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1.
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8 p, 715.4 KB |
Head and neck cancers survival in Europe, Taiwan, and Japan : results from RARECAREnet Asia based on a privacy-preserving federated infrastructure
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Botta, Laura (Department of Epidemiology and Data Science. Fondazione IRCCS Istituto Nazionale dei Tumori) ;
Matsuda, Tomohiro (Insititute of Cancer Control. National Cancer Center (Japò)) ;
Charvat, Hadrien (National Cancer Center (Japò)) ;
Chiang, Chung-Ju (Taiwan Cancer Registry Center) ;
Lee, Wen-Chung (Taiwan Cancer Registry Center) ;
van Gestel, Anna Jacoba (Department of Research & Development. Netherlands Comprehensive Cancer Organisation) ;
Martin, Frank (Department of Research & Development. Netherlands Comprehensive Cancer Organisation) ;
Geleijnse, Gijs (Department of Research & Development. Netherlands Comprehensive Cancer Organisation) ;
Cellamare, Mattheo (Department of Research & Development. Netherlands Comprehensive Cancer Organisation) ;
Bonfarnuzzo, Simone (Department of Epidemiology and Data Science. Fondazione IRCCS Istituto Nazionale dei Tumori) ;
Marcos-Gragera, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guevara, Marcela (Instituto de Investigación Sanitaria de Navarra) ;
Mousavi, Mohsen (East Switzerland Cancer Registry) ;
Craig, Stefano (Queen's University Belfast) ;
Rodrigues, Jessica (Porto Comprehensive Cancer Centre (Portugal)) ;
Rubió-Casadevall, Jordi (Institut de Recerca Biomèdica de Lleida) ;
Licitra, Lisa (Department of Oncology and Hemato-Oncology. University of Milan) ;
Cavalieri, Stephanie (Department of Oncology and Hemato-Oncology. University of Milan) ;
Resteghini, Carlo (Fondazione IRCCS Istituto Nazionale dei Tumori di Milano) ;
Gatta, Gemma (Fondazione IRCCS Istituto Nazionale dei Tumori di Milano) ;
Trama, Annalisa (Fondazione IRCCS Istituto Nazionale dei Tumori di Milano)
Background: The head and neck cancers (HNCs) incidence differs between Europe and East Asia. Our objective was to determine whether survival of HNC also differs between European and Asian countries. [...]
2023 -  10.3389/fonc.2023.1219111
Frontiers in Oncology, Vol. 13 (2023) , p. 1219111
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2.
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16 p, 2.6 MB |
uPA/uPAR and SERPINE1 in head and neck cancer : Role in tumor resistance, metastasis, prognosis and therapy
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Pavón, Miguel Angel (Centro de Investigación Biomédica en Red en Bioingeniería. Biomateriales y Nanomecidicina (CIBER-BBN)) ;
Arroyo-Solera, Irene (Centro de Investigación Biomédica en Red en Bioingeniería. Biomateriales y Nanomecidicina (CIBER-BBN)) ;
Céspedes, María Virtudes (Centro de Investigación Biomédica en Red en Bioingeniería. Biomateriales y Nanomecidicina (CIBER-BBN)) ;
Casanova Rigat, Isolda (Centro de Investigación Biomédica en Red en Bioingeniería. Biomateriales y Nanomecidicina (CIBER-BBN)) ;
León i Vintró, Xavier (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Mangues, Ramon 1957- (Centro de Investigación Biomédica en Red en Bioingeniería. Biomateriales y Nanomecidicina (CIBER-BBN)) ;
Universitat Autònoma de Barcelona
There is strong evidence supporting the role of the plasminogen activator system in head and neck squamous cell carcinoma (HNSCC), particularly of its uPA (urokinase plasminogen activator)/uPAR (urokinase plasminogen activator receptor) and SERPINE1 components. [...]
2016 - 10.18632/oncotarget.10344
Oncotarget, Vol. 7 Núm. 35 (2016) , p. 57351-57366
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3.
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7 p, 1.1 MB |
Multidisciplinary management of head and neck cancer : First expert consensus using Delphi methodology from the Spanish Society for Head and Neck Cancer (part 1)
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Maños, Manuel (Hospital Universitari de Bellvitge) ;
Giralt López de Sagredo, Jordi (Hospital Universitari Vall d'Hebron) ;
Rueda Domínguez, Antonio (Hospital Costa del Sol (Marbella)) ;
Cabrera, Joaquín (Hospital Infanta Cristina (Badajoz)) ;
Martínez-Trufero, Javier (Hospital Universitario Miguel Servet (Saragossa)) ;
Marruecos, Jordi (Institut Català d'Oncologia) ;
López Pousa, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Rodrigo, Juan Pablo (Hospital Universitario Central de Asturias) ;
Castelo Fernández, Beatriz (Hospital Universitario La Paz (Madrid)) ;
Martínez-Galán, Joaquina (Hospital Universitario Virgen de las Nieves (Granada)) ;
Arias-De-La-Vega, Fernando Carrillo (Complejo Hospitalario de Navarra) ;
Chaves, Manuel (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ;
Herranz, Jesús (Complejo Hospitalario Universitario de A Coruña) ;
Arrazubi, Virginia (Hospital de Basurto (Bilbao, Biscaia)) ;
Basté, Neus (Hospital Universitari Vall d'Hebron) ;
Castro, Almudena Vizcaya (Hospital Universitario La Paz (Madrid)) ;
Mesía, Ricard (Institut Català d'Oncologia (L'Hospitalet de Llobregat)) ;
Universitat Autònoma de Barcelona
Head and neck cancer is one of the most frequent malignances worldwide. Despite the site-specific multimodality therapy, up to half of the patients will develop recurrence. Treatment selection based on a multidisciplinary tumor board represents the cornerstone of head and neck cancer, as it is essential for achieving the best results, not only in terms of outcome, but also in terms of organ-function preservation and quality of life. [...]
2017 - 10.1016/j.oraloncology.2017.04.004
Oral Oncology, Vol. 70 (july 2017) , p. 58-64
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4.
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12 p, 813.5 KB |
Carotid blowout syndrome : Modern trends in management
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Suárez, C. (Universidad de Oviedo) ;
Fernández-Alvarez, Verónica (Hospital Universitario de Cabueñes (Gijón)) ;
Hamoir, Marc (St Luc University Hospital) ;
Mendenhall, W.M. (University of Florida) ;
Strojan, Primož (Institute of Oncology of Ljubljana) ;
Quer, Miquel (Institut d'Investigació Biomèdica Sant Pau) ;
Silver, C.E. (University of Arizona) ;
Rodrigo, Juan Pablo (Hospital Universitario Central de Asturias) ;
Rinaldo, Alessandra (University of Udine School of Medicine) ;
Ferlito, Alfio (International Head and Neck Scientific Group) ;
Universitat Autònoma de Barcelona
Carotid blowout syndrome (CBS) refers to rupture of the carotid artery and is an uncommon complication of head and neck cancer that can be rapidly fatal without prompt diagnosis and intervention. CBS develops when a damaged arterial wall cannot sustain its integrity against the patient's blood pressure, mainly in patients who have undergone surgical procedures and radiotherapy due to cancer of the head and neck, or have been reirradiated for a recurrent or second primary tumor in the neck. [...]
2018 - 10.2147/CMAR.S180164
Cancer Management and Research, Vol. 10 (2018) , p. 5617-5628
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5.
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12 p, 2.4 MB |
The use of HPV16-E5, EGFR, and PEGFR as prognostic biomarkers for oropharyngeal cancer patients
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Taberna, Miren (Hospital Universitari de Bellvitge) ;
Torres, Montserrat (Hospital Universitari de Bellvitge) ;
Alejo, María (Hospital General de l'Hospitalet) ;
Mena, Marisa (Centro de Investigación Biomédica en Red de Cáncer) ;
Tous, Sara (Centro de Investigación Biomédica en Red de Cáncer) ;
Marquez, Sandra (Hospital Universitari de Bellvitge) ;
Pavón, Miquel A. (Hospital Universitari de Bellvitge) ;
León, Xavier (Institut d'Investigació Biomèdica Sant Pau) ;
Garcia Lorenzo, J (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Guix, Marta (Hospital del Mar (Barcelona, Catalunya)) ;
Hijano, Rafael (Hospital del Mar (Barcelona, Catalunya)) ;
Bonfill Abella, Teresa (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Aguilà, Antón (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Lozano, Alicia (Hospital Universitari de Bellvitge) ;
Mesía, Ricard (Hospital Universitari de Bellvitge) ;
Alemany, Laia (Hospital Universitari de Bellvitge) ;
Bravo, Ignacio G. (Laboratory MIVEGEC (CNRS IRD Uni Montp)) ;
Universitat Autònoma de Barcelona
Anti-epidermal-growth-factor-receptor (EGFR) therapies in combination with radiotherapy are being studied on deescalation clinical trials for HPV-related oropharyngeal cancer (OPC) patients. The HPV16-E5 oncoprotein increases recycling of activated EGFR to the cell surface, enhancing factor signal transduction. [...]
2018 - 10.3389/fonc.2018.00589
Frontiers in Oncology, Vol. 8 Núm. DEC (2018) , p. 589
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6.
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12 p, 2.6 MB |
Concordance of p16INK4a and E6*I mRNA among HPV-DNA-Positive Oropharyngeal, Laryngeal, and Oral Cavity Carcinomas from the ICO International Study
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Mena, Marisa (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública. Instituto de Salud Carlos III) ;
Wang, Xin (Institut d'Investigació Biomèdica de Bellvitge) ;
Tous, Sara (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública. Instituto de Salud Carlos III) ;
Quirós, Beatriz (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública. Instituto de Salud Carlos III) ;
Clavero, Omar (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública. Instituto de Salud Carlos III) ;
Alejo, Maria (Hospital General de l'Hopitalet. Pathology Department) ;
Morey, Francisca (Institut d'Investigació Biomèdica de Bellvitge) ;
Taberna, Miren (Institut d'Investigació Biomèdica de Bellvitge) ;
León i Vintró, Xavier (Institut d'Investigació Biomèdica Sant Pau) ;
Lloveras Rubio, Belén (Hospital del Mar. Pathology Department) ;
Alos, Llucìa (Hospital Clínic i Provincial de Barcelona) ;
Mehanna, Hisham (Institute of Head and Neck Studies and Education. University of Birmingham) ;
Quint, Wim (DDL Diagnostic Laboratory) ;
Pawlita, Michael (Division of Molecular Diagnostics of Oncogenic Infections. Research Program Infection. Inflammation and Cancer. German Cancer Research Center (DKFZ)) ;
Tommasino, Massimo (Infections and Cancer Biology Group. International Agency for Research on Cancer (IARC)) ;
Pavón, Miguel Angel (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública. Instituto de Salud Carlos III) ;
Muñoz, Nubia (National Cancer Institute) ;
De Sanjose, Silvia (ISGlobal) ;
Bosch, Francesc Xavier (Universitat Oberta de Catalunya) ;
Alemany, Laia (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública. Instituto de Salud Carlos III)
Background: Tests or test algorithms for diagnosing HPV-driven oral cavity and laryngeal head and neck carcinomas (HNC) have not been yet validated, and the differences among oral cavity and laryngeal sites have not been comprehensively evaluated. [...]
2022 - 10.3390/cancers14153787
Cancers, Vol. 14 Núm. 15 (august 2022) , p. 3787
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11 p, 1018.7 KB |
Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe
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Mena, Marisa (Hospital Universitari de Bellvitge) ;
Frias-Gomez, Jon (Hospital Universitari de Bellvitge) ;
Taberna, Miren (Hospital Universitari de Bellvitge) ;
Quirós, Beatriz (Hospital Universitari de Bellvitge) ;
Marquez, Sandra (Hospital Universitari de Bellvitge) ;
Clavero, Omar (de Hospital Universitari de Bellvitge) ;
Baena, Antoni. (Hospital Universitari de Bellvitge) ;
Lloveras, Belén (Hospital del Mar (Barcelona, Catalunya)) ;
Alejo, María (Hospital General de l'Hospitalet) ;
León i Vintró, Xavier (Institut d'Investigació Biomèdica Sant Pau) ;
García, Jacinto Montero (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Mesía, Ricard (Institute Catala Oncologia) ;
Bermejo, Josep Oriol (Hospital Universitari de Bellvitge) ;
Bonfill Abella, Teresa (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Aguilà, Antón (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Guix, Marta (Hospital del Mar (Barcelona, Catalunya)) ;
Hijano, Rafael (Hospital del Mar (Barcelona, Catalunya)) ;
Pavón, Miguel Ángel (Hospital Universitari de Bellvitge) ;
Torres, Montserrat A. (Hospital Universitari de Bellvitge) ;
Tous, Sara (Hospital Universitari de Bellvitge) ;
Clèries, Ramón (Hospital Universitari de Bellvitge) ;
Alemany, Laia (Hospital Universitari de Bellvitge) ;
Universitat Autònoma de Barcelona
The incidence of human papillomavirus (HPV)-related oropharyngeal cancer is increasing in some regions. Nevertheless, the epidemiology of this disease has not been extensively investigated in southern Europe. [...]
2020 - 10.1038/s41598-020-70118-7
Scientific reports, Vol. 10 Núm. 1 (january 2020) , p. 13219
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14 p, 1.9 MB |
Outcomes Following Autologous Fat Grafting in Patients with Sequelae of Head and Neck Cancer Treatment
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Masià-Gridilla, Jorge (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gutiérrez-Santamaría, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Álvarez-Sáez, Iago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pamias Romero, Jorge (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Saez-Barba, Manel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bescós-Atin, Coro (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
In recent years, there have been relevant advances in the use of surgery, radiation therapy, and chemotherapy for the treatment of malignant tumors of the head and neck. Extensive tumor resection and radical radiotherapy frequently result in altered form and function of orofacial structures that can severely impact the patient's quality of life. [...]
2023 - 10.3390/cancers15030800
Cancers, Vol. 15 (january 2023)
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9.
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15 p, 4.0 MB |
A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model
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Rioja-Blanco, Elisa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gallardo, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Arroyo-Solera, Irene (Institut d'Investigació Biomèdica Sant Pau) ;
Álamo, Patricia (Institut d'Investigació Biomèdica Sant Pau) ;
Casanova Rigat, Isolda (Institut d'Investigació Biomèdica Sant Pau) ;
Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ;
Serna, Naroa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez-García, Laura (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Quer, Miquel (Institut d'Investigació Biomèdica Sant Pau) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
León i Vintró, Xavier (Institut d'Investigació Biomèdica Sant Pau) ;
Alba-Castellón, Lorena (Institut d'Investigació Biomèdica Sant Pau) ;
Mangues, Ramon 1957- (Institut d'Investigació Biomèdica Sant Pau)
Loco-regional recurrences and metastasis represent the leading causes of death in head and neck squamous cell carcinoma (HNSCC) patients, highlighting the need for novel therapies. Chemokine receptor 4 (CXCR4) has been related to loco-regional and distant recurrence and worse patient prognosis. [...]
2022 - 10.3390/pharmaceutics14040887
Pharmaceutics, Vol. 14 Núm. 4 (2022) , p. 887
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10.
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16 p, 1.7 MB |
Succinate Pathway in Head and Neck Squamous Cell Carcinoma : Potential as a Diagnostic and Prognostic Marker
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Terra, Ximena (Universitat Rovira i Virgili) ;
Ceperuelo Mallafré, Victòria (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
Merma Linares, Carla Vanessa (Universitat Rovira i Virgili) ;
Benaiges Moragrega, Ester (Universitat Rovira i Virgili) ;
Bosch Príncep, Ramon (Hospital de Tortosa Verge de la Cinta) ;
Castillo, Paola (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Flores, Joan Carles (Universitat Rovira i Virgili) ;
León i Vintró, Xavier (Institut d'Investigació Biomèdica Sant Pau) ;
Valduvieco, Izaskun (Hospital Clínic i Provincial de Barcelona) ;
Basté, Neus (Hospital Clínic i Provincial de Barcelona) ;
Cámara, Marina (Hospital Clínic i Provincial de Barcelona) ;
Lejeune, Marylène (Hospital de Tortosa Verge de la Cinta) ;
Gumà, Josep (Institut d'Investigació Sanitària Pere Virgili) ;
Vendrell, Joan (Universitat Rovira i Virgili) ;
Vilaseca, Isabel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Fernández-Veledo, Sonia (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
Avilés-Jurado, Francesc Xavier (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona
Emerging evidence points to succinate as an important oncometabolite in cancer development; however, the contribution of the succinate-SUCNR1 axis to cancer progression remains unclear. Head and neck squamous cell carcinoma (HNSCC) is associated with disease and treatment-related morbidity so there is an urgent need for innovation in treatment and diagnosis practices. [...]
2021 - 10.3390/cancers13071653
Cancers, Vol. 13 (april 2021)
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