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1.
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13 p, 1.1 MB |
Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity
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Sant'Anna, Ricardo (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gallego Alonso, Pablo (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Robinson, Lei Z. (Scripps Research Institute) ;
Pereira-Henriques, Alda (Instituto de Ciências Biomédicas de Abel Salazar (Porto, Portugal)) ;
Ferreira, Nelson (Instituto de Ciências Biomédicas de Abel Salazar (Porto, Portugal)) ;
Pinheiro, Francisca (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Esperante, Sebastián (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Huertas, Oscar (SOM-Biotech) ;
Almeida, Maria Rosário (Instituto de Ciências Biomédicas de Abel Salazar (Porto, Portugal)) ;
Reixach, Natàlia (Scripps Research Institute) ;
Insa, Raul (SOM-Biotech) ;
Velazquez-Campoy, Adrián (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular) ;
Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Reig, Núria (SOM-Biotech) ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native state stabilizers are promising drugs to treat TTR amyloidoses. [...]
2016 -  10.1038/ncomms10787
Nature communications, Vol. 7 (2016) , art. 10787
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2.
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12 p, 7.0 MB |
ATR is a multifunctional regulator of male mouse meiosis
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Widger, Alexander (The Francis Crick Institute) ;
Mahadevaiah, Shantha K. (Francis Crick Institute) ;
Lange, Julian (Memorial Sloan Kettering Cancer Center) ;
Elinati, Elias (The Francis Crick Institute) ;
Zohren, Jasmin (The Francis Crick Institute) ;
Hirota, Takayuki (The Francis Crick Institute) ;
Pacheco, Sarai (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Maldonado Linares, Andros (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Stanzione, Marcello (TU Dresden. Faculty of Medicine) ;
Ojarikre, Obah (The Francis Crick Institute) ;
Maciulyte, Valdone (The Francis Crick Institute) ;
De Rooij, Dirk G.. (University of Amsterdam. Center for Reproductive Medicine) ;
Tóth, Attila (TU Dresden. Faculty of Medicine) ;
Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Keeney, Scott (Memorial Sloan Kettering Cancer Center) ;
Turner, James M. A. (Francis Crick Institute)
Meiotic cells undergo genetic exchange between homologs through programmed DNA double-strand break (DSB) formation, recombination and synapsis. In mice, the DNA damage-regulated phosphatidylinositol-3-kinase-like kinase (PIKK) ATM regulates all of these processes. [...]
2018 - 10.1038/s41467-018-04850-0
Nature communications, Vol. 9 (2018) , art. 2621
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3.
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33 p, 2.7 MB |
Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies
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Eraña, Hasier (ATLAS Molecular Pharma S. L.) ;
Charco, Jorge M. (CIC bioGUNE) ;
Di Bari, Michele Angelo (CIC bioGUNE) ;
Díaz-Domínguez, Carlos M. (Istituto Superiore di Sanità. Department of Veterinary Public Health and Food Safety.) ;
López-Moreno, R. (CIC bioGUNE) ;
Vidal Barba, Enric (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
González-Miranda, E. (CIC bioGUNE) ;
Pérez-Castro, Miguel A. (CIC bioGUNE) ;
García-Martínez, Sandra (ATLAS Molecular Pharma S. L.) ;
Bravo Lopez, Susana Belén (Proteomics Lab. IDIS) ;
Fernández-Borges, Natalia (CIC bioGUNE) ;
Geijo, Maria V. (NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario) ;
D'Agostino, C. (Department of Veterinary Public Health and Food Safety. Istituto Superiore di Sanità) ;
Garrido, Joseba M (NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario) ;
Bian, J. (Colorado State University. Prion Research Center (PRC).) ;
König, A. (Heinrich-Heine-Universität Düsseldorf. Physikalische Biologie.) ;
Uluca-Yazgi, B. (Heinrich-Heine-Universität Düsseldorf. Physikalische Biologie.) ;
Sabate, R. (Universitat de Barcelona. Institut de Nanociència i Nanotecnologia) ;
Khaychuk, V. (Colorado State University. Prion Research Center (PRC).) ;
Vanni, Ilaria (Istituto Superiore di Sanità. Department of Veterinary Public Health and Food Safety.) ;
Telling, G. C. (Colorado State University. Prion Research Center (PRC).) ;
Heise, Henrike (Heinrich-Heine-Universität Düsseldorf. Physikalische Biologie.) ;
Nonno, Romolo (Istituto Superiore di Sanità. Department of Veterinary Public Health and Food Safety.) ;
Requena, Jesús R (Universidade de Santiago de Compostela) ;
Castilla, Joaquín (IKERBasque. Basque Foundation for Science)
The resolution of the three-dimensional structure of infectious prions at the atomic level is pivotal to understand the pathobiology of Transmissible Spongiform Encephalopathies (TSE), but has been long hindered due to certain particularities of these proteinaceous pathogens. [...]
2019 - 10.1371/journal.ppat.1008117
PLOS pathogens, Vol. 15 Núm. 10 (2019) , p. e1008117
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4.
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19 p, 6.1 MB |
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis
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Carballo-Carbajal, Iria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Laguna, Ariadna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Romero-Giménez, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cuadros, Thais (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bové, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinez-Vicente, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Parent, Annabelle (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
González Sepúlveda, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Peñuelas, Núria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Torra, Albert (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez-Galván, Beatriz (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ballabio, Andrea (Telethon Institute of Genetics and Medicine (TIGEM)) ;
Hasegawa, Takafumi (Department of Neurology. Tohoku University School of Medicin) ;
Bortolozzi, Analía (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Gelpi, Ellen (Institute of Neurology. Medical University of Vienna) ;
Vila Bover, Miquel (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
2019 - 10.1038/s41467-019-08858-y
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 973
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5.
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26 p, 3.5 MB |
A functional regulatory variant of MYH3 influences muscle fiber-type composition and intramuscular fat content in pigs
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Cho, In-Cheol (Rural Development Administration. National Institute of Animal Science) ;
Park, Hee-Bok (Kongju National University. College of Industrial Sciences. Department of Animal Resources Science) ;
Ahn, Jin Seop (Korea Research Institute of Bioscience and Biotechnology. Biotherapeutics Translational Research Center) ;
Han, Sang-Hyun (Jeju National University. Educational Science Research Institute) ;
Lee, JaeBong (Chonbuk National University. Korea Zoonosis Research Institute) ;
Lim, Hyun-Tae (Gyeongsang National University. College of Agriculture and Life Sciences) ;
Yoo, Chae-Kyoung (Gyeongsang National University. Institute of Agriculture and Life Science.) ;
Jung, Eun-Ji (Bio-Medical Science Co., Ltd) ;
Kim, Dong-Hwan (Korea Research Institute of Bioscience and Biotechnology. Biotherapeutics Translational Research Center) ;
Sun, Wu-Sheng (Korea Research Institute of Bioscience and Biotechnology. Biotherapeutics Translational Research Center) ;
Ramayo-Caldas, Yuliaxis (Institut de Recerca i Tecnologia Agroalimentàries) ;
Kim, Sang-Geum (Rural Development Administration. National Institute of Animal Science) ;
Kang, Yong-Jun (Rural Development Administration. National Institute of Animal Science) ;
Kim, YooKyung (Jeju National University. Educational Science Research Institute) ;
Shin, Hyun-Sook (Rural Development Administration. National Institute of Animal Science) ;
Seong, Pil-Nam (Rural Development Administration. National Institute of Animal Science) ;
Hwang, In-Sul (Rural Development Administration. National Institute of Animal Science) ;
Park, Beom-Young (Rural Development Administration. National Institute of Animal Science) ;
Hwang, Seongsoo (Rural Development Administration. National Institute of Animal Science) ;
Lee, Sung-Soo (Rural Development Administration. National Institute of Animal Science) ;
Ryu, Youn-Chul (Jeju National University. Division of Biotechnology. SARI) ;
Lee, Jun-Heon (Chungnam National University. Division of Animal and Dairy Science) ;
Ko, MoonSuck (Rural Development Administration. National Institute of Animal Science) ;
Lee, Kichoon (Ohio State University. College of Food Agricultural and Environmental Sciences) ;
Andersson, Göran (Swedish University of Agricultural Sciences. Department of Animal Breeding and Genetics) ;
Perez-Enciso, Miguel (Centre de Recerca en Agrigenòmica) ;
Lee, JeongWoong (Korea Research Institute of Bioscience and Biotechnology. Biotherapeutics Translational Research Center)
Muscle development and lipid accumulation in muscle critically affect meat quality of livestock. However, the genetic factors underlying myofiber-type specification and intramuscular fat (IMF) accumulation remain to be elucidated. [...]
2019 - 10.1371/journal.pgen.1008279
PLoS Genetics, Vol. 15, Núm. 10 (October 2019) , art. e1008279
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6.
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11 p, 1.0 MB |
ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer
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Cedó, Lídia (Institut d'Investigació Biomèdica Sant Pau) ;
García-León, Annabel (Institut d'Investigació Biomèdica Sant Pau) ;
Baila-Rueda, Lucía (Hospital Universitario Miguel Servet (Saragossa)) ;
Santos, David (Institut d'Investigació Biomèdica Sant Pau) ;
Grijalva, Victor (University of California. Department of Medicine) ;
Martínez Cignoni, Melanie Raquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Carbó, José María (Universitat de Barcelona) ;
Metso, Jari (Minerva Foundation Institute for Medical Research) ;
López Vilaró, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Zorzano Olarte, Antonio (Institute for Research in Biomedicine) ;
Valledor, Annabel F. (Universitat de Barcelona) ;
Cenarro, Ana (Hospital Universitario Miguel Servet (Saragossa)) ;
Jauhiainen, Matti (Minerva Foundation Institute for Medical Research) ;
Lerma Puertas, Enrique (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ;
Fogelman, Alan M. (University of California. Department of Medicine) ;
Reddy, Srinivasa T. (University of California. Department of Medicine) ;
Escolà-Gil, Joan Carles (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Blanco Vaca, Francisco (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Universitat Autònoma de Barcelona
Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported contradictory results with regard to the relationship between apolipoprotein (apo) A-I and breast cancer. [...]
2016 - 10.1038/srep36387
Scientific reports, Vol. 6 (November 2016) , art. 36387
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