1.
|
16 p, 1.9 MB |
Cross-sectional evaluation of circulating hepatitis B virus RNA and DNA : Different quasispecies?
/
García-García, Selene (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tabernero, David (Instituto de Salud Carlos II) ;
Gregori i Font, Josep (Instituto de Salud Carlos II) ;
Vila, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pacín Ruiz, Beatriz (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Quer, Josep 1963- (Instituto de Salud Carlos II) ;
Casillas, Rosario (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castillo-Ribelles, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ferrer-Costa, Roser (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ;
Trejo-Zahínos, Jesús (Hospital Universitari Vall d'Hebron) ;
Pumarola Suñé, Tomàs (Hospital Universitari Vall d'Hebron) ;
Casis-Saez, Ernesto (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteban, Rafael (Instituto de Salud Carlos II) ;
Riveiro Barciela, Mar (Instituto de Salud Carlos II) ;
Buti, Maria (Instituto de Salud Carlos II) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Different forms of pregenomic and other hepatitis B virus (HBV) RNA have been detected in patients' sera. These circulating HBV-RNAs may be useful for monitoring covalently closed circular DNA activity, and predicting hepatitis B e-antigen seroconversion or viral rebound after nucleos(t)ide analog cessation. [...]
2021 - 10.3748/wjg.v27.i41.7144
World Journal of Gastroenterology, Vol. 27 (november 2021) , p. 7144-7158
|
|
2.
|
12 p, 843.6 KB |
Association of hepatitis B virus infection status with outcomes of non-small cell lung cancer patients undergoing anti-PD-1/PD-L1 therapy
/
Zhang, Xuanye (Sun Yat-sen University Cancer Center) ;
Tian, Dan (Guangdong Academy of Medical Sciences) ;
Chen, Yue (The Eighth Affiliated Hospital of Sun Yat-sen University) ;
Chen, Chen (Sun Yat-sen University Cancer Center) ;
He, Li-Na (Sun Yat-sen University Cancer Center) ;
Zhou, Yixin (Sun Yat-sen University Cancer Center) ;
Li, Haifeng (Sun Yat-sen University Cancer Center) ;
Lin, Zuan (Sun Yat-sen University Cancer Center) ;
Chen, Tao (Sun Yat-sen University Cancer Center) ;
Wang, Yuhong (Sun Yat-sen University Cancer Center) ;
Russo, Alessandro (A.O. Papardo) ;
Nadal, Ernest (Hospital Universitari de Bellvitge) ;
Passiglia, Francesco (S. Luigi Gonzaga Hospital) ;
Soo, Ross Andrew (National University Health System) ;
Watanabe, Satoshi (Niigata University Graduate School of Medical and Dental Sciences) ;
Morán, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Oh, In-Jae (Hwasun Hospital) ;
Fu, Sha (Sun Yat-sen University) ;
Hong, Shaodong (Sun Yat-sen University Cancer Center) ;
Zhang, Li (Sun Yat-sen University Cancer Center) ;
Universitat Autònoma de Barcelona
The aim of this study was to evaluate the safety and survival outcomes of anti-programmed cell death (PD)-1/programmed cell death-ligand 1 (PD-L1) monotherapy in patients with advanced non-small cell lung cancer (NSCLC) and different hepatitis B virus (HBV) infection status. [...]
2021 - 10.21037/tlcr-21-455
Translational Lung Cancer Research, Vol. 10 (july 2021) , p. 3191-3202
|
|
3.
|
9 p, 1.4 MB |
ACE Score Identifies HBeAg-negative Inactive Carriers at a Single-point Evaluation, Regardless of HBV Genotype
/
Roade, Luisa (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Riveiro Barciela, Mar (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Palom, Adriana (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bes, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Salcedo, Maria-Teresa (Hospital Universitari Vall d'Hebron) ;
Casillas, Rosario (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vargas-Accarino, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tabernero, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sauleda, Silvia (Banc de Sang i Teixits (Barcelona, Catalunya)) ;
Esteban, Rafael (Hospital Universitari Vall d'Hebron) ;
Buti, Maria (Hospital Universitari Vall d'Hebron)
Hepatitis B virus (HBV) biomarkers have been used for a better categorization of patients, even though the lack of simple algorithms and the impact of genotypes limit their application. Our aim was to assess the usefulness of noninvasive markers for the identification of HBV inactive carriers (ICs) in a single-point evaluation and to design a predictive model for their identification. [...]
2022 - 10.14218/JCTH.2022.00068
Journal of Clinical and Translational Hepatology, Vol. 10 (april 2022) , p. 1068-1076
|
|
4.
|
18 p, 1.0 MB |
Hepatitis B Virus Variants with Multiple Insertions and/or Deletions in the X Open Reading Frame 3' End : Common Members of Viral Quasispecies in Chronic Hepatitis B Patients
/
García-García, Selene (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Caballero, Andrea (Hospital Universitari Vall d'Hebron) ;
Tabernero, David (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Cortese, Maria Francesca (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Gregori i Font, Josep (Hospital Universitari Vall d'Hebron) ;
Rodriguez-Algarra, Francisco (Queen Mary University of London) ;
Quer, Josep 1963- (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Homs, Maria (Institut Català de la Salut) ;
Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ;
Pacín Ruiz, Beatriz (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Vila, Marta (Hospital Universitari Vall d'Hebron) ;
Ferrer-Costa, Roser (Hospital Universitari Vall d'Hebron) ;
Pumarola Suñé, Tomàs (Hospital Universitari Vall d'Hebron) ;
Buti, Maria (Hospital Universitari Vall d'Hebron) ;
Rodríguez Frías, Francisco (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Deletions in the 3' end region of the hepatitis B virus (HBV) X open reading frame (HBX) may affect the core promoter (Cp) and have been frequently associated with hepatocellular carcinoma (HCC). The aim of this study was to investigate the presence of variants with deletions and/or insertions (Indels) in this region in the quasispecies of 50 chronic hepatitis B (CHB) patients without HCC. [...]
2022 - 10.3390/biomedicines10051194
Biomedicines, Vol. 10, Issue 5 (May 2022) , art. 1194
|
|
5.
|
11 p, 1.2 MB |
Viral and immune factors associated with successful treatment withdrawal in HBeAg-negative chronic hepatitis B patients
/
García-López, Mireia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Lens, Sabela (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pallett, Laura J. (University College London) ;
Testoni, Barbara (University of Lyon) ;
Rodríguez-Tajes, Sergio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Mariño, Zoe (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Bartres, Concepció (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
García-Pras, Ester (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Leonel, Thais (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Perpiñán, Elena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Lozano, Juan José (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron) ;
Koutsoudakis, George (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Zoulim, Fabien (University of Lyon) ;
Maini, Mala K. (University College London) ;
Forns, Xavier (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pérez-Del-Pulgar, Sofía (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Universitat Autònoma de Barcelona
Factors associated with a successful outcome upon nucleos(t)ide analogue (NA) treatment withdrawal in HBeAg-negative chronic hepatitis B (CHB) patients have yet to be clarified. The objective of this study was to analyse the HBV-specific T cell response, in parallel with peripheral and intrahepatic viral parameters, in patients undergoing NA discontinuation. [...]
2021 - 10.1016/j.jhep.2020.11.043
Journal of Hepatology, Vol. 74 (may 2021) , p. 1064-1074
|
|
6.
|
16 p, 3.5 MB |
Conservation and variability of hepatitis B core at different chronic hepatitis stages
/
Yll, Marçal (Hospital Universitari Vall d'Hebron) ;
Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ;
Guerrero Murillo, Mercedes (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Orriols, Gerard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gregori i Font, Josep (Hospital Universitari Vall d'Hebron) ;
Casillas, Rosario (Hospital Universitari Vall d'Hebron) ;
González, Carolina (Hospital Universitari Vall d'Hebron) ;
Sopena, Sara (Hospital Universitari Vall d'Hebron) ;
Godoy, Cristina (Hospital Universitari Vall d'Hebron) ;
Vila, Marta (Hospital Universitari Vall d'Hebron) ;
Tabernero, David (Hospital Universitari Vall d'Hebron) ;
Quer, Josep 1963- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ;
Lopez Martinez, Rosa (Hospital Universitari Vall d'Hebron) ;
Esteban, Rafael (Esteban Mur) (Hospital Universitari Vall d'Hebron) ;
Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Buti, Maria (Hospital Universitari Vall d'Hebron) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Since it is currently not possible to eradicate hepatitis B virus (HBV) infection with existing treatments, research continues to uncover new therapeutic strategies. HBV core protein, encoded by the HBV core gene (HBC), intervenes in both structural and functional processes, and is a key protein in the HBV life cycle. [...]
2020 - 10.3748/wjg.v26.i20.2584
World Journal of Gastroenterology, Vol. 26 (may 2020) , p. 2584-2598
|
|
7.
|
18 p, 2.2 MB |
Characterization of hepatitis B virus X gene quasispecies complexity in mono-infection and hepatitis delta virus superinfection
/
Godoy, Cristina (Hospital Universitari Vall d'Hebron) ;
Tabernero, David (Hospital Universitari Vall d'Hebron) ;
Sopena, Sara (Hospital Universitari Vall d'Hebron) ;
Gregori i Font, Josep (Roche Diagnostics SL) ;
Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ;
González, Carolina (Hospital Universitari Vall d'Hebron) ;
Casillas, Rosario (Hospital Universitari Vall d'Hebron) ;
Yll, Marçal (Hospital Universitari Vall d'Hebron) ;
Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ;
Lopez Martinez, Rosa (Hospital Universitari Vall d'Hebron) ;
Quer, Josep 1963- (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
González-Aseguinolaza, Gloria (Clínica Universidad de Navarra. Centro de Investigación Médica Aplicada) ;
Esteban, Rafael (Esteban Mur) (Hospital Universitari Vall d'Hebron) ;
Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Buti, Maria (Hospital Universitari Vall d'Hebron) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
BACKGROUND Hepatitis delta virus (HDV) seems to strongly suppress hepatitis B virus (HBV) replication, although little is known about the mechanism of this interaction. Both these viruses show a dynamic distribution of mutants, resulting in viral quasispecies. [...]
2019 - 10.3748/wjg.v25.i13.1566
World Journal of Gastroenterology, Vol. 25 (april 2019) , p. 1566-1579
|
|
8.
|
|
9.
|
14 p, 1.3 MB |
Detection of hyper-conserved regions in hepatitis B virus X gene potentially useful for gene therapy
/
González, Carolina (Hospital Universitari Vall d'Hebron) ;
Tabernero, David (Hospital Universitari Vall d'Hebron) ;
Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ;
Gregori i Font, Josep (Roche Diagnostics SL) ;
Casillas, Rosario (Hospital Universitari Vall d'Hebron) ;
Riveiro Barciela, Mar (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Godoy, Cristina (Hospital Universitari Vall d'Hebron) ;
Sopena, Sara (Hospital Universitari Vall d'Hebron) ;
Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ;
Yll, Marçal (Hospital Universitari Vall d'Hebron) ;
Lopez Martinez, Rosa (Hospital Universitari Vall d'Hebron) ;
Quer, Josep 1963- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteban, Rafael (Esteban Mur) (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Buti, Maria (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Rodríguez Frías, Francisco (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
To detect hyper-conserved regions in the hepatitis B virus (HBV) X gene (HBX) 5' region that could be candidates for gene therapy. The study included 27 chronic hepatitis B treatment-naive patients in various clinical stages (from chronic infection to cirrhosis and hepatocellular carcinoma, both HBeAg-negative and HBeAg-positive), and infected with HBV genotypes A-F and H. [...]
2018 - 10.3748/wjg.v24.i19.2095
World Journal of Gastroenterology, Vol. 24 (may 2018) , p. 2095-2107
|
|
10.
|
14 p, 1.3 MB |
Analysis of hepatitis B virus preS1 variability and prevalence of the rs2296651 polymorphism in a Spanish population
/
Casillas, Rosario (Hospital Universitari Vall d'Hebron) ;
Tabernero, David (Hospital Universitari Vall d'Hebron) ;
Gregori i Font, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Belmonte, Irene (Hospital Universitari Vall d'Hebron) ;
Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ;
González, Carolina (Hospital Universitari Vall d'Hebron) ;
Riveiro Barciela, Mar ;
López, Rosa Maria (Hospital Universitari Vall d'Hebron) ;
Quer, Josep 1963- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteban, Rafael (Esteban Mur) ;
Buti, Maria ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
To determine the variability/conservation of the domain of hepatitis B virus (HBV) preS1 region that interacts with sodium-taurocholate cotransporting polypeptide (hereafter, NTCP-interacting domain) and the prevalence of the rs2296651 polymorphism (S267F, NTCP variant) in a Spanish population. [...]
2018 - 10.3748/wjg.v24.i6.680
World Journal of Gastroenterology, Vol. 24 (february 2018) , p. 680-692
|
|