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11 p, 338.4 KB |
Early Macrophage Infiltration and Sustained Inflammation in Kidneys From Deceased Donors Are Associated With Long-Term Renal Function
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Guillén-Gómez, E. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Dasilva, I. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Silva, Irene (Institut d'Investigació Biomèdica Sant Pau) ;
Arce, Yolanda (Institut d'Investigació Biomèdica Sant Pau) ;
Facundo, C. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Ars, Elisabet (Institut d'Investigació Biomèdica Sant Pau) ;
Breda, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Ortiz, A. (IIS-Fundación Jiménez Díaz/UAM. REDinREN) ;
Guirado, Luis (Institut d'Investigació Biomèdica Sant Pau) ;
Ballarín, J.A. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Díaz Encarnación, Montserrat Mercedes (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Kidney transplants from living donors (LDs) have a better outcome than those from deceased donors (DDs). Different factors have been suggested to justify the different outcome. In this study, we analyzed the infiltration and phenotype of monocytes/macrophages and the expression of inflammatory and fibrotic markers in renal biopsy specimens from 94 kidney recipients (60 DDs and 34 LDs) at baseline and 4 months after transplantation. [...]
2017 -  10.1111/ajt.13998
American Journal of Transplantation, Vol. 17 Núm. 3 (january 2017) , p. 733-743
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25 p, 6.3 MB |
Principles of 3D chromosome folding and evolutionary genome reshuffling in mammals
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Álvarez-González, Lucía (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Arias-Sardá, Cristina (University of Kent. School of Biosciences) ;
Montes-Espuña, Laia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Marin Gual, Laia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Vara González, Covadonga (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Lister, Nicholas C. (University of New South Wales. School of Biotechnology and Biomolecular Sciences) ;
Cuartero, Yasmina (Centre de Regulació Genòmica) ;
García, Francisca (Universitat Autònoma de Barcelona. Servei de Cultius Cel·lulars, Producció d'Anticossos i Citometria) ;
Deakin, Janine (University of Canberra. Institute for Applied Ecology) ;
Renfree, Marilyn B. (The University of Melbourne. School of Biosciences) ;
Robinson, Terence J. (Stellenbosch University. Department of Botany and Zoology) ;
Martí-Renom, Marc A. (Centre de Regulació Genòmica) ;
Waters, Paul D. (University of New South Wales. School of Biotechnology and Biomolecular Sciences) ;
Farré, Marta (University of Kent. School of Biosciences) ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Studying the similarities and differences in genomic interactions between species provides fertile grounds for determining the evolutionary dynamics underpinning genome function and speciation. Here, we describe the principles of 3D genome folding in vertebrates and show how lineage-specific patterns of genome reshuffling can result in different chromatin configurations. [...]
2022 - 10.1016/j.celrep.2022.111839
Cell reports, Vol. 41, Issue 12 (December 2022) , art. 111839
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3.
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13 p, 3.4 MB |
TEMPRANILLO homologs in apple regulate flowering time in the woodland strawberry Fragaria vesca
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Dejahang, Ata (National Institute of Genetic Engineering and Biotechnology. Department of Plant Biotechnology (Iran)) ;
Maghsoudi, Naeimeh (University of Tabriz. Department of Horticultural Sciences) ;
Mousavi, Amir (National Institute of Genetic Engineering and Biotechnology. Department of Plant Biotechnology (Iran)) ;
Farsad-Akhtar, Nader (University of Tabriz. Department of Plant Biology) ;
Matias-Hernandez, Luis (Centre de Recerca en Agrigenòmica) ;
Pelaz, Soraya (Centre de Recerca en Agrigenòmica) ;
Folta, Kevin (University of Florida. Horticultural Sciences Department) ;
Mahna, Nasser (Centre de Recerca en Agrigenòmica)
The long juvenile period of fruit trees makes their breeding costly and time-consuming. Therefore, flowering time engineering and shortening the juvenile phase have become a breeding priority for the genetic improvement of fruit tree crops. [...]
2023 - 10.1038/s41598-023-29059-0
Scientific reports, Vol. 13 (February 2023) , art. 1968
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4.
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10 p, 3.2 MB |
Differential toxicity profile of secreted and processed α-Klotho expression over mineral metabolism and bone microstructure
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Roig-Soriano, Joan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Sánchez-de-Diego, Cristina (Hospital Universitari de Bellvitge) ;
Esandi-Jauregui, Jon (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Verdés, Sergi (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Abraham, Carmela R (Boston University School of Medicine) ;
Bosch i Merino, Assumpció (Hospital Universitari Vall d'Hebron) ;
Ventura, Francesc (Hospital Universitari de Bellvitge) ;
Chillón Rodríguez, Miguel (Hospital Universitari Vall d'Hebron)
The aging-protective gene α-Klotho (KL) produces two main transcripts. The full-length mRNA generates a transmembrane protein that after proteolytic ectodomain shedding can be detected in serum as processed Klotho (p-KL), and a shorter transcript which codes for a putatively secreted protein (s-KL). [...]
2023 - 10.1038/s41598-023-31117-6
Scientific reports, Vol. 13 (march 2023)
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28 p, 4.0 MB |
Mycobacterium manresensis induces trained immunity in vitro
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de Homdedeu, Miquel (Hospital Universitari Vall d'Hebron) ;
Sanchez-Moral, Lidia (Institut Germans Trias i Pujol) ;
Violán, Concepció (Universitat Autònoma de Barcelona) ;
Ràfols, Neus (Institut Germans Trias i Pujol) ;
Ouchi, Dan (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Martín, Berta (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Peinado, Miguel A. (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Rodriguez-Cortes, Alheli (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Arch Sisquella, Marta (Institut Germans Trias i Pujol) ;
Perez-Zsolt, Daniel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Muñoz-Basagoiti, Jordana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo Useros, Nuria (Centre for Biomedical Research on Infectious Diseases) ;
Salvador, Betlem (Jordi Gol University Research Institute in Primary Care) ;
Matllo, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
López-Serrano, Sergi (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Segalés Coma, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Vilaplana, Cristina (Direcció Clínica Territorial de Malalties Infeccioses i Salut Internacional de Gerència Territorial Metropolitana Nord) ;
Torán-Montserrat, Pere (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Morros, Rosa (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Monfà, Ramon (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Sarrias, Maria-Rosa (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Cardona, Pere-Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The COVID-19 pandemic posed a global health crisis, with new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants weakening vaccine-driven protection. Trained immunity could help tackle COVID-19 disease. [...]
2023 - 10.1016/j.isci.2023.106873
iScience, Vol. 26 (may 2023) , p. 106873
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17 p, 16.8 MB |
Expression strategies for the efficient synthesis of antimicrobial peptides in plastids
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Hoelscher, Matthijs P. (Utrecht University) ;
Forner, Joachim (Max-Planck-Institut für Molekulare Pflanzenphysiologie) ;
Calderone, Silvia (Centre de Recerca en Agrigenòmica) ;
Krämer, Carolin (Max-Planck-Institut für Molekulare Pflanzenphysiologie) ;
Taylor, Zachary (Max-Planck-Institut für Molekulare Pflanzenphysiologie) ;
Loiacono, F. Vanessa (Max-Planck-Institut für Molekulare Pflanzenphysiologie) ;
Agrawal, Shreya (Neoplants (Gif-sur-Yvette)) ;
Karcher, Daniel (Max-Planck-Institut für Molekulare Pflanzenphysiologie) ;
Moratti, Fabio (Max-Planck-Institut für Molekulare Pflanzenphysiologie) ;
Kroop, Xenia (Max-Planck-Institut für Molekulare Pflanzenphysiologie) ;
Bock, Ralph (Max-Planck-Institut für Molekulare Pflanzenphysiologie)
Antimicrobial peptides (AMPs) kill microbes or inhibit their growth and are promising next-generation antibiotics. Harnessing their full potential as antimicrobial agents will require methods for cost-effective large-scale production and purification. [...]
2022 - 10.1038/s41467-022-33516-1
Nature communications, Vol. 13 (October 2022) , art. 5856
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7.
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15 p, 4.7 MB |
Pollen tube emergence is mediated by ovary-expressed ALCATRAZ in cucumber
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Cheng, Zhihua (China Agricultural University) ;
Liu, Xiaofeng (China Agricultural University) ;
Yan, Shuangshuang (China Agricultural University) ;
Liu, Bin (Centre de Recerca en Agrigenòmica) ;
Zhong, Yanting (China Agricultural University) ;
Song, Weiyuan (China Agricultural University) ;
Chen, Jiacai (China Agricultural University) ;
Wang, Zhongyi (China Agricultural University) ;
Che, Gen (China Agricultural University) ;
Liu, Liu (China Agricultural University) ;
Ying, Ao (China Agricultural University) ;
Lv, Hanli (China Agricultural University) ;
Han, Lijie (China Agricultural University) ;
Li, Min (China Agricultural University) ;
Zhao, Jianyu (China Agricultural University) ;
Xu, Junqiang (Yunnan Agricultural University) ;
Yang, Zhengan (Yunnan Agricultural University) ;
Zhou, Zhaoyang (China Agricultural University) ;
Zhang, Xiaolan (China Agricultural University)
Pollen tube guidance within female tissues of flowering plants can be divided into preovular guidance, ovular guidance and a connecting stage called pollen tube emergence. As yet, no female factor has been identified to positively regulate this transition process. [...]
2023 - 10.1038/s41467-023-35936-z
Nature communications, Vol. 14 (January 2023) , art. 258
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11 p, 1.5 MB |
The frequency of defective genomes in Omicron differs from that of the Alpha, Beta and Delta variants
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Campos, Carolina (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Colomer-Castell, Sergi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Garcia-Cehic, D. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Gregori i Font, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andrés, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Piñana, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
González-Sánchez, Alejandra (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Borras Bermejo, Blanca (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Parés-Badell, Oleguer (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Adombi, Caroline Melanie (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ibañez-Lligoña, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esperalba, Juliana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Codina, María Gema (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ;
Saubí, Narcis (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteban Mur, Juan Ignacio (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pumarola Suñé, Tomàs (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Antón, Andrés (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Quer, Josep 1963- (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The SARS-CoV-2 Omicron variant emerged showing higher transmissibility and possibly higher resistance to current COVID-19 vaccines than other variants dominating the global pandemic. In March 2020 we performed a study in clinical samples, where we found that a portion of genomes in the SARS-CoV-2 viral population accumulated deletions immediately before the S1/S2 cleavage site (furin-like cleavage site, PRRAR/S) of the spike gene, generating a frameshift and appearance of a premature stop codon. [...]
2022 - 10.1038/s41598-022-24918-8
Scientific reports, Vol. 12 (december 2022)
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15 p, 1.7 MB |
Effect of cryoprotectant concentration on bovine oocyte permeability and comparison of two membrane permeability modelling approaches
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Garcia Martinez, Tania (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Mogas Amorós, Teresa (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Mullen, Steven F. (COOK Medical) ;
Martínez-Rodero, Iris (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Gulieva, Ramila E. (Oregon State University. School of Chemical, Biological and Environmental Engineering) ;
Higgins, Adam Z. (Oregon State University. School of Chemical, Biological and Environmental Engineering)
The plasma membrane permeability to water and cryoprotectant (CPA) significantly impacts vitrification efficiency of bovine oocytes. Our study was designed to determine the concentration-dependent permeability characteristics for immature (GV) and mature (MII) bovine oocytes in the presence of ethylene glycol (EG) and dimethyl sulphoxide (MeSO), and to compare two different modeling approaches: the two parameter (2P) model and a nondilute transport model. [...]
2021 - 10.1038/s41598-021-94884-0
Scientific reports, Vol. 11 (july 2021)
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