Results overview: Found 5 records in 0.03 seconds.
Articles, 5 records found
Articles 5 records found  
1.
15 p, 2.3 MB Biomphalaria glabrata metallothionein : Lacking metal specificity of the protein and missing gene upregulation suggest metal sequestration by exchange instead of through selective binding / Niederwanger, Michael (University of Innsbruck. Institute of Zoology and Center of Molecular Biosciences Innsbruck) ; Calatayud, Sara (Universitat de Barcelona. Departament de Biologia evolutiva. Institut de Recerca de la Biodiversitat) ; Zerbe, Oliver (University of Zürich. Department of Chemistry) ; Atrian, Silvia (Universitat de Barcelona. Departament de Biologia evolutiva. Institut de Recerca de la Biodiversitat) ; Albalat, Ricard (Universitat de Barcelona. Departament de Biologia evolutiva. Institut de Recerca de la Biodiversitat) ; Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ; Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ; Dallinger, Reinherd (University of Innsbruck. Institute of Zoology and Center of Molecular Biosciences Innsbruck)
The wild-type metallothionein (MT) of the freshwater snail Biomphalaria glabrata and a natural allelic mutant of it in which a lysine residue was replaced by an asparagine residue, were recombinantly expressed and analyzed for their metal-binding features with respect to Cd, Zn and Cu, applying spectroscopic and mass-spectrometric methods. [...]
2017 - 10.3390/ijms18071457
International journal of molecular sciences, Vol. 18, Num. 7 (July 2017) , art. 1457  
2.
16 p, 2.2 MB Hints for metal-preference protein sequence determinants : different metal binding features of the five Tetrahymena thermophila metallothioneins / Espart Herrero, Anna (Universitat de Barcelona. Departament de Genètica) ; Marín, Maribel (Universitat Autònoma de Barcelona. Departament de Química) ; Gil Moreno, Selene (Universitat Autònoma de Barcelona. Departament de Química) ; Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ; Amaro, Francisco (Universidad Complutense. Departamento de Microbiología-III) ; Martín-González, Ana (Universidad Complutense. Departamento de Microbiología-III) ; Gutiérrez, Juan C. (Universidad Complutense. Departamento de Microbiología-III) ; Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ; Atrian i Ventura, Sílvia (Universitat de Barcelona. Departament de Genètica)
The metal binding preference of metallothioneins (MTs) groups them in two extreme subsets, the Zn/Cd- and the Cu-thioneins. Ciliates harbor the largest MT gene/protein family reported so far, including 5 paralogs that exhibit relatively low sequence similarity, excepting MTT2 and MTT4. [...]
2015 - 10.7150/ijbs.11060
International journal of biological sciences, Vol. 11 (March 2015) , p. 456-471  
3.
16 p, 2.3 MB Analysis of metal-binding features of the wild type and two domain-truncated mutant variants of Littorina littorea metallothionein reveals its cd-specific character / Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ; Jiménez Martí, Elena (Universitat de Barcelona. Departament de Genètica) ; Niederwanger, Michael (University of Innsbruck. Institute of Zoology and Center of Molecular Biosciences) ; Gil Moreno, Selene (Universitat Autònoma de Barcelona. Departament de Química) ; Zerbe, Oliver (University of Zurich. Institute of Organic Chemistry) ; Atrian i Ventura, Sílvia (Universitat de Barcelona. Departament de Genètica) ; Dallinger, Reinhard (University of Innsbruck. Institute of Zoology and Center of Molecular Biosciences) ; Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química)
After the resolution of the 3D structure of the Cd9-aggregate of the Littorina littorea metallothionein (MT), we report here a detailed analysis of the metal binding capabilities of the wild type MT, LlwtMT, and of two truncated mutants lacking either the N-terminal domain, Lltr2MT, or both the N-terminal domain, plus four extra flanking residues (SSVF), Lltr1MT. [...]
2017 - 10.3390/ijms18071452
International journal of molecular sciences, Vol. 18 Núm. 7 (july 2017) , p. 1452  
4.
12 p, 5.5 MB Influence of transgenic metallothionein-1 on gliosis, CA1 neuronal loss, and brain metal levels of the Tg2576 mouse model of Alzheimer's disease / Comes Orpinell, Gemma (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Manso Sanz, Yasmina (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Escrig, Anna (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Fernandez Gayol, Olaya (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Sanchis Tortosa, Paula (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Molinero Egea, María Amalia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Giralt Carbonell, Mercedes (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Carrasco Trancoso, Javier (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
The mouse model of Alzheimer's disease (AD), Tg2576 mice (APP), has provided valuable information, such as the role of the metallothionein (MT) family in their behavioral and amyloidosis phenotypes. In this study, we further characterize the role of MT-1 by crossing Mt1-overexpressing mice with Tg2576 mice (APPTgMT). [...]
2017 - 10.3390/ijms18020251
International journal of molecular sciences, Vol. 18, issue 2 (Feb. 2017) , art. 251  
5.
13 p, 1.3 MB Does Variation of the Inter-Domain Linker Sequence Modulate the Metal Binding Behaviour of Helix pomatia Cd-Metallothionein? / Gil Moreno, Selene (Universitat Autònoma de Barcelona. Departament de Química) ; Jiménez Martí, Elena (Universitat de Barcelona. Departament de Genètica) ; Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ; Zerbe, Oliver (University of Zurich. Institute of Organic Chemistry) ; Dallinger, Reinhard (University of Innsbruck. Institute of Zoology and Center of Molecular Biosciences) ; Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ; Atrian i Ventura, Sílvia (Universitat de Barcelona. Departament de Genètica)
Snail metallothioneins (MTs) constitute an ideal model to study structure/function relationships in these metal-binding polypeptides. Helix pomatia harbours three MT isoforms: the highly specific CdMT and CuMT, and an unspecific Cd/CuMT, which represent paralogous proteins with extremely different metal binding preferences while sharing high sequence similarity. [...]
2016 - 10.3390/ijms17010006
International journal of molecular sciences, Vol. 17 Núm. 6 (2016) , p. 1-13  

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