|
1.
|
|
16 p, 12.4 MB |
H2AFX and MDC1 promote maintenance of genomic integrity in male germ cells
/
Testa, Erika. (Università degli Studi di Roma "Tor Vergata". Dipartimento di Biomedicina e Prevenzione) ;
Nardozi, Daniela (Università degli Studi di Roma "Tor Vergata". Dipartimento di Biomedicina e Prevenzione) ;
Antinozzi, Cristina (Università degli Studi di Roma "Tor Vergata". Dipartimento di Biomedicina e Prevenzione) ;
Faieta, Monica (Università degli Studi di Roma "Tor Vergata". Dipartimento di Biomedicina e Prevenzione) ;
Di Cecca, Stefano (Università degli Studi di Roma "Tor Vergata". Dipartimento di Biomedicina e Prevenzione) ;
Caggiano, Cinzia (Università degli Studi di Roma "Tor Vergata". Dipartimento di Biomedicina e Prevenzione) ;
Fukuda, Tomoyuki (Niigata University Graduate School of Medical and Dental Sciences. Department of Cellular Physiology) ;
Bonanno, Elena (Università degli Studi di Roma "Tor Vergata". Unità di Anatomia patologica) ;
Zhenkun, Lou (Mayo Clinic. Department of Oncology.) ;
Maldonado Linares, Andros (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Roig, I. (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Di Giacomo, Monica (European Molecular Biology Laboratory) ;
Barchi, Marco (Università degli Studi di Roma "Tor Vergata". Dipartimento di Biomedicina e Prevenzione)
In somatic cells, H2afx and Mdc1 are close functional partners in DNA repair and damage response. However, it is not known whether they are also involved in the maintenance of genome integrity in meiosis. [...]
2018 -  10.1242/jcs.214411
Journal of Cell Science, Vol. 131, issue 6 (2018) , p. jcs214411
|
|
|
2.
|
|
14 p, 6.4 MB |
ATR is required to complete meiotic recombination in mice
/
Pacheco, Sarai (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Maldonado Linares, Andros (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Marcet-Ortega, Marina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Rojas, Cristina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Martínez Marchal, Ana (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Fuentes-Lazaro, Judit (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Lange, Julian (Memorial Sloan Kettering Cancer Center) ;
Jasin, Maria (Memorial Sloan Kettering Cancer Center) ;
Keeney, Scott (Memorial Sloan Kettering Cancer Center) ;
Fernández-Capetillo, Oscar (Centro Nacional de Investigaciones Oncológicas.) ;
Garcia-Caldés, Montserrat (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Roig, I. (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Precise execution of recombination during meiosis is essential for forming chromosomally-balanced gametes. Meiotic recombination initiates with the formation and resection of DNA double-strand breaks (DSBs). [...]
2018 - 10.1038/s41467-018-04851-z
Nature communications, Vol. 9 (2018) , art. 2622
|
|
|
3.
|
|
12 p, 7.0 MB |
ATR is a multifunctional regulator of male mouse meiosis
/
Widger, Alexander (The Francis Crick Institute) ;
Mahadevaiah, Shantha K. (Francis Crick Institute) ;
Lange, Julian (Memorial Sloan Kettering Cancer Center) ;
Elinati, Elias (The Francis Crick Institute) ;
Zohren, Jasmin (The Francis Crick Institute) ;
Hirota, Takayuki (The Francis Crick Institute) ;
Pacheco, Sarai (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Maldonado Linares, Andros (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Stanzione, Marcello (TU Dresden. Faculty of Medicine) ;
Ojarikre, Obah (The Francis Crick Institute) ;
Maciulyte, Valdone (The Francis Crick Institute) ;
De Rooij, Dirk G. (University of Amsterdam. Center for Reproductive Medicine) ;
Tóth, Attila (TU Dresden. Faculty of Medicine) ;
Roig, I. (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Keeney, Scott (Memorial Sloan Kettering Cancer Center) ;
Turner, James M.A. (Francis Crick Institute)
Meiotic cells undergo genetic exchange between homologs through programmed DNA double-strand break (DSB) formation, recombination and synapsis. In mice, the DNA damage-regulated phosphatidylinositol-3-kinase-like kinase (PIKK) ATM regulates all of these processes. [...]
2018 - 10.1038/s41467-018-04850-0
Nature communications, Vol. 9 (2018) , art. 2621
|
|
|
4.
|
|
24 p, 25.7 MB |
p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes
/
Marcet-Ortega, Marina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pacheco, Sarai (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Martínez Marchal, Ana (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Castillo, Helena (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Flores, Elsa (The University of Texas M. D. Anderson Cancer Center) ;
Jasin, Maria (Memorial Sloan Kettering Cancer Center) ;
Keeney, Scott (Memorial Sloan Kettering Cancer Center) ;
Roig, I. (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
To protect germ cells from genomic instability, surveillance mechanisms ensure meiosis occurs properly. In mammals, spermatocytes that display recombination defects experience a so-called recombination-dependent arrest at the pachytene stage, which relies on the MRE11 complex-ATM-CHK2 pathway responding to unrepaired DNA double-strand breaks (DSBs). [...]
2017 - 10.1371/journal.pgen.1006845
PLoS Genetics, Vol. 13, issue 6 (2017) , art. e1006845
|
|
|
5.
|
|
13 p, 6.6 MB |
Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination
/
Abreu, Carla M. (Memorial Sloan Kettering Cancer Center) ;
Prakash, Rohit (Memorial Sloan Kettering Cancer Center) ;
Romanienko, Peter J. (Rutgers-Cancer Institute of New Jersey) ;
Roig, I. (Ignasi) (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Keeney, Scott (Memorial Sloan Kettering Cancer Center) ;
Jasin, Maria (Memorial Sloan Kettering Cancer Center) ;
Universitat Autònoma de Barcelona.
Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
The DNA-damage repair pathway homologous recombination (HR) requires factors that promote the activity of strand-exchange protein RAD51 and its meiosis-specific homolog DMC1. Here we show that the Shu complex SWS1-SWSAP1, a candidate for one such HR regulator, is dispensable for mouse viability but essential for male and female fertility, promoting the assembly of RAD51 and DMC1 on early meiotic HR intermediates. [...]
2018 - 10.1038/s41467-018-06384-x
Nature communications, Vol. 9 (2018) , art. 3961
|
|
|
6.
|
|
10 p, 3.0 MB |
CENP-A binding domains and recombination patterns in horse spermatocytes
/
Cappelletti, Eleonora (Università degli Studi di Pavia. Dipartimento di Biologia e Biotecnologie "L. Spallanzani") ;
Piras, Francesca M. (Università degli Studi di Pavia. Dipartimento di Biologia e Biotecnologie "L. Spallanzani") ;
Badiale, Claudia (Università degli Studi di Pavia. Dipartimento di Biologia e Biotecnologie "L. Spallanzani") ;
Bambi, Marina (Università degli Studi di Pavia. Dipartimento di Biologia e Biotecnologie "L. Spallanzani") ;
Santagostino, Marco (Università degli Studi di Pavia. Dipartimento di Biologia e Biotecnologie "L. Spallanzani") ;
Vara, Covadonga (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Masterson, Teri A. (National University of Ireland. Centre for Chromosome Biology) ;
Sullivan, Kevin F. (National University of Ireland. Centre for Chromosome Biology) ;
Nergadze, Solomon G. (Università degli Studi di Pavia. Dipartimento di Biologia e Biotecnologie "L. Spallanzani") ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Giulotto, Elena (Università degli Studi di Pavia. Dipartimento di Biologia e Biotecnologie "L. Spallanzani")
Centromeres exert an inhibitory effect on meiotic recombination, but the possible contribution of satellite DNA to this "centromere effect" is under debate. In the horse, satellite DNA is present at all centromeres with the exception of the one from chromosome 11. [...]
2019 - 10.1038/s41598-019-52153-1
Scientific reports (Nature Publishing Group), Vol. 9, issue 1 (Jan. 2019) , art. 15800
|
|
|
7.
|
|
|
8.
|
|
|
9.
|
|
|
10.
|
|
24 p, 287.2 KB |
Radiobiology and Reproduction : What Can We Learn from Mammalian Females?
/
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
García Haro, Francisca (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
García, M. (Montserrat) (Universitat Autònoma de Barcelona. Unitat de Biologia Cel·lular i Genètica Mèdica)
Ionizing radiation damages DNA and induces mutations as well as chromosomal reorganizations. Although radiotherapy increases survival among cancer patients, this treatment does not come without secondary effects, among which the most problematic is gonadal dysfunction, especially in women. [...]
2012 - 10.3390/genes3030521
Genes, Vol. 3 (2012) , p. 521-544
|
|
visitante ::
identificación
alerta personal vía correo electrónico o subscríbase al 
canal RSS.
