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12 p, 1.1 MB |
Ligelizumab improves angioedema, disease severity and quality-of-life in patients with chronic spontaneous urticaria
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Metz, Martin (Fraunhofer Institute for Translational Medicine and Pharmacology ITMP (Berlin, Alemanya)) ;
Bernstein, Jonathan (University of Cincinnati College of Medicine and Bernstein Clinical Research Center) ;
Giménez-Arnau, Ana M 1961- (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Hide, Michihiro (Hiroshima City Hospital) ;
Maurer, Marcus (Fraunhofer Institute for Translational Medicine and Pharmacology ITMP) ;
Sitz, Karl (Little Rock Allergy and Asthma Clinic) ;
Soong, Weily (AllerVie Health-Alabama Allergy and Asthma Center) ;
Sussman, Gordon (University of Toronto) ;
Hua, Eva (Shanghai Novartis Trading Ltd) ;
Barve, Avantika (Novartis Pharmaceuticals Corporation) ;
Barbier, Nathalie (Novartis Pharma AG) ;
Balp, Maria Magdalena (Novartis Pharma AG) ;
Severin, Thomas (Novartis Pharma AG) ;
Universitat Autònoma de Barcelona
Disease burden is particularly high in Chronic Spontaneous Urticaria (CSU) patients with angioedema, and patients whose signs and symptoms are inadequately controlled by H-antihistamines need new treatment options. [...]
2022 -  10.1016/j.waojou.2022.100716
The World Allergy Organization Journal, Vol. 15 (november 2022)
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12 p, 2.9 MB |
Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients
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Sans-de San Nicolàs, Lídia (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Figueras-Nart, Ignasi (Hospital Universitari de Bellvitge) ;
García-Jiménez, Irene (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Bonfill-Ortí, Montserrat (Hospital Universitari de Bellvitge) ;
Guilabert, Antonio (Hospital General de Granollers) ;
Curto-Barredo, Laia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Bertolín-Colilla, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Ferran, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Serra-Baldrich, E (Institut d'Investigació Biomèdica Sant Pau) ;
Pujol Vallverdú, Ramón M (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Santamaria-Babí, Luis F. (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Universitat Autònoma de Barcelona
The role of allergen sensitization in IL-31 production by T cells and specifically in the clinical context of atopic dermatitis (AD) has not been characterized. The response to house dust mite (HDM) in purified memory T cells cocultured with epidermal cells from AD patients (n=58) and control subjects (n=11) was evaluated. [...]
2023 - 10.3389/fimmu.2023.1124018
Frontiers in immunology, Vol. 14 (march 2023)
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13 p, 4.3 MB |
Poly-L-Lysine-Based αGal-Glycoconjugates for Treating Anti-αGal IgE-Mediated Diseases
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Olivera-Ardid, Sara (RemAb Therapeutics) ;
Bello-Gil, Daniel (RemAb Therapeutics) ;
Tuzikov, Alexander (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences) ;
Araujo, Ricardo N. (Laboratório de Artrópodes Hematófagos (Brasil)) ;
Ferrero-Alves, Yara (Universitat Autònoma de Barcelona) ;
García Figueroa, Blanca Esther (Instituto de Salud Carlos III) ;
Labrador Horrillo, Moises (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Pérez, Ana L. (Instituto Vasco de Investigación de Desarrollo Agrario) ;
Bovin, Nicolai (Institute of Bioorganic Chemistry Russian Academy of Sciences) ;
Mañez, Rafael (Institut d'Investigació Biomèdica de Bellvitge) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Anti-αGal IgE antibodies mediate a spreading allergic condition known as αGal-syndrome (AGS). People exposed to hard tick bites are sensitized to αGal, producing elevated levels of anti-αGal IgE, which are responsible for AGS. [...]
2022 - 10.3389/fimmu.2022.873019
Frontiers in immunology, Vol. 13 (march 2022)
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14 p, 3.8 MB |
dIvergEnt : How IgE Axis Contributes to the Continuum of Allergic Asthma and Anti-IgE Therapies
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Palomares, Óscar (Universidad Complutense de Madrid) ;
Sánchez-Ramón, Silvia (Universidad Complutense de Madrid. Departamento de Microbiología y Parasitología) ;
Dávila, Ignacio (Instituto de Investigación Biomédica de Salamanca) ;
Prieto, Luis (Hospital Universitari Doctor Peset (València)) ;
Pérez de Llano, Luis (Hospital Universitario Lucus Augusti (Lugo)) ;
Lleonart, Marta (Novartis Farmacéutica (Espanya)) ;
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Nieto, Antonio (Hospital Universitari i Politècnic La Fe (València)) ;
Universitat Autònoma de Barcelona
Asthma is an airway disease characterised by chronic inflammation with intermittent or permanent symptoms including wheezing, shortness of breath, chest tightness, and cough, which vary in terms of their occurrence, frequency, and intensity. [...]
2017 - 10.3390/ijms18061328
International journal of molecular sciences, Vol. 18 (june 2017)
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17 p, 1.6 MB |
In Vitro and In Vivo Validation of EP2-Receptor Agonism to Selectively Achieve Inhibition of Mast Cell Activity
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Plaza, Judith (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Torres Blanch, Rosa (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Urbano, Adrián (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Picado, César (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Mora Pérez, Fernando de (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Agonism of the prostaglandin E2 receptor, E-prostanoid receptor 2 (EP2), may represent an alternative protective mechanism in mast cell (MC)-mediated diseases. Previous studies have suggested that activation of the MC EP2 receptor prevents pathological changes in the murine models of allergic asthma. [...]
2020 - 10.4168/aair.2020.12.4.712
Allergy, Asthma & Immunology Research, Vol. 12 (april 2020) , p. 712-728
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50 p, 1.2 MB |
IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper
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Ansotegui Zubeldia, Ignacio Javier (Hospital Quironsalud Bizkaia) ;
Melioli, Giovanni (Humanitas University, Pieve Emanuele) ;
Canonica, G. Walter (Humanitas University) ;
Caraballo, Luis (University of Cartagena, Cartagena, Colombia) ;
Villa, Elisa (Azienda Sanitaria Locale di Vercelli) ;
Ebisawa, Motohiro (Sagamihara National Hospital (Japó)) ;
Passalacqua, Giovanni (University of Genoa) ;
Savi, Eleonora (Ospedale Civile, Gossolengo) ;
Ebo, Didier (University Hospital Antwerp (Bèlgica)) ;
Gómez, R. Maximiliano (Universidad Católica de Salta) ;
Luengo Sánchez, Olga (Hospital Universitari Vall d'Hebron) ;
Oppenheimer, John J. (Pulmonary & Allergy Associates, Denville) ;
Jensen-Jarolim, Erika (Medical University Vienna) ;
Fischer, David A. (Fischer Medicine Professional Corporation) ;
Haahtela, Tari (Skin and Allergy Hospital) ;
Antila, Martti (Clínica de Alergía, Sorocaba) ;
Bousquet, Jean (CHU Montpellier) ;
Cardona, Victoria (Hospital Universitari Vall d'Hebron) ;
Chiang, Wen Chin (Mount Elizabeth Medical Centre) ;
Demoly, Pascal (Sorbonne Université) ;
DuBuske, Lawrence M. (Immunology Research Institute of New England) ;
Ferrer Puga, Marta (Clínica Universidad de Navarra) ;
Gerth van Wijk, Roy (Erasmus MC, Sector Allergologie) ;
González Díaz, Sandra Nora (Universidad Autónoma de Nuevo León (Mèxic)) ;
Gonzalez-Estrada, Alexei (Mayo Clinic) ;
Jares, Edgardo (Femeca Femedica) ;
Kalpaklioğlu, Ayse Füsun (Kirikkale Universitesi) ;
Kase Tanno, Luciana (Hospital Sírio LibanêsSão Paulo) ;
Kowalski, Marek L. (Medical University of Łódź) ;
Ledford, Dennis K. (University of South Florida College of Medicine) ;
Monge Ortega, Olga Patricia (Hospital San Juan de Dios (San José, Costa Rica)) ;
Morais Almeida, Mário (Hospital CUF-Descobertas) ;
Pfaar, Oliver (University Hospital of Giessen and Marburg (Alemanya)) ;
Poulsen, Lars K. (Gentofte University Hospital) ;
Pawankar, Ruby (Nippon Medical School) ;
Renz, Harald E. (University Hospital GI & MR GmbH) ;
Romano, Antonino G. (Stallergenes) ;
Rosário Filho, Nelson A. (University of Parana) ;
Rosenwasser, Lanny (University of Missouri at Kansas City) ;
Sánchez Borges, Mario A. (Centro Médico Docente La Trinidad, Caracas) ;
Scala, Enrico (Istituto Dermopatico dell'Immacolata) ;
Senna, Gian-Enrico (Ospedale Civile Maggiore) ;
Sisul, Juan Carlos (Allergy & Asthma Institute, Asunción) ;
Tang, Mimi L. K. (Royal Children's Hospital) ;
Thong, Bernard Yu-Hor (Tan Tock Seng Hospital) ;
Valenta, Rudolf (Sechenov First Moscow State Medical University) ;
Wood, Robert A. (Johns Hopkins Hospital) ;
Zuberbier, Torsten (Campus Charite Mitte) ;
Universitat Autònoma de Barcelona
Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. [...]
2020 - 10.1016/j.waojou.2019.100080
The World Allergy Organization Journal, Vol. 13 (february 2020)
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29 p, 1.3 MB |
Highly sensitive dendrimer-based nanoplasmonic biosensor for drug allergy diagnosis
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Soler Aznar, Maria (Institut Català de Nanociència i Nanotecnologia) ;
Mesa Antúnez, Pablo (Universidad de Málaga) ;
Estévez, M. Carmen (Institut Català de Nanociència i Nanotecnologia) ;
Ruiz Sánchez, Antonio Jesús (Universidad de Málaga) ;
Otte Ortiz, Marinus Albertus (Institut Català de Nanociència i Nanotecnologia) ;
Sepúlveda, Borja (Institut Català de Nanociència i Nanotecnologia) ;
Collado, Daniel (Universidad de Málaga) ;
Mayorga, Cristobalina (Centro Andaluz de Nanomedicina y Biotecnología (BIONAND)) ;
Torres, María José (Centro Andaluz de Nanomedicina y Biotecnología (BIONAND)) ;
Pérez Inestrosa, Ezequiel (Universidad de Málaga) ;
Lechuga, Laura M (Institut Català de Nanociència i Nanotecnologia)
A label-free biosensing strategy for amoxicillin (AX) allergy diagnosis based on the combination of novel dendrimer-based conjugates and a recently developed nanoplasmonic sensor technology is reported. [...]
2015 - 10.1016/j.bios.2014.10.081
Biosensors & bioelectronics, Vol. 66 (April 2015) , p. 115-123
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8 p, 594.3 KB |
Expression of toll-like receptors 2 and 4 in subjects with asthma by total serum IgE level
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Crespo Lessmann, Astrid (Institut d'Investigació Biomèdica Sant Pau) ;
Mateus, Eder (Institut d'Investigació Biomèdica Sant Pau) ;
Vidal, Silvia (Institut d'Investigació Biomèdica Sant Pau) ;
Ramos-Barbón, David (Institut d'Investigació Biomèdica Sant Pau) ;
Torrejón, Montserrat (Institut d'Investigació Biomèdica Sant Pau) ;
Giner, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Soto, Lorena (Institut d'Investigació Biomèdica Sant Pau) ;
Juarez, Candido (Institut d'Investigació Biomèdica Sant Pau) ;
Plaza, Vicente (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Universitat Autònoma de Barcelona
Emerging data suggest that innate immunity may play a role in asthma, particularly the toll-like receptors (TLRs). Some studies pointed to an involvement of TLRs 2 and 4 in the pathogenesis of allergic asthma, and other studies related TLRs to IgE. [...]
2016 - 10.1186/s12931-016-0355-2
Respiratory Research, Vol. 17 (april 2016)
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