Resultados globales: 22 registros encontrados en 0.03 segundos.
Artículos, Encontrados 9 registros
Documentos de investigación, Encontrados 13 registros
Artículos Encontrados 9 registros  
1.
15 p, 955.9 KB SEOM clinical guidelines for the treatment of non-small cell lung cancer (2018) / Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ; Juan, O. (Hospital Universitari i Politècnic La Fe) ; Insa, A. (Hospital Clínico Universitario de Valencia) ; Reguart, N. (Universitat de Barcelona. Hospital Clínic) ; Trigo, J. M. (Hospital Universitario Virgen de la Victoria) ; Carcereny, E. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; García-Campelo, R. (Complexo Hospitalario Universitario A Coruña) ; García, Y. (Universitat Autònoma de Barcelona. Departament de Medicina) ; Guirado, M. (Hospital General Universitario de Elche. Medical Oncology Department) ; Provencio, M. (Universidad Autónoma de Madrid.Hospital Universitario Puerta de Hierro)
Non-small cell lung cancer (NSCLC) accounts for up to 85% of all lung cancers. The last few years have seen the development of a new staging system, diagnostic procedures such as liquid biopsy, treatments like immunotherapy, as well as deeper molecular knowledge; so, more options can be offered to patients with driver mutations. [...]
2018 - 10.1007/s12094-018-1978-1
Clinical & Translational Oncology, Vol. 21 (november 2018) , p. 3-17  
2.
12 p, 2.5 MB Liposome-based immunotherapy against autoimmune diseases : Therapeutic effect on multiple sclerosis / Pujol Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Mansilla López, Maria José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodríguez Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cano Sarabia, Antonia María (Institut Català de Nanociència i Nanotecnologia) ; Navarro-Barriuso, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ampudia, Rosa Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rius, Aleix (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; García Jimeno, Sonia (Institut Català de Nanociència i Nanotecnologia) ; Perna Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Based on the ability of apoptosis to induce immunological tolerance, liposomes were generated mimicking apoptotic cells, and they arrest autoimmunity in Type 1 diabetes. Our aim was to validate the immunotherapy in other autoimmune disease: multiple sclerosis. [...]
2017 - 10.2217/nnm-2016-0410
Nanomedicine, Vol. 12, Issue 11 (June 2017) , p. 1231-1242  
3.
17 p, 2.4 MB Phosphatidylserine-liposomes promote tolerogenic features on dendritic cells in human type 1 diabetes by apoptotic mimicry / Rodriguez Fernandez, Silvia (Institut Germans Trias i Pujol) ; Pujol Autonell, Irma (Institut Germans Trias i Pujol) ; Brianso, Ferran (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ; Perna Barrull, David (Institut Germans Trias i Pujol) ; Cano Sarabia, Antonia María (Institut Català de Nanociència i Nanotecnologia) ; García Jimeno, Sonia (Institut Català de Nanociència i Nanotecnologia) ; Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ; Sanchez, Alex (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ; Aguilera, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Vazquez, Federico (Hospital Universitari Germans Trias i Pujol. Servei d'Endocrinologia) ; Verdaguer, Joan (Universitat de Lleida. Departament de Medicina Experimental) ; Maspoch Comamala, Daniel (Institució Catalana de Recerca i Estudis Avançats) ; Vives-Pi, Marta (Institut Germans Trias i Pujol)
Type 1 diabetes (T1D) is a metabolic disease caused by the autoimmune destruction of insulin-producing β-cells. With its incidence increasing worldwide, to find a safe approach to permanently cease autoimmunity and allow β-cell recovery has become vital. [...]
2018 - 10.3389/fimmu.2018.00253
Frontiers in immunology, Vol. 9 (Feb. 2018) , art. 253  
4.
14 p, 6.3 MB CD40-activated B cells induce anti-tumor immunity in vivo / Wennhold, Kerstin (Cologne Interventional Immunology (CII), Department I of Internal Medicine, University Hospital of Cologne) ; Weber, Tanja M. (Cologne Interventional Immunology (CII), Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany) ; Klein-Gonzalez, Nela (Hospital Universitari Vall d'Hebron. Departament d'Hematologia) ; Thelen, Martin (Cologne Interventional Immunology (CII), Department I of Internal Medicine, University Hospital of Cologne) ; Garcia-Marquez, Maria (Cologne Interventional Immunology (CII), Department I of Internal Medicine, University Hospital of Cologne) ; Chakupurakal, Geothy (Cologne Interventional Immunology (CII), Department I of Internal Medicine, University Hospital of Cologne) ; Fiedler, Anne (Cologne Interventional Immunology (CII), Department I of Internal Medicine, University Hospital of Cologne) ; Schlösser, Hans A. (Department of General, Visceral and Cancer Surgery, University Hospital of Cologne) ; Fischer, Rieke (Department I of Internal Medicine, University Hospital of Cologne) ; Theurich, Sebastian (Laboratory for Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research Cologne) ; Shimabukuro-Vornhagen, Alexander (Cologne Interventional Immunology (CII), Department I of Internal Medicine, University Hospital of Cologne) ; von Bergwelt-Baildon, Michael (Cologne Interventional Immunology (CII), Department I of Internal Medicine, University Hospital of Cologne) ; Universitat Autònoma de Barcelona. Vall d'Hebron Institut de Recerca (VHIR) ; Universitat Autònoma de Barcelona
The introduction of checkpoint inhibitors represents a major advance in cancer immunotherapy. Some studies on checkpoint inhibition demonstrate that combinatorial immunotherapies with secondary drivers of anti-tumor immunity provide beneficial effects for patients that do not show a strong endogenous immune response. [...]
2016 - 10.18632/oncotarget.7720
Oncotarget, Vol. 8 (february 2016) , p. 27740-27753  
5.
19 p, 1.2 MB Use of autoantigen-loaded phosphatidylserine-liposomes to arrest autoimmunity in type 1 diabetes / Pujol Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Serracant Prat, Arnau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cano Sarabia, Antonia María (Institut Català de Nanociència i Nanotecnologia) ; Ampudia, Rosa Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodriguez Fernandez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Sànchez, Àlex (Sànchez Pla) (Universitat de Barcelona. Departament d'Estadística) ; Izquierdo Castro, Cristina (Universitat de Barcelona. Departament de Fisiologia i Immunologia) ; Stratmann, Thomas (Universitat de Barcelona. Departament de Fisiologia i Immunologia) ; Puig Domingo, Manuel Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Verdaguer, Joan (Universitat de Lleida. Departament de Medicina Experimental) ; Vives Pi, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Universitat Autònoma de Barcelona
INTRODUCTION: The development of new therapies to induce self-tolerance has been an important medical health challenge in type 1 diabetes. An ideal immunotherapy should inhibit the autoimmune attack, avoid systemic side effects and allow β-cell regeneration. [...]
2015 - 10.1371/journal.pone.0127057
PloS one, Vol. 19, Issue 6 (June 2015) , p. e0127057  
6.
44 p, 2.3 MB Early intervention in the 3xTg-AD mice with an amyloid β-antibody fragment ameliorates first hallmarks of Alzheimer disease / Giménez Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Rivera Hernández, Geovanny (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Marin Argany, Marta (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Sánchez Quesada, José Luis (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya). Departament de Bioquímica) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
The single-chain variable fragment, scFv-h3D6, has been shown to prevent in vitro toxicity induced by the amyloid β (Aβ) peptide in neuroblastoma cell cultures by withdrawing Aβ oligomers from the amyloid pathway. [...]
2013 - 10.4161/mabs.25424
mAbs, Vol. 5 Issue 5(Sep 2013) , p. 665-864  
7.
17 p, 1.5 MB Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragmen / Esquerda-Canals, Gisela (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Martí Clúa, Joaquim (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Rivera Hernández, Geovanny (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Giménez Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
The therapeutic potential of scFv-h3D6 has recently been shown in the 3xTg-AD mice. A clear effect on amyloid β (Aβ) oligomers and certain apolipoproteins in the brain was found, but no effect was seen in the cerebellum. [...]
2013 - 10.4161/mabs.25428
mAbs, Vol. 5 Issue 5 (Sep.-Oct. 2013) , p. 660-664  
8.
2 p, 1.3 MB Elongation of the C-terminal domain of an anti-amyloid β single-chain variable fragment increases its thermodynamic stability and decreases its aggregation tendency / Rivera Hernández, Geovanny (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Marin Argany, Marta (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Blasco Moreno, B. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Bonet, Jaume (Universitat Pompeu Fabra. Unitat de Recerca en Informàtica Biomèdica) ; Oliva Miguel, Baldomero (Universitat Pompeu Fabra. Unitat de Recerca en Informàtica Biomèdica) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Amyloid β (Aβ) immunotherapy is considered a promising approach to Alzheimer disease treatment. In contrast to the use of complete antibodies, administration of single-chain variable fragments (scFv) has not been associated with either eningoencephalitis or cerebral hemorrhage. [...]
2013 - 10.4161/mabs.25382
mAbs, Vol. 5 Issue 5 (Sep.-Oct. 2013) , p. 678-689  
9.
22 p, 433.8 KB Kupfer-type immunological synapses in vivo : Raison D'être of SMAC / Mitxitorena, Izaskun (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Saavedra López, Elena (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Barcia, Carlos (Universitat Autònoma de Barcelona. Institut de Neurociències)
T cells engage with antigen-presenting cells to form immunological synapses. These intimate contacts are characterized by the complex arrangement of molecules at the intercellular interface, which has been described as the supramolecular activation cluster (SMAC). [...]
2015 - 10.1038/icb.2014.80
Immunology and Cell Biology, Vol. 93, no. 1 (2015) , p. 51-56  

Documentos de investigación Encontrados 13 registros  1 - 10siguiente  ir al registro:
1.
1 p, 852.4 KB APC Vaccines in iNKT Cell-Mediated Antitumoral Immunotherapy / Garcia Ortega, Sara ; Universitat Autònoma de Barcelona. Facultat de Biociències
2018
Grau en Ciències Biomèdiques [832]  
2.
1 p, 521.3 KB Invariant Natural Killer T cell-based Immunotherapy against Cancer / Barbao Carrasco, Paula ; Universitat Autònoma de Barcelona. Facultat de Biociències
2018
Grau en Ciències Biomèdiques [832]  
3.
11 p, 1.3 MB Engineered Oncolytic Herpes Simplex Virus as Treatment for Glioblastoma / Rúbies Bedós, Marta ; Universitat Autònoma de Barcelona. Facultat de Biociències
Since they were discovered over a century ago, oncolytic viruses have been expected to produce a cure for cancer. Although results so far have not been promising, the FDA approval of an oncolytic virus (T-VEC) for malignant melanoma in the United States in 2015 has yet opened again the door for this therapy as a potential treatment for cancer. [...]
2018
Grau en Ciències Biomèdiques [832]  
4.
1 p, 1.9 MB Engineered oncolytic viruses as targetd therapy for pancreatic ductal adenocarcinoma / Ramal García, Maria ; Lizcano de Vega, José Miguel, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
Pancreatic Ductal Adenocarcinoma (PDAC), the most prevalent subtype of pancreatic cancer, is a medical challenge owing to its lethality and the poor effectiveness of current treatments, specially because of the hardly penetrable microenvironment that exerts an immunosuppressive effect. [...]
2019-05-30
Grau en Biotecnologia [815]  
5.
1 p, 2.4 MB CRISPR technology and its application in cancer / Fagoaga Eugui, Maider ; Duñach Masjuan, Mireia, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
CRISPR is a revolutionary genome-editing technology derived from the adaptive immune system of prokaryotes, which integrate short fragments of foreign nucleic acids in their genome in a specific manner and this serves as a vaccination card or cellular memory of past invaders. [...]
2019-05-31
Grau en Bioquímica [814]  
6.
1 p, 751.8 KB Type 1 diabetes mellitus immunotherapy : using regulatory T cells to balance the immune response / Crespo Galván, Raquel ; Álvarez, Iñaki, dir., (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2017
Grau en Microbiologia [816]  
7.
1 p, 682.5 KB Natural killer T cell-based immunotherapy for cancer / Vila Gatius, Jaume ; Castaño García, A. Raúl, (Ángel Raúl) dir., (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2017
Grau en Biologia [812]  
8.
1 p, 6.1 MB Tumour neoantigens : towards personalized cancer immunotherapy / Moya Borrego, Laura ; Farrés i Vicén, Jaume, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2016
Grau en Ciències Biomèdiques [832]  
9.
1 p, 2.1 MB Antitumoral immune response : NKT cell-mediated immunotherapy / Montpeyó Garcia-Moreno, Marta ; Castaño García, A. Raúl, (Ángel Raúl) dir. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2016
Grau en Ciències Biomèdiques [832]  
10.
1 p, 741.0 KB Chimeric antigen receptor-engineered T cells for B acute lymphocytic leukemia / Altadill Ferrando, Cinta ; Bosch i Merino, Assumpció, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Ciències
2015
Grau en Biotecnologia [815]  

Documentos de investigación : Encontrados 13 registros   1 - 10siguiente  ir al registro:
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