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9 p, 419.0 KB |
Transmission of HIV drug resistance and the predicted effect on current first-line regimens in Europe
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Hofstra, L.M. (University Medical Center Utrecht) ;
Sauvageot, N. ;
Albert, J. ;
Alexiev, I. ;
Garcia, F. ;
Struck, D. ;
Van De Vijver, D.A.M.C. ;
Åsjö, B. ;
Beshkov, D. ;
Coughlan, S. ;
Descamps, D. ;
Griskevicius, A. ;
Hamouda, O. ;
Horban, A. ;
Van Kasteren, M. ;
Kolupajeva, T. ;
Kostrikis, L.G. ;
Liitsola, K. ;
Linka, M. ;
Mor, O. ;
Nielsen, C. ;
Otelea, D. ;
Paraskevis, D. ;
Paredes, R. ;
Puchhammer-Stöckl, E. (Medical University Vienna) ;
Sönnerborg, A. ;
Staneková, D. (Slovak Medical University) ;
Stanojevic, M. (University of Belgrade) ;
Van Laethem, K. ;
Zazzi, M. ;
Lepej, S.Z. ;
Boucher, C.A.B. ;
Schmit, J.C. ;
Wensing, A.M.J. ;
Puchhammer-Stockl, E. ;
Sarcletti, M. ;
Schmied, B. ;
Geit, M. ;
Balluch, G. ;
Vandamme, A. M. ;
Vercauteren, J. ;
Derdelinckx, I. ;
Sasse, A. ;
Bogaert, M. ;
Ceunen, H. ;
De Roo, A. ;
De Wit, S. ;
Echahidi, F. ;
Fransen, K. ;
Goffard, J.C. ;
Goubau, P. ;
Goudeseune, E. ;
Yombi, J.C. ;
Lacor, P. ;
Liesnard, C. ;
Moutschen, M. ;
Pierard, D. ;
Rens, R. ;
Schrooten, Y. ;
Vaira, D. ;
Vandekerckhove, L.P.R. ;
Van Den Heuvel, A. ;
Van Der Gucht, B. ;
Van Ranst, M. ;
Van Wijngaerden, E. ;
Vandercam, B. ;
Vekemans, M. ;
Verhofstede, C. ;
Clumeck, N. ;
Begovac, J. ;
Demetriades, I. ;
Kousiappa, I. ;
Demetriou, V. ;
Hezka, J. ;
Maly, M. ;
Machala, L. ;
Jørgensen, L.B. ;
Gerstoft, J. ;
Mathiesen, L. ;
Pedersen, C. ;
Nielsen, H. ;
Laursen, A. ;
Kvinesdal, B. ;
Ristola, M. ;
Suni, J. ;
Sutinen, J. ;
Assoumou, L. ;
Castor, G. ;
Grude, M. ;
Flandre, P. ;
Storto, A. ;
Kücherer, C. ;
Berg, T. ;
Braun, P. ;
Poggensee, G. ;
Däumer, M. ;
Eberle, J. ;
Heiken, H. ;
Kaiser, R. ;
Knechten, H. ;
Korn, K. ;
Müller, H. ;
Neifer, S. ;
Schmidt, B. ;
Walter, H. ;
Gunsenheimer-Bartmeyer, B. ;
Harrer, T. ;
Hatzakis, A. ;
Zavitsanou, A. ;
Vassilakis, A. ;
Lazanas, M. ;
Chini, M. ;
Lioni, A. ;
Sakka, V. ;
Kourkounti, S. ;
Paparizos, V. ;
Antoniadou, A. ;
Papadopoulos, A. ;
Poulakou, G. ;
Katsarolis, I. ;
Protopapas, K. ;
Chryssos, G. ;
Drimis, S. ;
Gargalianos, P. ;
Xylomenos, G. ;
Lourida, G. ;
Psichogiou, M. ;
Daikos, G.L. ;
Sipsas, N.V. ;
Kontos, A. ;
Gamaletsou, M.N. ;
Koratzanis, G. ;
Sambatakou, E. ;
Mariolis, H. ;
Skoutelis, A. ;
Papastamopoulos, V. ;
Georgiou, O. ;
Panagopoulos, P. ;
Maltezos, E. ;
De Gascun, C. ;
Byrne, C. ;
Duffy, M. ;
Bergin, C. ;
Reidy, D. ;
Farrell, G. ;
Lambert, Jo ;
O'Connor, E. ;
Rochford, A. ;
Low, J. ;
Coakely, P. ;
O'Dea, S. ;
Hall, W. ;
Levi, I. ;
Chemtob, D. ;
Grossman, Z. ;
De Luca, A. ;
Balotta, C. ;
Riva, C. ;
Mussini, C. ;
Caramma, I. ;
Capetti, A. ;
Colombo, M.C. ;
Rossi, C. ;
Prati, F. ;
Tramuto, F. ;
Vitale, F. ;
Ciccozzi, M. ;
Angarano, G. ;
Rezza, G. ;
Vasins, O. ;
Lipnickiene, V. ;
Hemmer, R. ;
Arendt, V. ;
Michaux, C. ;
Staub, T. ;
Sequin-Devaux, C. ;
Van Kessel, A. ;
Van Bentum, P.H.M. ;
Brinkman, K. ;
Connell, B.J. ;
Van Der Ende, M.E. ;
Hoepelman, I.M. ;
Kuipers, M. ;
Langebeek, N. ;
Richter, C. ;
Santegoets, R.M.W.J. ;
Schrijnders-Gudde, L. ;
Schuurman, R. ;
Van De Ven, B.J.M. ;
Kran, A.M.B. ;
Ormaasen, V. ;
Aavitsland, P. ;
Stanczak, J.J. ;
Stanczak, G.P. ;
Firlag-Burkacka, E. ;
Wiercinska-Drapalo, A. ;
Jablonowska, E. ;
Maolepsza, E. ;
Leszczyszyn-Pynka, M. ;
Szata, W. ;
Camacho, R. ;
Palma, C. ;
Borges, F. ;
Paixão, T. ;
Duque, V. ;
Araújo, F. ;
Paraschiv, S. ;
Tudor, A.M. ;
Cernat, R. ;
Chiriac, C. ;
Dumitrescu, F. ;
Prisecariu, L.J. ;
Jevtovic, D. ;
Salemovic, D. ;
Stanekova, D. ;
Habekova, M. ;
Chabadová, Z. ;
Drobkova, T. ;
Bukovinova, P. ;
Shunnar, A. ;
Truska, P. ;
Lunar, M. ;
Babic, D. ;
Tomazic, J. ;
Vidmar, L. ;
Vovko, T. ;
Karner, P. ;
Monge, S. ;
Moreno, S. ;
Del Amo, J. ;
Asensi, V. ;
Sirvent, J.L. ;
De Mendoza, C. ;
Delgado, Raquel (Institut d'Investigació Biomèdica Sant Pau) ;
Gutiérrez, F. ;
Berenguer, J. ;
Garcia-Bujalance, S. ;
Stella, N. ;
De Los Santos, I. ;
Blanco, J.R. ;
Dalmau, D. ;
Rivero, M. ;
Segura, F. ;
Elías, M.J.P. ;
Álvarez, Mar ;
Chueca, N. ;
Rodríguez-Martín, C. ;
Vidal, C. ;
Palomares, J.C. ;
Viciana, I. ;
Viciana, P. ;
Cordoba, J. ;
Aguilera, A. ;
Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau) ;
Galindo, M.J. ;
Miralles, C. ;
Del Pozo, M.A. ;
Ribera, E. ;
Iribarren, J.A. ;
Ruiz, L. ;
De La Torre, J. ;
Vidal, F. ;
Clotet Sala, Bonaventura ;
Heidarian, A. ;
Aperia-Peipke, K. ;
Axelsson, M. ;
Mild, M. ;
Karlsson, A. ;
Thalme, A. ;
Navér, L. ;
Bratt, G. ;
Blaxhult, A. ;
Gisslén, M. ;
Svennerholm, B. ;
Björkman, P. ;
Säll, C. ;
Mellgren, None ;
Lindholm, A. ;
Kuylenstierna, N. ;
Montelius, R. ;
Azimi, F. ;
Johansson, B. ;
Carlsson, M. ;
Johansson, E. ;
Ljungberg, B. ;
Ekvall, H. ;
Strand, A. ;
Mäkitalo, S. ;
Öberg, S. ;
Holmblad, P. ;
Höfer, M. ;
Holmberg, H. ;
Josefson, P. ;
Ryding, U. ;
Bergbrant, I. ;
Universitat Autònoma de Barcelona
Numerous studies have shown that baseline drug resistance patterns may influence the outcome of antiretroviral therapy. Therefore, guidelines recommend drug resistance testing to guide the choice of initial regimen. [...]
2016 -  10.1093/cid/civ963
Clinical Infectious Diseases, Vol. 62 Núm. 5 (january 2016) , p. 655-663
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25 p, 1.8 MB |
Identification of HIV-reservoir cells with reduced susceptibility to antibody-dependent immune response
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Astorga-Gamaza, Antonio (Hospital Universitari Vall d'Hebron) ;
Grau Expósito, Judith (Hospital Universitari Vall d'Hebron) ;
Burgos, Joaquín (Hospital Universitari Vall d'Hebron) ;
Navarro, Jordi (Hospital Universitari Vall d'Hebron) ;
Curran, Adrian (Hospital Universitari Vall d'Hebron) ;
Planas, Bibiana (Hospital Universitari Vall d'Hebron) ;
Suanzes, Paula (Hospital Universitari Vall d'Hebron) ;
Falcó, Vicenç (Hospital Universitari Vall d'Hebron) ;
Genescà Ferrer, Meritxell (Hospital Universitari Vall d'Hebron) ;
Buzón, Maria José (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Human immunodeficiency virus (HIV) establishes a persistent infection in heterogeneous cell reservoirs, which can be maintained by different mechanisms including cellular proliferation, and represent the main obstacle to curing the infection. [...]
2022 - 10.7554/eLife.78294
eLife, Vol. 11 (may 2022)
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14 p, 1.0 MB |
Metabolic, mitochondrial, renal and hepatic safety of enfuvirtide and raltegravir antiretroviral administration : Randomized crossover clinical trial in healthy volunteers
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Barroso, Sergio (Universitat Autònoma de Barcelona) ;
Morén, Constanza (Universitat de Barcelona) ;
González-Segura, Àlex (Universitat de Barcelona) ;
Riba, Neus (Hospital Clínic i Provincial de Barcelona) ;
Arnaiz, Joan A. (Hospital Clínic i Provincial de Barcelona) ;
Manríquez, Marcela (Hospital Clínic i Provincial de Barcelona) ;
Santana, Gemina (Hospital Clínic i Provincial de Barcelona) ;
Blanco, José L. (Hospital Clínic i Provincial de Barcelona) ;
Larousse, María (Hospital Clínic i Provincial de Barcelona) ;
Loncà, Montse (Hospital Clínic i Provincial de Barcelona) ;
de Lazzari, Elisa (Universitat de Barcelona) ;
Llopis, Jaume (Universitat de Barcelona) ;
Mallolas Masferrer, Josep (Hospital Clínic i Provincial de Barcelona) ;
Miró, Oscar (Hospital Clínic i Provincial de Barcelona) ;
Carné, Xavier (Hospital Clínic i Provincial de Barcelona) ;
Gatell, José M. (Hospital Clínic i Provincial de Barcelona) ;
Garrabou, Glòria (Universitat de Barcelona) ;
Martínez, Esteban (Hospital Clínic i Provincial de Barcelona)
Context Classical antiretroviral agents may acutely impact on metabolic, mitochondrial, renal and hepatic function in HIV-infected and uninfected persons. Fusion and integrase inhibitors are supposed to be safer, but have been scarcely investigated. [...]
2019 - 10.1371/journal.pone.0216712
PloS one, Vol. 14 Núm. 5 (may 2019) , p. e0216712
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6 p, 177.5 KB |
HIV-1 drug resistance by ultra-deep sequencing following short course zidovudine, single-dose nevirapine, and single-dose tenofovir with emtricitabine for prevention of mother-to-child transmission
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Samuel, Reshmi (University of KwaZulu-Natal. Department of Virology) ;
Noguera-Julian, Marc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Paredes, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Parboosing, Raveen (University of KwaZulu-Natal. Department of Virology) ;
Moodley, Pravi (University of KwaZulu-Natal. Department of Virology) ;
Singh, Lavanya (University of KwaZulu-Natal. Department of Virology) ;
Naidoo, Anneta (University of KwaZulu-Natal. Department of Virology) ;
Gordon, Michelle (University of KwaZulu-Natal. Department of Virology) ;
Universitat Autònoma de Barcelona
Antiretroviral drug resistance following pMTCT strategies remains a significant problem. With rapid advancements in next generation sequencing technologies, there is more focus on HIV drug-resistant variants of low frequency, or the so-called minority variants. [...]
2016 - 10.1097/QAI.0000000000001116
Journal of acquired immune deficiency syndromes (1999), Vol. 73, issue 4 (Dec. 2016) , p. 384-389
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6 p, 189.4 KB |
A post-partum single-dose TDF/FTC tail does not prevent the selection of NNRTI resistance in women receiving pre-partum ZDV and intrapartum single-dose nevirapine to prevent mother-to- child HIV-1 transmission
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Samuel, Reshmi (University of KwaZulu-Natal) ;
Paredes, Roger (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Parboosing, Raveen (University of KwaZulu-Natal) ;
Moodley, Pravi (University of KwaZulu-Natal) ;
Singh, Lavanya (University of KwaZulu-Natal) ;
Naidoo, Anneta (University of KwaZulu-Natal) ;
Gordon, Michelle (HIV Pathogenesis Laboratory, Nelson R. Mandela Medical School, University of KwaZulu-Natal) ;
Universitat Autònoma de Barcelona
Although the rates of vertical transmission of HIV in the developing world have improved to around 3% in countries like South Africa, resistance to antiretrovirals (ARV) used in Prevention of Mother-to-Child transmission (pMTCT) strategies may thwart such outcomes and affect the efficacy of future ARV regimens in mothers and children. [...]
2015 - 10.1002/jmv.24220
Journal of Medical Virology, Vol. 87 (may 2015) , p. 1662-1667
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Variants in the CYP7B1 gene region do not affect natural resistance to HIV-1 infection
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Sironi, Manuela (San Raffaele Scientific Institute (Milà, Itàlia)) ;
Biasin, Mara (University of Milan (Itàlia)) ;
Pontremoli, Chiara (San Raffaele Scientific Institute (Milà, Itàlia)) ;
Cagliani, Rachele (San Raffaele Scientific Institute (Milà, Itàlia)) ;
Saulle, Irma (University of Milan (Itàlia)) ;
Trabattoni, Daria (University of Milan (Itàlia)) ;
Vichi, Francesca (Santa Maria Annunziata Hospital (Florència, Itàlia)) ;
Lo Caputo, Sergio (Santa Maria Annunziata Hospital (Florència, Itàlia)) ;
Mazzotta, Francesco (Santa Maria Annunziata Hospital (Florència, Itàlia)) ;
Aguilar-Jimenez, Wbeimar (Universidad de Antioquia) ;
Rugeles, María Teresa (Universidad de Antioquia) ;
Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Sanchez, Jorge (Asociación Civil Impacta Salud y Educación (Lima, Perú)) ;
Brander, Christian (Universitat de Vic) ;
Clerici, Mario (Foundation ONLUS (Milà, Itàlia)) ;
Universitat Autònoma de Barcelona
Abstract. BACKGROUND: The genetic bases of natural resistance to HIV-1 infection remain largely unknown. Recently, two genome-wide association studies suggested a role for variants within or in the vicinity of the CYP7B1 gene in modulating HIV susceptibility. [...]
2015 - 10.1186/s12977-015-0206-0
Retrovirology, Vol. 12 Núm. 80 (september 2015)
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