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15 p, 3.7 MB |
Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance
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Botta, Cirino (Clínica Universidad de Navarra) ;
Perez, Cristina (Clínica Universidad de Navarra) ;
Larrayoz, Marta (Clínica Universidad de Navarra) ;
Puig, Noemí (Hospital Universitario de Salamanca) ;
Cedena, María Teresa (Hospital Universitario 12 de Octubre) ;
Termini, Rosalinda (Clínica Universidad de Navarra) ;
Goicoechea, Ibai (Clínica Universidad de Navarra) ;
Rodriguez, Sara (Clínica Universidad de Navarra) ;
Zabaleta, Aintzane (Clínica Universidad de Navarra) ;
Lopez, Aitziber (Clínica Universidad de Navarra) ;
Sarvide, Sarai (Clínica Universidad de Navarra) ;
Blanco, Laura (Clínica Universidad de Navarra) ;
Papetti, Daniele Marco (Department of Informatics. University of Milano-Bicocca) ;
Nobile, M.S. (Biostatistics and Bioimaging Centre-B4) ;
Besozzi, Daniela (Biostatistics and Bioimaging Centre-B4) ;
Gentile, Massimo (Department of Oncohematology. "Annunziata" Hospital) ;
Correale, Pierpaolo (Great Metropolitan Hospital "Riuniti" of Reggio Calabria) ;
Siragusa, Sergio (Department of Health Promotion. University of Palermo) ;
Oriol, Albert (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
González-Garcia, Maria Esther (Hospital Universitario de Cabueñes (Gijón)) ;
Sureda, Anna (Institut d'Investigació Biomèdica de Bellvitge) ;
de Arriba, Felipe (Instituto Murciano de Investigación Biosanitaria) ;
Ríos-Tamayo, Rafael (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Moraleda, José María (Instituto Murciano de Investigación Biosanitaria) ;
Gironella, Mercedes (Hospital Universitari Vall d'Hebron) ;
Hernández, Miguel T. (Hospital Universitario de Canarias (Illes Canàries)) ;
Bargay, Joan (Hospital Universitari Son Llàtzer (Illes Balears)) ;
Palomera, Luís (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
Pérez-Montaña, Albert (Hospital Universitari Son Espases (Illes Balears)) ;
Goldschmidt, Hartmut (Department of Internal Medicine V. University of Heidelberg) ;
Avet-Loiseau, Hervé (IUC-T Oncopole) ;
Roccaro, Aldo (Department of Hematology. ASST Spedali Civili di Brescia) ;
Orfao, Alberto (Universidad de Salamanca. Departament de Medicina) ;
Martinez-Lopez, Joaquín (Hospital Universitario 12 de Octubre) ;
Rosiñol, Laura (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Lahuerta, J. J (Hospital Universitario 12 de Octubre) ;
Bladé Creixenti, Juan (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Mateos, M. V (Hospital Universitario de SalamancaBiomedica de Salamanca (IBSAL). Centro de Investigación del Cancer (IBMCC-USAL. CSIC)) ;
San-Miguel, J (Clínica Universidad de Navarra) ;
Martinez Climent, Juan-José (Clínica Universidad de Navarra) ;
Paiva, Bruno (Clínica Universidad de Navarra)
Tumor recognition by T cells is essential for antitumor immunity. A comprehensive characterization of T cell diversity may be key to understanding the success of immunomodulatory drugs and failure of PD-1 blockade in tumors such as multiple myeloma (MM). [...]
2023 -  10.1038/s41467-023-41562-6
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 5825
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15 p, 2.7 MB |
ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma
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Mensali, Nadia (Department of Cellular Therapy. Oslo University Hospital) ;
Köksal, Hakan (Oslo University Hospital) ;
Joaquina, Sandy (Oslo University Hospital) ;
Wernhoff, Patrick (Oslo University Hospital) ;
Casey, Nicholas P. (Oslo University Hospital) ;
Romecín, Paola Alejandra (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Panisello, Carla (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rodríguez, René (Instituto de Salud Carlos III) ;
Vimeux, Lene (Université de Paris) ;
Juzeniene, Asta (Oslo University Hospital) ;
Myhre, Marit R. (Oslo University Hospital) ;
Fåne, Anne (Oslo University Hospital) ;
Castilla-Ramirez, Carolina (Virgen del Rocio University Hospital) ;
Maggadottir, Solrun Melkork (Oslo University Hospital) ;
Duru, Adil Doganay (Nova Southeastern University) ;
Georgoudaki, Anna-Maria (Department of Oncology-Pathology. Karolinska Institutet) ;
Grad, Iwona (Oslo University Hospital) ;
Maturana, Andrés Daniel (Nagoya University) ;
Gaudernack, Gustav (Department of Cancer Immunology. Oslo University Hospital) ;
Kvalheim, Gunnar (Department of Cellular Therapy. Oslo University Hospital) ;
Carcaboso, Angel M. (Institut de Recerca Sant Joan de Déu) ;
De Álava, Enrique (Universidad de Sevilla) ;
Donnadieu, Emma (Université de Paris) ;
Bruland, Øyvind S (University of Oslo) ;
Menendez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Inderberg, Else Marit (Oslo University Hospital) ;
Wälchli, Sébastien (Oslo University Hospital)
Osteosarcoma (OS) remains a dismal malignancy in children and young adults, with poor outcome for metastatic and recurrent disease. Immunotherapies in OS are not as promising as in some other cancer types due to intra-tumor heterogeneity and considerable off-target expression of the potentially targetable proteins. [...]
2023 - 10.1038/s41467-023-39097-x
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 3375
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19 p, 2.3 MB |
B Cells in Breast Cancer Pathology
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Li, Mengyuan (King's College London) ;
Quintana, Angela (Vall d'Hebron Institut d'Oncologia) ;
Alberts, Elena (The Francis Crick Institute) ;
Hung, Miu Shing (King's College London) ;
Boulat, Victoire (King's College London) ;
Martí, Mercè (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Grigoriadis, Anita (School of Cancer and Pharmaceutical Sciences) ;
Universitat Autònoma de Barcelona.
Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
B cells in the tumour microenvironment and lymph nodes have affirmed their role in breast cancer pathology. Multiplex imaging, single cell, and spatial transcriptomics of cancer patients' breast carcinomas and lymph nodes have illustrated the diversity and spatial context of B cells in this disease. [...]
2023 - 10.3390/cancers15051517
Cancers, Vol. 15, Issue 5 (February 2023) , art. 1517
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18 p, 9.8 MB |
Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses
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Rodríguez-Ubreva, J. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Arutyunyan, A. (University of Cambridge) ;
Bonder, M.J. (German Cancer Research Center) ;
Del Pino-Molina, L. (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Clark, S.J. (Babraham Institute) ;
de la Calle-Fabregat, Carlos (Institut d'Investigació Biomèdica de Bellvitge) ;
Garcia-Alonso, L. (CeWellcome Sanger Institute) ;
Handfield, L.F. (Wellcome Trust Sanger Institute (Regne Unit)) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Andrés-León, Eduardo (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Krueger, F. (Babraham Institute) ;
Català-Moll, Francesc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rodríguez-Cortez, V.C. (Institut d'Investigació Biomèdica de Bellvitge) ;
Polanski, K. (Wellcome Trust Sanger Institute (Regne Unit)) ;
Mamanova, L. (Wellcome Trust Sanger Institute (Regne Unit)) ;
van Dongen, S. (Wellcome Trust Sanger Institute (Regne Unit)) ;
Kiselev, V.Y. (Wellcome Trust Sanger Institute (Regne Unit)) ;
Martínez-Saavedra, M.T. (Hospital Universitario de Gran Canaria Dr. Negrín) ;
Heyn, Holger (Universitat Pompeu Fabra) ;
Martín, Javier (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Warnatz, K. (University of Freiburg) ;
López-Granados, E. (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Rodríguez-Gallego, C. (University Fernando Pessoa) ;
Stegle, O. (Wellcome Trust Sanger Institute (Regne Unit)) ;
Kelsey, G. (Babraham Institute) ;
Vento Tormo, Roser (University of Cambridge) ;
Ballestar, Esteban (East China Normal University) ;
Universitat Autònoma de Barcelona
Common variable immunodeficiency (CVID), the most prevalent symptomatic primary immunodeficiency, displays impaired terminal B-cell differentiation and defective antibody responses. Incomplete genetic penetrance and ample phenotypic expressivity in CVID suggest the participation of additional pathogenic mechanisms. [...]
2022 - 10.1038/s41467-022-29450-x
Nature communications, Vol. 13 Núm. 1 (december 2022) , p. 1779
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14 p, 2.8 MB |
Endothelial damage and dysfunction in acute graft-versus-host disease
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Cordes, Steffen (Charité - Universitätsmedizin Berlin) ;
Mokhtari, Zeinab (Department of Medicine II. Würzburg University Hospital. Interdisciplinary Center for Clinical Research (IZKF). Laboratory for Experimental Stem Cell Transplantation) ;
Bartosova, Maria (Pediatric Nephrology. Center for Pediatric and Adolescent Medicine. University Hospital Heidelberg) ;
Mertlitz, Sarah (Charité - Universitätsmedizin Berlin) ;
Riesner, Katarina (Charité - Universitätsmedizin Berlin) ;
Shi, Yu (Charité - Universitätsmedizin Berlin) ;
Mengwasser, Jörg (Department of Surgery. Charité Universitätsmedizin Berlin) ;
Kalupa, Martina (Charité - Universitätsmedizin Berlin) ;
McGeary, Aleixandria (Charité - Universitätsmedizin Berlin) ;
Schleifenbaum, Johanna (Institute of Vegetative. Charité Universitätsmedizin Berlin) ;
Schrezenmeier, Jens (Charité - Universitätsmedizin Berlin) ;
Bullinger, Lars (Charité - Universitätsmedizin Berlin) ;
Diaz-Ricart, Maribel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Palomo, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Beutel, Gernot (Hannover Medical School) ;
Schmitt, Claus Peter (Center for Child and Adolescent Medicine (Heidelberg, Alemanya)) ;
Beilhack, Andreas (Würzburg University Hospital) ;
Penack, Olaf (Charité - Universitätsmedizin Berlin) ;
Universitat Autònoma de Barcelona
Clinical studies have suggested a potential involvement of endothelial dysfunction and damage in the development and severity of acute graft-versus-host disease (aGvHD). Accordingly, we found an increased percentage of apoptotic caspase 3 positive blood vessels in duodenal and colonic mucosa biopsies of patients with severe aGvHD. [...]
2021 - 10.3324/haematol.2020.253716
Haematologica, Vol. 106 Núm. 8 (august 2021) , p. 2147-2160
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36 p, 800.8 KB |
Establishment and validation of surface model for biodosimetry based on γ-H2AX foci detection
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López Vásquez, Juan Sebastián (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Pujol Canadell, Mònica (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Puig, Pedro (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ;
Ribas, Montserrat (Institut d'Investigació Biomèdica Sant Pau) ;
Carrasco de Fez, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Armengol Rosell, Gemma (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Barquinero, Joan Francesc (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia)
Introduction: In the event of a radiation accident detecting γ-H2AX foci is being accepted as fast method for triage and dose assessment. However, due to their disappearance kinetics, published calibrations have been constructed at specific post-irradiation times. [...]
2022 - 10.1080/09553002.2022.1998706
International Journal of Radiation Biology, Vol. 98, Issue 1 (2022) , p. 1-10
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