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12 p, 478.7 KB Modeling the longitudinal latent effect of pregabalin on self-reported changes in sleep disturbances in outpatients with generalized anxiety disorder managed in routine clinical practice / Ruiz, Miguel A. (Universidad Autónoma de Madrid) ; Álvarez, Enrique (Álvarez Martínez) (Institut d'Investigació Biomèdica Sant Pau) ; Carrasco, Jose L. (Hospital Clínico San Carlos (Madrid)) ; Olivares, José M.. (Complexo Hospitalario Universitario de Vigo) ; Pérez, María (Medical Department, Pfizer, S.L.U.) ; Rejas, Javier (Health Economics and Outcomes Research Department, Pfizer, S.L.U.)
Anxiety disorders are among the most common psychiatric illnesses, with generalized anxiety disorder (GAD) being one of the most common. Sleep disturbances are highly prevalent in GAD patients. While treatment with pregabalin has been found to be associated with significant improvement in GAD-related sleep disturbance across many controlled clinical trials, mediational analysis has suggested that a substantial portion of this effect could be the result of a direct effect of pregabalin. [...]
2015 - 10.2147/DDDT.S88238
Drug Design, Development and Therapy, Vol. 9 (august 2015) , p. 4329-4340  
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