Resultats globals: 42 registres trobats en 0.03 segons.
Articles, 30 registres trobats
Documents de recerca, 12 registres trobats
Articles 30 registres trobats  1 - 10següentfinal  anar al registre:
1.
14 p, 1.7 MB Reduced accuracy of MRI deep grey matter segmentation in multiple sclerosis : an evaluation of four automated methods against manual reference segmentations in a multi-center cohort / de Sitter, Alexandra (Amsterdam Neuroscience, Amsterdam UMC, Location VUmc. Department of Radiology and Nuclear Medicine, MS Center Amsterdam) ; Verhoeven, Tom (Amsterdam Neuroscience, Amsterdam UMC, Location VUmc. Department of Radiology and Nuclear Medicine, MS Center Amsterdam) ; Burggraaff, Jessica (Amsterdam Neuroscience, Amsterdam UMC, Location VUmc. Department of Neurology, MS Center Amsterdam) ; Liu, Yaou (Amsterdam Neuroscience, Amsterdam UMC, Location VUmc. Department of Radiology and Nuclear Medicine, MS Center Amsterdam) ; Simoes, Jorge (Amsterdam Neuroscience, Amsterdam UMC, Location VUmc. Department of Radiology and Nuclear Medicine, MS Center Amsterdam) ; Ruggieri, Serena (San Camillo Forlanini Hospital. Department of Neurosciences) ; Palotai, Miklos (Harvard Medical School. Center for Neurological Imaging, Department of Radiology, Brigham and Women's Hospital) ; Brouwer, Iman (Amsterdam Neuroscience, Amsterdam UMC, Location VUmc. Department of Radiology and Nuclear Medicine, MS Center Amsterdam) ; Versteeg, Adriaan (Amsterdam Neuroscience, Amsterdam UMC, Location VUmc. Department of Radiology and Nuclear Medicine, MS Center Amsterdam) ; Wottschel, Viktor (Amsterdam Neuroscience, Amsterdam UMC, Location VUmc. Department of Radiology and Nuclear Medicine, MS Center Amsterdam) ; Ropele, Stefan (Medical University of Graz. Department of Neurology) ; Rocca, Mara A. (IRCCS San Raffaele Scientific Institute. Neurology Unit) ; Gasperini, Claudio (San Camillo Forlanini Hospital. Department of Neurosciences) ; Gallo, Antonio (University of Campania "Luigi Vanvitelli". Division of Neurology and MRI Research Center, Department of Medical, Surgical, Neurologic, Metabolic and Aging Sciences) ; Yiannakas, Marios C. (University College London. Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology) ; Rovira, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Enzinger, Christian (University of Graz. Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology Medical) ; Filippi, Massimo (Vita-Salute San Raffaele University) ; De Stefano, Nicola (University of Siena. Department of Neurological and Behavioural Sciences) ; Kappos, Ludwig (University Hospital, Kantonsspital. Department of Neurology) ; Frederiksen, Jette L. (Glostrup University Hospital Copenhagen. Department of Neurology) ; Uitdehaag, Bernard M. J. (Amsterdam Neuroscience, Amsterdam UMC, Location VUmc. Department of Neurology, MS Center Amsterdam) ; Barkhof, Frederik (UCL London. Institutes of Neurology and Healthcare Engineering) ; Guttmann, Charles R. G. (Harvard Medical School. Center for Neurological Imaging, Department of Radiology, Brigham and Women's Hospital) ; Vrenken, Hugo (Amsterdam Neuroscience, Amsterdam UMC, Location VUmc. Department of Radiology and Nuclear Medicine, MS Center Amsterdam) ; Universitat Autònoma de Barcelona
Deep grey matter (DGM) atrophy in multiple sclerosis (MS) and its relation to cognitive and clinical decline requires accurate measurements. MS pathology may deteriorate the performance of automated segmentation methods. [...]
2020 - 10.1007/s00415-020-10023-1
Journal of Neurology, Vol. 267 (july 2020) , p. 3541-3554  
2.
12 p, 2.1 MB The long-term outcomes of CIS patients in the Barcelona inception cohort : Looking back to recognize aggressive MS / Tintoré, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Arrambide, Georgina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Otero-Romero, Susana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Río, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Tur, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Nos, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Arévalo, María Jesús (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Anglada, Elisenda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Menendez, Rebeca (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Midaglia, Luciana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Galán, Ingrid (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Castilló, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Mulero, P (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Zabalza, Ana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodríguez-Acevedo, Breogan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodriguez, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Espejo, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sequeira, Joao (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Mitjana, Raquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; de Barros, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pareto, Deborah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Auger, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pérez-Hoyos, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rovira, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
To explore the long-term outcomes of patients with clinically isolated syndromes from the Barcelona cohort. We selected patients with a follow-up longer than 10 years to (1) estimate the risks of multiple sclerosis (MS) and disability accumulation according to the baseline number of T2 lesions and to compare treated versus untreated patients and early versus delayed treatment, and (2) to study baseline features of patients with aggressive MS (Expanded Disability Status Scale (EDSS) ⩾6. [...]
2019 - 10.1177/1352458519877810
Multiple sclerosis, Vol. 26 (october 2019) , p. 1658-1669  
3.
14 p, 930.3 KB Aggressive multiple sclerosis (1) : Towards a definition of the phenotype / Iacobaeus, Ellen ; Arrambide, Georgina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Amato, Maria Pia ; Derfuss, Tobias ; Vukusic, Sandra ; Hemmer, Bernhard ; Tintoré, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Brundin, Lou ; Universitat Autònoma de Barcelona
While the major phenotypes of multiple sclerosis (MS) and relapsing-remitting, primary and secondary progressive MS have been well characterized, a subgroup of patients with an active, aggressive disease course and rapid disability accumulation remains difficult to define and there is no consensus about their management and treatment. [...]
2020 - 10.1177/1352458520925369
Multiple sclerosis, Vol. 26 (june 2020) , p. 1031-1044  
4.
19 p, 669.3 KB Aggressive multiple sclerosis (2) : Treatment / Arrambide, Georgina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Iacobaeus, Ellen ; Amato, Maria Pia ; Derfuss, Tobias ; Vukusic, Sandra ; Hemmer, Bernhard ; Brundin, Lou ; Tintoré, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
The natural history of multiple sclerosis (MS) is highly heterogeneous. A subgroup of patients has what might be termed aggressive MS. These patients may have frequent, severe relapses with incomplete recovery and are at risk of developing greater and permanent disability at the earlier stages of the disease. [...]
2020 - 10.1177/1352458520924595
Multiple sclerosis, Vol. 26 (june 2020) , p. 1045-1063  
5.
9 p, 776.0 KB Multiple sclerosis management during the COVID-19 pandemic / Moss, Brandon P ; Mahajan, Kedar R ; Bermel, Robert A ; Hellisz, Kelsey ; Hua, Le H ; Hudec, Timothy ; Husak, Scott ; McGinley, Marisa P ; Ontaneda, Daniel ; Wang, Zhini ; Weber, Malory ; Tagliani, Paula (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cárdenas-Robledo, Simón (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Zabalza, Ana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Arrambide, Georgina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodríguez-Barranco, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Tintoré, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Douglas, Morgan ; Ogbuokiri, Esther ; Aravidis, Berna ; Cohen, Jeffrey A ; Mowry, Ellen M ; Fitzgerald, Kathryn C ; Universitat Autònoma de Barcelona
People with multiple sclerosis (MS) may be at higher risk for complications from the 2019 coronavirus (COVID-19) pandemic due to use of immunomodulatory disease modifying therapies (DMTs) and greater need for medical services. [...]
2020 - 10.1177/1352458520948231
Multiple sclerosis, august 2020  
6.
12 p, 774.2 KB Kappa free light chains is a valid tool in the diagnostics of MS : A large multicenter study / Leurs, CE ; Twaalfhoven, HAM ; Lissenberg-Witte, BI ; van Pesch, V ; Dujmovic, I ; Drulovic, J ; Castellazzi, M ; Bellini, T ; Pugliatti, M ; Kuhle, J ; Villar, LM ; Alvarez-Cermeño, JC ; Alvarez-Lafuente, R ; Hegen, H ; Deisenhammer, F ; Walchhofer, LM ; Thouvenot, E ; Comabella, M (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Montalban, X (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vécsei, L ; Rajda, C ; Galimberti, D ; Scarpini, E ; Altintas, A ; Rejdak, K ; Frederiksen, JL ; Pihl-Jensen, G ; Jensen, PEH ; Khalil, M ; Voortman, MM ; Fazekas, F ; Saiz, Albert ; La Puma, D ; Vercammen, M ; Vanopdenbosch, L ; Uitdehaag, BMJ ; Killestein, J ; Bridel, C ; Teunissen, C ; Universitat Autònoma de Barcelona
To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS). We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. [...]
2019 - 10.1177/1352458519845844
Multiple sclerosis, Vol. 26 (may 2019) , p. 912-923  
7.
10 p, 1.6 MB Exome sequencing study in patients with multiple sclerosis reveals variants associated with disease course / Gil-Varea, Elia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Urcelay, Elena (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)) ; Vilariño-Güell, Carles (University of British Columbia. Department of Medical Genetics) ; Costa, Carme (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Midaglia, Luciana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Matesanz, Fuencisla (Instituto de Parasitología y Biomedicina "López Neyra", Consejo Superior de Investigaciones Científicas (IPBLN-CSIC). Department of Cell Biology and Immunology) ; Rodríguez-Antigüedad, Alfredo (Hospital Universitario Basurto-Osakidetza. Servicio de Neurología) ; Oksenberg, Jorge (University of California. Department of Neurology) ; Espino-Paisan, Laura (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)) ; Dessa Sadovnick, A. (University of British Columbia. Department of Medical Genetics) ; Saiz, Albert (Hospital Clinic and Institut d'Investigació Biomèdica Pi i Sunyer (IDIBAPS). Neurology Service) ; Villar, Luisa M. (Hospital Ramon y Cajal, (IRYCIS). Departments of Immunology and Neurology, Multiple Sclerosis Unit) ; García-Merino, Juan Antonio (Puerta de Hierro University Hospital and Research Institute, Universidad Autónoma de Madrid. Neuroimmunology Unit) ; Ramió-Torrentà, Lluís (Neuroimmunology and Multiple Sclerosis Unit, Department of Neurology, Hospital Dr Josep Trueta, IDIBGI, University of Girona, Girona, Spain) ; Triviño, Juan Carlos (Genomic Systems, Valencia, Spain) ; Quintana, Ester (Neuroimmunology and Multiple Sclerosis Unit, Department of Neurology, Hospital Dr Josep Trueta, IDIBGI, University of Girona, Girona, Spain) ; Robles, René (Neuroimmunology and Multiple Sclerosis Unit, Department of Neurology, Hospital Dr Josep Trueta, IDIBGI, University of Girona, Girona, Spain) ; Sánchez-López, Antonio (Puerta de Hierro University Hospital and Research Institute, Universidad Autónoma de Madrid. Neuroimmunology Unit) ; Arroyo, Rafael (Hospital Universitario Quirón Salud. Servicio de Neurología) ; Alvarez-Cermeño, Jose C. (Hospital Ramon y Cajal, (IRYCIS). Departments of Immunology and Neurology, Multiple Sclerosis Unit) ; Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Malhotra, Sunny (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fissolo, Nicolas (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
It remains unclear whether disease course in multiple sclerosis (MS) is influenced by genetic polymorphisms. Here, we aimed to identify genetic variants associated with benign and aggressive disease courses in MS patients. [...]
2018 - 10.1186/s12974-018-1307-1
Journal of neuroinflammation, Vol. 15 (september 2018)  
8.
8 p, 976.6 KB Efficacy and safety of ozanimod in multiple sclerosis : Dose-blinded extension of a randomized phase II study / Cohen, Jeffrey A ; Comi, Giancarlo ; Arnold, Douglas L ; Bar-Or, Amit ; Selmaj, Krzysztof W ; Steinman, Lawrence ; Havrdová, Eva K ; Cree, Bruce AC ; Montalbán, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina) ; Hartung, Hans-Peter ; Huang, Vivian ; Frohna, Paul ; Skolnick, Brett E ; Kappos, Ludwig
Ozanimod, an oral immunomodulator, selectively targets sphingosine 1-phosphate receptors 1 and 5. Evaluate efficacy, safety, and tolerability of ozanimod in relapsing multiple sclerosis. In the RADIANCE Part A phase II study (NCT01628393), participants with relapsing multiple sclerosis were randomized (1:1:1) to once-daily ozanimod hydrochloride (0. [...]
2018 - 10.1177/1352458518789884
Multiple sclerosis, Vol. 25 (july 2018) , p. 1255-1262  
9.
10 p, 1.4 MB Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI / Amiri, Houshang (Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands) ; de Sitter, Alexandra (Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands) ; Bendfeldt, Kerstin (Medical Image Analysis Center (MIAC AG) Basel, Switzerland) ; Battaglini, Marco (Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy) ; Gandini Wheeler-Kingshott, Claudia A.M. (NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, UK) ; Calabrese, Massimiliano (Multiple Sclerosis Centre, Neurology Section, Department of Neurosciences, Biomedicine and Movements, University of Verona, Italy) ; Geurts, Jeroen J.G. (Anatomy & Neurosciences, VU University Medical Center, Amsterdam Neuroscience, Amsterdam, The Netherlands) ; Rocca, Maria A. (Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy) ; Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ; Enzinger, Christian (Department of Neurology & Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Austria) ; de Stefano, Nicola (Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy) ; Filippi, Massimo (Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy) ; Rovira, Álex (Hospital Universitari Vall d'Hebron) ; Barkhof, Frederik (Institutes of Neurology and Healthcare Engineering, UCL, London, UK) ; Vrenken, Hugo (Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands) ; Universitat Autònoma de Barcelona
Atrophy of the brain grey matter (GM) is an accepted and important feature of multiple sclerosis (MS). However, its accurate measurement is hampered by various technical, pathological and physiological factors. [...]
2018 - 10.1016/j.nicl.2018.04.023
NeuroImage, Vol. 19 (april 2018) , p. 466-475  
10.
8 p, 2.1 MB Impact of cytomegalovirus infection on B cell differentiation and cytokine production in multiple sclerosis / Zabalza, Ana (Institut Hospital del Mar d'Investigacions Mèdiques) ; Vera, Andrea (Institut Hospital del Mar d'Investigacions Mèdiques) ; Alari-Pahissa, Elisenda (Universitat Pompeu Fabra) ; Munteis, Elvira (Institut Hospital del Mar d'Investigacions Mèdiques) ; Moreira Villanueva, Antía (Althaia Xarxa Assistencial Universitària de ManresaAlthaia Xarxa Assistencial Universitària de Manresa) ; Yélamos, Jose (Institut Hospital del Mar d'Investigacions Mèdiques) ; Llop, Mireia (Institut Hospital del Mar d'Investigacions Mèdiques) ; López-Botet, Miguel (Institut Hospital del Mar d'Investigacions Mèdiques) ; Martínez-Rodríguez, Jose E. (Institut Hospital del Mar d'Investigacions Mèdiques) ; Universitat Autònoma de Barcelona. Departament de Medicina
Human cytomegalovirus (HCMV) infection has been recently associated with a low risk of multiple sclerosis (MS), yet the basis behind this observation remains uncertain. In this study, we aimed to determine in MS patients whether HCMV induces modifications in the peripheral B cell compartment. [...]
2020 - 10.1186/s12974-020-01840-2
Journal of neuroinflammation, Vol. 17 (may 2020)  

Articles : 30 registres trobats   1 - 10següentfinal  anar al registre:
Documents de recerca 12 registres trobats  1 - 10següent  anar al registre:
1.
1 p, 915.4 KB Interaction between CNS-resident cells and gut dysbiosis in multiple sclerosis : consequences on neuroinflammation / Garcia Garcia, Joana ; de Sousa Valente, Juan Tony, dir. ; Universitat Autònoma de Barcelona. Facultat de Biociències
Chronic neuroinflammation is an important component in multiple sclerosis (MS) progression, since the persistent microglial and astrocytic activation promotes neurodegeneration and a consequent neurological disability. [...]
2019
Grau en Ciències Biomèdiques [832]  
2.
1 p, 2.8 MB Epstein Barr virus and its role on Burkitt lymphoma and multiple sclerosis / Aira Gómez, Andrea ; Ferrer Miralles, Neus, dir. (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2015
Grau en Microbiologia [816]  
3.
1 p, 2.9 MB Retinal abnormalities in neurodegenerative diseases / Maté Goldar, Carla ; López Vales, Rubén, dir. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2015
Grau en Ciències Biomèdiques [832]  
4.
378 p, 4.0 MB Eficacia y tolerabilidad de placebo y cannabinoides en esclerosis múltiple / Torres Moreno, M. Carmen ; Farré Albaladejo, Magí, dir. (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ; Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia
Introducció. L'esclerosi múltiple (EM) és una malaltia neurodegenerativa caracteritzada per la inflamació i la destrucció de la mielina al sistema nerviós central (SNC). Es presenta principalment en adults joves, considerant-se la primera causa de discapacitat en aquesta població. [...]
Introducción. La esclerosis múltiple (EM) es una enfermedad neurodegenerativa caracterizada por la inflamación y la destrucción selectiva de la mielina en el sistema nervioso central (SNC). Se presenta sobretodo en adultos jóvenes, siendo la primera causa de discapacidad en esta población. [...]
Background. Multiple sclerosis (MS) is a neurodegenerative disease characterized by inflammation and selective destruction of myelin in the central nervous system (CNS). It occurs mainly in young adults, being the first cause of disability in this population. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2015  
5.
128 p, 1.0 MB Brain volume and brain metabolite changes in the first stages of primary progressive multiple sclerosis / Sastre Garriga, Jaume ; Montalban Gairín, Xavier, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
Antecedents: Hi ha escassa informació disponible sobre l'atròfia cerebral global i de substància gris i blanca (SG i SB) en l'esclerosi múltiple primària progressiva (EMPP) i en la seva relació amb paràmetres clínics i de ressonància magnètica (RM); per altra banda, les anomalies en el teixit cerebral d'aparença normal poden contribuir a la discapacitat. [...]
Background: There is little information available on global and on grey and white matter (GM and WM) atrophy in primary progressive multiple sclerosis (PPMS) and on their relationship with clinical and with other magnetic resonance imaging (MRI) measures; on the other hand abnormalities in normal-appearing brain tissues may contribute to disability in PPMS, where fewer lesions are seen on conventional imaging. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2015  
6.
220 p, 3.9 MB Búsqueda de Biomarcadores asociados a la conversión a esclerosis múltiple en pacientes con síndromes clínicos aislados / Cantó Puig, Ester ; Comabella López, Manuel, dir. ; Montalbán Gairín, Xavier, dir. (Universitat Autònoma de Barcelona. Departament de Medicina) ; Jaraquemada, Dolores, tut. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
Aproximadamente el 85% de los pacientes con esclerosis múltiple (EM) inician la enfermedad con un síndrome clínico aislado (CIS), pero se ha descrito que entre un 30 y un 85% de los pacientes que presentan un CIS finalmente desarrollan EM clínicamente definida (EMCD). [...]
In about 85% of patients with multiple sclerosis (MS) the disease starts with a clinically isolated syndrome (CIS), but only 30 to 85% of patients with CIS finally develop clinically definite MS (CDMS). [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2015  
7.
197 p, 12.8 MB Función de las semaforinas 3A y 7A en la neurorregeneración y en la regulación de la respuesta inmunitaria en la encefalomielitis autoinmune experimental / Gutiérrez Franco, Ana ; Espejo Ruiz, Carmen, dir. ; Eixarch, Herena, dir. ; Montalbán Gairín, Xavier, dir. (Universitat Autònoma de Barcelona. Departament de Medicina) ; Universitat Autònoma de Barcelona. Departament de Medicina
Las semaforinas se describieron como moléculas de guía axonal durante el desarrollo del sistema nervioso central (SNC) aunque en la actualidad se sabe que también se expresan en tejidos adultos y que participan en procesos fisiológicos y patológicos. [...]
Semaphorins have been described as guide axonal cues during the development of the central nervous system (CNS). Nowadays they have also been found to be expressed in adult tissues taking part in physiological and pathological processes. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2014  
8.
215 p, 4.1 MB Implicación de la vía del TLR4 y de la vía de los IFNs de tipo I y los monocitos en la respuesta clínica a interferón-beta en pacientes con esclerosis múltiple / Fernández Bustamante, Marta ; Comabella López, Manuel, dir. ; Montalbán Gairín, Xavier, dir. (Universitat Autònoma de Barcelona. Departament de Medicina) ; Jaraquemada, Dolores, tut. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Comabella, Manuel, dir. ; Montalbán, Xavier, dir. ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
Introducción: El interferón-beta (IFN-β) se utiliza como tratamiento para los pacientes con esclerosis múltiple remitente-recurrente (EMRR). A pesar de su probada eficacia, un considerable porcentaje de pacientes no responden al tratamiento. [...]
Introduction: Recombinant IFN-β is widely used as a treatment for relapsing-remitting multiple sclerosis (RRMS). Although its efficacy has been demonstrated, some patients do not respond to the treatment. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2015  
9.
201 p, 5.6 MB Estudio de la función de la heat shock protein-70 en la patogenia de la esclerosis múltiple / Mansilla López, María José ; Espejo Ruiz, Carmen, dir. ; Montalban Gairin, Xavier, dir. ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
La proteína de choque térmico [heat shock protein (Hsp)-70] es una chaperona inducible por condiciones de estrés celular que puede ejercer una función citoprotectora y antiapoptótica a nivel intracelular, mientras que cuando es secretada al medio extracelular la Hsp70 actúa promoviendo la respuesta inmune, tanto la innata como la adaptativa. [...]
Heat shock protein (Hsp)-70 is a chaperone induced by cellular stress conditions which can mediate cytoprotective and antiapoptotic functions intracellularly, but when it is released to the extracellular milieu, Hsp70 acts triggering the immune response both innate and adaptive. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2015  
10.
1 p, 295.3 KB Gene therapy for multiple sclerosis : does interferon beta regulate MHC class II antigen presenting? / Lladó Santaeularia, Manel ; Bosch i Merino, Assumpció, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2014
Grau en Ciències Biomèdiques [832]  

Documents de recerca : 12 registres trobats   1 - 10següent  anar al registre:
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