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29 p, 401.7 KB |
Epigenetic targets in B- and T-cell lymphomas : latest developments
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Ribeiro, Marcelo L. (Sao Francisco University Medical School) ;
Sánchez Vinces, Salvador (Sao Francisco University Medical School) ;
Mondragón, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Roué, Gaël (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Non-Hodgkin's lymphomas (NHLs) comprise a diverse group of diseases, either of mature B-cell or of T-cell derivation, characterized by heterogeneous molecular features and clinical manifestations. While most of the patients are responsive to standard chemotherapy, immunotherapy, radiation and/or stem cell transplantation, relapsed and/or refractory cases still have a dismal outcome. [...]
2023 -  10.1177/20406207231173485
Therapeutic Advances in Hematology, Vol. 14 (1-12 2023)
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3.3 MB |
HIVconsv Vaccines and Romidepsin in Early-Treated HIV-1-Infected Individuals : Safety, Immunogenicity and Effect on the Viral Reservoir (Study BCN02)
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Mothe, Beatriz (Universitat de Vic - Universitat Central de Catalunya) ;
Rosás-Umbert, Miriam (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Coll, Pep (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Manzardo, Christian (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Moron-Lopez, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Miranda, Cristina (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
López, Miriam (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Alarcón-Soto, Yovaninna (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ;
Melis, Guadalupe Gómez (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ;
Langohr, Klaus (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ;
Barriocanal, Ana María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Toro, Jessica (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Ruiz, Irene (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rovira, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Carrillo, Antonio (Institut Germans Trias i Pujol) ;
Meulbroek, Michael (BCN Checkpoint. Projecte dels NOMS-Hispanosida) ;
Crook, Alison (University of Oxford. The Jenner Institute) ;
Wee, Edmund G. (University of Oxford. The Jenner Institute) ;
Miró, José M (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Clotet Sala, Bonaventura (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Valle, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Martinez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats) ;
Hanke, Tomáš (Kumamoto University. Joint Research Center for Human Retrovirus Infection) ;
Brander, Christian (Institució Catalana de Recerca i Estudis Avançats) ;
Moltó, José (Institut Germans Trias i Pujol)
Kick&kill strategies combining drugs aiming to reactivate the viral reservoir with therapeutic vaccines to induce effective cytotoxic immune responses hold potential to achieve a functional cure for HIV-1 infection. [...]
2020 - 10.3389/fimmu.2020.00823
Frontiers in immunology, Vol. 11 (May 2020) , art. 823
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1.1 MB |
In vivo Effects of Romidepsin on T-Cell Activation, Apoptosis and Function in the BCN02 HIV-1 Kick&Kill Clinical Trial
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Rosás-Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz-Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fernández, Marco A. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marszalek, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Coll, Pep (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Manzardo, Christian (Hospital Clínic i Provincial de Barcelona) ;
Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Miró, José M. (Hospital Clínic i Provincial de Barcelona) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hanke, Tomáš (University of Oxford) ;
Moltó, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Romidepsin (RMD) is a well-characterized histone deacetylase inhibitor approved for the treatment of cutaneous T-cell lymphoma. in vitro and in vivo studies have demonstrated that it is able to induce HIV-1 gene expression in latently infected CD4 + T cells from HIV-1 + individuals on suppressive antiretroviral therapy. [...]
2020 - 10.3389/fimmu.2020.00418
Frontiers in immunology, Vol. 11 (march 2020)
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11 p, 1.2 MB |
Up-regulation of HDACs, a harbinger of uraemic endothelial dysfunction, is prevented by defibrotide
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Palomo, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vera, Manuel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Martín, Susana (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Torramadé-Moix, S. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Martinez-Sanchez, Julia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Belen Moreno, A. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Escolar, Ginès (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Cases, A. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Diaz-Ricart, Maribel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Endothelial dysfunction is an earlier contributor to the development of atherosclerosis in chronic kidney disease (CKD), in which the role of epigenetic triggers cannot be ruled out. Endothelial protective strategies, such as defibrotide (DF), may be useful in this scenario. [...]
2020 - 10.1111/jcmm.14865
Journal of Cellular and Molecular Medicine, Vol. 24 Núm. 2 (january 2020) , p. 1713-1723
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24 p, 2.0 MB |
Recent advances in the targeting of epigenetic regulators in b-cell non-hodgkin lymphoma
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Ribeiro, Marcelo L. (Vall d'Hebron Institut d'Oncologia) ;
Reyes Garau, Diana (Vall d'Hebron Institut d'Oncologia) ;
Armengol, Marc Antoni (Vall d'Hebron Institut d'Oncologia) ;
Roué, Gaël (Vall d'Hebron Institut d'Oncologia) ;
Universitat Autònoma de Barcelona
In the last 10 years, major advances have been made in the diagnosis and development of selective therapies for several blood cancers, including B-cell non-Hodgkin lymphoma (B-NHL), a heterogeneous group of malignancies arising from the mature B lymphocyte compartment. [...]
2019 - 10.3389/fgene.2019.00986
Frontiers in genetics, Vol. 10 Núm. OCT (2019) , p. 986
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12 p, 3.2 MB |
Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type
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Karnezis, Anthony N. (University of British Columbia. Department of Pathology and Laboratory Medicine) ;
Wang, Yemin (University of British Columbia. Department of Pathology and Laboratory Medicine) ;
Ramos, Pilar (Translational Genomics Research Institute) ;
Hendricks, William P. D. (Translational Genomics Research Institute) ;
Oliva, Esther (Massachusetts General Hospital (Boston)) ;
D'Angelo, Emanuela (Institut d'Investigació Biomèdica Sant Pau) ;
Prat, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Nucci, Marisa R. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Nielsen, Torsten O. (University of British Columbia. Department of Pathology and Laboratory Medicine) ;
Chow, Christine (University of British Columbia. Genetic Pathology Evaluation Centre) ;
Leung, Samuel (University of British Columbia. Genetic Pathology Evaluation Centre) ;
Kommoss, Friedrich (Synlab MVZ Pathologie) ;
Kommoss, Stefan (University Hospital of Tübingen (Alemanya)) ;
Silva, Annacarolina (Harvard Medical School. The James Homer Wright Pathology Laboratories) ;
Ronnett, Brigitte M. (The Johns Hopkins Hospital. Department of Pathology) ;
Rabban, Joseph T. (University of California San Francisco. Department of Anatomic Pathology) ;
Bowtell, David D. (Peter MacCallum Cancer Centre) ;
Weissman, Bernard E. (University of North Carolina. Department of Pathology and Laboratory Medicine) ;
Trent, Jeffrey M. (Translational Genomics Research Institute) ;
Gilks, C. Blake (University of British Columbia. Department of Pathology and Laboratory Medicine) ;
Huntsman, David G. (University of British Columbia. Department of Pathology and Laboratory Medicine) ;
Universitat Autònoma de Barcelona
Small cell carcinoma of the ovary, hypercalcaemic type () is a lethal and sometimes familial ovarian tumour of young women and children. We and others recently discovered that over 90% of harbour inactivating mutations in the chromatin remodelling gene with concomitant loss of its encoded protein (), one of two mutually exclusive of the / chromatin remodelling complex. [...]
2015 - 10.1002/path.4633
The Journal of Pathology, Vol. 238, Issue 3 (december 2015) , p. 389-400
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