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1.
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9 p, 1.5 MB |
Cost-benefit analysis of ALK diagnosis vs. non-diagnosis in patients with advanced non-small cell lung cancer in Spain
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Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Álvarez, Rosa (Hospital General Universitario Gregorio Marañón) ;
Ortega, Ana Laura (Hospital Universitario de Jaén) ;
de Alda, Lucía Ruiz (Roche Farma) ;
Gordo, Rocío (Roche Farma) ;
García, J.Francisco (Roche Farma) ;
Ivanova-Markova, Yoana (Weber) ;
González-Domínguez, Almudena (Weber) ;
San Cristóbal, Raquel Sánchez (Weber) ;
Rojo, Federico (Hospital Universitario Fundación Jiménez Díaz) ;
Universitat Autònoma de Barcelona
In recent years, target therapies to specific molecular alterations in advanced non-small cell lung cancer (NSCLC) have been identified and have shown superior efficacy compared to non-targeted treatments. [...]
2022 -  10.33393/GRHTA.2022.2449
Global and Regional Health Technology Assessment, Vol. 9 (january 2022) , p. 82-90
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2.
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6 p, 870.5 KB |
Characterization of a cohort of metastatic lung cancer patients harboring KRAS mutations treated with immunotherapy : differences according to KRAS G12C vs. non-G12C
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Notario, Lucía (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cucurull, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cerdà, Gabriela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sanz, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carcereny, Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muñoz-Mármol, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hernández, Ainhoa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domènech, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Morán, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sanchez-Cespedes, Montse (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Costa, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mate, Jose Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Esteve, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Saigí, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Approximately 20% of lung adenocarcinomas harbor activating mutations at KRAS, an oncogene with the ability to alter the tumor immune microenvironment. In this retrospective study, we examined 103 patients with KRAS-mutant lung adenocarcinoma who were treated with immunotherapy-based regimens and we evaluated the clinical outcomes according to PD-L1 expression and the type of KRAS mutation. [...]
2023 - 10.3389/fonc.2023.1239000
Frontiers in Oncology, Vol. 13 (october 2023)
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3.
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10 p, 666.8 KB |
Clinical management and outcome of patients with advanced NSCLC carrying EGFR mutations in Spain
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Arriola, Edurne (Hospital del Mar (Barcelona, Catalunya)) ;
García Gómez, Ramón (Hospital General Universitario Gregorio Marañón) ;
Diz Taín, Pilar (Hospital Universitario de León) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez Aguillo, Maite (Complejo Hospitalario de Navarra) ;
Valdivia, Javier (Hospital Universitario Virgen de las Nieves (Granada)) ;
Paredes, Alfredo (Hospital de Donostia (Sant Sebastià, País Basc)) ;
Sánchez-Torres, José Miguel (Hospital Universitario de la Princesa (Madrid)) ;
Peralta Muñoz, Sergio (Hospital Universitari Sant Joan de Reus (Tarragona)) ;
Barneto Aranda, Isidoro (Hospital Universitario Reina Sofía (Córdoba, Espanya)) ;
Gutierrez, Vanesa (Hospital Regional Universitario Carlos Haya (Málaga)) ;
Andrade Santiago, Jesús Manuel (Hospital Virgen de la Salud (Toledo)) ;
Aparisi, Francisco (Hospital Virgen de los Lirios) ;
Isla, Dolores (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
Ponce, Santiago (Hospital 12 de Octubre (Madrid)) ;
Vicente Baz, David (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Artal, Ángel (Hospital Universitario Miguel Servet (Saragossa)) ;
Amador, Mariluz (AstraZeneca) ;
Provencio, Mariano (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Universitat Autònoma de Barcelona
Although the benefit of first-line epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitors (TKIs) over chemotherapy has been demonstrated in several clinical trials, data from clinical practice is lacking and the optimal EGFR TKI to be used remains unclear. [...]
2018 - 10.1186/s12885-018-4004-7
BMC Cancer, Vol. 18 Núm. 1 (30 2018) , p. 106
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4.
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11 p, 639.3 KB |
Seroprevalence and immunological memory against SARS-CoV-2 in lung cancer patients : the SOLID study
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Provencio, Mariano (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Rodríguez-Abreu, Delvys (Hospital Universitario Insular de Gran Canaria) ;
Ortega Granados, Ana Laura (Hospital Universitario de Jaén) ;
Serrano, Gloria (Hospital Universiario Infanta Leonor (Madrid)) ;
Aguado, Carlos (Hospital Clínico San Carlos (Madrid)) ;
Franco, Fernando (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Gutierrez, Vanesa (Hospital Universitario Regional de Málaga) ;
López-Vivanco, Guillermo (Hospital Universitario Cruces (Barakaldo, País Basc)) ;
Guirado Risueño, María (Hospital General Universitario de Elche) ;
Benítez, Gretel (Hospital Universitario Insular de Gran Canaria) ;
Estival, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Calvo, Virginia (Hospital Universitario Puerta de Hierro Majadahonda) ;
Jiménez, Beatriz (Hospital Universitario HM Sanchinarro (Madrid)) ;
Arasanz, Hugo (Complejo Hospitalario Navarra-Navarrabiomeed) ;
Coves, Juan (Hospital Universitari Son LLàtzer (Palma de Mallorca, Balears)) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Massutí, Bartomeu (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Vázquez, Sergio (Hospital Universitario Lucus Augusti (Lugo)) ;
Juan, Óscar (Hospital Universitario y Politécnico La Fe) ;
Collazo-Lorduy, Ana (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Gozálvez, Clara L. (Hospital Universitari Sant Joan de Reus (Tarragona)) ;
Barco, Edel D. (Hospital Clínico Universitario (Salamanca)) ;
Rosero, Adriana (Hospital Universitario Infanta Cristina) ;
Bosch-Barrera, J. (Institut Català d'Oncologia) ;
Moreno, María A. (Hospital Universitario de Puerto Real (Cadis)) ;
Mielgo-Rubio, X. (Hospital Universitario Fundación Alcorcón) ;
Villa, J.C. (Hospital General Universitario Ciudad Real) ;
López-Martin, A. (Hospital Universitario Severo Ochoa) ;
Córdoba Ortega, Juan Felipe (Hospital Universitario Arnau de Vilanova) ;
de Asís Aparisi, F. (Hospital General Universitario de Valencia) ;
Zafra, M. (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Mosquera, J. (Complejo Hospitalario Universitario de A Coruña) ;
Altozano, J.P. (Hospital Virgen de los Lirios) ;
Nadal, E. (Institut Català d'Oncologia. Hospitalet de Llobregat) ;
Catot, S. (Altaia. Xarxa Assistencial Universitaria Manresa) ;
Balsalobre, J. (Hospital General Universitario Santa Lucia Cartagena) ;
de Portugal, T. (Complejo Hospitalario de Zamora) ;
Martín, P. (Hospital Clínic Universitari (València)) ;
de Juan, S.C. (Laboratorio Central) ;
Cobo, M. (Hospital Universitario Regional de Málaga) ;
Universitat Autònoma de Barcelona
At present, we did not find any articles that studied seroprevalence and its persistence several months later in lung cancer patients in the setting of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. [...]
2022 - 10.21037/tlcr-21-504
Translational Lung Cancer Research, Vol. 11 Núm. 1 (january 2022) , p. 53-63
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8 p, 855.8 KB |
Experimental supporting data on the influence of platelet-derived factors of malignant pleural effusions on T cell effector functions and their relevance in predicting prognosis of lung adenocarcinoma patients with pleural metastasis
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Mulet Gual, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Zamora, Carlos (Institut d'Investigació Biomèdica Sant Pau) ;
Porcel, José M (Hospital Universitari Arnau de Vilanova) ;
Nieto Sáchica, Juan Camilo (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Pajares Ruiz, Virginia (Institut d'Investigació Biomèdica Sant Pau) ;
Muñoz-Fernandez, Ana M. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Calvo, Nuria (Institut d'Investigació Biomèdica Sant Pau) ;
Esquerda, Aureli (Universitat de Lleida) ;
Vidal, Silvia (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
The data described in this article are supplementary to our primary article "Platelet factor 4 regulates T cell effector functions in malignant pleural effusions". Malignant pleural effusion (MPE) is a common complication of advanced lung adenocarcinoma (LAC) associated with a poor life expectancy [1]. [...]
2020 - 10.1016/j.dib.2020.106266
Data in brief, Vol. 32 (october 2020) , p. 106266
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6.
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14 p, 1.8 MB |
Usefulness of two independent DNA and rna tissue-based multiplex assays for the routine care of advanced NSCLC patients
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Marin, Elba (Hospital Clínic i Provincial de Barcelona) ;
Teixidó, Cristina (Hospital Clínic i Provincial de Barcelona) ;
Carmona Rocha, Elena (Hospital Clínic i Provincial de Barcelona) ;
Reyes, Roxana (Hospital Clínic i Provincial de Barcelona) ;
Arcocha, Ainara (Hospital Clínic i Provincial de Barcelona) ;
Viñolas, Nuria (Hospital Clínic i Provincial de Barcelona) ;
Rodríguez-Mues, M Carmen (Hospital Clínic i Provincial de Barcelona) ;
Cabrera, Carlos (Instituto Oncologico Dr. Rosell) ;
Sánchez, Marcelo (Hospital Clínic i Provincial de Barcelona) ;
Vollmer, Ivan G. (Hospital Clínic i Provincial de Barcelona) ;
Castillo, Sergi (Hospital General de Granollers) ;
Muñoz, Silvia (Hospital General de Granollers) ;
Sullivan, Ivana (Institut d'Investigació Biomèdica Sant Pau) ;
Rodríguez, Adela (Hospital Clínic i Provincial de Barcelona) ;
Garcia, Mireia (Hospital Clínic i Provincial de Barcelona) ;
Alos, Silvia (Hospital Clínic i Provincial de Barcelona) ;
Jares, Pedro (Hospital Clínic i Provincial de Barcelona) ;
Martinez, Antonio (Hospital Clínic i Provincial de Barcelona) ;
Prat, Aleix (Hospital Clínic i Provincial de Barcelona) ;
Molina-Vila, Miguel Ángel (Quirón Dexeus University Hospital) ;
Reguart, Noemi (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona
Personalized medicine is nowadays a paradigm in lung cancer management, offering important benefits to patients. This study aimed to test the feasibility and utility of embedding two multiplexed genomic platforms as the routine workup of advanced non-squamous non-small cell lung cancer (NSCLC) patients. [...]
2020 - 10.3390/cancers12051124
Cancers, Vol. 12 Núm. 5 (may 2020) , p. 1124
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6 p, 380.2 KB |
Clinical activity of a htert (vx-001) cancer vaccine as post-chemotherapy maintenance immunotherapy in patients with stage IV non-small cell lung cancer : final results of a randomised phase 2 clinical trial
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Gridelli, C. (S.G. Moscati Hospital) ;
Ciuleanu, Tudor Eliade (Institutui. Oncologic I. Chircuta) ;
Domine, M. (Fundacion Jimenez Diaz) ;
Szczesna, A. (Mazowieckie Centrum) ;
Bover, I. (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears)) ;
Cobo, M. (Instituto de Investigaciones Biomédicas (IBIMA)) ;
Kentepozidis, N. (251 General Airforce Hospital) ;
Zarogoulidis, K. (Papanikolaou General Hospital) ;
Kalofonos, C. (University Hospital of Patras) ;
Kazarnowisz, A. (Oddzial Onkologiiz Pododdziatem) ;
Korozan, M. (Hospicjum Dutkiewicza SAC) ;
de las Peñas, R (Hospital Provincial de Castellon) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Chella, A. (A.O.U. di Pisa Hospital) ;
Griesinger, F. (Pius Hospital) ;
Bournakis, E. (University Hospital "Aretaieion") ;
Sadjadian, P. (Johannes Wesling Klinikum) ;
Kotsakis, A. (University General Hospital of Larissa) ;
Chinet, T. (Hopital Ambroise Paré) ;
Syrigos, K.N. (General Hospital of Thoracic Diseases "Sotiria") ;
Correale, P. (University Hospital of Siena) ;
Gallou, C. (Vaxon-Biotech) ;
Jamet, J.M. (Vaxon-Biotech) ;
Vetsika, E.K. (University General Hospital of Heraklion) ;
Kosmatopoulos, K. (Vaxon-Biotech) ;
Georgoulias, V. (University General Hospital of Heraklion) ;
Universitat Autònoma de Barcelona
The cancer vaccine Vx-001, which targets the universal tumour antigen TElomerase Reverse Transcriptase (TERT), can mount specific Vx-001/TERT CD8 + cytotoxic T cells; this immune response is associated with improved overall survival (OS) in patients with advanced/metastatic non-small cell lung cancer (NSCLC). [...]
2020 - 10.1038/s41416-020-0785-y
British Journal of Cancer, Vol. 122 Núm. 10 (december 2020) , p. 1461-1466
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12 p, 843.6 KB |
Association of hepatitis B virus infection status with outcomes of non-small cell lung cancer patients undergoing anti-PD-1/PD-L1 therapy
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Zhang, Xuanye (Sun Yat-sen University Cancer Center) ;
Tian, Dan (Guangdong Academy of Medical Sciences) ;
Chen, Yue (The Eighth Affiliated Hospital of Sun Yat-sen University) ;
Chen, Chen (Sun Yat-sen University Cancer Center) ;
He, Li-Na (Sun Yat-sen University Cancer Center) ;
Zhou, Yixin (Sun Yat-sen University Cancer Center) ;
Li, Haifeng (Sun Yat-sen University Cancer Center) ;
Lin, Zuan (Sun Yat-sen University Cancer Center) ;
Chen, Tao (Sun Yat-sen University Cancer Center) ;
Wang, Yuhong (Sun Yat-sen University Cancer Center) ;
Russo, Alessandro (A.O. Papardo) ;
Nadal, Ernest (Hospital Universitari de Bellvitge) ;
Passiglia, Francesco (S. Luigi Gonzaga Hospital) ;
Soo, Ross Andrew (National University Health System) ;
Watanabe, Satoshi (Niigata University Graduate School of Medical and Dental Sciences) ;
Morán, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Oh, In-Jae (Hwasun Hospital) ;
Fu, Sha (Sun Yat-sen University) ;
Hong, Shaodong (Sun Yat-sen University Cancer Center) ;
Zhang, Li (Sun Yat-sen University Cancer Center) ;
Universitat Autònoma de Barcelona
The aim of this study was to evaluate the safety and survival outcomes of anti-programmed cell death (PD)-1/programmed cell death-ligand 1 (PD-L1) monotherapy in patients with advanced non-small cell lung cancer (NSCLC) and different hepatitis B virus (HBV) infection status. [...]
2021 - 10.21037/tlcr-21-455
Translational Lung Cancer Research, Vol. 10 (july 2021) , p. 3191-3202
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11 p, 1.6 MB |
Cancer Histology and Natural History of Patients with Lung Cancer and Venous Thromboembolism
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Ruiz-Artacho, Pedro (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Lecumberri, Ramón (Instituto de Salud Carlos III) ;
Trujillo-Santos, Javier (Hospital General Universitario Santa Lucía (Cartagena, Múrcia)) ;
Font, Carme (Hospital Clínic i Provincial de Barcelona) ;
López Núñez, Juan José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Peris, María Luisa (Consorci Hospitalari Provincial de Castelló) ;
Díaz-Pedroche, Carmen (Hospital Universitario 12 de Octubre (Madrid)) ;
Lobo, José Luis (Arabako Unibertsitate Ospitalea (Vitoria, País Basc)) ;
López Jiménez, Luciano (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
López Reyes, Raquel (Hospital Universitari i Politècnic La Fe (València)) ;
Jara-Palomares, Luis (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Pedrajas, José María (Hospital Clínico San Carlos (Madrid)) ;
Mahé, Isabelle (Hôpital Louis Mourier) ;
Monreal, Manuel (Universidad Católica San Antonio de Murcia) ;
Universitat Autònoma de Barcelona
Cancer is a widely heterogeneous disease, and the natural history of patients with cancer-associated thrombosis may differ according to the cancer site. Lung cancer is the most common malignancy, and a leading cause of death. [...]
2022 - 10.3390/cancers14174127
Cancers, Vol. 14 (august 2022)
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10.
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16 p, 1.4 MB |
Changes in Treatment Patterns and Costs for Lung Cancer Have Not Resulted in Relevant Improvements in Survival : A Population-Based Observational Study in Catalonia
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Guarga, Laura (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Paco, Noelia (Servei Català de la Salut) ;
Vela, Emili (Institut d'Investigació Biomèdica de Bellvitge) ;
Cleries, Montserrat (Institut d'Investigació Biomèdica de Bellvitge) ;
Corral, Julieta (Institut d'Investigació Biomèdica de Bellvitge) ;
Delgadillo Duarte, Joaquin (Banc de Sang i Teixits) ;
Pontes García, Caridad (Institut d'Investigació Biomèdica de Bellvitge) ;
Borras, Josep M (Universitat de Barcelona)
Real-world data collect clinical and economic information from daily clinical practice and can support decisions in the context of health evaluation and management. The aim of our retrospective cohort study was to describe the different approaches used for treating lung cancer in Catalonia in 2014 and 2018 and to assess the associated cost and impact on patient survival until December 2021. [...]
2022 - 10.3390/cancers14235791
Cancers, Vol. 14 (november 2022)
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