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Articles, 11 registres trobats
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Articles 11 registres trobats  1 - 10següent  anar al registre:
1.
15 p, 676.0 KB Mechanisms of abrupt loss of virus control in a cohort of previous HIV controllers / Rosás Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Llano, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Bellido, Rocío (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ruiz-Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Rocafort, Muntsa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Fernández, Marco A. (Institut Germans Trias i Pujol) ; Cobarsi, Patricia (Institut Germans Trias i Pujol) ; Crespo, Manel (Complexo Hospitalario Universitario de Vigo) ; Dorrell, Lucy (Nuffield Department of Medicine, University of Oxford,) ; del Romero, Jorge (Centro Sanitario Sandoval, Madrid) ; Alcami, José (Instituto de Salud Carlos III, Madrid) ; Paredes, Roger (Universitat Autònoma de Barcelona. Departament de Medicina) ; Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
A few individuals can control HIV infection without the need for antiretroviral treatment and are referred to as HIV controllers. We have studied HIV controllers who suddenly lose this ability and present with high in vivo viral replication and decays in their CD4 + T-cell counts to identify potential immune and virological factors that were responsible for initial virus control. [...]
2019 - 10.1128/JVI.01436-18
Journal of Virology, Vol. 93 (february 2019)  
2.
12 p, 1.2 MB Identification of HIV-1–Based Virus-like Particles by Multifrequency Atomic Force Microscopy / González-Domínguez, Irene (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; Gutiérrez Granados, Sonia (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; Cervera García, Laura (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; Gòdia i Casablancas, Francesc (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química Biològica i Ambiental) ; Domingo Marimon, Neus (Institut Català de Nanociència i Nanotecnologia)
Virus-like particles (VLPs) have become a promising platform for vaccine production. VLPs are formed by structural viral proteins that inherently self-assemble when expressed in a host cell. They represent a highly immunogenic and safe vaccine platform, due to the absence of the viral genome and its high protein density. [...]
2016 - 10.1016/j.bpj.2016.07.046
Biophysical Journal, Vol. 111, Núm. 6 (September 2016) , p. 1173-1179  
3.
9 p, 590.6 KB A baseline metabolomic signature is associated with immunological CD4 + T-cell recovery after 36 months of antiretroviral therapy in HIV-infected patients / Rodríguez-Gallego, Esther (Hospital Universitari Joan XXIII) ; Gómez, Josep (Hospital Universitari Joan XXIII) ; Pacheco, Yolanda M. (Instituto de Biomedicina de Sevilla) ; Peraire, Joaquim (Hospital Universitari Joan XXIII) ; Viladés, Consuelo (Hospital Universitari Joan XXIII) ; Beltrán Debón, Raúl (Hospital Universitari Joan XXIII) ; Mallol, Roger (Universitat Rovira i Virgili. Departament d'Enginyeria Electrònica) ; López Dupla, Miguel (Hospital Universitari Joan XXIII) ; Veloso, Sergi (Hospital Universitari Joan XXIII) ; Alba, Verónica (Hospital Universitari Joan XXIII) ; Blanco, Julià (Institut Germans Trias i Pujol. Fundació IrsiCaixa) ; Cañellas, Nicolau (Universitat Rovira i Virgili. Departament d'Enginyeria Electrònica) ; Rull, Anna (Hospital Universitari Joan XXIII) ; Leal, Manuel (Instituto de Biomedicina de Sevilla) ; Correig, Xavier (Universitat Rovira i Virgili. Departament d'Enginyeria Electrònica) ; Domingo, Pere (Domingo Pedrol) (Institut d'Investigació Biomèdica Sant Pau) ; Vidal, Francesc (Hospital Universitari Joan XXIII)
Poor immunological recovery in treated HIV-infected patients is associated with greater morbidity and mortality. To date, predictive biomarkers of this incomplete immune reconstitution have not been established. [...]
2018 - 10.1097/QAD.0000000000001730
AIDS (London, England), Vol. 32 (march 2018) , p. 565-573  
4.
15 p, 4.1 MB Lack of concordance between residual viremia and viral variants driving de novo infection of CD4 + T cells on ART / Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Noguera-Julian, Marc (Universitat de Vic – Universitat Central de Catalunya (UVic-UCC), Vic, Spain) ; Massanella, Marta (Département de Microbiologie, Infectiologie et Immunologie, Centre de Recherche du CHUM et Université de Montréal) ; Pou, Christian (Department of Cell and Molecular Biology, Karolinska Institutet, Solna, Stockholm Sweden) ; Buzón, María José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Clotet, Bonaventura (Universitat de Vic – Universitat Central de Catalunya (UVic-UCC), Vic, Spain) ; Stevenson, Mario (Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, USA) ; Paredes, Roger (Universitat de Vic – Universitat Central de Catalunya (UVic-UCC), Vic, Spain) ; Blanco, Julià (Universitat de Vic – Universitat Central de Catalunya (UVic-UCC), Vic, Spain) ; Martínez Picado, Francisco Javier (Institució Catalana de Recerca i Estudis Avançats (ICREA))
In most patients, current antiretroviral therapy (ART) regimens can rapidly reduce plasma viral load. However, even after years of effective treatment, a significant proportion of patients show residual plasma viremia below the clinical detection limit. [...]
2016 - 10.1186/s12977-016-0282-9
Retrovirology, Vol. 13 (august 2016)  
5.
12 p, 2.8 MB Gut microbiota linked to sexual preference and HIV infection / Noguera-Julian, Marc (Institut Germans Trias i Pujol. IrsiCaixa) ; Rocafort, Muntsa (Institut Germans Trias i Pujol. IrsiCaixa) ; Guillén, Yolanda (Institut Germans Trias i Pujol. IrsiCaixa) ; Rivera, Javier (Institut Germans Trias i Pujol. IrsiCaixa) ; Casadellà, Maria (Institut Germans Trias i Pujol. IrsiCaixa) ; Nowak, Piotr (Karolinska Universitetssjukhuset) ; Hildebrand, Falk (European Molecular Biology Laboratory) ; Zeller, Georg (European Molecular Biology Laboratory) ; Parera, Mariona (Institut Germans Trias i Pujol. IrsiCaixa) ; Bellido, Rocío (Institut Germans Trias i Pujol. IrsiCaixa) ; Rodríguez, Cristina (Institut Germans Trias i Pujol. IrsiCaixa) ; Carrillo, Jorge (Institut Germans Trias i Pujol. IrsiCaixa) ; Mothe, Beatriz (Institut Germans Trias i Pujol. IrsiCaixa) ; Coll, Josep (Institut Germans Trias i Pujol. IrsiCaixa) ; Bravo, Isabel (Hospital Universitari Germans Trias i Pujol) ; Estany, Carla (Hospital Universitari Germans Trias i Pujol) ; Herrero, Cristina (Hospital Universitari Germans Trias i Pujol) ; Saz, Jorge (BCN Checkpoint,) ; Sirera, Guillem (Hospital Universitari Germans Trias i Pujol) ; Torrela, Ariadna (Hospital Universitari Vall d'Hebrón) ; Navarro, Jordi (Hospital Universitari Vall d'Hebrón) ; Crespo, Manel (Hospital Universitari Vall d'Hebrón) ; Brander, Christian (Institut Germans Trias i Pujol. IrsiCaixa) ; Negredo, Eugènia (Universitat de Vic) ; Blanco, Julià (Institut Germans Trias i Pujol. IrsiCaixa) ; Guarner, Francisco (Hospital Universitari Vall d'Hebrón) ; Calle, Maria Luz (Universitat de Vic) ; Bork, Peer (European Molecular Biology Laboratory) ; Sönnerborg, Anders (Karolinska Universitetssjukhuset) ; Clotet, Bonaventura (Institut Germans Trias i Pujol. IrsiCaixa) ; Paredes, Roger (Institut Germans Trias i Pujol. IrsiCaixa)
The precise effects of HIV-1 on the gut microbiome are unclear. Initial cross-sectional studies provided contradictory associations between microbial richness and HIV serostatus and suggested shifts from Bacteroides to Prevotella predominance following HIV-1 infection, which have not been found in animal models or in studies matched for HIV-1 transmission groups. [...]
2016 - 10.1016/j.ebiom.2016.01.032
EBioMedicine, Vol. 5 (March 2016) , p. 135-146  
6.
22 p, 834.8 KB EPICE-HIV: An Epidemiologic Cost-Effectiveness Model for HIV Treatment / Vandewalle, Björn (Exigo Consultores (Lisboa, Portugal)) ; Llibre Codina, Josep Maria (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ; Parienti, Jean-Jacques (Côte de Nacre University Hospital (Caen, França)) ; Ustianowski, Andrew (North Manchester General Hospital) ; Camacho, Ricardo (Catholic University of Leuven (Bèlgica)) ; Smith, Colette (University College London) ; Miners, Alec (London School of Hygiene and Tropical Medicine)) ; Ferreira, Diana (Exigo Consultores (Lisboa, Portugal)) ; Félix, Jorge (Exigo Consultores (Lisboa, Portugal))
The goal of this research was to establish a new and innovative framework for cost-effectiveness modeling of HIV-1 treatment, simultaneously considering both clinical and epidemiological outcomes. EPICE-HIV is a multi-paradigm model based on a within-host micro-simulation model for the disease progression of HIV-1 infected individuals and an agent-based sexual contact network (SCN) model for the transmission of HIV-1 infection. [...]
2016 - 10.1371/journal.pone.0149007
PloS one, Vol. 11 Núm. 2 (February 2016)  
7.
15 p, 3.1 MB HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells / Pino, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Erikson, Elina (University of Frankfurt (Alemanya)) ; Fernández Figueras, Maria Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Guerrero, Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Rausell, Antonio (University of Lausanne (Suïssa)) ; Ciuffi, Angela (University of Lausanne (Suïssa)) ; Keppler, Oliver T. (University of Frankfurt (Alemanya)) ; Telenti, Amalio (University of Lausanne (Suïssa)) ; Kräusslich, Hans-Georg (University of Heidelberg (Alemanya)) ; Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Universitat Autònoma de Barcelona
Myeloid cells are key players in the recognition and response of the host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, a mechanism that promotes HIV-1 transmission to target cells via viral capture and storage. [...]
2015 - 10.1186/s12977-015-0160-x
Retrovirology, Vol 12, article 37 (May 2015)  
8.
23 p, 3.3 MB A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques / Mothe Pujadas, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Hu, Xintao (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ; Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Rosati, Margherita (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ; Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Kulkarni, Viraj (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ; Valentin, Antonio (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ; Alicea, Cándido (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ; Pilkington, Guy R. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ; Sardesai, Niranjan Y. (Inovio Pharmaceuticals) ; Rocafort, Muntsa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Crespo, Manel (Hospital Universitari Vall d'Hebron) ; Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Marco, Andrés (Centre Penitenciari d'Homes (Barcelona, Catalunya)) ; Mullins, James I. (University of Washington (Estats Units d'Amèrica)) ; Dorrell, Lucy (John Radcliffe Hospital (Oxford, Regne Unit)) ; Hanke, Tomáš (University of Oxford (Regne Unit)) ; Clotet i Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Pavlakis, George N. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ; Felber, Barbara K. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ; Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Universitat Autònoma de Barcelona
BACKGROUND: None of the HIV T-cell vaccine candidates that have reached advanced clinical testing have been able to induce protective T cell immunity. A major reason for these failures may have been suboptimal T cell immunogen designs. [...]
2015 - 10.1186/s12967-015-0392-5
Journal of translational medicine, Vol. 13 Núm. 60 (february 2015)  
9.
18 p, 1.7 MB Gp120/CD4 blocking antibodies are frequently elicited in ART-naïve chronically HIV-1 infected individuals / Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Molinos-Albert, Luis Manuel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Rodríguez de la Concepción, Maria Luisa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Marfil, Silvia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; García, Elisabet (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Derking, Ronald (University of Amsterdam) ; Sanders, Rogier W. (University of Amsterdam) ; Clotet i Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Blanco Arbués, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Universitat Autònoma de Barcelona
Antibodies with the ability to block the interaction of HIV-1 envelope glycoprotein (Env) gp120 with CD4, including those overlapping the CD4 binding site (CD4bs antibodies), can protect from infection by HIV-1, and their elicitation may be an interesting goal for any vaccination strategy. [...]
2015 - 10.1371/journal.pone.0120648
PloS one, Vol. 10, No. 3 (March 2015) , p. e0120648  
10.
9 p, 5.6 MB HIV and mature dendritic cells : Trojan exosomes riding the Trojan horse? / Izquierdo Useros, Nuria (IrsiCaixa Foundation) ; Naranjo Gómez, María del Mar (Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol) ; Erkizia, Itziar (IrsiCaixa Foundation) ; Puertas, María Carmen (IrsiCaixa Foundation) ; Borràs Serres, Francesc Enric (Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol) ; Blanco, Julià (IrsiCaixa Foundation) ; Martínez Picado, Francisco Javier (Institució Catalana de Recerca i Estudis Avançats)
Exosomes are secreted cellular vesicles that can induce specific CD4+ T cell responses in vivo when they interact with competent antigen-presenting cells like mature dendritic cells (mDCs). The Trojan exosome hypothesis proposes that retroviruses can take advantage of the cell-encoded intercellular vesicle traffic and exosome exchange pathway, moving between cells in the absence of fusion events in search of adequate target cells. [...]
2010
PLoS Pathogens, Vol. 6, Issue 3 (March 2010) , p. e1000740  

Articles : 11 registres trobats   1 - 10següent  anar al registre:
Documents de recerca 1 registres trobats  
1.
1 p, 4.2 MB Study of biomarkers in HIV-1 infected individuals with neurocognitive disorders (HAND) / Llorà i Valls, Mireia ; Universitat Autònoma de Barcelona. Facultat de Biociències
2018
Graduat o Graduada en Biotecnologia [815]  

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