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1.
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6 p, 2.0 MB |
Cerebral gliosarcoma with perivascular involvement in a cat
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Álvarez, Patricia (Pride Veterinary Centre, Derby. Neurology and Neurosurgery Service) ;
Wessmann, Annette (Pride Veterinary Centre, Derby. Neurology and Neurosurgery Service) ;
Pascual, Mireia (BalmesVet. ClínicaVeterinaria (Barcelona)) ;
Comas, Oriol (BalmesVet. ClínicaVeterinaria (Barcelona)) ;
Pi, Dolors (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Case summary A 5-year-old neutered male domestic shorthair cat presented with an 18-month history of facial tics, and progressive general ataxia, weakness, lethargy and anorexia of 2 weeks' duration. [...]
2019 -  10.1177/2055116919879783
Journal of feline medicine and surgery, Vol. 5, Num. 2 (2019)
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2.
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13 p, 2.4 MB |
Alternative splicing of human telomerase reverse transcriptase in gliomas and its modulation mediated by CX-5461
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Li, Guihong (Zhengzhou, 450000 China) ;
Shen, Jing (Department of Cardiology, Shengze Hospital of Jiangsu Province, Suzhou, 215200 China) ;
Cao, Junguo (Changchun, 130021 China) ;
Zhou, Guangtong (Zhengzhou, 450000 China) ;
Lei, Ting (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sun, Yuxue (Changchun, 130021 China) ;
Gao, Haijun (Changchun, 130021 China) ;
Ding, Yaonan (Changchun, 130021 China) ;
Xu, Weidong (Changchun, 130021 China) ;
Zhan, Zhixin (Changchun, 130021 China) ;
Chen, Yong (Changchun, 130021 China) ;
Huang, Haiyan (Changchun, 130021 China) ;
Universitat Autònoma de Barcelona
Glioma is a heterogeneous, invasive primary brain tumor with a wide range of patient survival and a lack of reliable prognostic biomarkers. Human telomerase reverse transcriptase (hTERT) has been reported in the presence of multiple transcripts in various tumor systems. [...]
2018 - 10.1186/s13046-018-0749-8
Journal of Experimental & Clinical Cancer Research : CR, Vol. 37 (april 2018)
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9 p, 559.9 KB |
Long-term follow-up of surgical resection alone for primary intracranial rostrotentorial tumors in dogs : 29 cases (2002-2013)
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Suñol, Anna ;
Mascort, Joan ;
Font, Cristina ;
Bastante, Alicia Rami ;
Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Feliu-Pascual, Alejandro Lujan
Intracranial neoplasia is frequently encountered in dogs. After a presumptive diagnosis of intracranial neoplasia is established based on history, clinical signs and advanced imaging characteristics, the decision to treat and which treatment to choose must be considered. [...]
2017 - 10.4314/ovj.v7i4.14
Open Veterinary Journal, Vol. 7 (december 2017) , p. 375-383
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4.
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14 p, 1.9 MB |
Pharmacokinetic, pharmacodynamic and biomarker evaluation of transforming growth factor-β receptor I kinase inhibitor, galunisertib, in phase 1 study in patients with advanced cancer
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Rodón, Jordi (Hospital Universitari Vall d'Hebron) ;
Carducci, Michael (Johns Hopkins Kimmel Cancer Center) ;
Sepulveda-Sánchez, Juan M. (Hospital Universitario 12 de Octubre) ;
Azaro, Analía (Hospital Universitari Vall d'Hebron) ;
Calvo, Emiliano (START Madrid, Centro Integral Oncológico Clara Campal) ;
Seoane, Joan (Hospital Universitari Vall d'Hebron) ;
Braña, Irene (Hospital Universitari Vall d'Hebron) ;
Sicart, Elisabet (Hospital Universitari Vall d'Hebron) ;
Gueorguieva, Ivelina (Eli Lilly and Company) ;
Cleverly, Ann (Eli Lilly and Company) ;
Pillay, N. Sokalingum (Eli Lilly and Company) ;
Desaiah, Durisala (Eli Lilly and Company) ;
Estrem, Shawn T. (Eli Lilly and Company) ;
Paz-Ares, Luis (Hospital Virgen del Rocío, Sevilla, Spain) ;
Holdhoff, Matthias (Johns Hopkins Kimmel Cancer Center) ;
Blakeley, Jaishri (Johns Hopkins University) ;
Lahn, Michael M. (Eli Lilly and Company) ;
Baselga, Jose (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Purpose Transforming growth factor-beta (TGF-β) signaling plays a key role in epithelial-mesenchymal transition (EMT) of tumors, including malignant glioma. Small molecule inhibitors (SMI) blocking TGF-β signaling reverse EMT and arrest tumor progression. [...]
2014 - 10.1007/s10637-014-0192-4
Investigational New Drugs, Vol. 33 (december 2014) , p. 357-370
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29 p, 14.8 MB |
Metabolomics of Therapy Response in Preclinical Glioblastoma : a Multi-Slice MRSI-Based Volumetric Analysis for Noninvasive Assessment of Temozolomide Treatment
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Arias-Ramos, Nuria (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Ferrer-Font, Laura (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Lope Piedrafita, Silvia (Universitat Autònoma de Barcelona. Servei de Ressonància Magnètica Nuclear) ;
Mocioiu, Victor (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Julià Sapé, Ma. Margarita (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Arús i Caraltó, Carles (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Candiota Silveira, Ana Paula (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Glioblastoma (GBM) is the most common aggressive primary brain tumor in adults, with a short survival time even after aggressive therapy. Non-invasive surrogate biomarkers of therapy response may be relevant for improving patient survival. [...]
2017 - 10.3390/metabo7020020
Metabolites, Vol. 7, Num. 2 (2017) , p. p1-29
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12 p, 450.2 KB |
Safety and Efficacy of 5-Aminolevulinic Acid for High Grade Glioma in Usual Clinical Practice: A Prospective Cohort Study
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Teixidor, Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Arráez, Miguel Ángel (Hospital Regional Universitario de Málaga) ;
Villalba, Glòria (Hospital del Mar (Barcelona, Catalunya)) ;
Garcia, Roser (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tardáguila, Manel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
González Sánchez, Juan José (Hospital Clínic i Provincial de Barcelona) ;
Rimbau, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vidal Guitart, Xavier (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Montané, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Background: During the last decade, the use of 5-aminolevulinic acid (5-ALA) has been steadily increasing in neurosurgery. The study's main objectives were to prospectively evaluate the effectiveness and safety of 5-ALA when used in clinical practice setting on high-grade gliomas' patients. [...]
2016 - 10.1371/journal.pone.0149244
PloS one, Vol. 11 Núm. 2 (February 2016)
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7.
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18 p, 1.8 MB |
Targeting protein kinase CK2 : evaluationg CX-4945 potential for GL261 glioblastoma therapy in immunocompetent mice
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Ferrer-Font, Laura (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Villamañán de Santiago, Lucía (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Arias-Ramos, Nuria (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Vilardell Vilà, Jordi (Università degli studi di Padova. Dipartimento di Scienze Biomediche) ;
Plana i Coll, Maria (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Ruzzene, Maria (Università degli studi di Padova. Dipartimento di Scienze Biomediche) ;
Pinna, Lorenzo A. (Università degli studi di Padova. Dipartimento di Scienze Biomediche) ;
Itarte, Emilio (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Arús i Caraltó, Carles (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Candiota Silveira, Ana Paula (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Glioblastoma (GBM) causes poor survival in patients even with aggressive treatment. Temozolomide (TMZ) is the standard chemotherapeutic choice for GBM treatment but resistance always ensues. Protein kinase CK2 (CK2) contributes to tumour development and proliferation in cancer, and it is overexpressed in human GBM. [...]
2017 - 10.3390/ph10010024
Pharmaceuticals, Vol. 10 Núm. 1 (2017) , p. art 24
2 documents
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8.
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17 p, 1.8 MB |
Protein kinase CK2 content in GL261 mouse glioblastoma
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Ferrer-Font, Laura (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Alcaraz Muñoz, Estefania (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Plana i Coll, Maria (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Candiota Silveira, Ana Paula (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Itarte, Emilio (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Arús i Caraltó, Carles (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Glioblastoma (GBM) is the most prevalent and aggressive human glial tumour with a median survival of 14-15 months. Temozolomide (TMZ) is the standard chemotherapeutic choice for GBM treatment. Unfortunately, chemoresistence always ensues with concomitant tumour regrowth. [...]
2016 - 10.1007/s12253-015-9987-7
Pathology & oncology research, Vol. 22, Issue 3 (July 2016) , p. 633-637
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10.
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10 p, 2.3 MB |
Imaging the microanatomy of astrocyte-T-cell interactions in immune-mediated inflammation
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Barcia, Carlos (Consorci Hospital General Universitari (Valencia). Departament de Neurocirurgia) ;
Mitxitorena, Izaskun (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Carrillo-de Sauvage, Maria A. (Institut d'Imagerie Biomédicale) ;
Gallego, José Maria (Consorci Hospital General Universitari (Valencia). Departament de Neurocirurgia) ;
Pérez-Vallés, Ana (Consorci Hospital General Universitari (Valencia). Departament de Patologia) ;
Barcia, Carlos (Universitat Autònoma de Barcelona. Institut de Neurociències)
The role of astrocytes in the immune-mediated inflammatory response in the brain is more prominent than previously thought. Astrocytes become reactive in response to neuro-inflammatory stimuli through multiple pathways, contributing significantly to the machinery that modifies the parenchymal environment. [...]
2013 - 10.3389/fncel.2013.00058
Frontiers in cellular neuroscience, Vol. 7 (April 2013) , p. 1-10
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