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10 p, 903.6 KB |
Outcomes in Patients with FLT3-Mutated Relapsed/ Refractory Acute Myelogenous Leukemia Who Underwent Transplantation in the Phase 3 ADMIRAL Trial of Gilteritinib versus Salvage Chemotherapy
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Perl, Alexander E. (University of Pennsylvania) ;
Larson, Richard A (University of Chicago) ;
Podoltsev, Nikolai A. (Yale School of Medicine) ;
Strickland, Stephen (Vanderbilt-Ingram Cancer Center) ;
Wang, Eunice S. (Roswell Park Comprehensive Cancer Center) ;
Atallah, Ehab (Medical College of Wisconsin) ;
Schiller, Gary J. (David Geffen School of Medicine at UCLA) ;
Martinelli, Giovanni (IRCCS Istituto Scientifico Romagnolo per lo Studio dei Tumori "Dino Amadori" IRST S.r.l) ;
Neubauer, Andreas (Universitätsklinikum Giessen und Marburg GmbH) ;
Sierra, Jorge (Institut d'Investigació Biomèdica Sant Pau) ;
Montesinos, Pau (Hospital Universitari i Politècnic La Fe (València)) ;
Recher, Christian (Centre Hospitalier Universitaire de Toulouse. Institut Universitaire du Cancer de Toulouse Oncopole. Université de Toulouse 3 Paul Sabatier) ;
Yoon, Sung-Soo (Seoul National University Hospital) ;
Maeda, Yoshinobu (Okayama University Hospital) ;
Hosono, Naoko (University of Fukui) ;
Onozawa, Masahiro (Hokkaido University) ;
Kato, Takayrasu (Department of Hematology. University of Tsukuba) ;
Kim, Hee-Je (Catholic Hematology Hospital. College of Medicine. The Catholic University of Korea) ;
Hasabou, Nahla (Astellas Pharma US. Inc.) ;
Nuthethi, Rishita (Astellas Pharma US. Inc.) ;
Tiu, Ramon (Astellas Pharma US. Inc.) ;
Levis, Mark J. (Sidney Kimmel Comprehensive Cancer Center. Johns Hopkins University)
The fms-like tyrosine kinase 3 (FLT3) inhibitor gilteritinib improved the survival of patients with relapsed or refractory (R/R) FLT3-mutated acute myelogenous leukemia (AML) in the phase 3 ADMIRAL trial. [...]
2023 -  10.1016/j.jtct.2022.12.006
Transplantation and Cellular Therapy, Vol. 29 Núm. 4 (april 2023) , p. 265.e1-265.e10
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16 p, 1.1 MB |
Endothelial activation and damage as a common pathological substrate in different pathologies and cell therapy complications
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Palomo, Marta (Hospital Clínic i Provincial de Barcelona) ;
Moreno-Castaño, Ana Belén (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Salas, María Queralt (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Escribano-Serrat, Silvia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rovira, Montserrat (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Guillen-Olmos, Elena (Hospital Clínic i Provincial de Barcelona) ;
Fernandez, Sara (Hospital Clínic i Provincial de Barcelona) ;
Ventosa-Capell, Helena (Hospital Clínic i Provincial de Barcelona) ;
Youssef, Lina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Crispi, Fatima (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Nomdedeu, Meritxell (Hospital Clínic i Provincial de Barcelona) ;
Martinez-Sanchez, Julia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
De Moner, Blanca (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Diaz-Ricart, Maribel (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
The endothelium is a biologically active interface with multiple functions, some of them common throughout the vascular tree, and others that depend on its anatomical location. Endothelial cells are continually exposed to cellular and humoral factors, and to all those elements (biological, chemical, or hemodynamic) that circulate in blood at a certain time. [...]
2023 - 10.3389/fmed.2023.1285898
Frontiers in Medicine, Vol. 10 (2023) , p. 1285898
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3 p, 444.0 KB |
Prevention of veno-occlusive disease/sinusoidal obstruction syndrome : a never-ending story and no easy answer
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Corbacioglu, Selim (University of Regensburg) ;
Grupp, S.A. (The Children's Hospital of Philadelphia) ;
Richardson, Paul G.. (Dana-Farber Cancer Institute (Estats Units d'Amèrica)) ;
Duarte, R. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Pagliuca, A. (King's College Hospital and Anthony Nolan Research Institute) ;
Ruutu, T. (Helsinki University Hospital) ;
Mahadeo, K. (Duke University Children's Hospital) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
2023 - 10.1038/s41409-023-02007-2
Bone marrow transplantation, Vol. 58 Núm. 8 (august 2023) , p. 839-841
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9 p, 1.2 MB |
Bone Marrow WT1 Levels in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia and Myelodysplasia : Clinically Relevant Time Points and 100 Copies Threshold Value
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Nomdedeu, Josep (Institut d'Investigació Biomèdica Sant Pau) ;
Esquirol, Albert (Institut d'Investigació Biomèdica Sant Pau) ;
Carricondo, Maite (Institut d'Investigació Biomèdica Sant Pau) ;
Pratcorona, Marta (Institut d'Investigació Biomèdica Sant Pau) ;
Hoyos Colell, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Garrido, Ana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rubio, Miguel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bussaglia, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Garcia Cadenas, Irene (Institut d'Investigació Biomèdica Sant Pau) ;
Estivill, Camino (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Brunet, Salut (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau) ;
Malouf Sierra, Jorge 1971- (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
The outcome of allogeneic hematopoietic stem cell transplantation (HCT) in patients with myeloid malignancies is better in those without minimal residual disease (MRD) than in those with MRD+, as assessed by multiparametric flow cytometry (MPFC). [...]
2018 - 10.1016/j.bbmt.2017.09.001
Biology of blood and marrow transplantation, Vol. 24 Núm. 1 (january 2018) , p. 55-63
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9 p, 534.4 KB |
Rapid and accurate method for quantifying busulfan in plasma samples by isocratic liquid chromatography-tandem mass spectrometry (LC-MS/MS)
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Villena-Ortiz, Yolanda (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Castellote, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martínez Sánchez, Luisa María (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Benítez-Carabante, María I. (Vall d'Hebron Institut de Recerca. Departament d'Hematologia i Oncologia Pediàtrica) ;
Miarons, Marta (Vall d'Hebron Institut de Recerca. Departament de Farmàcia) ;
Vima-Bofarull, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Barquin-DelPino, Raquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Paciucci, Rosanna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez Frías, Francisco (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Ferrer-Costa, Roser (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Casis-Saez, Ernesto (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
López-Hellín, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Objectives: Administration of busulfan is extending rapidly as a part of a conditioning regimen in patients undergoing hematopoietic stem cell transplantation (HSCT). Monitoring blood plasma levels of busulfan is recommended for identifying the optimal dose in patients and for minimizing toxicity. [...]
2022 - 10.1515/almed-2022-0016
Advances in Laboratory Medicine, Vol. 3, Issue 3 (September 2022) , p. 263-271
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8 p, 316.8 KB |
Solid organ transplantation after hematopoietic stem cell transplantation in childhood : A multicentric retrospective survey
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Faraci, Maura (Istituto G Gaslini) ;
Bertaina, Alice (Stanford University) ;
Dalissier, Arnaud (European Society for Blood and Marrow Transplantation Pediatric Disease Working Party) ;
Ifversen, Marianne (Copenhagen University Hospital) ;
Schulz, Ansgar (University Medical Center) ;
Gennery, Andrew (Great North Children's Hospital) ;
Burkhardt, Birgit (University Hospital of Münster (Alemanya)) ;
Badell Serra, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Díaz de Heredia, Cristina (Vall d'Hebron Institut d'Oncologia) ;
Lanino, Edoardo (Istituto G Gaslini) ;
Lankester, Arjan C. (Leiden University Medical Center) ;
Gruhn, Bernd (Jena University Hospital (Alemania)) ;
Matthes-Martin, Susanne Medical University of Vienna ;
Kühl, Joern S. (Universitätsklinikum Leipzig) ;
Varotto, Stefania (University Hospital of Padova (Pàdua, Itàlia)) ;
Paillard, Catherine (Hôpital Hautepierre) ;
Guilmatre, Audrey (Hôpital Armand Trousseau (París, França)) ;
Sastre, Ana (Hospital Universitario La Paz (Madrid)) ;
Abecasis, Manuel (Instute Portugues Oncologia Lisboa) ;
Garwer, Birgit (University Hospital Eppendorf) ;
Sedlacek, Petr (University Hospital Motol) ;
Boelens, Jaap Jan (Memorial Sloan Kettering Cancer Center) ;
Beohou, Eric (European Society for Blood and Marrow Transplantation Pediatric Disease Working Party) ;
Bader, Peter (University Hospital of Frankfurt (Alemanya)) ;
Universitat Autònoma de Barcelona
We report data obtained from a retrospective multicenter pediatric survey on behalf of the European Society for Blood and Marrow Transplantation (EBMT). Information on solid organ transplantation (SOT) performed in pediatric recipients of either autologous or allogeneic hematopoietic stem cell transplantation (HSCT) between 1984 and 2016 was collected in 20 pediatric EBMT Centers (25. [...]
2019 - 10.1111/ajt.15240
American Journal of Transplantation, Vol. 19 Núm. 6 (june 2019) , p. 1798-1805
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7 p, 473.0 KB |
Association of uric acid levels before start of conditioning with mortality after allogeneic hematopoietic stem cell transplantation - a prospective, non-interventional study of the EBMT Transplant Complication Working Party
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Penack, Olaf (Charité - Universitätsmedizin Berlin) ;
Peczynski, Christophe (EBMT Statistical Unit) ;
van der Werf, Steffie (EBMT Data Office) ;
Finke, Jürgen (University of Freiburg) ;
Ganser, Arnold (Hannover Medical School) ;
Schoemans, Helene (University Hospitals Leuven (Bèlgica)) ;
Pavlu, Jiri (Imperial College London) ;
Niittyvuopio, Riitta. (HUCH Comprehensive Cancer Center) ;
Schroyens, Wilfried (University Hospital Antwerp (Bèlgica)) ;
Kaynar, Leylagül (Erciyes University Medical Faculty) ;
Blau, Igor W. (Charité - Universitätsmedizin Berlin) ;
van der Velden, Walter (Radboud University - Nijmegen Medical Centre) ;
Sierra, Jorge (Institut d'Investigació Biomèdica Sant Pau) ;
Cortelezzi, Agostino (Fondazione IRCCS - Ca'Granda) ;
Wulf, Gerald (Universitätsklinikum Göttingen) ;
Turlure, Pascal (CHRU Limoges) ;
Rovira, Montserrat (Hospital Clínic i Provincial de Barcelona) ;
Ozkurt, Zubeydenur (Gazi University) ;
Pascual-Cascon, Maria J. (Hospital Regional Universitario de Málaga) ;
Moreira, Maria C. (Instituto National do Cancer) ;
Clausen, Johannes (Ordensklinikum Linz Elisabethinen) ;
Greinix, Hildegard (LKH - University Hospital Graz) ;
Duarte, Rafael F. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Basak, Grzegorz (Medical University of Warsaw) ;
Universitat Autònoma de Barcelona
ric acid is a danger signal contributing to inflammation. Its relevance to allogeneic stem cell transplantation (alloSCT) derives from preclinical models where the depletion of uric acid led to improved survival and reduced graft-versus-host disease (GvHD). [...]
2020 - 10.3324/haematol.2019.228668
Haematologica, Vol. 105 Núm. 7 (january 2020) , p. 1977-1983
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10 p, 1.0 MB |
Case report : Challenges in immune reconstitution following hematopoietic stem cell transplantation for CTLA-4 insufficiency-like primary immune regulatory disorders
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Margarit-Soler, Adriana (Hospital Sant Joan de Déu (Manresa)) ;
Deyà-Martínez, Ángela (Hospital Clínic i Provincial de Barcelona) ;
Canizales, Juan Torres (Hospital Clínic i Provincial de Barcelona) ;
Vlagea, Alexandru (Hospital Clínic i Provincial de Barcelona) ;
García-García, Ana (Hospital Clínic i Provincial de Barcelona) ;
Marsal, Júlia (Hospital Sant Joan de Déu (Manresa)) ;
Trabazo del Castillo, María (Hospital Sant Joan de Déu (Manresa)) ;
Planas, Sílvia (Hospital Sant Joan de Déu (Manresa)) ;
Simó, Sílvia (Hospital Sant Joan de Déu (Manresa)) ;
Esteve-Sole, Ana (Hospital Clínic i Provincial de Barcelona) ;
Suárez-Lledó Grande, María (Hospital Clínic i Provincial de Barcelona) ;
Badell Serra, Isabel (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Rovira Tarrats, Montserrat (Hospital Clínic i Provincial de Barcelona) ;
Fernandez Aviles, Francesc (Hospital Clínic i Provincial de Barcelona) ;
Alsina Manrique, Laia (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona
Cytotoxic T-lymphocyte antigen-4 (CTLA-4) haploinsufficiency is a T-cell hyperactivation disorder that can manifest with both immunodeficiency and immune dysregulation. Approximately one-third of patients may present mild symptoms and remain stable under supportive care. [...]
2022 - 10.3389/fimmu.2022.1070068
Frontiers in immunology, Vol. 13 (december 2022)
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10 p, 723.5 KB |
Experience of the Spanish Group for Hematopoietic Transplantation (GETMON-GETH) in allogenic hematopoietic stem cell transplantation in Philadelphia acute lymphoblastic leukemia Experiencia del Grupo Español de Trasplante Hematopoyético (GETMON-GETH) en el trasplante alogénico de progenitores hematopoyéticos en leucemia aguda linfoblástica Philadelphia
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Galán Gómez, Víctor (Hospital Universitario La Paz (Madrid)) ;
de la Fuente Regaño, Lydia (Universidad Autónoma de Madrid. Facultad de Medicina) ;
Rodríguez Villa, Antonia (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Díaz de Heredia, Cristina (Hospital Universitari Vall d'Hebron) ;
González Vicent, Marta (Hospital Infantil Universitario Niño Jesús (Madrid)) ;
Badell Serra, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Fernández, José María (Hospital Universitari i Politècnic La Fe (València)) ;
Pascual Martínez, Antonia Isabel (Hospital Materno Infantil Carlos Haya. Hemato-Oncología Pediátrica) ;
Pérez Hurtado, José María (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
López Duarte, Mónica (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Maldonado Regalado, M.Soledad (Hospital Universitario Ramón y Cajal (Madrid)) ;
Pérez-Martínez, Antonio (Hospital Universitario La Paz (Madrid))
Introduction: Outcomes in patients diagnosed of acute lymphoblastic leukemia with Philadelphia chromosome (Ph-ALL) remains unfavourable compared to other subtypes of acute lymphoblastic leukemia despite improvements in drug treatments as well as advances in hematopoietic stem cell transplantation (HSCT). [...]
2022 - 10.1016/j.anpedi.2021.02.015
Anales de pediatría, Vol. 96 Núm. 4 (abril 2022) , p. 309-318
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17 p, 1.4 MB |
Upregulation of NKG2D ligands impairs hematopoietic stem cell function in Fanconi anemia
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Casado, José A (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Valeri, A. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Sanchez-Dominguez, R. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Vela, P. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Lopez, A. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Navarro, S. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Alberquilla, Omaira (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Hanenberg, H. (Heinrich Heine University. Department of Otorhinolaryngology and Head and Neck Surgery) ;
Pujol, Roser (Institut d'Investigació Biomèdica Sant Pau) ;
Segovia, J. C. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Minguillon, J. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Surrallés i Calonge, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
De Heredia, C.D. (Vall d'Hebron Institut d'Oncologia) ;
Sevilla, J. (Hospital Nino Jesus) ;
Rio, P. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Bueren, Juan (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Universitat Autònoma de Barcelona
Fanconi anemia (FA) is the most prevalent inherited bone marrow failure (BMF) syndrome. Nevertheless, the pathophysiological mechanisms of BMF in FA have not been fully elucidated. Since FA cells are defective in DNA repair, we hypothesized that FA hematopoietic stem and progenitor cells (HSPCs) might express DNA damage-associated stress molecules such as natural killer group 2 member D ligands (NKG2D-Ls). [...]
2022 - 10.1172/JCI142842
The journal of clinical investigation, Vol. 132 Núm. 15 (january 2022) , p. e142842
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