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9 p, 1012.4 KB |
Plasma Aβ42/40 ratio alone or combined with FDG-PET can accurately predict amyloid-PET positivity : A cross-sectional analysis from the AB255 Study
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Pérez-Grijalba, Virginia (Araclon Biotech S.L.) ;
Arbizu, Javier (Clínica Universidad de Navarra) ;
Romero, Judith (Araclon Biotech S.L.) ;
Prieto, Elena (Clínica Universidad de Navarra) ;
Pesini, Pedro (Araclon Biotech S.L.) ;
Sarasa, Leticia (Araclon Biotech S.L.) ;
Guillen, Fernando (Clínica Universidad de Navarra) ;
Monleón, Inmaculada (Araclon Biotech S.L.) ;
San-José, Itziar (Araclon Biotech S.L.) ;
Martínez-Lage, Pablo (Fundación CITA-Alzheimer) ;
Munuera, Josep (Institut de Recerca Sant Joan de Déu) ;
Hernández, Isabel (Instituto de Salud Carlos III) ;
Buendía, Mar (Universitat Internacional de Catalunya) ;
Sotolongo-Grau, Oscar (Universitat Internacional de Catalunya) ;
Alegret, Montserrat (Instituto de Salud Carlos III) ;
Ruiz, Agustín (Instituto de Salud Carlos III) ;
Tárraga, Lluís (Instituto de Salud Carlos III) ;
Boada, Mercè (Instituto de Salud Carlos III) ;
Sarasa, Manuel (Araclon Biotech S.L.) ;
Goñi Imízcoz, Miguel (Hospital Divino Vallés (Burgos)) ;
Pujadas, Francesc ;
Villarejo, Alberto ;
Frank, Ana ;
Peña-Casanova, Jordi ;
Fernández, Manuel ;
Piñol, Gerard ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Gil, Pedro ;
Pascual, Luis F. ;
Aguilar Barberà, Miquel ;
Frisoni, Giovanni B. ;
Matias-Guiu, Jorge ;
Andreasen, Niels ;
Antúnez, Carmen ;
Universitat Autònoma de Barcelona
To facilitate population screening and clinical trials of disease-modifying therapies for Alzheimer's disease, supportive biomarker information is necessary. This study was aimed to investigate the association of plasma amyloid-beta (Aβ) levels with the presence of pathological accumulation of Aβ in the brain measured by amyloid-PET. [...]
2019 -  10.1186/s13195-019-0549-1
Alzheimer's research & therapy, Vol. 11 Núm. 1 (january 2019) , p. 96
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2.
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10 p, 876.7 KB |
Measuring cognitive impairment and monitoring cognitive decline in Huntington's disease : a comparison of assessment instruments
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Horta, Andrea (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Martinez-Horta, Saul (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Pérez-Pérez, Jesús (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Puig-Davi, Arnau (Institut d'Investigació Biomèdica Sant Pau) ;
de Lucia, Natascia (University of Naples "Federico II", Naples, Italy) ;
de Michele, Giuseppe (University of Naples "Federico II", Naples, Italy) ;
Salvatore, Elena (University of Naples "Federico II", Naples, Italy) ;
Kehrer, Stefanie (Charité-Universitätsmedizin, Berlin, Germany) ;
Priller, Josef (Charité-Universitätsmedizin, Berlin, Germany) ;
Migliore, Simone (Fondazione IRCCS Casa Sollievo Della Sofferenza Research Hospital, San Giovanni Rotondo, Italy) ;
Squitieri, Ferdinando (Fondazione IRCCS Casa Sollievo Della Sofferenza Research Hospital, San Giovanni Rotondo, Italy) ;
Castaldo, Ana (Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy) ;
Mariotti, Caterina (Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy) ;
Mañanes, Verónica (Hospital Universitario Ramon Y Cajal) ;
Lopez-Sendon, José Luís (Hospital Universitario Ramon Y Cajal) ;
Rodriguez, Noelia (Fundación Jimenez Diaz) ;
Martinez-Descals, Asunción (Fundación Jimenez Diaz) ;
Júlio, Filipa (Coimbra University Hospital) ;
Januário, Cristina (Coimbra University Hospital) ;
Delussi, marianna (European Huntington's Disease Network (EHDN), Ulm, Germany) ;
de Tommaso, Marina (European Huntington's Disease Network (EHDN), Ulm, Germany) ;
Noguera, Sandra (Hospital Mare de Deu de La Mercè) ;
Ruiz-Idiago, Jesús (Hospital Mare de Deu de La Mercè) ;
Sitek, Emilia J. (St. Adalbert Hospital, Copernicus, Gdańsk, Poland) ;
Wallner, Renata (Medical University of Wroclaw, Wroclaw, Poland) ;
Nuzzi, Angela (European Huntington's Disease Network (EHDN), Ulm, Germany) ;
Pagonabarraga Mora, Javier (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Kulisevsky, Jaime (Universitat Autònoma de Barcelona. Departament de Medicina)
Background: Progressive cognitive decline is an inevitable feature of Huntington's disease (HD) but specific criteria and instruments are still insufficiently developed to reliably classify patients into categories of cognitive severity and to monitor the progression of cognitive impairment. [...]
2023 - 10.1007/s00415-023-11804-0
Journal of Neurology, Vol. 270, Num. 11 (november 2023) , p. 5408-5417
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4.
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22 p, 3.7 MB |
A 3D deep learning model to predict the diagnosis of dementia with Lewy bodies, Alzheimer's disease, and mild cognitive impairment using brain 18F-FDG PET
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Etminani, Kobra (Center for Applied Intelligent Systems Research (CAISR). Halmstad University) ;
Soliman, Amira (Center for Applied Intelligent Systems Research (CAISR). Halmstad University) ;
Davidsson, Anette (Department of Clinical Physiology. Department of Health. Medicine and Caring Sciences. Linköping University) ;
Chang, Jose R. (National Cheng Kung University in Tainan) ;
Martínez-Sanchis, Begoña (Hospital Universitari i Politècnic La Fe (València)) ;
Byttner, Stefan (Center for Applied Intelligent Systems Research (CAISR). Halmstad University) ;
Camacho, Valle (Institut d'Investigació Biomèdica Sant Pau) ;
Bauckneht, Matteo (Nuclear Medicine Unit. IRCCS Ospedale Policlinico San Martino) ;
Stegeran, Roxana (Department of Diagnostic Radiology. Linköping University Hospital) ;
Ressner, Marcus (Department of Medical Physics. Linköping University Hospital) ;
Agudelo-Cifuentes, Marc (Hospital Universitari i Politècnic La Fe (València)) ;
Chincarini, Andrea (National Institute of Nuclear Physics (INFN)) ;
Brendel, Matthias (Department of Nuclear Medicine. University Hospital. LMU Munich) ;
Rominger, Axel (Department of Nuclear Medicine. Inselspital. University Hospital Bern) ;
Bruffaerts, Rose (Biomedical Research Institute. Hasselt University) ;
Vandenberghe, Rik (Neurology Department. University Hospitals Leuven) ;
Kramberger, Milica G. (Department of Neurology. University Medical Centre) ;
Trost, Maja (Univerza V Ljubljani) ;
Nicastro, Nicolas (Department of Clinical Neurosciences. Geneva University Hospitals) ;
Frisoni, Giovanni B. (LANVIE (Laboratoire de Neuroimagerie du Vieillissement). Department of Psychiatry. University Hospitals) ;
Lemstra, Afina W. (Department of Neurology. Alzheimer Center) ;
van Berckel, Bart N.M. (Department of Radiology & Nuclear Medicine. Amsterdam UMC. location VUmc) ;
Pilotto, Andrea (Parkinson's Disease Rehabilitation Centre) ;
Padovani, Alessandro (Neurology Unit. Department of Clinical and Experimental Sciences. University of Brescia) ;
Morbelli, Silvia (Department of Health Sciences. University of Genoa) ;
Aarsland, Dag (Department of Old Age Psychiatry. Institute of Psychiatry. Psychology and Neuroscience. King's College London) ;
Nobili, Flavio (Clinical Neurology. IRCCS Ospedale Policlinico San Martino) ;
Garibotto, Valentina (Division of Nuclear Medicine and Molecular Imaging. University Hospitals of Geneva and NIMTLab. Faculty of Medicine. University of Geneva) ;
Ochoa-Figueroa, Miguel (Center for Medical Image Science and Visualization (CMIV). Linköping University) ;
Universitat Autònoma de Barcelona
Purpose: The purpose of this study is to develop and validate a 3D deep learning model that predicts the final clinical diagnosis of Alzheimer's disease (AD), dementia with Lewy bodies (DLB), mild cognitive impairment due to Alzheimer's disease (MCI-AD), and cognitively normal (CN) using fluorine 18 fluorodeoxyglucose PET (18F-FDG PET) and compare model's performance to that of multiple expert nuclear medicine physicians' readers. [...]
2022 - 10.1007/s00259-021-05483-0
European Journal of Nuclear Medicine and Molecular Imaging, Vol. 49 Núm. 2 (january 2022) , p. 563-584
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19 p, 5.2 MB |
Plasma extracellular vesicles reveal early molecular differences in amyloid positive patients with early-onset mild cognitive impairment
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Cano, Amanda (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Esteban-De Antonio, Ester (Universitat Internacional de Catalunya) ;
Bernuz, Mireia (Universitat Autònoma de Barcelona. Departament de Química) ;
Puerta, Raquel (Universitat Internacional de Catalunya) ;
García-González, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
De Rojas, Itziar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Olivé, Claudia (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Pérez-Cordón, Alba (Universitat Internacional de Catalunya) ;
Montrreal, Laura (Universitat Internacional de Catalunya) ;
Núñez-Llaves, Raúl (Universitat Internacional de Catalunya) ;
Sotolongo Grau, Oscar (Universitat Internacional de Catalunya) ;
Alarcón-Martín, Emilio (Universitat Internacional de Catalunya) ;
Valero, Sergi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Martín, Elvira (Universitat Internacional de Catalunya) ;
Martino-Adami, Pamela V. (University of Cologne. Department of Psychiatry and Psychotherapy) ;
Ettcheto, Miren (Universitat de Barcelona. Institut de Neurociències) ;
Camins, Antoni (Universitat de Barcelona. Institut de Neurociències) ;
Vivas, Assumpta (Clínica Corachan) ;
Gomez-Chiari, Marta (Clínica Corachan) ;
Tejero, Miguel Ángel (Clínica Corachan) ;
Orellana, Adelina (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Marquié, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Ramirez, Alfredo (Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne) ;
Martí, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ;
Pividori, María Isabel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Ruiz, Agustín (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
In the clinical course of Alzheimer's disease (AD) development, the dementia phase is commonly preceded by a prodromal AD phase, which is mainly characterized by reaching the highest levels of Aβ and p-tau-mediated neuronal injury and a mild cognitive impairment (MCI) clinical status. [...]
2023 - 10.1186/s12951-023-01793-7
Journal of nanobiotechnology, Vol. 21 (February 2023) , art. 54
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12 p, 1.4 MB |
Macular vessel density in the superficial plexus is not associated to cerebrospinal fluid core biomarkers for Alzheimer's disease in individuals with mild cognitive impairment : The NORFACE cohort
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Marquié, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
García-Sánchez, Ainhoa (Universitat Internacional de Catalunya) ;
Alarcón-Martín, Emilio (Universitat Internacional de Catalunya) ;
Martínez, Joan (Universitat Internacional de Catalunya) ;
Castilla Marti, Miguel (Clínica Oftalmológica Dr. Castilla) ;
Castilla-Martí, Luis (Universitat Autònoma de Barcelona. Departament de Cirurgia) ;
Orellana, Adelina (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Montrreal, Laura (Universitat Internacional de Catalunya) ;
De Rojas, Itziar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
García-González, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Puerta, Raquel (Universitat Internacional de Catalunya) ;
Olivé, Clàudia (Universitat Internacional de Catalunya) ;
Cano, Amanda (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Hernández, Isabel (Universitat Internacional de Catalunya) ;
Rosende-Roca, Maitée (Universitat Internacional de Catalunya) ;
Vargas, Liliana (Universitat Internacional de Catalunya) ;
Tartari, Juan Pablo (Universitat Internacional de Catalunya) ;
Esteban-De Antonio, Ester (Universitat Internacional de Catalunya) ;
Bojaryn, Urszula (Universitat Internacional de Catalunya) ;
Ricciardi, Mario (Universitat Internacional de Catalunya) ;
Ariton, Diana María (Universitat Internacional de Catalunya) ;
Pytel, Vanesa (Universitat Internacional de Catalunya) ;
Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Ortega, Gemma (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Espinosa, Ana (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Pérez-Cordón, Alba (Universitat Internacional de Catalunya) ;
Sanabria, Ángela (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Muñoz, Nathalia (Universitat Internacional de Catalunya) ;
Lleonart, Núria (Universitat Internacional de Catalunya) ;
Aguilera, Núria (Universitat Internacional de Catalunya) ;
Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Valero, Sergi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Ruiz, Agustín (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Optical coherence tomography angiography (OCT-A) is a novel method in the dementia field that allows the detection of retinal vascular changes. The comparison of OCT-A measures with established Alzheimer's disease (AD)-related biomarkers is essential to validate the former as a marker of cerebrovascular impairment in the AD continuum. [...]
2023 - 10.3389/fnins.2023.1076177
Frontiers in Neuroscience, Vol. 17 (february 2023)
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11 p, 2.4 MB |
The effects of white matter hyperintensities on MEG power spectra in population with mild cognitive impairment
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Torres-Simon, Lucia (Universidad Complutense de Madrid. Departamento de Psicología Experimental) ;
Cuesta, Pablo (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
del Cerro-Leon, Alberto (Universidad Complutense de Madrid. Departamento de Psicología Experimental) ;
Chino, Brenda (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Orozco, Lucia H. (Universidad Complutense de Madrid. Centro de Neurociencia Cognitiva y Computacional) ;
Marsh, Elisabeth B. (Department of Neurology, The Johns Hopkins School of Medicine) ;
Gil Gregorio, Pedro (Hospital Universitario Clínico San Carlos (Madrid)) ;
Maestu, Fernando (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Cerebrovascular disease is responsible for up to 20% of cases of dementia worldwide, but also it is a major comorbid contributor to the progression of other neurodegenerative diseases, like Alzheimer's disease. [...]
2023 - 10.3389/fnhum.2023.1068216
Frontiers in human neuroscience, Vol. 17 (february 2023)
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12 p, 801.4 KB |
Different Inflammatory Signatures in Alzheimer's Disease and Frontotemporal Dementia Cerebrospinal Fluid
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Boström, Gustaf (Department of Public Health and Caring Sciences. Geriatrics. Uppsala University) ;
Freyhult, Eva (Department of Medical Sciences. Science for Life Laboratory. National Bioinformatics Infrastructure Sweden. Uppsala University) ;
Virhammar, Johan (Department of Neuroscience. Neurology. Uppsala University Hospital) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Tumani, Hayrettin (Department of Neurology. Ulm University Hospital) ;
Otto, Markus (Department of Neurology. Ulm University Hospital) ;
Brundin, Rose-Marie (Department of Public Health and Caring Sciences. Geriatrics. Uppsala University) ;
Kilander, Lena (Department of Public Health and Caring Sciences. Geriatrics. Uppsala University) ;
Löwenmark, Malin (Department of Public Health and Caring Sciences. Geriatrics. Uppsala University) ;
Giedraitis, Vilmantas (Department of Public Health and Caring Sciences. Geriatrics. Uppsala University) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Von Arnim, Christine A.F. (Department of Geriatric Medicine. University Medical Center Göttingen. Georg-August-University) ;
Kultima, Kim (Department of Medical Sciences. Clinical Chemistry. Uppsala University) ;
Ingelsson, Martin (Department of Public Health and Caring Sciences. Geriatrics. Uppsala University)
Background: Neuroinflammatory processes are common in neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), but current knowledge is limited as to whether cerebrospinal fluid (CSF) levels of neuroinflammatory proteins are altered in these diseases. [...]
2021 - 10.3233/jad-201565
Journal of Alzheimer's disease, Vol. 81 Núm. 2 (2021) , p. 629-640
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16 p, 1.8 MB |
Neural signatures of predictive language processing in Parkinson's disease with and without mild cognitive impairment
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León-Cabrera, Patricia (Institut d'Investigació Biomèdica de Bellvitge) ;
Pagonabarraga Mora, Javier (Institut d'Investigació Biomèdica Sant Pau) ;
Morís, J. (Department of Educational and Evolutive Psychology. University of Granada) ;
Martinez-Horta, Saul (Institut d'Investigació Biomèdica Sant Pau) ;
Marín-Lahoz, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Horta, Andrea (Institut d'Investigació Biomèdica Sant Pau) ;
Bejr-kasem, Helena (Institut d'Investigació Biomèdica Sant Pau) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Rodríguez-Fornells, A. (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
Cognitive deficits are common in Parkinson's disease (PD), with some PD patients meeting criteria for mild cognitive impairment (MCI). An unaddressed question is whether linguistic prediction is preserved in PD. [...]
2021 - 10.1016/j.cortex.2021.03.032
Cortex, Vol. 141 (august 2021) , p. 112-127
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10 p, 743.4 KB |
Neuropsychiatric Profile as a Predictor of Cognitive Decline in Mild Cognitive Impairment
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Roberto Herrero, Natalia (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Portella, Maria J.. (Institut d'Investigació Biomèdica Sant Pau) ;
Marquié, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Hernández, Isabel (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Mauleón, Ana (Universitat Internacional de Catalunya) ;
Rosende-Roca, Maitee (Universitat Internacional de Catalunya) ;
Abdelnour, Carla (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Esteban de Antonio, Ester (Universitat Internacional de Catalunya) ;
Tartari, Juan P. (Universitat Internacional de Catalunya) ;
Vargas, Liliana (Universitat Internacional de Catalunya) ;
López-Cuevas, Rogelio (Universitat Internacional de Catalunya) ;
Bojaryn, Urszula (Universitat Internacional de Catalunya) ;
Espinosa, Ana (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Ortega, Gemma (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Pérez-Cordón, Alba (Universitat Internacional de Catalunya) ;
Sanabria, Ángela (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Orellana, Adelina (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
De Rojas, Itziar (Universitat Internacional de Catalunya) ;
Moreno-Grau, Sonia (Universitat Internacional de Catalunya) ;
Montrreal, Laura (Universitat Internacional de Catalunya) ;
Alarcón-Martín, Emilio (Universitat Internacional de Catalunya) ;
Ruiz, Agustín (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Valero, Sergi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Introduction: Mild cognitive impairment is often associated with affective and other neuropsychiatric symptoms (NPS). This co-occurrence might have a relevant impact on disease progression, from MCI to dementia. [...]
2021 - 10.3389/fnagi.2021.718949
Frontiers in aging neuroscience, Vol. 13 (august 2021) , p. 718949
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