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1.
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15 p, 2.2 MB |
Recovering What Matters : High Protein Recovery after Endotoxin Removal from LPS-Contaminated Formulations Using Novel Anti-Lipid A Antibody Microparticle Conjugates
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Casonato Melo, Cristiane (Paris Lodron University of Salzburg. Department of Biosciences & Medical Biology) ;
Fux, Alexandra C. (Paris Lodron University of Salzburg. Department of Biosciences & Medical Biology) ;
Himly, Martin (Paris Lodron University of Salzburg. Department of Biosciences & Medical Biology) ;
Bastús, Neus G (Institut Català de Nanociència i Nanotecnologia) ;
Schlahsa, Laura (Miltenyi Biotec B.V. & Co) ;
Siewert, Christiane (Miltenyi Biotec B.V. & Co) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Duschl, Albert (Paris Lodron University of Salzburg. Department of Biosciences & Medical Biology) ;
Gessner, Isabel (Miltenyi Biotec B.V. & Co) ;
Fauerbach, Jonathan A. (Miltenyi Biotec B.V. & Co)
Endotoxins or lipopolysaccharides (LPS), found in the outer membrane of Gram-negative bacterial cell walls, can stimulate the human innate immune system, leading to life-threatening symptoms. Therefore, regulatory limits for endotoxin content apply to injectable pharmaceuticals, and excess LPS must be removed before commercialization. [...]
2023 -  10.3390/ijms241813971
International journal of molecular sciences, Vol. 24, Issue 18 (September 2023) , art. 13971
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2.
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15 p, 2.3 MB |
Induction of Innate Memory in Human Monocytes Exposed to Mixtures of Bacterial Agents and Nanoparticles
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Della Camera, Giacomo (European Commission. Joint Research Centre) ;
Liu, Tinghao (China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation) ;
Yang, Wenjie (China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation) ;
Li, Yang (China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Gioria, Sabrina (European Commission. Joint Research Centre) ;
Italiani, Paola (China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation) ;
Boraschi, Diana (China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation)
We assessed whether concomitant exposure of human monocytes to bacterial agents and different engineered nanoparticles can affect the induction of protective innate memory, an immune mechanism that affords better resistance to diverse threatening challenges. [...]
2022 - 10.3390/ijms232314655
International journal of molecular sciences, Vol. 23, Issue 23 (November 2022) , art. 14655
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3.
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20 p, 14.1 MB |
In Vivo Evaluation of ECP Peptide Analogues for the Treatment of Acinetobacter baumannii Infection
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Li, Jiarui (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Prats-Ejarque, Guillem (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Torrent Burgas, Marc (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Andreu Martínez, David (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Brandenburg, Klaus (Brandenburg Antiinfektiva GmbH) ;
Fernández-Millán, Pablo (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Boix i Borràs, Esther (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Antimicrobial peptides (AMPs) are alternative therapeutics to traditional antibiotics against bacterial resistance. Our previous work identified an antimicrobial region at the N-terminus of the eosinophil cationic protein (ECP). [...]
2022 - 10.3390/biomedicines10020386
Biomedicines, Vol. 10 Núm. 2 (february 2022) , p. 386
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4.
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40 p, 2.2 MB |
Epigenetic differences in the innate response after immune stimulation during zebrafish sex differentiation
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Moraleda-Prados, J. (Institut de Ciències del Mar) ;
Caballero-Huertas, M. (Institut de Ciències del Mar) ;
Valdivieso, A. (Institut de Ciències del Mar) ;
Joly, S. (Institut de Ciències del Mar) ;
Ji, Jie (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Roher Armentia, Nerea (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ribas, Laia (Institut de Ciències del Mar)
Infections are able to trigger epigenetic modifications; however, epigenetic-mediating infections in the immune system in fish is currently unavailable. Within this purpose, zebrafish were immune-stimulated with three lipopolysaccharides (LPS) during sex differentiation. [...]
2021 - 10.1016/j.dci.2020.103848
Developmental and Comparative Immunology, Vol. 114 (January 2021) , art. 103848
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5.
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18 p, 7.7 MB |
RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation
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Wong, Jerry (Department Pathology, San Diego, California) ;
Garcia-Carbonell, Ricard (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Zelic, Matija (University of Massachusetts Medical School) ;
Ho, Samuel B. (VA San Diego Healthcare System, San Diego, California) ;
Boland, Brigid S. (San Diego Digestive Disease Research Center, San Diego, California) ;
Yao, Shih-Jing (Department Pathology, San Diego, California) ;
Desai, Shalin A. (Department Pathology, San Diego, California) ;
Das, Soumita (Department Pathology, San Diego, California) ;
Planell, Núria (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Harris, Philip A. (Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania) ;
Font-Burgada, Joan (Department Pathology, San Diego, California) ;
Taniguchi, Koji (Department Pathology, San Diego, California) ;
Bertin, John (University of Massachusetts Medical School) ;
Salas, Azucena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pasparakis, Manolis (University of Cologne, Cologne, Germany) ;
Gough, Pete J. (Pattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, Pennsylvania) ;
Kelliher, Michelle (University of Massachusetts Medical School) ;
Karin, Michael (Department Pathology, San Diego, California) ;
Guma, Monica 1971- (Universitat Autònoma de Barcelona. Departament de Medicina)
Tumor necrosis factor (TNF) is a major pathogenic effector and a therapeutic target in inflammatory bowel disease (IBD), yet the basis for TNF-induced intestinal epithelial cell (IEC) death is unknown, because TNF does not kill normal IECs. [...]
2019 - 10.1016/j.jcmgh.2019.10.002
Cellular and Molecular Gastroenterology and Hepatology, Vol. 9 (october 2019) , p. 295-312
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6.
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21 p, 4.7 MB |
Extending Immunological Profiling in the Gilthead Sea Bream, Sparus aurata, by Enriched cDNA Library Analysis, Microarray Design and Initial Studies upon the Inflammatory Response to PAMPs
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Boltana, Sebastian (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Castellana, Barbara (The Child & Family Research Institute (Vancouver, Canadà)) ;
Goetz, Giles (Northwest Fisheries Science Centre (Seattle, Estats Units d'Amèrica)) ;
Tort Bardolet, Lluís (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Teles, Mariana (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Mulero, Víctor (Universidad de Murcia. Departamento de Biología Celular e Histología) ;
Novoa, Beatriz (Instituto de Investigaciones Marinas (Vigo, Espanya)) ;
Figueras, Antonio (Instituto de Investigaciones Marinas (Vigo, Espanya)) ;
Goetz, Frederick W. (Northwest Fisheries Science Centre (Seattle, Estats Units d'Amèrica)) ;
Gallardo-Escárate, Cristian (Universidad de Concepción (Concepción, Xile)) ;
Planas, Josep V. (Universitat de Barcelona. Departament de Fisiologia i Immunologia) ;
Mackenzie, Simon (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
This study describes the development and validation of an enriched oligonucleotide-microarray platform for Sparus aurata (SAQ) to provide a platform for transcriptomic studies in this species. A transcriptome database was constructed by assembly of gilthead sea bream sequences derived from public repositories of mRNA together with reads from a large collection of expressed sequence tags (EST) from two extensive targeted cDNA libraries characterizing mRNA transcripts regulated by both bacterial and viral challenge. [...]
2017 - 10.3390/ijms18020317
International journal of molecular sciences, Vol. 18 Núm. 2 (2017) , p. 1-21
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7.
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15 p, 3.4 MB |
Detoxifying Escherichia coli for endotoxin-free production of recombinant proteins
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Mamat, Uwe (Forschungszentrum Borstel) ;
Wilke, Kathleen (Forschungszentrum Borstel) ;
Bramhill, David (Research Corporation Technologies (Tucson)) ;
Schromm, Andra Beate (Forschungszentrum Borstel) ;
Lindner, Buko (Forschungszentrum Borstel) ;
Kohl, Thomas Andreas (Forschungszentrum Borstel) ;
Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Schaffer, Lana (Scripps Research Institute) ;
Head, Steven Robert (Scripps Research Institute) ;
Souvignier, Chad (Research Corporation Technologies (Tucson)) ;
Meredith, Timothy Charles (Pennsylvania State University. Department of Biochemistry and Molecular Biology) ;
Woodard, Ronald Wesley (Bramhill Biological Consulting)
Background: lipopolysaccharide (LPS), also referred to as endotoxin, is the major constituent of the outer leaflet of the outer membrane of virtually all Gram-negative bacteria. The lipid A moiety, which anchors the LPS molecule to the outer membrane, acts as a potent agonist for Toll-like receptor 4/myeloid differentiation factor 2-mediated pro-inflammatory activity in mammals and, thus, represents the endotoxic principle of LPS. [...]
2015 - 10.1186/s12934-015-0241-5
Microbial cell factories, Vol. 14, Issue 57 (2015)
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8.
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18 p, 391.8 KB |
Production of functional inclusion bodies in endotoxin-free Escherichia coli
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Rueda, Fabián (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Cano-Garrido, Olivia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Mamat, Uwe (Forschungszentrum Borstel) ;
Wilke, Kathleen (Forschungszentrum Borstel) ;
Seras-Franzoso, Joaquin (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Garcia-Fruitos, Elena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Escherichia coli is the workhorse for gene cloning and production of soluble recombinant proteins in both biotechnological and biomedical industries. The bacterium is also a good producer of several classes of protein-based self-assembling materials such as inclusion bodies (IBs). [...]
2014 - 10.1007/s00253-014-6008-9
Applied microbiology and biotechnology, Vol. 98 issue 22 (Nov. 2014) , p. 9229-9238
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