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21 p, 4.8 MB |
Different Structures-Similar Effect : Do Substituted 5-(4-Methoxyphenyl)-1 H -indoles and 5-(4-Methoxyphenyl)-1 H -imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15?
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Zhuravlev, Alexander (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ;
Cruz Saez, Alejandro (Universitat Autònoma de Barcelona. Departament de Química) ;
Aksenov, Vladislav (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry) ;
Golovanov, Alexey (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ;
Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Kuhn, Hartmut (Charite-University Medicine Berlin. Department of Biochemistry) ;
González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ivanov, Igor (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies)
Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer and inflammation models. The pathophysiological role of linoleic acid- and arachidonic acid-derived ALOX15 metabolites rendered this enzyme a target for pharmacological research. [...]
2023 -  10.3390/molecules28145418
Molecules, Vol. 28, Issue 14 (July 2023) , art. 5418
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2.
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29 p, 20.1 MB |
Hydroperoxidation of Docosahexaenoic Acid by Human ALOX12 and pigALOX15-mini-LOX
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Canyelles-Niño, Miquel (Universitat Autònoma de Barcelona. Departament de Química) ;
González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Human lipoxygenase 12 (hALOX12) catalyzes the conversion of docosahexaenoic acid (DHA) into mainly 14S-hydroperoxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid (14S-H(p)DHA). This hydroperoxidation reaction is followed by an epoxidation and hydrolysis process that finally leads to maresin 1 (MaR1), a potent bioactive specialized pro-resolving mediator (SPM) in chronic inflammation resolution. [...]
2023 - 10.3390/ijms24076064
International journal of molecular sciences, Vol. 24, Issue 7 (April 2023) , art. 6064
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11 p, 1.1 MB |
Heterogeneous Microscopic Dynamics of Intruded Water in a Superhydrophobic Nanoconfinement : Neutron Scattering and Molecular Modeling
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Wolanin, Julie (Université Grenoble Alpes) ;
Michel, Lucas 1923- (Université Grenoble Alpes) ;
Tabacchioni, D. (Université Grenoble Alpes) ;
Zanotti, Jean-Marc (Université Paris-Saclay) ;
Peters, Jens-Uwe (Institut Laue Langevin) ;
Imaz, Inhar (Institut Català de Nanociència i Nanotecnologia) ;
Coasne, Benoit (Université Grenoble Alpes) ;
Plazanet, Marie (Université Grenoble Alpes) ;
Picard, Cyril (Université Grenoble Alpes)
With their strong confining porosity and versatile surface chemistry, zeolitic imidazolate frameworks-including the prototypical ZIF-8-display exceptional properties for various applications. In particular, the forced intrusion of water at high pressure (∼25 MPa) into ZIF-8 nanopores is of interest for energy storage. [...]
2021 - 10.1021/acs.jpcb.1c06791
Journal of physical chemistry B, Vol. 125, Num. 36 (September 2021) , p. 10392-10399
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14 p, 12.6 MB |
Rational Design of Hydrogels for Cationic Antimicrobial Peptide Delivery : A Molecular Modeling Approach
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Pereira, Alfredo (Universidad de Chile) ;
Valdés-Muñoz, Elizabeth (Universidad Católica del Maule) ;
Marican, Adolfo (Universidad de Talca) ;
Cabrera-Barjas, Gustavo (Universidad de Concepción) ;
Vijayakumar, Sekar (Shandong University) ;
Valdés, Oscar (Universidad Católica del Maule) ;
Rafael, Diana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andrade, Fernanda (Universitat de Barcelona. Departament de Farmàcia i Tecnologia Farmacèutica, i Fisicoquímica) ;
Abaca, Paulina (Universidad de Talca. Instituto Ciencias Biologicas) ;
Bustos, Daniel (Universidad Católica del Maule) ;
Durán-Lara, Esteban F. (Universidad de Talca) ;
Universitat Autònoma de Barcelona
In light of the growing bacterial resistance to antibiotics and in the absence of the development of new antimicrobial agents, numerous antimicrobial delivery systems over the past decades have been developed with the aim to provide new alternatives to the antimicrobial treatment of infections. [...]
2023 - 10.3390/pharmaceutics15020474
Pharmaceutics, Vol. 15 (january 2023)
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6.
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8 p, 4.8 MB |
Ammonia capture in rhodium(II)-based metal-organic polyhedra via synergistic coordinative and H-bonding interactions
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Carné-Sánchez, Arnau (Institut Català de Nanociència i Nanotecnologia) ;
Martínez-Esaín, Jordi (Institut Català de Nanociència i Nanotecnologia) ;
Rookard, Tanner (Oregon State University. Department of Chemistry) ;
Flood, Christopher J. (Oregon State University. Department of Chemistry) ;
Faraudo, Jordi (Institut de Ciència de Materials de Barcelona) ;
Stylianou, Kyriakos C (Oregon State University. Department of Chemistry) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia)
Ammonia (NH) is among the world's most widely produced bulk chemicals, given its extensive use in diverse sectors such as agriculture; however, it poses environmental and health risks at low concentrations. [...]
2023 - 10.1021/acsami.2c19206
ACS applied materials & interfaces, Vol. 15, issue 5 (Feb. 2023) , p. 6747-6754
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40 p, 1.1 MB |
Computational design of molecularly imprinted polymer for direct detection of melamine in milk
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Bates, Ferdia (Universitat Autònoma de Barcelona. Departament de Química) ;
Busato, Mirko (University of Verona. Department of Biotechnology) ;
Piletska, Elena (University of Leicester. Department of Chemistry) ;
Whitcombe, Michael J. (University of Leicester. Department of Chemistry) ;
Karim, Kal (University of Leicester. Department of Chemistry) ;
Guerreiro, Antonio (University of Leicester. Department of Chemistry) ;
Valle Zafra, Manuel del (Universitat Autònoma de Barcelona. Departament de Química) ;
Giorgetti, Alejandro (University of Verona. Department of Biotechnology) ;
Piletsky, Sergey (University of Leicester. Department of Chemistry)
A novel protocol for use of molecularly imprinted polymer (MIP) in analysis of melamine is presented. Design of polymer for melamine has been achieved using a combination of computational techniques and laboratory trials, the former greatly reducing the duration of the latter. [...]
2017 - 10.1080/01496395.2017.1287197
Separation Science and Technology, Vol. 52, Issue 8 (March 2017) , p. 1441-1453
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8 p, 829.7 KB |
Strong suppression of thermal conductivity in the presence of long terminal alkyl chains in low-disorder molecular semiconductors
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Selezneva, Ekaterina (University of Cambridge. Optoelectronics Group) ;
Vercouter, Alexandre (University of Mons. Laboratory for Chemistry of Novel Materials) ;
Schweicher, Guillaume (University of Cambridge. Optoelectronics Group) ;
Lemaur, Vincent (University of Mons. Laboratory for Chemistry of Novel Materials) ;
Broch, Katharina (Universität Tübingen. Institut für Angewandte Physik) ;
Antidormi, Aleandro (Institut Català de Nanociència i Nanotecnologia) ;
Takimiya, Kazuo (RIKEN Center for Emergent Matter Science) ;
Coropceanu, Veaceslav (Georgia Institute of Technology. School of Chemistry and Biochemistry) ;
Brédas, Jean-Luc (The University of Arizona. Department of Chemistry and Biochemistry) ;
Melis, Claudio (Universita di Cagliari. Dipartimento di Fisica) ;
Cornil, Jerome (University of Mons. Laboratory for Chemistry of Novel Materials) ;
Sirringhaus, Henning (University of Cambridge. Optoelectronics Group)
While the charge transport properties of organic semiconductors have been extensively studied over the recent years, the field of organics-based thermoelectrics is still limited by a lack of experimental data on thermal transport and of understanding of the associated structure-property relationships. [...]
2021 - 10.1002/adma.202008708
Advanced materials, Vol. 33, issue 37 (Sep. 2021) , art. 2008708
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8 p, 2.8 MB |
Emerging properties of non-crystalline phases of graphene and boron nitride based materials
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Antidormi, Aleandro (Institut Català de Nanociència i Nanotecnologia) ;
Colombo, Luigi (The University of Texas at Dallas. Department of Materials Science and Engineering) ;
Roche, Stephan (Institut Català de Nanociència i Nanotecnologia)
We review recent developments on the synthesis and properties of two-dimensional materials which, although being mainly of an sp bonding character, exhibit highly disordered, non-uniform and structurally random morphologies. [...]
2022 - 10.1016/j.nanoms.2021.03.003
Nano Materials Science, Vol. 4, issue 1 (March 2022) , p. 10-17
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