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13 p, 4.7 MB |
Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis
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Agraz-Doblás, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rogers, R. B. (Department of Medicine. University of Cambridge. Cambridge Biomedical Campus) ;
Roy, A. (Department of Paediatrics. University of Oxford) ;
Schneider, P. (Princess Maxima Center for Pediatric Oncology) ;
Bardini, Michela (Università degli Studi di Milano-Bicocca) ;
Ballerini, Paola (Pediatric Hematology. A. Trousseau Hospital) ;
Cazzaniga, Giovanni (Centro Ricerca Tettamanti. Department of Pediatrics. University of Milano Bicocca. Fondazione MBBM) ;
Moreno, T. (Instituto de Biomedicina y Biotecnología de Cantabria. Universidad de Cantabria-CSIC) ;
Revilla, C. (Instituto de Biomedicina y Biotecnología de Cantabria. Universidad de Cantabria-CSIC) ;
Gut, Marta (Universitat Pompeu Fabra) ;
Valsecchi, M. G. (Interfant Trial Data Center. University of Milano-Bicocca) ;
Roberts, I. (MRC Molecular Haematology Unit. MRC Weatherall Institute of Molecular Medicine. University of Oxford) ;
Pieters, R. (Princess Maxima Center for Pediatric Oncology) ;
De Lorenzo, P. (Interfant Trial Data Center. University of Milano-Bicocca) ;
Varela, Ignacio (Instituto de Biomedicina y Biotecnología de Cantabria. Universidad de Cantabria-CSIC) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Stam, R. W. (Princess Maxima Center for Pediatric Oncology) ;
Universitat Autònoma de Barcelona
Bcell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell acute lymphoblastic leukemia remains fatal, especially in patients with t(4;11), present in ~80% of cases. The pathogenesis of t(4;11)/KMT2A-AFF1 (MLL-AF4) infant B-cell acute lymphoblastic leukemia remains difficult to model, and the pathogenic contribution in cancer of the reciprocal fusions resulting from derivative translocated-chromosomes remains obscure. [...]
2019 -  10.3324/haematol.2018.206375
Haematologica, Vol. 104 Núm. 6 (2019) , p. 1176-1188
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18 p, 6.6 MB |
A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer
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López de Maturana, Evangelina (Centro de Investigación Biomédica en Red de Cáncer) ;
Rodríguez, Juan Antonio (Centre de Regulació Genòmica) ;
Alonso, Lola (Centro de Investigación Biomédica en Red de Cáncer) ;
Lao, Oscar (Centre de Regulació Genòmica) ;
Molina-Montes, Esther (Centro de Investigación Biomédica en Red de Cáncer) ;
Martín-Antoniano, Isabel Adoración (Centro de Investigación Biomédica en Red de Cáncer) ;
Gómez-Rubio, Paulina (Centro de Investigación Biomédica en Red de Cáncer) ;
Lawlor, Rita (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer and Department of Pathology and Diagnostics) ;
Carrato, Alfredo (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Hidalgo, Manuel (Weill Cornell Medicine) ;
Iglesias, Mar (Parc de Salut MAR de Barcelona) ;
Molero, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Löhr, Matthias (Gastrocentrum, Karolinska Institutet and University Hospital) ;
Michalski, Christopher (Martin-Luther-University Halle-WittenberHalle (Saale). Department of Visceral, Vascular and Endocrine Surgery) ;
Perea, José (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
O'Rorke, Michael (The University of Iowa. College of Public Health) ;
Barberà, Victor Manuel (Hospital General Universitario de Elche) ;
Tardón, Adonina (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Farré, Antoni (Institut d'Investigació Biomèdica Sant Pau) ;
Muñoz-Bellvís, Luís (Instituto de Investigación Biomédica de Salamanca) ;
Crnogorac-Jurcevic, Tanja (Queen Mary University of London. Barts Cancer Institute, Centre for Molecular Oncology) ;
Domínguez-Muñoz, Enrique (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Gress, Thomas (University Hospital of Giessen and Marburg (Alemanya)) ;
Greenhalf, William (University of Liverpool. Department of Molecular and Clinical Cancer Medicine) ;
Sharp, Linda (Newcastle University, Institute of Health & Society) ;
Arnes, Luís (Columbia University Medical Center. Department of Systems Biology) ;
Cecchini, Lluís (Parc de Salut MAR de Barcelona) ;
Balsells, Joaquim (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Costello, Eithne (University of Liverpool. Department of Molecular and Clinical Cancer Medicine) ;
Ilzarbe, Lucas (Parc de Salut MAR de Barcelona) ;
Kleeff, Jörg (Martin-Luther-University Halle-WittenberHalle (Saale). Department of Visceral, Vascular and Endocrine Surgery) ;
Kong, Bo (Technical University of Munich. Department of Surgery) ;
Márquez, Mirari (Centro de Investigación Biomédica en Red de Cáncer) ;
Mora Brugués, Josefina (Institut d'Investigació Biomèdica Sant Pau) ;
O'Driscoll, Damian (University College Cork. National Cancer Registry Ireland and HRB Clinical Research Facility) ;
Scarpa, Aldo (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer and Department of Pathology and Diagnostics) ;
Ye, Weimin (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ;
Yu, Jingru (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ;
García-Closas, Montserrat (Centro Nacional de Investigaciones Oncológicas) ;
Kogevinas, M.. (Hospital del Mar (Barcelona, Catalunya)) ;
Rothman, Nathaniel (Centro Nacional de Investigaciones Oncológicas) ;
Silverman, Debra T. (Centro Nacional de Investigaciones Oncológicas) ;
Albanes, Demetrius (Centro Nacional de Investigaciones Oncológicas) ;
Arslan, Alan A. (New York University School of Medicine. Department of Population Health) ;
Beane-Freeman, Laura (Centro Nacional de Investigaciones Oncológicas) ;
Bracci, Paige M. (University of California. Department of Epidemiology and Biostatistics) ;
Brennan, Paul (International Agency for Research on Cancer (IARC)) ;
Bueno-de-Mesquita, Bas (National Institute for Public Health and the Environment (RIVM). Deparment for Determinants of Chronic Diseases (DCD)) ;
Buring, Julie (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Canzian, Federico (German Cancer Research Center (DKFZ. Genomic Epidemiology Group) ;
Du, Margaret (Memorial Sloan Kettering Cancer Center) ;
Gallinger, Steven (Sinai Health System. Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute) ;
Gaziano, J. Michael (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Goodman, Phyllis J. (SWOG Statistical Center, Fred Hutchinson Cancer Research Center) ;
Gunter, Marc (International Agency for Research on Cancer (IARC)) ;
LeMarchand, Loic (University of Hawaii Cancer Center. Cancer Epidemiology Program) ;
Li, Donghui (University of Texas MD Anderson Cancer Center) ;
Neale, Rachael E. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia). Population Health Department) ;
Peters, Ulrika (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences) ;
Petersen, Gloria M. (Mayo Clinic College of Medicine. Department of Health Sciences Research) ;
Risch, Harvey A. (Yale School of Public Health. Department of Chronic Disease Epidemiology) ;
Sánchez, Maria José (Universidad de Granada) ;
Shu, Xiao-Ou (Vanderbilt University School of Medicine. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center) ;
Thornquist, Mark D. (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences) ;
Visvanathan, Kala (Mayo Clinic College of Medicine. Department of Health Sciences Research) ;
Zheng, Wei (Vanderbilt University School of Medicine. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center) ;
Chanock, Stephen (Centro Nacional de Investigaciones Oncológicas) ;
Easton, Douglas F (University of Cambridge. Centre for Cancer Genetic Epidemiology) ;
Wolpin, Brian M. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Stolzenberg-Solomon, Rachael Z. (Centro Nacional de Investigaciones Oncológicas) ;
Klein, Alison P. (Johns Hopkins School of Medicine. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center) ;
Amundadottir, Laufey T. (National Cancer Institute (Bethesda, Estats Units d'Amèrica)) ;
Marti-Renom, Marc A. (Universitat Pompeu Fabra. Centre de Regulació Genòmica (CRG-UPF)) ;
Real, Francisco X (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Malats, Núria (Centro de Investigación Biomédica en Red de Cáncer)
Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4. [...]
2021 - 10.1186/s13073-020-00816-4
Genome Medicine, Vol. 13 (february 2021)
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13 p, 1.4 MB |
Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status
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Lyons, Paul A. (Uniit)) ;
Peters, James E. (Health Data Research UK) ;
Alberici, Federico (University of Milano) ;
Liley, James (Cambridge Institute of Public Health) ;
Coulson, Richard M. R. (University of Cambridge School of Clinical Medicine. University of Cambridge) ;
Astle, William (NHS Blood and Transplant) ;
Baldini, Chiara (University of Pisa) ;
Bonatti, Francesco (University Hospital of Parma) ;
Cid, María Cinta (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Elding, Heather (Wellcome Trust Sanger Institute (Regne Unit)) ;
Emmi, Giacomo (University of Firenze) ;
Epplen, Jörg (Ruhr University Bochum) ;
Guillevin, Loïc (Hôpital Cochin) ;
Jayne, David R. W. (University of Cambridge School of Clinical Medicine) ;
Jiang, Tao (University of Cambridge) ;
Gunnarsson, Iva (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Lamprecht, Peter (University of Lübeck) ;
Leslie, Stephen (Data Science. Murdoch Children's Research Institute) ;
Little, Mark A. (Tallaght Hospital) ;
Martorana, Davide (University Hospital of Parma) ;
Moosig, Frank (Rheumazentrum Schleswig-Holstein Mitte) ;
Neumann, Thomas (Department of Rheumatology. Immunology and Rehabilitation. Cantonal Hospital St. Gallen) ;
Ohlsson, Sophie (Department of Nephrology. Division of Clinical Sciences. Lund University) ;
Quickert, Stefan (Department of Internal Medicine 4 (Gastroenterology. Hepatology. and Infectious Diseases). Jena University Hospital) ;
Ramirez, Giuseppe A. (Unit of Immunology. Rheumatology. Allergy and Rare Diseases. Università Vita Salute San Raffaele and IRCCS Ospedale San Raffaele) ;
Rewerska, Barbara (Jagiellonian University Medical College) ;
Schett, George (Department of Internal Medicine 3. Rheumatology and Immunology. Friedrich Alexander University Erlangen-Nuremberg and Universitatsklinikum Erlangen) ;
Sinico, Renato A. (Università degli Studi di Milano-Bicocca) ;
Szczeklik, Wojciech (Jagiellonian University Medical College) ;
Tesar, Vladimir (Charles University) ;
Vukcevic, Damjan (Murdoch Children's Research Institute) ;
Akil, Mohammed (Sheffield Royal Hallamshire Hospital) ;
Barratt, Jonathan (University of Leicester) ;
Basu, Neil (University of Glasgow) ;
Butterworth, Adam (University of Cambridge) ;
Bruce, Ian (The University of Manchester) ;
Clarkson, Michael (Cork University Hospital) ;
Conlon, Niall (St James' Hospital Dublin) ;
DasGupta, Bhaskar (Southend University Hospital) ;
Doulton, Timothy W. R. (EKent and Canterbury Hospital) ;
Espígol-Frigolé, Georgina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Flossmann, Oliver (Royal Berkshire Hospital NHS Trust) ;
Gabrielli, Armando (Ospedali Riuniti-Università) ;
Gasior, Jolanta (University Hospital. Department of allergy and immunology) ;
Gregorini, Gina (Nephrology Unit. Spedali Civili) ;
Guida, Giuseppe (ASL TO2 Birago di Vische Hospital) ;
Hernández Rodríguez, José (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Hruskova, Zdenka (Charles University) ;
Hudson, Amy (Data Science. Murdoch Children's Research Institute) ;
Knight, Ann (Department of Medical Sciences. Uppsala University) ;
Lanyon, Peter (Nottingham University Hospitals NHS Trust (Regne Unit)) ;
Luqmani, Raashid (Nuffield Orthopaedic Centre) ;
Magliano, Malgorzata (Stoke Mandeville Hospital) ;
Manfredi, Angelo A. (Università Vita Salute San Raffaele and IRCCS Ospedale San Raffaele) ;
Marguerie, Christopher (South Warwickshire NHS Foundation Trust) ;
Maritati, Federica (University of Firenze) ;
Marvisi, Chiara (University of Firenze) ;
McHugh, Neil J. (Royal National Hospital for Rheumatic Disease) ;
Molloy, Eaminn (St Vincent's Hospital Dublin) ;
Motyer, Allan (University of Melbourne) ;
Mukhtyar, Chetan (Norfolk and Norwich University Hospital) ;
Padyukov, Leonid (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Pesci, Alberto (University of Milano Bicocca) ;
Prieto-Gonzalez, Sergio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ramentol-Sintas, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Reis, Petra (Friedrich Alexander University Erlangen-Nuremberg) ;
Roccatello, Dario (University of Torino) ;
Rovere-Querini, Patrizia (Jena University Hospital (Alemanya)) ;
Salvarani, Carlo (Università di Modena e Reggio Emilia) ;
Santarsia, Francesca (University Hospital of Parma) ;
Solans, Roser (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Soranzo, Nicole (University of Cambridge) ;
Taylor, Jo (Dorset County Hospital) ;
Wessels, Julie (Royal Stoke University Hospital) ;
Zwerina, Jochen (Friedrich Alexander University Erlangen-Nuremberg and Universitatsklinikum Erlangen) ;
Terrier, Benjamin (Service de Médecine Interne. Hôpital Cochin) ;
Watts, Richard A. (Norwich Medical School. University of East Anglia) ;
Vaglio, Augusto (University of Firenze) ;
Holle, Julia U. (Rheumazentrum Schleswig-Holstein Mitte) ;
Wallace, Chris (Cambridge Institute of Public Health) ;
Smith, Kenneth G. C. (Jeffrey Cheah Biomedical Centre University of Cambridge) ;
Universitat Autònoma de Barcelona
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO). [...]
2019 - 10.1038/s41467-019-12515-9
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 5120
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18 p, 2.1 MB |
Comparing the mRNA expression profile and the genetic determinism of intramuscular fat traits in the porcine gluteus medius and longissimus dorsi muscles
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González Prendes, Rayner (Centre de Recerca en Agrigenòmica) ;
Quintanilla, Raquel (Institut de Recerca i Tecnologia Agroalimentàries) ;
Mármol-Sánchez, Emilio (Centre de Recerca en Agrigenòmica) ;
Pena i Subirà, Ramona Natacha (Universitat de Lleida. Departament de Ciència Animal) ;
Ballester Devis, Maria (Institut de Recerca i Tecnologia Agroalimentàries) ;
Cardoso, Tainã Figueiredo (Centre de Recerca en Agrigenòmica) ;
Manunza, Arianna (Centre de Recerca en Agrigenòmica) ;
Casellas Vidal, Joaquim (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Cánovas, Angela (University of Guelph. Centre for Genetic Improvement of Livestock. Department of Animal Biosciences (Canada)) ;
Díaz, Isabel (Institut de Recerca i Tecnologia Agroalimentàries) ;
Noguera, José Luis (Institut de Recerca i Tecnologia Agroalimentàries. Programa de cria i genètica d'animals) ;
Castelló Farré, Anna (Centre de Recerca en Agrigenòmica) ;
Mercadé Carceller, Anna (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Amills i Eras, Marcel (Centre de Recerca en Agrigenòmica) ;
Universitat Autònoma de Barcelona.
Departament de Ciència Animal i dels Aliments
Background: Intramuscular fat (IMF) content and composition have a strong impact on the nutritional and organoleptic properties of porcine meat. The goal of the current work was to compare the patterns of gene expression and the genetic determinism of IMF traits in the porcine gluteus medius (GM) and longissimus dorsi (LD) muscles. [...]
2019 - 10.1186/s12864-019-5557-9
BMC genomics, Vol. 20 (March 2019) , art. 170
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12 p, 237.4 KB |
A genome-wide association analysis for porcine serum lipid traits reveals the existence of age-specific genetic determinants
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Manunza, Arianna (Centre de Recerca en Agrigenòmica) ;
Casellas Vidal, Joaquim (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Quintanilla, Raquel (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
González Prendes, Rayner (Centre de Recerca en Agrigenòmica) ;
Pena i Subirà, Ramona Natacha (Universitat de Lleida. Departament de Producció Animal) ;
Tibau, Joan (Institut de Recerca i Tecnologia Agroalimentàries) ;
Mercadé Carceller, Anna (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Castelló Farré, Anna (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Aznárez, Nitdia (Institut de Recerca i Tecnologia Agroalimentàries) ;
Hernández Sánchez, Jules (Institut de Recerca i Tecnologia Agroalimentàries) ;
Amills i Eras, Marcel (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Background: The genetic determinism of blood lipid concentrations, the main risk factor for atherosclerosis, is practically unknown in species other than human and mouse. Even in model organisms, little is known about how the genetic determinants of lipid traits are modulated by age-specific factors. [...]
2014 - 10.1186/1471-2164-15-758
BMC genomics, Vol. 15, N. 758 (September 2014) , p. 1-12
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