Results overview: Found 20 records in 0.03 seconds.
Articles, 13 records found
Research literature, 7 records found
Articles 13 records found  1 - 10next  jump to record:
1.
Label-free DNA-methylation detection by direct ds-DNA fragment screening using poly-purine hairpins / Sánchez Huertas, César (Institut Català de Nanociència i Nanotecnologia) ; Aviñó, Anna (Institut de Química Avançada de Catalunya) ; Kurachi, Cristina (Institut Català de Nanociència i Nanotecnologia) ; Piqué, Albert (Institut Català de Nanociència i Nanotecnologia) ; Sandoval, Juan (Institut de Recerca Biomèdia Bellvitge) ; Eritja, Ramon (Institut de Química Avançada de Catalunya) ; Esteller, Manel (Institucio Catalana de Recerca i Estudis Avançats (ICREA)) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Cancer diagnosis continuously evolves due to the better understanding of tumorigenic processes. DNA-methylation is consolidated as an effective biomarker for cancer prognosis and diagnostic even in tumors of unknown origin. [...]
2018 - 10.1016/j.bios.2018.08.027
Biosensors and bioelectronics, Vol. 120 (November 2018) , p. 47-54  
2.
60 p, 1.6 MB The Physcomitrella patens chromosome‐scale assembly reveals moss genome structure and evolution / Lang, Daniel (Helmholtz Center Munich. Plant Genome and Systems Biology) ; Ullrich, Kristian K. (University of Marburg. Faculty of Biology) ; Murat, Florent (Institut national de la recherche agronomique. UMR 1095 Genetics. Diversity and Ecophysiology of Cereals) ; Fuchs, Jorg (Leibniz Institute of Plant Genetics and Crop Plant Research) ; Jenkins, Jerry (HudsonAlpha Institute for Biotechnology) ; Haas, Fabian B. (University of Marburg. Faculty of Biology) ; Piednoel, M. (Max Planck Institute for Plant Breeding Research) ; Gundlach, H. (Helmholtz Center Munich. Plant Genome and Systems Biology) ; Van Bel, M. (VIB-UGent Center for Plant Systems Biology) ; Meyberg, R. (University of Marburg. Faculty of Biology) ; Vives, Cristina (Centre de Recerca en Agrigenòmica) ; Morata, Jordi (Centre de Recerca en Agrigenòmica) ; Symeonidi, Aikaterini (University of Marburg. Faculty of Biology) ; Hiss, Manuel (University of Marburg. Faculty of Biology) ; Muchero, Wellington (Oak Ridge National Laboratory. Biosciences Division) ; Kamisugi, Yasuko (University of Leeds. Centre for Plant Sciences) ; Saleh, Omar (University of Freiburg. Faculty of Biology) ; Blanc, Guillaume (Aix-Marseille Université. Structural and Genomic Information Laboratory) ; Decker, Eva L. (University of Freiburg. Faculty of Biology) ; van Gessel, Nico (University of Freiburg. Faculty of Biology) ; Grimwood, Jane (HudsonAlpha Institute for Biotechnology) ; Hayes, Richard D. (DOE Joint Genome Institute) ; Graham, Sean W. (University of British Columbia. Department of Botany) ; Gunter, Lee E. (Oak Ridge National Laboratory. Biosciences Division) ; McDaniel, Stuart F. (University of Florida. Department of Biology) ; Hoernstein, Sebastian N.W. (University of Freiburg. Faculty of Biology) ; Larsson, Anders (Uppsala University. Evolutionary Biology Centre) ; Li, Fay-Wei (Boyce Thompson Institute) ; Perroud, Pierre-François (University of Marburg. Faculty of Biology) ; Phillips, Jeremy (DOE Joint Genome Institute) ; Ranjan, Priya (Oak Ridge National Laboratory) ; Rokshar, Daniel S. (DOE Joint Genome Institute) ; Rothfels, Carl J. (University of California. Department of Integrative Biology) ; Schneider, Lucas (University of Marburg. Faculty of Biology) ; Shu, Shengqiang (DOE Joint Genome Institute) ; Stevenson, Dennis W. (New York Botanical Garden) ; Thümmler, Fritz (Vertis Biotechnologie AG) ; Tillich, Michael (Max Planck Institute of Molecular Plant Physiology) ; Villarreal Aguilar, Juan C. (Université Laval. Department of Biology) ; Widiez, Thomas (University of Geneva. Department of Plant Biology) ; Wong, Gane Ka-Shu (University of Alberta. Department of Biological Sciences) ; Wymore, Ann (Oak Ridge National Laboratory) ; Zhang, Yong (Shenzhen Huahan Gene Life Technology Co. Ltd) ; Zimmer, Aandreas D. (University of Freiburg. Faculty of Biology) ; Quatrano, Ralph S. (Washington University. Department of Biology) ; Mayer, Klaus F. X. (Technical University Munich) ; Goodstein, David (DOE Joint Genome Institute) ; Casacuberta i Suñer, Josep M. (Centre de Recerca en Agrigenòmica) ; Vandepoele, Klaas (Ghent University. Department of Plant Biotechnology and Bioinformatics) ; Reski, Ralph (University of Freiburg. Faculty of Biology) ; Cuming, Andrew C. (University of Leeds. Faculty of Biological Sciences) ; Tuskan, Gerald A. (Oak Ridge National Laboratory. Biosciences Division) ; Maumus, Florian (Institut National de la Recherche Agronomique . Unité de Recherche Génomique Info) ; Salse, Jerome (Institut national de la recherche agronomique. UMR 1095 Genetics. Diversity and Ecophysiology of Cereals) ; Schmutz, Jeremy (DOE Joint Genome Institute) ; Rensing, Stefan A. (University of Freiburg. BIOSS Centre for Biological Signalling Studies)
The draft genome of the moss model, Physcomitrella patens, comprised approximately 2000 unordered scaffolds. In order to enable analyses of genome structure and evolution we generated a chromosome-scale genome assembly using genetic linkage as well as (end) sequencing of long DNA fragments. [...]
2018 - 10.1111/tpj.13801
Plant journal, Vol. 93, issue 3 (Feb. 2018) , p. 515-533  
3.
14 p, 4.9 MB Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs / Nogales, Vanesa (Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain) ; Reinhold, William C. (Genomics and Bioinformatics Group, Developmental Therapeutics Branch, National Cancer Institute, Bethesda, MD, USA) ; Varma, Sudhir (Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA) ; Martinez-Cardus, Anna (Institut de Recerca Biomèdica Bellvitge (IDIBELL)) ; Moutinho, Catia (Institut de Recerca Biomèdica Bellvitge (IDIBELL)) ; Moran, Sebastian (Institut de Recerca Biomèdica Bellvitge (IDIBELL)) ; Heyn, Holger (Institut de Recerca Biomèdica Bellvitge (IDIBELL)) ; Sebio, Ana (Institut d'Investigació Biomèdica Sant Pau) ; Barnadas i Molins, Agustí (Institut d'Investigació Biomèdica Sant Pau) ; Pommier, Yves (Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA) ; Esteller, Manel (Institucio Catalana de Recerca i Estudis Avançats (ICREA)) ; Universitat Autònoma de Barcelona
Platinum-derived drugs such as cisplatin and carboplatin are among the most commonly used cancer chemotherapy drugs, but very few specific molecular and cellular markers predicting differential sensitivity to these agents in a given tumor type have been clearly identified. [...]
2015 - 10.18632/oncotarget.6413
Oncotarget, Vol. 7 (november 2015) , p. 3084-3097  
4.
18 p, 2.2 MB Aberrant epigenome in ‐derived dopaminergic neurons from Parkinson's disease patients / Fernández‐Santiago, Rubén (Universitat de Barcelona) ; Carballo‐Carbajal, Iria (Vall d'Hebron Institut de Recerca (VHIR)) ; Castellano, Giancarlo (Universitat de Barcelona. Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Torrent, Roger (Universitat de Barcelona. Institut de Biomedicina (IBUB)) ; Richaud, Yvonne (Biomaterials and Nanomedicine (CIBER‐BBN). Centre for Networked Biomedical Research on Bioengineering) ; Sánchez‐Danés, Adriana (Universitat de Barcelona. Institut de Biomedicina (IBUB)) ; Vilarrasa‐Blasi, Roser (Universitat de Barcelona. Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Sánchez‐Pla, Alex (Vall d'Hebron Institut de Recerca (VHIR)) ; Mosquera, José Luis (Universitat de Barcelona) ; Soriano, Jordi (Universitat de Barcelona) ; López‐Barneo, José (Universidad de Sevilla. Hospital Universitario Virgen del Rocío.) ; Canals, Josep M (Universitat de Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Alberch, Jordi (Universitat de Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Raya, Ángel (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ; Vila Bover, Miquel (Vall d'Hebron Institut de Recerca (VHIR)) ; Consiglio, Antonella (University of Brescia and National Institute of Neuroscience) ; Martín‐Subero, José I (Universitat de Barcelona. Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Ezquerra, Mario (Universitat de Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Tolosa, Eduardo (Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED)) ; Universitat Autònoma de Barcelona
The epigenomic landscape of Parkinson's disease () remains unknown. We performed a genomewide methylation and a transcriptome studies in induced pluripotent stem cell ()‐derived dopaminergic neurons (n) generated by cell reprogramming of somatic skin cells from patients with monogenic 2‐associated (L2) or sporadic (), and healthy subjects. [...]
2015 - 10.15252/emmm.201505439
EMBO Molecular Medicine, Vol. 7, Núm. 12 (October 2015) , p. 1529-1546  
5.
11 p, 577.8 KB A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancers / Diesch, Jeannine (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Zwick, Anabel (Technical University Munich. Department of Medicine) ; Garz, Anne-Kathrin (German Cancer Research Center (Heidelberg, Alemanya)) ; Palau, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Götze, Katharina S. (German Cancer Research Center (Heidelberg, Alemanya))
The azanucleosides azacitidine and decitabine are currently used for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) in patients not only eligible for intensive chemotherapy but are also being explored in other hematologic and solid cancers. [...]
2016 - 10.1186/s13148-016-0237-y
Clinical epigenetics, Vol. 8 Núm. 71 (Juny 2016)  
6.
15 p, 2.3 MB Muscle cell identity requires Pax7-mediated lineage-specific DNA demethylation / Carrió Gaspar, Elvira ((Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Magli, Alessandro (Lillehei Heart Institute (Minneapolis, Estats Units d'Amèrica)) ; Muñoz, Mar (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Peinado Morales, Miguel Á. (Miguel Ángel) (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Perlingeiro, Rita (Lillehei Heart Institute (Minneapolis, Estats Units d'Amèrica)) ; Suelves Esteban, Mònica (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
BACKGROUND: Skeletal muscle stem cells enable the formation, growth, maintenance, and regeneration of skeletal muscle throughout life. The regeneration process is compromised in several pathological conditions, and muscle progenitors derived from pluripotent stem cells have been suggested as a potential therapeutic source for tissue replacement. [...]
2016 - 10.1186/s12915-016-0250-9
BMC Biology, Vol. 14, Núm. 30 (2016)  
7.
13 p, 2.1 MB Epigenetic Alterations in Fanconi Anaemia : Role in Pathophysiology and Therapeutic Potential / Belo, Hélio (Universidade Nova de Lisboa. Faculdade de Ciências Médicas) ; Silva, Gabriela (Universidade Nova de Lisboa. Faculdade de Ciências Médicas) ; Cardoso, Bruno A. (Universidade Nova de Lisboa. Faculdade de Ciências Médicas) ; Porto, Beatriz (Instituto de Ciências Biomédicas de Abel Salazar (Porto, Portugal)) ; Minguillón, Jordi (Universitat Autonoma de Barcelona. Departament de Genètica i de Microbiologia) ; Barbot, José (Centro Hospitalar do Porto (Porto, Portugal)) ; Coutinho, Jorge (Centro Hospitalar do Porto (Porto, Portugal)) ; Casado, José A. (Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT)) ; Benedito, Manuela (Centro Hospitalar e Universitário de Coimbra (Coimbra, Portugal)) ; Saturnino, Hema (Centro Hospitalar e Universitário de Coimbra (Coimbra, Portugal)) ; Costa, Emília (Centro Hospitalar do Porto (Porto, Portugal)) ; Bueren, Juan A. (Centro Hospitalar do Porto (Porto, Portugal)) ; Surrallés i Calonge, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Almeida, Antonio (Universidade Nova de Lisboa. Faculdade de Ciências Médicas)
Fanconi anaemia (FA) is an inherited disorder characterized by chromosomal instability. The phenotype is variable, which raises the possibility that it may be affected by other factors, such as epigenetic modifications. [...]
2015 - 10.1371/journal.pone.0139740
PLoS one, Vol. 10, Num. 10 (October 2015) , p. 1-13  
8.
12 p, 1.5 MB DNA methylation dynamics in muscle development and disease / Carrió Gaspar, Elvira (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Suelves Esteban, Mònica (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
DNA methylation is an essential epigenetic modification for mammalian development and is crucial for the establishment and maintenance of cellular identity. Traditionally, DNA methylation has been considered as a permanent repressive epigenetic mark. [...]
2015 - 10.3389/fnagi.2015.00019
Frontiers in aging neuroscience, Vol. 7 Núm. 19 (2015)  
9.
15 p, 3.0 MB Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer / Alonso, Sergio (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; González, Beatriz (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Ruiz-Larroya, Tatiana (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Durán Domínguez, Mercedes (Instituto de Biología y Genética Molecular (Valladolid)) ; Kato, Takaharu (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Matsunaga, Akihiro (Sanford Burnham Prebys Medical Discovery Institute (Califòrnia)) ; Suzuki, Koichi (Jichi Medical University (Japó)) ; Strongin, Alex Y. (Sanford Burnham Prebys Medical Discovery Institute (Califòrnia)) ; Giménez Bonafé, Pepita (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Perucho, Manuel (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
BACKGROUND: ADAMTS19 encodes a member of the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) protein family with emerging roles in carcinogenesis and metastasis. ADAMTS shares several distinct protein modules including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. [...]
2015 - 10.1186/s13148-015-0158-1
Clinical Epigenetics, Vol. 7, No. 124 (December 2015)  
10.
22 p, 1.4 MB Overlapping DNA methylation dynamics in mouse intestinal cell differentiation and early stages of malignant progression / Forn Bernaus, Marta (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Díez-Villanueva, Anna (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Merlos-Suárez, Anna (Institute for Research in Biomedicine (IRB Barcelona)) ; Muñoz, Mar (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Lois, Sergi (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Carrió Gaspar, Elvira (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Jordà Ramos, Mireia (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Bigas Salvans, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ; Batlle, Eduard (Institute for Research in Biomedicine (IRB Barcelona)) ; Peinado Morales, Miguel Á. (Miguel Ángel) (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
Mouse models of intestinal crypt cell differentiation and tumorigenesis have been used to characterize the molecular mechanisms underlying both processes. DNA methylation is a key epigenetic mark and plays an important role in cell identity and differentiation programs and cancer. [...]
2015 - 10.1371/journal.pone.0123263
PLoS One, Vol. 10, No. 5 (May 2015) , p. e0123263  

Articles : 13 records found   1 - 10next  jump to record:
Research literature 7 records found  
1.
1 p, 2.3 MB Designing a novel methylation array for head and neck squamous cell carcinoma (HNSCC) detection / Vergara Ucin, Xabier ; Pallarès i Goitiz, Irantzu, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2016
Graduat o Graduada en Bioquímica [814]  
2.
1 p, 738.6 KB Epigenetics as biomarker for Alzheimer's disease : a new approach to prevention, diagnosis and treatment / Martínez Ruiz, Elena ; Barquinero, J. F., (Joan Francesc), dir. (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2015
Graduat o Graduada en Ciències Biomèdiques [832]  
3.
1 p, 642.4 KB Post-translational modifications of histones linked with gliomas : H3K27me3 (¿Methylated or demethylated?, that is the question) / Fábregas Ordóñez, Cristina ; Roque Córdova, Alicia, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2015
Graduat o Graduada en Biotecnologia [815]  
4.
138 p, 2.6 MB LKB1/ AMPK / TSC2 signaling pathway alterations in non-small-cell-lung-carcinoma / de Aguirre Egaña, Itziar ; Vertino, Paula, dir. ; Rosell i Costa, Rafael, dir. ; Universitat Autònoma de Barcelona. Departament de Mitjans, Comunicació i Cultura
El gen supresor tumoral LKB1/STK11b, codifica una serina/treonina quinasa. Las mutaciones de línea germinal en LKB1 están asociadas al síndrome de Peutz-Jeghers (PJS), trastorno dominante autosómico caracterizado por el crecimiento de pólipos en el tracto gastrointestinal, y depósitos de melanina mucocutánea, aumentando el riesgo de ciertos cánceres, incluido el de pulmón. [...]
LKB1, also known as STK11b, is a serine/threonine kinase that functions as a suppressor of tumor growth. Germ line mutations in LKB1 are associated with the Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by benign hemartomas of the gastrointestinal tract and mucocutaneous melanin deposits and an increased risk of certain cancers, including lung. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2014  
5.
1 p, 520.8 KB Monozygous twins discrimination in forensic medicine / Mendizuri Sánchez, Saioa ; Pereira dos Santos, Cristina Maria, dir. (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2013
Graduat o Graduada en Genètica [833]  
6.
1 p, 1.7 MB A way to solve the problem in the discrimination of monozygotic twins / Mañas García, Laura ; Pereira dos Santos, Cristina Maria, dir. (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2013
Graduat o Graduada en Genètica [833]  
7.
1 p, 570.5 KB Role of the epigenetic regulation of chromatin in breast cancer / Giralt Buch, Irina ; Roque Córdova, Alicia, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2013
Graduat o Graduada en Bioquímica [814]  

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