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Articles, 2 records found

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11 p, 871.5 KB

Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors / Powers, R. K. (Department of Pharmacology. University of Colorado Anschutz Medical Campus) ; Culp-Hill, R. (Department of Biochemistry and Molecular Genetics. University of Colorado Anschutz Medical Campus) ; Ludwig, M. P. (Department of Pharmacology. University of Colorado Anschutz Medical Campus) ; Smith, K. P. (Linda Crnic Institute for Down Syndrome. University of Colorado Anschutz Medical Campus) ; Waugh, K. A. (Linda Crnic Institute for Down Syndrome. University of Colorado Anschutz Medical Campus) ; Minter, R. (Linda Crnic Institute for Down Syndrome. University of Colorado Anschutz Medical Campus) ; Tuttle, K. D. (Linda Crnic Institute for Down Syndrome. University of Colorado Anschutz Medical Campus) ; Lewis, H. C. (Linda Crnic Institute for Down Syndrome. University of Colorado Anschutz Medical Campus) ; Rachubinski, A. L. (Department of Pediatrics. University of Colorado Anschutz Medical Campus) ; Granrath, R. E. (Linda Crnic Institute for Down Syndrome. University of Colorado Anschutz Medical Campus) ; Carmona Iragui, María (Institut d'Investigació Biomèdica Sant Pau) ; Wilkerson, R. B. (Department of Biochemistry and Molecular Genetics. University of Colorado Anschutz Medical Campus) ; Kahn, D. E. (Linda Crnic Institute for Down Syndrome. University of Colorado Anschutz Medical Campus) ; Joshi, M. (Functional Genomics Facility. University of Colorado Anschutz Medical Campus) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; D'Alessandro, A. (Department of Biochemistry and Molecular Genetics. University of Colorado Anschutz Medical Campus) ; Costello, J. C. (Department of Pharmacology. University of Colorado Anschutz Medical Campus) ; Sullivan, K. D. (Functional Genomics Facility. University of Colorado Anschutz Medical Campus) ; Espinosa, J. M. (Department of Molecular. Cellular and Developmental Biology. University of Colorado Boulder) ; Universitat Autònoma de Barcelona
Trisomy 21 (T21) causes Down syndrome (DS), affecting immune and neurological function by ill-defined mechanisms. Here we report a large metabolomics study of plasma and cerebrospinal fluid, showing in independent cohorts that people with DS produce elevated levels of kynurenine and quinolinic acid, two tryptophan catabolites with potent immunosuppressive and neurotoxic properties, respectively. [...]
2019 - DOI (Digital Object Identifier)

10.1038/s41467-019-12739-9
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 4766

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13 p, 6.6 MB

Inflammatory conditions dictate the effect of Mesenchymal stem or Stromal cells on B cell function / Luk, Franka (Erasmus University Medical Center, Rotterdam) ; Carreras-Planella, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Korevaar, Sander S. (Erasmus University Medical Center, Rotterdam) ; de Witte, Samantha F. H. (Erasmus University Medical Center, Rotterdam) ; Borràs i Serres, Francesc Enric (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Betjes, Michiel G. H. (Erasmus University Medical Center, Rotterdam) ; Baan, Carla C. (Erasmus University Medical Center, Rotterdam) ; Hoogduijn, Martin J. (Erasmus University Medical Center, Rotterdam) ; Franquesa, Marcella (Erasmus University Medical Center, Rotterdam)
The immunomodulatory capacity of mesenchymal stem or stromal cells (MSC) makes them a promising tool for treatment of immune disease and organ transplantation. The effects of MSC on B cells are characterized by an abrogation of plasmablast formation and induction of regulatory B cells (Bregs). [...]
2017 - DOI (Digital Object Identifier)

10.3389/fimmu.2017.01042
Frontiers in immunology, Vol. 8 (august 2017) , p. 1-13

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