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Results overview: Found 5 records in 0.02 seconds.
Articles, 5 records found
Articles 5 records found  
1.
17 p, 7.9 MB Defect-free graphene enhances enzyme delivery to fibroblasts derived from patients with lysosomal storage disorders / Chen, Yingxian (University of Manchester. Nanomedicine Lab) ; Taufiq, Tooba (The University of Manchester) ; Zeng, Niting (University of Manchester. Department of Chemistry) ; Lozano, Neus (Institut Català de Nanociència i Nanotecnologia) ; Karakasidi, Angeliki (University of Manchester. Nanomedicine Lab) ; Church, Heather (Manchester Centre for Genomic Medicine) ; Jovanovic, Ana (Salford Royal NHS Foundation Trust) ; Jones, Simon A. (Manchester Centre for Genomic Medicine) ; Panigrahi, Adyasha (University of Manchester. Department of Chemistry) ; Larrosa, Igor (University of Manchester. Department of Chemistry) ; Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ; Casiraghi, Cinzia (University of Manchester. Department of Chemistry) ; Vranic, Sandra (University of Manchester. Nanomedicine Lab)
Enzyme replacement therapy shows remarkable clinical improvement in treating lysosomal storage disorders. However, this therapeutic approach is hampered by limitations in the delivery of the enzyme to cells and tissues. [...]
2023 - 10.1039/d2nr04971f
Nanoscale, Vol. 15, Issue 21 (June 2023) , p. 9348-9364  
Detailed record - Creative Commons
2.
25 p, 864.4 KB The Emerging Role of the Lysosome in Parkinson's Disease / Navarro-Romero, Alba (Universitat Autònoma de Barcelona) ; Montpeyó Garcia-Moreno, Marta (Universitat Autònoma de Barcelona) ; Martinez-Vicente, Marta (Universitat Autònoma de Barcelona)
Lysosomal function has a central role in maintaining neuronal homeostasis, and, accordingly, lysosomal dysfunction has been linked to neurodegeneration and particularly to Parkinson's disease (PD). Lysosomes are the converging step where the substrates delivered by autophagy and endocytosis are degraded in order to recycle their primary components to rebuild new macromolecules. [...]
2020 - 10.3390/cells9112399
Cells, Vol. 9 (november 2020)  
Detailed record - Creative Commons
3.
16 p, 3.1 MB Ursolic Acid Inhibits Collective Cell Migration and Promotes JNK-Dependent Lysosomal Associated Cell Death in Glioblastoma Multiforme Cells / Conway, Gillian E. (In-Vitro Toxicology Group, Institute of Life Science, Swansea University Medical School) ; Zizyte, Deimante (School of Food Science and Environmental Health, Technological University Dublin) ; Mondala, Julie Rose Mae (School of Food Science and Environmental Health, Technological University Dublin) ; He, Zhonglei (Environmental Sustainability and Health Institute (ESHI) and FOCAS Research Institute, Technological University Dublin) ; Lynam, Lorna (School of Food Science and Environmental Health, Technological University Dublin) ; Lecourt, Mathilde (School of Food Science and Environmental Health, Technological University Dublin) ; Barcia, Carlos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Howe, Orla (School of Biological Sciences and Health Sciences, Technological University Dublin) ; Curtin, James (Dublin Institute of Technology. School of Food Science and Environmental Health)
Ursolic acid (UA) is a bioactive compound which has demonstrated therapeutic efficacy in a variety of cancer cell lines. UA activates various signalling pathways in Glioblastoma multiforme (GBM) and offers a promising starting point in drug discovery; however, understanding the relationship between cell death and migration has yet to be elucidated. [...]
2021 - 10.3390/ph14020091
Pharmaceuticals, Vol. 14 (january 2021)  
Detailed record - Creative Commons
4.
14 p, 2.6 MB Dual lysosomal-mitochondrial targeting by antihistamines to eradicate leukaemic cells / Cornet-Masana, Josep Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Banús, Antònia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Carbó, José María (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Torrente, M. Á. (Hospital Clínic i Provincial de Barcelona) ; Guijarro, F. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Cuesta-Casanovas, Laia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Esteve Reyner, Jordi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Risueño, Ruth M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Universitat Autònoma de Barcelona
Background: Despite great efforts to identify druggable molecular targets for AML, there remains an unmet need for more effective therapies. Methods: An in silico screening was performed using Connectivity Maps to identify FDA-approved drugs that may revert an early leukaemic transformation gene signature. [...]
2019 - 10.1016/j.ebiom.2019.08.021
EBioMedicine, Vol. 47 (september 2019) , p. 221-234  
Detailed record - Creative Commons
5.
21 p, 3.4 MB NAADP mediates ATP-induced Ca2+ signals in astrocytes / Barceló Torns, Miquel (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Lewis, Alexander M. (University of Oxford) ; Gubern Burset, Albert (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Barneda, David (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Bloor-Young, Duncan (University of Oxford) ; Picatoste Ramón, Fernando (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Churchill, Grant C. (University of Oxford) ; Claro Izaguirre, Enrique (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Masgrau Juanola, Roser (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Intracellular Ca2+ signals provide astrocytes with a specific form of excitability that enables them to regulate synaptic transmission. In this study, we demonstrate that NAADP-AM, a membrane-permeant analogue of the new second messenger nicotinic acid-adenine dinucleotide phosphate (NAADP), mobilizes Ca2+ in astrocytes and that the response is blocked by Ned-19, an antagonist of NAADP signalling. [...]
2011 - 10.1016/j.febslet.2011.05.062
FEBS letters, Vol. 585, Num. 14 (2011) , p. 2300-2306  
Detailed record - Creative Commons

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