ;
Martínez-Cano, J. (Immune system development and function Unit. Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas -Universidad Autónoma de Madrid)) ;
Palmi, C. (Centro Ricerca Tettamanti. Dept of Medicine. University of Milan Bicocca) ;
Fazio, G. (Centro Ricerca Tettamanti. Dept of Medicine. University of Milan Bicocca) ;
Orfao, A. (Servicio de Citometría. Departamento de Medicina. Biomedical Research Networking Centre on Cancer CIBER- CIBERONC (CB16/12/00400). Institute of Health Carlos III. and Instituto de Biología Molecular y Celular del Cáncer. CSIC/Universidad de Salamanca) ;
Ribera Salas, Jordi (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ribera, Jose-Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zamora, Lurdes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Raboso-Gallego, J. (Institute for Biomedical Research of Salamanca (IBSAL)) ;
Blanco, O. (Departamento de Anatomía Patológica. Universidad de Salamanca) ;
Alonso-López, D. (Bioinformatics Unit. Cancer Research Center (CSIC-USAL)) ;
De Las Rivas, J. (Bioinformatics and Functional Genomics Research Group. Cancer Research Center (CSIC-USAL)) ;
Jiménez, R. (Departamento de Fisiología y Farmacología. Universidad de Salamanca) ;
García Criado, F.J. (Departamento de Cirugía. Universidad de Salamanca) ;
García Cenador, M.B. (Departamento de Cirugía. Universidad de Salamanca) ;
Ramírez-Orellana, M. (Department of Pediatric Hematology and Oncology. Hospital Infantil Universitario Niño Jesús. Universidad Autónoma de Madrid) ;
Cazzaniga, G. (Centro Ricerca Tettamanti. Dept of Medicine. University of Milan Bicocca) ;
Cobaleda, C. (Immune system development and function Unit. Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas -Universidad Autónoma de Madrid)) ;
Vicente-Dueñas, C. (Institute for Biomedical Research of Salamanca (IBSAL)) ;
Sánchez-García, I. (Institute for Biomedical Research of Salamanca (IBSAL)) ;
Universitat Autònoma de Barcelona
PAX5 is one of the most frequently mutated genes in B-cell acute lymphoblastic leukemia (B-ALL), and children with inherited preleukemic PAX5 mutations are at a higher risk of developing the disease. [...]
2020 - 10.1038/s41598-020-76206-y
Scientific reports (Nature Publishing Group), Vol. 10 Núm. 1 (january 2020) , p. 19189
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3.
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11 p, 1.3 MB |
A novel targeted RNA-Seq panel identifies a subset of adult patients with acute lymphoblastic leukemia with BCR-ABL1-like characteristics
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Sánchez, R. (Haematological Malignancies Clinical Research Unit. Spanish National Cancer Research Centre (CNIO)) ;
Ribera Salas, Jordi (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Morgades, Mireia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ayala, R. (Universidad Complutense de Madrid) ;
Onecha, E. (Instituto de Investigación Hospital 12 Octubre (i+12)) ;
Ruiz-Heredia, Y. (Hematology Department. Hospital Universitario 12 de Octubre) ;
Juárez-Rufián, A. (Hematology Department. Hospital Universitario 12 de Octubre) ;
de Nicolás, R. (Hematology Department. Hospital Universitario 12 de Octubre) ;
Sánchez-Pina, J. (Hematology Department. Hospital Universitario 12 de Octubre) ;
Vives Polo, Susana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zamora, Lurdes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mercadal, S. (Hematology Department. ICO - Hospital Duran i Reynals (Bellvitge)) ;
Coll, R. (Hospital Universitari de Girona Doctor Josep Trueta) ;
Cervera, M. (Hospital Universitari Joan XXIII de Tarragona) ;
García, Olga (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ribera, Jose-Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martínez-López, J. (Universidad Complutense de Madrid) ;
Universitat Autònoma de Barcelona
BCR-ABL1-like B-cell precursor acute lymphoblastic leukemia (BCP-ALL) remains poorly characterized in adults. We sought to establish the frequency and outcome of adolescent and adult BCR-ABL1-like ALL using a novel RNA-Seq signature in a series of patients with BCP-ALL. [...]
2020 - 10.1038/s41408-020-0308-3
Blood Cancer Journal, Vol. 10 Núm. 4 (january 2020) , p. 43
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7 p, 812.6 KB |
Genetics and epigenetics of leukemia and lymphoma : from knowledge to applications, meeting report of the Josep Carreras Leukaemia Research Institute
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Parra, Maribel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Baptista, Maria Joao (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Genescà, Eulàlia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Llinàs-Arias, Pere (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
The meeting, which brought together leading scientists and clinicians in the field of leukemia and lymphoma, was held at the new headquarters of the Josep Carreras Leukaemia Research Institute (IJC) in Badalona, Catalonia, Spain, September 19-20, 2019. [...]
2020 - 10.1002/hon.2725
Hematological Oncology, Vol. 38 Núm. 4 (january 2020) , p. 432-438
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6.
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12 p, 860.8 KB |
Molecular profiling of immunoglobulin heavy-chain gene rearrangements unveils new potential prognostic markers for multiple myeloma patients
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Medina, Alejandro (Hospital Universitario de Salamanca (HUSAL). IBSAL. IBMCC (USAL-CSIC). CIBERONC) ;
Jiménez, C. (Hospital Universitario de Salamanca (HUSAL). IBSAL. IBMCC (USAL-CSIC). CIBERONC) ;
Sarasquete, M.E. (Hospital Universitario de Salamanca (HUSAL). IBSAL. IBMCC (USAL-CSIC). CIBERONC) ;
González, M. (Hospital Universitario de Salamanca (HUSAL). IBSAL. IBMCC (USAL-CSIC). CIBERONC) ;
Chillón, M.C. (Hospital Universitario de Salamanca (HUSAL). IBSAL. IBMCC (USAL-CSIC). CIBERONC) ;
Balanzategui, A. (Hospital Universitario de Salamanca (HUSAL). IBSAL. IBMCC (USAL-CSIC). CIBERONC) ;
Prieto-Conde, I. (Hospital Universitario de Salamanca (HUSAL). IBSAL. IBMCC (USAL-CSIC). CIBERONC) ;
García-Álvarez, M. (Hospital Universitario de Salamanca (HUSAL). IBSAL. IBMCC (USAL-CSIC). CIBERONC) ;
Puig, N. (Hospital Universitario de Salamanca (HUSAL). IBSAL. IBMCC (USAL-CSIC). CIBERONC) ;
González-Calle, V. (Hospital Universitario de Salamanca (HUSAL). IBSAL. IBMCC (USAL-CSIC). CIBERONC) ;
Alcoceba, M. (Hospital Universitario de Salamanca (HUSAL). IBSAL. IBMCC (USAL-CSIC). CIBERONC) ;
Cuenca, I. (Hospital 12 de Octubre. CIBERONC) ;
Barrio, S. (Hospital 12 de Octubre. CIBERONC) ;
Escalante, F. (Complejo Hospitalario) ;
Gutiérrez, N.C. (Hospital Universitario de Salamanca (HUSAL). IBSAL. IBMCC (USAL-CSIC). CIBERONC) ;
Gironella, Mercedes (Hospital Universitari Vall d'Hebron) ;
Hernández, M.T. (Hospital Universitario de Canarias) ;
Sureda, A. (Institut Català d'Oncologia) ;
Oriol, Albert (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bladé, J. (Hospital Clínic i Provincial. Institut de Investicacions Biomediques August Pi i Sunyer (IDIBAPS)) ;
Lahuerta, J.J. (Hospital 12 de Octubre. CIBERONC) ;
San Miguel, J.F. (Clínica Universidad de Navarra (CUN). Centro de Investigación Médica Aplicada. IDISNA. CIBERONC) ;
Mateos, M.V. (Hospital Universitario de Salamanca (HUSAL). IBSAL. IBMCC (USAL-CSIC). CIBERONC) ;
Martínez-López, J. (Hospital 12 de Octubre. CIBERONC) ;
Calasanz, M.J. (Clínica Universidad de Navarra (CUN). Centro de Investigación Médica Aplicada. IDISNA. CIBERONC) ;
Garcia-Sanz, R (Hospital Universitario de Salamanca (HUSAL). IBSAL. IBMCC (USAL-CSIC). CIBERONC) ;
Universitat Autònoma de Barcelona
Multiple myeloma is a heterogeneous disease whose pathogenesis has not been completely elucidated. Although B-cell receptors play a crucial role in myeloma pathogenesis, the impact of clonal immunoglobulin heavy-chain features in the outcome has not been extensively explored. [...]
2020 - 10.1038/s41408-020-0283-8
Blood Cancer Journal, Vol. 10 Núm. 2 (january 2020) , p. 14
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7.
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12 p, 12.8 MB |
Gut eukaryotic communities in pigs : diversity, composition and host genetics contribution
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Ramayo-Caldas, Yuliaxis (Institut de Recerca i Tecnologia Agroalimentàries) ;
Prenafeta-Boldú, Francesc (Institut de Recerca i Tecnologia Agroalimentàries) ;
Zingaretti, Laura M. (Centre de Recerca en Agrigenòmica) ;
Gonzalez-Rodriguez, Olga (Institut de Recerca i Tecnologia Agroalimentàries) ;
Dalmau Bueno, Antoni (Institut de Recerca i Tecnologia Agroalimentàries) ;
Quintanilla, Raquel (Institut de Recerca i Tecnologia Agroalimentàries) ;
Ballester Devis, Maria (Institut de Recerca i Tecnologia Agroalimentàries)
Background. The pig gut microbiome harbors thousands of species of archaea, bacteria, viruses and eukaryotes such as protists and fungi. However, since the majority of published studies have been focused on prokaryotes, little is known about the diversity, host-genetic control, and contributions to host performance of the gut eukaryotic counterparts. [...]
2020 - 10.1186/s42523-020-00038-4
Animal Microbiome, Vol. 2 (May 2020) , art. 18
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8.
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22 p, 7.3 MB |
Yeast Ppz1 protein phosphatase toxicity involves the alteration of multiple cellular targets
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Velázquez, Diego (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Albacar, Marcel (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Zhang, Chunyi (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Calafí, Carlos (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
López Malo, María (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Torres Torronteras, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martí, Ramón (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Kovalchuk, Sergey I. (University of Southern Denmark. Department of Biochemistry & Molecular Biology and VILLUM Center for Bioanalytical Sciences (Denmark)) ;
Pinson, Benoit (Centre National de la Recherche Scientifique. Université de Bordeaux (France)) ;
Jensen, Ole N. (University of Southern Denmark. Department of Biochemistry & Molecular Biology and VILLUM Center for Bioanalytical Sciences (Denmark)) ;
Daignan-Fornier, Bertrand (Centre National de la Recherche Scientifique. Université de Bordeaux (France)) ;
Casamayor Gracia, Antonio (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ariño Carmona, Joaquín (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Control of the protein phosphorylation status is a major mechanism for regulation of cellular processes, and its alteration often lead to functional disorders. Ppz1, a protein phosphatase only found in fungi, is the most toxic protein when overexpressed in Saccharomyces cerevisiae. [...]
2020 - 10.1038/s41598-020-72391-y
Scientific reports (Nature Publishing Group), Vol. 10 (September 2020) , art. 15613
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26 p, 1.8 MB |
Molecular and Clinicopathologic Characterization of Intravenous Leiomyomatosis
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Ordulu, Zehra (Department of Pathology, Massachusetts General Hospital, Boston, MA, United States) ;
Chai, Hongyan (Department of Genetics, Yale University School of Medicine; New Haven, CT) ;
Peng, Gang (Department of Biostatistics, Yale School of Public Health, New Haven, CT) ;
McDonald, Anna G (Department of Pathology, Wake Forest Baptist Medical Center, Winston Salem, NC) ;
De Nictolis, Michele (Department of Pathology, San Salvatore Hospital, Pesaro, Italy) ;
Garcia-Fernandez, Eugenia (Department of Pathology, Hospital Universitario La Paz, IdiPAZ, and Faculty of Medicine, Universidad Autónoma de Madrid, Spain) ;
Hardisson, David (Department of Pathology, Hospital Universitario La Paz, IdiPAZ, and Faculty of Medicine, Universidad Autónoma de Madrid, Spain) ;
Prat, Jaime (Department of Pathology, Hospital de la Sta Creu i Sant Pau, Barcelona, Spain) ;
Li, Peining (Department of Genetics, Yale University School of Medicine; New Haven, CT) ;
Hui, Pei (Department of Pathology, Yale University School of Medicine; New Haven, CT) ;
Oliva, Esther (Department of Pathology, Massachusetts General Hospital, Boston, MA, United States) ;
Buza, Natalia (Department of Pathology, Yale University School of Medicine; New Haven, CT)
Intravenous leiomyomatosis (IVL) is an unusual uterine smooth muscle proliferation that can be associated with aggressive clinical behavior despite a histologically benign appearance. It has some overlapping molecular characteristics with both uterine leiomyoma and leiomyosarcoma based on limited genetic data. [...]
2020 - 10.1038/s41379-020-0546-8
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 33 (april 2020) , p. 1844-1860
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