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18 p, 1.1 MB |
Motor Fluctuations Development Is Associated with Non-Mostor Symptoms Burden Progression in Parkinson's Disease Patients : A 2-Year Follow-Up Study
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Santos-García, D. (Complejo Hospitalario Universitario de A Coruña (CHUAC)) ;
Deus Fonticoba, T.D. (Complejo Hospitalario Universitario de Ferrol) ;
Bartolomé, C.C. (Complejo Hospitalario Universitario de A Coruña (CHUAC)) ;
Feal Painceiras, M.J. (Complejo Hospitalario Universitario de A Coruña (CHUAC)) ;
Castro, E.S. (Complejo Hospitalario Universitario de Ferrol) ;
Canfield, H. (Complejo Hospitalario Universitario de Ferrol) ;
Miró, C.M. (Complejo Hospitalario Universitario de A Coruña (CHUAC)) ;
Jesús, S. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Aguilar, M. (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Pastor, P. (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Planellas, Lluis (Hospital Clínic i Provincial de Barcelona) ;
Cosgaya, Marina (Hospital Clínic i Provincial de Barcelona) ;
Caldentey, J.G. ;
Caballol, Nuria (Hospital de Sant Joan Despí Moisès Broggi) ;
Legarda, I. (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Hernández-Vara, Jorge (Hospital Universitari Vall d'Hebron) ;
Cabo, I. (Complejo Hospitalario Universitario de Pontevedra) ;
Manzanares, L.L. (Hospital Universitario de la Princesa (Madrid)) ;
Aramburu, I.G. (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Ávila Rivera, M.A. (Consorci Sanitari Integral. Hospital General de L'Hospitalet) ;
Mayordomo, V.G. (Hospital Universitario Clínico San Carlos (Madrid)) ;
Nogueira, V. (Hospital Da Costa) ;
Puente, Víctor (Hospital del Mar (Barcelona, Catalunya)) ;
García-Soto, J.D. (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Borrué, C. (Hospital Universitario Infanta Sofía (San Sebastián de los Reyes)) ;
Vila, B.S. (Institut Català de la Salut) ;
Sauco, M.Á. (Hospital General Universitario de Elche) ;
Vela, L. (Hospital Universitario Fundación Alcorcón) ;
Escalante, S. (Hospital de Tortosa Verge de la Cinta) ;
Cubo, E. (Complejo Asistencial Universitario de Burgos) ;
Padilla, F.C. (Hospital Universitario de Canarias (La Laguna)) ;
Martínez Castrillo, J.C. (Hospital Universitario Ramón y Cajal (Madrid)) ;
Alonso, P.S. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Alonso Losada, M.G. (Hospital Álvaro Cunqueiro (Vigo)) ;
Ariztegui, N.L. (Complejo Hospitalario de Toledo) ;
Gastón, I. (Complejo Hospitalario de Navarra) ;
Kulisevsky, Jaime (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Blázquez Estrada, M. (Hospital Universitario Central de Asturias) ;
Seijo, M. (Complejo Hospitalario Universitario de Pontevedra) ;
Martínez, J.R. (Hospital de Donostia (Sant Sebastià, País Basc)) ;
Valero, C. (Hospital Arnau de Vilanova (València)) ;
Kurtis, M. (Hospital Ruber Internacional) ;
Fàbregues-Boixar i Nebot, Oriol de (Hospital Universitari Vall d'Hebron) ;
Ardura, J.G. (Hospital Universitario de Cabueñes (Gijón)) ;
Redondo, R.A. (Hospital Universitario Lucus Augusti (Lugo)) ;
Ordás, C. (Hospital Universitario Rey Juan Carlos (Madrid)) ;
López Díaz, L.M. (Complejo Hospitalario Universitario de Ourense) ;
McAfee, D. (University of Maryland School of Medicine) ;
Martinez-Martin, P. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Mir, P. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Santacruz, Pilar (Hospital Clínic i Provincial de Barcelona) ;
Pascual-Sedano, Berta María (Institut d'Investigació Biomèdica Sant Pau) ;
Pagonabarraga Mora, Javier (Institut d'Investigació Biomèdica Sant Pau) ;
Martí, Maria José (Hospital Clínic i Provincial de Barcelona) ;
Martí-Andres, Gloria (Hospital Universitari Vall d'Hebron) ;
Lucas-del-Pozo, Sara (Hospital Universitari Vall d'Hebron) ;
Horta, Andrea (Institut d'Investigació Biomèdica Sant Pau) ;
Crespo Cuevas, Ane Miren (Hospital del Mar (Barcelona, Catalunya)) ;
Cámara Lorenzo, Ana (Hospital Clínic i Provincial de Barcelona) ;
Bejr-kasem, Helena (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Universitat Autònoma de Barcelona
The aim of the present study was to analyze the progression of non-motor symptoms (NMS) burden in Parkinson's disease (PD) patients regarding the development of motor fluctuations (MF). PD patients without MF at baseline, who were recruited from January 2016 to November 2017 (V0) and evaluated again at a 2-year follow-up (V2) from 35 centers of Spain from the COPPADIS cohort, were included in this analysis. [...]
2022 -  10.3390/diagnostics12051147
Diagnostics, Vol. 12 Núm. 5 (may 2022) , p. 1147
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4 p, 200.3 KB |
Multiple lifestyle risk behaviours and excess weight among adolescents in Barcelona, Spain Múltiples conductas de riesgo y exceso de peso en adolescentes de Barcelona, España
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Continente, Xavier (Institut d'Investigació Biomèdica Sant Pau) ;
Pérez Giménez, Anna (Institut d'Investigació Biomèdica Sant Pau) ;
Espelt, Albert 1981- (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Ariza, Carles (Institut d'Investigació Biomèdica Sant Pau) ;
López Medina, María José (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
We aimed to analyse the prevalence of having multiple lifestyle risk behaviours (LRB) and the potential relationship between excess weight (including overweight and obesity) and cumulative multiple LRB among adolescents in Barcelona, Spain. [...]
2017 - 10.1016/j.gaceta.2017.01.003
Gaceta sanitaria, Vol. 31 Núm. 4 (julio 2017) , p. 332-335
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8 p, 826.6 KB |
Levodopa-carbidopa intestinal gel in advanced Parkinson's : Final results of the GLORIA registry
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Antonini, Angelo (University of Padua) ;
Poewe, Werner (Medical University of Innsbruck) ;
Chaudhuri, K.Ray (King's College and King's College Hospital) ;
Jech, Robert (General University Hospital in Prague) ;
Pickut, Barbara (Michigan State University) ;
Pirtošek, Zvezdan (University Medical Center Ljubljana) ;
Szasz, Jozsef (University of Medicine and Pharmacy Tirgu-Mures) ;
Valldeoriola, Francesc (Hospital Clínic i Provincial de Barcelona) ;
Winkler, Christian (Lindenbrunn Hospital) ;
Bergmann, Lars (AbbVie Inc.) ;
Yegin, Ashley (AbbVie Inc.) ;
Onuk, Koray (AbbVie Inc.) ;
Barch, David (AbbVie Inc.) ;
Odin, Per (Lund University) ;
Amalia, Ene (University Emergency Hospital) ;
Arnold, Guy (Sindelfingen Hospital) ;
Bajenaru, Ovidiu (University of Medicine and Pharmacy "Carol Davila") ;
Bergmans, Bruno (AZ St-Jan Brugge-Oostende AV) ;
Bjornara, Kari Anne (Drammen Hospital) ;
Blackie, Jeff (John Hunter Hospital) ;
Bode, Matthias (Odense University Hospital (Dinamarca)) ;
Bourgeois, Paul (Department of Neurology AZ Groeninge) ;
Bohlhalter, Stephan (Neurology and Neurorehabilitation Center) ;
Buraga, Ioan (Colentina Hospital) ;
Burkhard, Pierre R. (Geneva University Hospitals) ;
Busson, Philippe (Centre Hospitalier Avranches Granvilles) ;
Calopa, Matilde (Hospital Universitari de Bellvitge) ;
Clausen, Jesper (Rigshospitalet/Glostup) ;
Danielsen, Erik Hvid (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Defebvre, Luc (Université of Lille) ;
Delvaux, Valerie (University of Liege) ;
Dethy, Sophie (Chu-Tivoli) ;
Dietrichs, Espen (University of Oslo) ;
Fàbregues-Boixar i Nebot, Oriol de (Hospital Universitari Vall d'Hebron) ;
Gerhard, Ransmayr (Kepler University Hospital) ;
Gusmaroli, Graziano (Ospedale degli Infermi di Biella) ;
Hahn, Kirsten ;
Hauptmann, Björn (Neurologisches Zentrum) ;
Henriksen, Tove (University Hospital of Bispebjerg) ;
Hernández-Vara, Jorge (Hospital Universitari Vall d'Hebron) ;
Jeanjean, A. (Université catholique de Louvain) ;
Kaiserova, Michaela (Palacky University) ;
Kassubek, Jan (University of Ulm) ;
Kimber, Thomas (University of Adelaide) ;
Konitsiotis, Spyridon (University of Ioannina) ;
Krüger, Rejko (University of Tübingen) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Leenders, Jo (Sint-Dimpa Ziekenhuis) ;
Lundqvist, Christofer (Akershus University Hospital) ;
Ory Magne, F. (Toulouse University Hospital) ;
Marano, Pietro (Nuova Casa di Cura D'Anna) ;
Milanov, Ivan (University Neurological Hospital "St. Naum") ;
Modugno, Nicola (IRCCS Neuromed) ;
Misbahuddin, Anjum (Essex Centre for Neurological Sciences) ;
Nevrly, Martin (University Hospital and Faculty of Medicine and Dentistry of Palacky University) ;
Panayiotis, Zikos (251 Hellenic Air Force Hospital) ;
Pedersen, Kenn Freddy (Stavanger University Hospital) ;
Pedersen, Stephen W. (Glostrup Hospital University of Copenhagen) ;
Perju-Dumbrava, Lacramioara (University of Medicine and Pharmacy "Iuliu Hatieganu") ;
Ponsen, M.M. (Meander Medical Center) ;
Popescu, Bogdan O. (Carol Davila University of Medicine and Pharmacy) ;
Rijntjes, Michel (University Clinic Freiburg) ;
Puente, V. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Redecker, Christoph (Jena University Hospital (Alemania)) ;
Schrader, Christoph (Hannover Medical School) ;
Sensi, Mariachiara (Arcispedale S.Anna) ;
Simu, Michaela (UMF"Victor Babes") ;
Spanaki, Cleanthe (University of Crete) ;
Storch, Alexander (University of Rostock) ;
Storstein, Anette (Haukeland University Hospital (Bergen, Noruega)) ;
Tomantschger, Volker (Gailtal-Klinik Hermagor) ;
van der Linden, Chris (St. Lucas Hospital Ghent) ;
van Laar, T. (University Medical Center Groningen) ;
Viallet, F. (CH du pays d'Aix) ;
Witjas, Tatiana (University Hospital Timone) ;
Wolz, Martin (Elblandklinikum Meissen) ;
Zibetti, Maurizio (University of Torino) ;
Van Zandijcke, Michel (AZ Sint-Jan Brugge) ;
Universitat Autònoma de Barcelona
This registry evaluated the 24-month safety and efficacy of levodopa-carbidopa intestinal gel (LCIG) treatment in advanced Parkinson's disease (PD) patients under routine clinical care. Motor fluctuations, dyskinesia, non-motor symptoms, quality of life, and safety were evaluated. [...]
2017 - 10.1016/j.parkreldis.2017.09.018
Parkinsonism and Related Disorders, Vol. 45 (december 2017) , p. 13-20
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36 p, 1.1 MB |
New Pieces for an Old Puzzle : Approaching Parkinson's Disease from Translatable Animal Models, Gut Microbiota Modulation, and Lipidomics
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Ortega Moreno, Lorena (University Rey Juan Carlos) ;
Bagues, Ana (University Rey Juan Carlos) ;
Martínez Perea, Vicente (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Abalo, Raquel (University Rey Juan Carlos) ;
Universitat Autònoma de Barcelona.
Institut de Neurociències
Parkinson's disease (PD) is a severe neurodegenerative disease characterized by disabling motor alterations that are diagnosed at a relatively late stage in its development, and non-motor symptoms, including those affecting the gastrointestinal tract (mainly constipation), which start much earlier than the motor symptoms. [...]
2023 - 10.3390/nu15122775
Nutrients, Vol. 15, Num. 12 (June 2023) , art. 2775
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13 p, 3.5 MB |
Proteomic Analysis of Human iPSC-Derived Neural Stem Cells and Motor Neurons Identifies Proteasome Structural Alterations
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Álvarez Pérez, Iñaki (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Tirado-Herranz, Adrián (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Alvarez-Palomo, Belén (Banc de Sang i Teixits (Barcelona, Catalunya)) ;
Osete, Jordi Requena (Oslo University Hospital (Oslo, Noruega)) ;
Edel, Michael J (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques)
Background: Proteins targeted by the ubiquitin proteasome system (UPS) are identified for degradation by the proteasome, which has been implicated in the development of neurodegenerative diseases. Major histocompatibility complex (MHC) molecules present peptides broken down by the proteasome and are involved in neuronal plasticity, regulating the synapse number and axon regeneration in the central or peripheral nervous system during development and in brain diseases. [...]
2023 - 10.3390/cells12242800
Cells, Vol. 12 (december 2023)
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11 p, 265.1 KB |
Safinamide in clinical practice : A Spanish multicenter cohort study
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Martí-Andrés, Gloria (Clínica Universidad de Navarra) ;
Jiménez-Bolaños, Rayco (Hospital Universitario Insular de Gran Canaria) ;
Arbelo, José Matías (Hospital Universitario Insular de Gran Canaria) ;
Pagonabarraga Mora, Javier (Institut d'Investigació Biomèdica Sant Pau) ;
Duran-Herrera, Carmen (Hospital Universitario de Badajoz) ;
Valenti-Azcarate, Rafael (Clínica Universidad de Navarra) ;
Luquin, Maria-Rosario (Clínica Universidad de Navarra) ;
Universitat Autònoma de Barcelona
Safinamide is an approved drug for the treatment of motor fluctuations of Parkinson's Disease (PD) patients with a potential benefit on non-motor symptoms (NMS). A retrospective multicenter cohort study was conducted, in which the clinical effect of safinamide on both motor and NMS was assessed by the Clinical Global Impression of Change scale. [...]
2019 - 10.3390/brainsci9100272
Brain sciences, Vol. 9 Núm. 10 (october 2019) , p. 272
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8 p, 391.2 KB |
Comparison of the Results of a Parkinson's Holter Monitor With Patient Diaries, in Real Conditions of Use : A Sub-analysis of the MoMoPa-EC Clinical Trial
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Pérez-López, Carlos (Consorci Sanitari de l'Alt Penedès i Garraf. Department of Investigation) ;
Hernández-Vara, Jorge (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Caballol, Nuria (Hospital Quirón-Teknon. Unitat de Parkinson i Trastorns del moviment) ;
Bayés, Àngels (Hospital Quirón-Teknon. Unitat de Parkinson i Trastorns del moviment) ;
Buongiorno, María Teresa (Hospital Universitari Mútua Terrassa. Servei de Neurologia) ;
Lopez-Ariztegui, Núria (Hospital Universitario de Toledo. Servicio de Neurología) ;
Gironell, Alexandre (Institut d'Investigació Biomèdica Sant Pau) ;
López-Sánchez, José (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Martínez-Castrillo, Juan Carlos (Hospital Ramón y Cajal. Unidad de Trastornos del Movimiento y Enfermedades Neurodegenerativas. IRYCIS) ;
Alvarez Sauco M. (Hospital General de Elche. Servicio de Neurología) ;
López-Manzanares, Lydia (Hospital Universitario de la Princesa. Servicio de Neurología) ;
Escalante-Arroyo, Sonia (Hospital de Tortosa Verge de la Cinta. Servicio de Neurología) ;
Pérez-Martínez, David A. (Hospital Universitario 12 de Octubre. Servicio de Neurología) ;
Rodríguez-Molinero, Alejandro (Consorci Sanitari de l'Alt Penedès i Garraf) ;
Universitat Autònoma de Barcelona
Background: For specialists in charge of Parkinson's disease (PD), one of the most time-consuming tasks of the consultations is the assessment of symptoms and motor fluctuations. This task is complex and is usually based on the information provided by the patients themselves, which in most cases is complex and biased. [...]
2022 - 10.3389/fneur.2022.835249
Frontiers in neurology, Vol. 13 (May 2022) , p. 835249
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13 p, 1.7 MB |
Voluntary Modulation of Evoked Responses Generated by Epidural and Transcutaneous Spinal Stimulation in Humans with Spinal Cord Injury
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Calvert, Jonathan S. (Mayo Clinic) ;
Gill, Megan L. (Mayo Clinic) ;
Linde, Margaux B. (Mayo Clinic) ;
Veith, Daniel D. (Mayo Clinic) ;
Thoreson, Andrew R. (Mayo Clinic) ;
Lopez, Cesar (Mayo Clinic) ;
Lee, Kendall H. (Mayo Clinic) ;
Gerasimenko, Yury P. (University of Louisville) ;
Edgerton, Victor (Institut Germans Trias i Pujol. Institut Guttmann) ;
Lavrov, Igor A. (Mayo Clinic) ;
Zhao, Kristin D. (Mayo Clinic) ;
Grahn, Peter J. (Mayo Clinic) ;
Sayenko, Dimitry G. (Houston Methodist Research Institute) ;
Universitat Autònoma de Barcelona
Transcutaneous (TSS) and epidural spinal stimulation (ESS) are electrophysiological techniques that have been used to investigate the interactions between exogenous electrical stimuli and spinal sensorimotor networks that integrate descending motor signals with afferent inputs from the periphery during motor tasks such as standing and stepping. [...]
2021 - 10.3390/jcm10214898
Journal of clinical medicine, Vol. 10 (october 2021)
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1 p, 64.0 KB |
Corrigendum : EEG biomarkers related with the functional state of stroke patients
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Sebastián-Romagosa, Marc (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Udina i Bonet, Esther (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Ortner, Rupert (g.tec Medical Engineering Spain SL) ;
Dinarès-Ferran, Josep (Universitat de Vic - Universitat Central de Catalunya) ;
Cho, Woosang (g.tec Medical Engineering GmbH) ;
Murovec, Nensi (g.tec Medical Engineering GmbH) ;
Matencio-Peralba, Clara (g.tec Medical Engineering Spain SL) ;
Sieghartsleitner, Sebastian (g.tec Medical Engineering GmbH) ;
Allison, Brendan Z. (University of California at San Diego) ;
Guger, Christoph (g.tec Medical Engineering GmbH)
[This corrects the article DOI: 10. 3389/fnins. 2020. 00582. ].
2022 - 10.3389/fnins.2022.1032959
Frontiers in Neuroscience, Vol. 16 (september 2022)
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