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1.
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44 p, 10.1 MB |
Intra- and interchromosomal contact mapping reveals the Igh locus has extensive conformational heterogeneity and interacts with B-lineage genes
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Mielczarek, O. (Nuclear Dynamics Programme. Babraham Institute. Babraham Research Campus) ;
Rogers, C.H. (Immunology Programme. Babraham Institute. Babraham Research Campus) ;
Zhan, Y. (Friedrich Miescher Institute for Biomedical Research) ;
Matheson, L.S. (Immunology Programme. Babraham Institute. Babraham Research Campus) ;
Stubbington, M.J.T. (Nuclear Dynamics Programme. Babraham Institute. Babraham Research Campus) ;
Schoenfelder, S. (Nuclear Dynamics Programme. Babraham Institute. Babraham Research Campus) ;
Bolland, D.J. (Immunology Programme. Babraham Institute. Babraham Research Campus) ;
Javierre, B. M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Wingett, S.W. (Bioinformatics Group. Babraham Institute. Babraham Research Campus) ;
Várnai, C. (Nuclear Dynamics Programme. Babraham Institute. Babraham Research Campus) ;
Segonds-Pichon, A. (Bioinformatics Group. Babraham Institute. Babraham Research Campus) ;
Conn, S.J. (Flinders Health and Medical Research Institute. College of Medicine and Public Health. Flinders University) ;
Krueger, F. (Babraham Institute) ;
Andrews, S. (Babraham Institute) ;
Fraser, P. (Nuclear Dynamics Programme. Babraham Institute. Babraham Research Campus) ;
Giorgetti, L. (Friedrich Miescher Institute for Biomedical Research) ;
Corcoran, A.E. (Immunology Programme. Babraham Institute. Babraham Research Campus)
To produce a diverse antibody repertoire, immunoglobulin heavy-chain (Igh) loci undergo large-scale alterations in structure to facilitate juxtaposition and recombination of spatially separated variable (V), diversity (D), and joining (J) genes. [...]
2023 -  10.1016/j.celrep.2023.113074
Cell reports, Vol. 42 Núm. 9 (26 2023) , p. 113074
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2.
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15 p, 1.1 MB |
Novel genetic variants of KHDC3L and other members of the subcortical maternal complex associated with Beckwith-Wiedemann syndrome or Pseudohypoparathyroidism 1B and multi-locus imprinting disturbances
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Pignata, Laura (Università Degli Studi Della Campania "Luigi Vanvitelli") ;
Cecere, Francesco (Università Degli Studi Della Campania "Luigi Vanvitelli") ;
Verma, Ankit (Institute of Genetics and Biophysics (IGB)) ;
Hay Mele, Bruno (Università Degli Studi Di Napoli "Federico II") ;
Monticelli, Maria (Università Degli Studi Di Napoli "Federico II") ;
Acurzio, Basilia (Institute of Genetics and Biophysics (IGB)) ;
Giaccari, Carlo (Institute of Genetics and Biophysics (IGB)) ;
Sparago, Angela (Università Degli Studi Della Campania "Luigi Vanvitelli") ;
Hernandez Mora, José Ramon (Institut d'Investigació Biomèdica de Bellvitge) ;
Monteagudo-Sánchez, Ana (Institut d'Investigació Biomèdica de Bellvitge) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Pereda, Arrate (Araba University Hospital-Txagorritxu) ;
Tenorio-Castano, Jair (ITHACA. European Reference Network) ;
Palumbo, Orazio (Fondazione IRCCS "Casa Sollievo Della Sofferenza") ;
Carella, Massimo (Fondazione IRCCS "Casa Sollievo Della Sofferenza") ;
Prontera, Paolo (Medical Genetics Unit. University and Hospital of Perugia) ;
Piscopo, Carmelo ("Antonio Cardarelli" Hospital) ;
Accadia, Maria (Hospital "Cardinale G. Panico") ;
Lapunzina, Pablo (ITHACA. European Reference Network) ;
Cubellis, Maria Vittoria (Università Degli Studi Di Napoli "Federico II") ;
Pérez de Nanclares, Guiomar (Araba University Hospital-Txagorritxu) ;
Monk, David (University of East Anglia) ;
Riccio, Andrea (Institute of Genetics and Biophysics (IGB)) ;
Cerrato, Flavia (Università Degli Studi Della Campania "Luigi Vanvitelli") ;
Universitat Autònoma de Barcelona
Background: Beckwith-Wiedemann syndrome (BWS) and Pseudohypoparathyroidism type 1B (PHP1B) are imprinting disorders (ID) caused by deregulation of the imprinted gene clusters located at 11p15. 5 and 20q13. [...]
2022 - 10.1186/s13148-022-01292-w
Clinical Epigenetics, Vol. 14 Núm. 1 (december 2022), p. 71
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3.
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22 p, 2.2 MB |
Lower Locus Coeruleus MRI intensity in patients with late-life major depression
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Guinea-Izquierdo, Andrés (Hospital Universitari de Bellvitge) ;
Giménez, Mónica (Hospital Universitari de Bellvitge) ;
Martínez-Zalacaín, Ignacio (Hospital Universitari de Bellvitge) ;
del Cerro, Inés (Hospital Universitari de Bellvitge) ;
Canal-Noguer, Pol (Universitat Politècnica de Catalunya) ;
Blasco, Gerard (Hospital Universitari de Bellvitge) ;
Gascón, Jordi (Hospital Universitari de Bellvitge) ;
Reñé, Ramon (Hospital Universitari de Bellvitge) ;
Rico, Inmaculada (Hospital Universitari de Bellvitge) ;
Camins, Angels (Hospital Universitari de Bellvitge) ;
Aguilera, Carlos (Hospital Universitari de Bellvitge) ;
Urretavizcaya, Mikel (Hospital Universitari de Bellvitge) ;
Ferrer, Isidro (Hospital Universitari de Bellvitge) ;
Menchón Magriñá, José Manuel (Hospital Universitari de Bellvitge) ;
Soria, Virginia (Hospital Universitari de Bellvitge) ;
Soriano-Mas, Carles (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
The locus coeruleus (LC) is the major noradrenergic source in the central nervous system. Structural alterations in the LC contribute to the pathophysiology of different neuropsychiatric disorders, which may increase to a variable extent the likelihood of developing neurodegenerative conditions. [...]
2021 - 10.7717/peerj.10828
PeerJ, Vol. 9 (february 2021)
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4.
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9 p, 1.6 MB |
Locus coeruleus connectivity alterations in late-life major depressive disorder during a visual oddball task
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del Cerro, Inés (Centro de Investigación Biomédica en Red de Salud Mental) ;
Martínez-Zalacaín, Ignacio (Universitat de Barcelona. Departament de Ciències Clíniques) ;
Guinea-Izquierdo, Andrés (Universitat de Barcelona. Departament de Ciències Clíniques) ;
Gascon-Bayarri, Jordi (Institut d'Investigació Biomèdica de Bellvitge) ;
Viñas-Diez, Vanesa (Institut d'Investigació Biomèdica de Bellvitge) ;
Urretavizcaya, Mikel (Centro de Investigación Biomédica en Red de Salud Mental) ;
Naval-Baudin, Pablo (Institut d'Investigació Biomèdica de Bellvitge) ;
Aguilera, Carlos (Institut d'Investigació Biomèdica de Bellvitge) ;
Reñé-Ramírez, Ramón (Institut d'Investigació Biomèdica de Bellvitge) ;
Ferrer, Isidro (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Menchón, José M. (Centro de Investigación Biomédica en Red de Salud Mental) ;
Soria, Virginia (Centro de Investigación Biomédica en Red de Salud Mental) ;
Soriano-Mas, Carles (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
The Locus Coeruleus (LC) is the major source of noradrenergic neurotransmission. Structural alterations in the LC have been observed in neurodegenerative disorders and at-risk individuals, although functional connectivity studies between the LC and other brain areas have not been yet performed in these populations. [...]
2020 - 10.1016/j.nicl.2020.102482
NeuroImage, Vol. 28 (october 2020)
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5.
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17 p, 5.0 MB |
Noncoding SNPs influence a distinct phase of Polycomb silencing to destabilize long-term epigenetic memory at Arabidopsis FLC
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Qüesta, Julia I. (Norwich Research Park. John Innes Centre (UK)) ;
Antoniou-Kourounioti, Rea Laila (Norwich Research Park. John Innes Centre (UK)) ;
Rosa, Stefanie (Norwich Research Park. John Innes Centre (UK)) ;
Li, Peijin (Norwich Research Park. John Innes Centre (UK)) ;
Duncan, Susan (Norwich Research Park. John Innes Centre (UK)) ;
Whittaker, Charles (Norwich Research Park. John Innes Centre (UK)) ;
Howard, Martin (Norwich Research Park. John Innes Centre (UK)) ;
Dean, Caroline (Norwich Research Park. John Innes Centre (UK))
In Arabidopsis thaliana, the cold-induced epigenetic regulation of FLOWERING LOCUS C (FLC) involves distinct phases of Polycomb repressive complex 2 (PRC2) silencing. During cold, a PHD-PRC2 complex metastably and digitally nucleates H3K27me3 within FLC. [...]
2020 - 10.1101/gad.333245.119
Genes & Development, Vol. 34, Issue 5-6 (March 2020) , p. 446-461
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7.
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15 p, 1.7 MB |
Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications
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Carrillo-Reixach, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Torrens, L. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Simón-Coma, Marina (Institut Germans Trias i Pujol) ;
Royo, Laura (Institut Germans Trias i Pujol) ;
Domingo-Sàbat, Montse (Institut Germans Trias i Pujol) ;
Abril-Fornaguera, Jordi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Akers, N. (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica)) ;
Sala Llinas, Margarita (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ragull, Sonia (Institut Germans Trias i Pujol) ;
Arnal, Magdalena (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Villalmanzo, Núria (Institut Germans Trias i Pujol) ;
Cairo, Stefano (Instituto di Ricerca Pediatrica. Corso Stati Uniti 4) ;
Villanueva, Alberto (Institut d'Investigació Biomèdica de Bellvitge) ;
Kappler, R. (Department of Pediatric Surgery. Dr. von Hauner Children's Hospital. Ludwig-Maximilians-University Munich) ;
Garrido-Pontnou, Marta (Hospital Universitari Vall d'Hebron) ;
Guerra, Laura (Hospital Universitario La Paz (Madrid)) ;
Sábado, Constantino (Hospital Universitari Vall d'Hebron) ;
Guillén, Gabriela (Hospital Universitari Vall d'Hebron) ;
Mallo, Maria del Mar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Piñeyro, David (Institut Germans Trias i Pujol) ;
Vázquez-Vitali, María (Institut Germans Trias i Pujol) ;
Kuchuk, O. (Mount Sinai Liver Cancer Program. Divisions of Liver Diseases. Tisch Cancer Institute. Icahn School of Medicine at Mount Sinai) ;
Mateos, María Elena (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Ramírez, G. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Santamaría, María (Hospital Universitario La Paz (Madrid)) ;
Mozo, Y. (Hospital Universitario La Paz (Madrid)) ;
Soriano, Aroa (Hospital Universitari Val d'Hebron. Institut de Recerca) ;
Grotzer, M. (Department of Pediatric Oncology. University Children's Hospital Zurich. University of Zurich) ;
Branchereau, S. (Bicêtre Hospital) ;
de Andoin, N. G. (Hospital Universitario de Donostia (Sant Sebastià, País Basc)) ;
López-Ibor, B. (Department of Pediatric Hematology and Oncology. HM Montepríncipe Hospital) ;
López-Almaraz, R. (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Salinas, J. A. (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Torres, B. (Hospital Universitari i Politècnic La Fe (València)) ;
Hernández, Francisco (Hospital Universitario La Paz (Madrid)) ;
Uriz, J. J. (Hospital Universitario de Donostia (Sant Sebastià, País Basc)) ;
Fabre, M. (Department of Pathology. Hôpital Universitaire Necker-Enfants Malades. Assistance Publique-Hôpitaux de Paris. Université Paris Descartes) ;
Blanco, J. (Joan) (Joan) (Universitat de Vic - Universitat Central de Catalunya) ;
Paris, C. (Stem Cell Transplant Unit. Hospital Luis Calvo Mackenna) ;
Bajčiová, V. (Department of Pediatric Oncology. Childrens University Hospital Brno) ;
Laureys, G. (Ghent University Hospital. (Bèlgica)) ;
Masnou, Helena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Clos, Ariadna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Beléndez, Cristina (Hospital General Universitario Gregorio Marañón) ;
Guettier, C. (Bicêtre Hospital) ;
Sumoy, Lauro (Institut Germans Trias i Pujol) ;
Planas, Ramón (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jordà, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Nonell, Lara (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Czauderna, P. (Department of Surgery and Urology for Children and Adolescents. Medical University of Gdansk) ;
Morland, B. (Birmingham Women's Hospital) ;
Sia, D. (Mount Sinai Liver Cancer Program. Divisions of Liver Diseases. Tisch Cancer Institute. Icahn School of Medicine at Mount Sinai) ;
Losic, B. (Icahn Institute for Data Science and Genomic Technology (Nova York, Estats Units d'Amèrica)) ;
Buendia, M. A. (INSERM. UMR 1193. Paul-Brousse Hospital. Hepatobiliary Centre) ;
Sarrias, Maria-Rosa (Institut Germans Trias i Pujol) ;
Llovet, J. M. (Institució Catalana de Recerca i Estudis Avançats) ;
Armengol, Carolina (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Background & Aims: Hepatoblastoma (HB) is a rare disease. Nevertheless, it is the predominant pediatric liver cancer, with limited therapeutic options for patients with aggressive tumors. Herein, we aimed to uncover the mechanisms of HB pathobiology and to identify new biomarkers and therapeutic targets in a move towards precision medicine for patients with advanced HB. [...]
2020 - 10.1016/j.jhep.2020.03.025
Journal of Hepatology, Vol. 73 Núm. 2 (august 2020) , p. 328-341
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12 p, 4.9 MB |
Role of noradrenergic inputs from locus coeruleus on changes induced on axotomized motoneurons by physical exercise
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Arbat-Plana, Ariadna (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Puigdomenech, Maria (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Udina, Esther (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Physical rehabilitation is one of the cornerstones for the treatment of lesions of the nervous system. After peripheral nerve injuries, activity dependent therapies promote trophic support for the paralyzed muscles, enhance axonal growth and also modulate the maladaptive plastic changes induced by the injury at the spinal level. [...]
2019 - 10.3389/fncel.2019.00065
Frontiers in cellular neuroscience, Vol. 13 (29 2019) , p. 65
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9.
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14 p, 1.9 MB |
The effects of cobalt protoporphyrin IX and tricarbonyldichlororuthenium (II) dimer treatments and its interaction with nitric oxide in the locus coeruleus of mice with peripheral inflammation
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Moreno, Patricia (Institut d'Investigació Biomèdica Sant Pau) ;
Cazuza, R. A. (Department of Psychology. University of São Paulo) ;
Gomes-Mendes, J. (Department of Psychology. University of São Paulo) ;
Díaz, A. F. (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Polo, S. (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Leánez, Sergi (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Leite-Panissi, C. R. A. (Department of Psychology. University of São Paulo) ;
Pol, Olga. (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Universitat Autònoma de Barcelona
Heme oxygenase 1 (HO-1) and carbon monoxide were shown to normalize oxidative stress and inflammatory reactions induced by neuropathic pain in the central nervous system, but their effects in the locus coeruleus (LC) of animals with peripheral inflammation and their interaction with nitric oxide are unknown. [...]
2019 - 10.3390/ijms20092211
International journal of molecular sciences, Vol. 20, Issue 9 (January 2019) , p. 2211
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11 p, 297.8 KB |
Ensaiando lugares de escuta : diálogos entre a psicologia e o conceito de lugar de fala
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Gorjon, Melina Garcia (Universidade Estadual Paulista "Júlio Mesquita Filho") ;
Mezzari, Danielly Christina de Souza (Universidade Estadual Paulista "Júlio Mesquita Filho") ;
Basoli, Laura Pampana (Universidade Estadual Paulista "Júlio Mesquita Filho")
Com o intuito de responder eticamente a demanda de emergência dos lugares de fala, problematizaremos neste trabalho o "lugar de escuta" desde as posições de privilégios. Fazemos um jogo com o conceito "escuta" da psicologia, a "escuta terapêutica/psicológica", para ir mais além do termo restrito ao instrumento dos psicólogos e trazer a urgência da escuta enquanto um exercício de "alteridade". [...]
In order to respond ethically to the emergency demand of the places of speech, we pro-pose the discussion of a "locus of listening" of the subjects of privileges. We play a game with the word "listening" of psychology, "therapeutic / psychological listening", to go be-yond the term restricted to the instrument of psychologists and bring the urgency of lis-tening as an exercise of "otherness. [...]
2019 - 10.5565/rev/qpsicologia.1455
Quaderns de psicologia, Vol. 21 Núm. 1 (2019) , e. 1455 (Artículos)
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