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9 p, 439.7 KB |
Hopelessness in Patients with Early-Stage Relapsing-Remitting Multiple Sclerosis
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Sainz de la Maza, Susana (Hospital Universitario Ramón y Cajal) ;
Maurino, Jorge (Roche Farma) ;
Castillo-Triviño, Tamara (Hospital Universitario Donostia) ;
Borges, Mónica (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Sebastián Torres, Berta (Hospital Universitario Miguel Servet) ;
Sotoca Fernández, Javier (Hospital Universitari Vall d'Hebron) ;
Alonso Torres, Ana María (Hospital Regional Universitario de Málaga) ;
Caminero, Ana B (Complejo Asistencial de Ávila) ;
Borrega, Laura (Hospital Universitario Fundación Alcorcón) ;
Sánchez-Menoyo, José L (Hospital de Galdakao-Usansolo) ;
Barrero-Hernández, Francisco J (D Hospital Universitario Clínico San Cecilio) ;
Calles, Carmen (Hospital Universitari Son Espases) ;
Brieva Ruiz, Luis (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Blasco, María Rosario (Hospital Universitario Puerta de Hierro) ;
Dotor García-Soto, Julio (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Rodríguez-Regal, Ana (Complejo Hospitalario Universitario de Pontevedra) ;
Navarro-Cantó, Laura (Hospital General Universitario de Elche) ;
Agüera-Morales, Eduardo (Hospital Universitario Reina Sofía) ;
Garcés, Moisés (Hospital Clínico Universitario Lozano Blesa) ;
Carmona, Olga (Fundació Salut Empordà) ;
Gabaldón-Torres, Laura (Hospital Francesc de Borja) ;
Forero, Lucía (Hospital Universitario Puerta del Mar) ;
Hervás, Mariona (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Gómez-Ballesteros, Rocío (Roche Farma) ;
Universitat Autònoma de Barcelona
Hopelessness is a risk factor for depression and suicide. There is little information on this phenomenon among patients with relapsing-remitting multiple sclerosis (RRMS), one of the most common causes of disability and loss of autonomy in young adults. [...]
2023 -  10.2147/PPA.S411069
Patient preference and adherence, Vol. 17 (june 2023) , p. 1431-1439
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18 p, 3.4 MB |
Single-cell multi-omics analysis of COVID-19 patients with pre-existing autoimmune diseases shows aberrant immune responses to infection
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Barmada, Anis (Department of Medical Genetics. University of Cambridge) ;
Handfield, Louis-François (Wellcome Sanger Institute (Regne Unit)) ;
Godoy-Tena, Gerard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
de la Calle-Fabregat, Carlos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Arutyunyan, Anna (Wellcome Sanger Institute (Regne Unit)) ;
Andrés-León, Eduardo (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Hoo, Regina (Wellcome Sanger Institute (Regne Unit)) ;
Porter, Tarryn (Wellcome Sanger Institute (Regne Unit)) ;
Oszlanczi, Agnes (Wellcome Sanger Institute (Regne Unit)) ;
Richardson, Laura (Wellcome Sanger Institute (Regne Unit)) ;
Calero-Nieto, Fernando (Department of Haematology and Wellcome & MRC Cambridge Stem Cell Institute. University of Cambridge) ;
Wilson, Nicola K. (Department of Haematology and Wellcome & MRC Cambridge Stem Cell Institute. University of Cambridge) ;
Marchese, Domenica (Centre de Regulació Genòmica) ;
Sancho-Serra, Carmen (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Presas-Rodríguez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ramo-Tello, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz-Sanmartin, Adolfo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruiz-Rodriguez, Juan Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martínez Gallo, Mónica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Munera-Campos, Mónica (Institut Germans Trias i Pujol) ;
Carrascosa, José Manuel (Institut Germans Trias i Pujol) ;
Göttgens, Berthold (Department of Haematology and Wellcome & MRC Cambridge Stem Cell Institute. University of Cambridge) ;
Heyn, Holger (Universitat Pompeu Fabra) ;
Prigmore, Elena (Wellcome Sanger Institute (Regne Unit)) ;
Casafont-Solé, Ivette (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Solanich, Xavier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sánchez-Cerrillo, Idelfonso (Department of Immunology. Hospital Universitario La Princesa) ;
González-Álvaro, Isidoro (Rheumatology Service. Hospital Universitario La Princesa) ;
Raimondo, Maria Gabriella (Deutsches Zentrum Immuntherapie. Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen) ;
Ramming, Andreas (Deutsches Zentrum Immuntherapie. Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen) ;
Martin, Javier (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vento-Tormo1, Roser (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Rodríguez-Ubreva, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
In COVID-19, hyperinflammatory and dysregulated immune responses contribute to severity. Patients with pre-existing autoimmune conditions can therefore be at increased risk of severe COVID-19 and/or associated sequelae, yet SARS-CoV-2 infection in this group has been little studied. [...]
2024 - 10.1002/eji.202350633
European Journal of Immunology, Vol. 54 Núm. 1 (january 2024) , p. 2350633
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7 p, 817.8 KB |
Hepatitis B reactivation is a rare event among patients with resolved infection undergoing anti-CD20 antibodies in monotherapy without antiviral prophylaxis : results from the HEBEM study
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Marzo Escartin, Blanca (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron) ;
Robles-Sanchez, Miguel-Angel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Otero-Romero, Susana (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Buti, Maria (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Riveiro Barciela, Mar (Universitat Autònoma de Barcelona. Departament de Medicina)
INTRODUCTION: Prospective data on the risk of hepatitis B reactivation (HBVr) among patients with resolved HBV infection undergoing anti-CD20 antibodies monotherapy is scarce. We aimed to assess the risk of HBVr in patients with resolved HBV infection treated with rituximab or ocrelizumab in monotherapy for multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD) without antiviral prophylaxis. [...]
D. Steinkopff-Verlag, 2023 - 10.1007/s00415-023-11973-y
Journal of Neurology, Vol. 271 (2024) p. 134-140
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13 p, 527.1 KB |
Autonomic response to walk tests is useful for assessing outcome measures in people with multiple sclerosis
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Kontaxis, Spyridon (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Laporta, Estela (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Garcia, Esther (Universitat Autònoma de Barcelona. Departament de Microelectrònica i Sistemes Electrònics) ;
Guerrero, Ana Isabel (Hospital Universitari Vall d'Hebron) ;
Zabalza, Ana (Hospital Universitari Vall d'Hebron) ;
Matteo, Martinis (Vita Salute San Raffaele University) ;
Lucia, Roselli (Vita Salute San Raffaele University) ;
Simblett, Sara (King's College London) ;
Weyer, Janice (RADAR-CNS Patient Advisory Board) ;
Hotopf, Matthew (King's College London) ;
Narayan, Vaibhav A. (Research and Development Information Technology) ;
Rashid, Zulqarnain (King's College London) ;
Folarin, Amos A. (University College London) ;
Dobson, Richard J. B. (University College London) ;
Buron, Mathias Due (Copenhagen University Hospital Rigshospitalet) ;
Leocani, Letizia (Vita Salute San Raffaele University) ;
Cummins, Nicholas (King's College London) ;
Vairavan, Srinivasan (Research and Development Information Technology) ;
Costa, Gloria Dalla (Vita Salute San Raffaele University) ;
Magyari, Melinda (Copenhagen University Hospital Rigshospitalet) ;
Sørensen, Per Soelberg (Copenhagen University Hospital Rigshospitalet) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron) ;
Bailón, Raquel (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Comi, Giancarlo (Casa di Cura del Policlinico (Milà, Itàlia)) ;
the RADAR-CNS Consortium, None (The RADAR-CNS Consortium)
The aim of this study was to evaluate the association between changes in the autonomic control of cardiorespiratory system induced by walk tests and outcome measures in people with Multiple Sclerosis (pwMS). [...]
2023 - 10.3389/fphys.2023.1145818
Frontiers in physiology, Vol. 14 (april 2023)
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12 p, 1.3 MB |
The Need for the Closer Monitoring of Novel Drugs in MS : A Siponimod Retrospective Cohort Study (Realhes Study)
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Sancho-López, Arantxa (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Ruiz-Antorán, Belén (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Iglesias Hernangómez, Teresa (Hospital Universitario Clínico San Carlos (Madrid)) ;
Ramírez-García, Almudena (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Gómez-Estévez, Irene (Universidad Complutense de Madrid) ;
Sanabria-Cabrera, Judith (Plataforma ISCIII de Investigación Clínica) ;
Llop Rius, Roser (Hospital Universitari de Bellvitge) ;
Pedrós, Consuelo (Hospital General Universitario de Valencia) ;
Campodonico, Diana (Hospital Universitario de la Princesa (Madrid)) ;
Jiménez-Jorge, Silvia (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
García Luque, Amelia (University of Alcalá (IRYCIS)) ;
Costa-Frossard, Lucienne (Hospital Universitario Ramón y Cajal (Madrid)) ;
Montané Esteva, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Aldea-Perona, Ana (Hospital del Mar (Barcelona, Catalunya)) ;
Téllez Lara, Nieves (Hospital Clínico Universitario de Valladolid) ;
Bosch Ferrer, Montserrat (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodriguez Jiménez, Consuelo (Complejo Hospitalario Universitario e Canarias) ;
Bonilla-Toyos, Elvira (Plataforma ISCIII de Investigación Clínica) ;
Sabín Muñoz, Julia (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Avendaño Sola, Cristina (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Blasco Quilez, María Rosario (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Universitat Autònoma de Barcelona
Severe cases of lymphopenia have been reported during siponimod clinical trials, which may negatively impact its benefit/risk profile. We aimed to evaluate the incidence of lymphopenia following the initiation of siponimod treatment in clinical practice. [...]
2023 - 10.3390/jcm12206471
Journal of clinical medicine, Vol. 12 (october 2023)
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7 p, 631.6 KB |
Gadolinium-enhanced brain lesions in multiple sclerosis relapse Lesiones cerebrales captantes de gadolinio en el brote de los pacientes con esclerosis múltiple
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Martín-Aguilar, Lorena (Institut d'Investigació Biomèdica Sant Pau) ;
Presas-Rodriguez, S. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rovira, None (Hospital Universitari Vall d'Hebron) ;
Capellades, J. (Hospital del Mar (Barcelona, Catalunya)) ;
Massuet-Vilamajó, A. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ramió-Torrentà, Lluís (Hospital Universitari de Girona Doctor Josep Trueta. Unitat d'Esclerosi Múltiple) ;
Tintoré, M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Brieva Ruiz, Luis (Hospital Universitari Arnau de Vilanova. IRBLLEIDA. Unitat d'Esclerosi Múltiple) ;
Moral, E. (Hospital de Sant Joan Despí Moisès Broggi) ;
Cano-Orgaz, A. (Hospital de Mataró. Servei de Neurologia) ;
Blanco, Yolanda (Hospital Clínic i Provincial de Barcelona. Unitat d'Esclerosi Múltiple) ;
Batlle-Nadal, J. (Hospital de Sant Pau i Santa Tecla) ;
Carmona, O. (Hospital de Figueres. Servei de Neurologia) ;
Gea, M. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hervás-García, J.V. (Hospital Universitari de Girona Doctor Josep Trueta. Unitat d'Esclerosi Múltiple) ;
Ramo-Tello, C. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Objective: To study the clinico-radiological paradox in multiple sclerosis (MS) relapse by analyzing the number and location of gadolinium-enhanced (Gd+) lesions on brain MRI before methylprednisolone (MP) treatment. [...]
2022 - 10.1016/j.nrl.2021.10.005
Neurología, Vol. 37 Núm. 7 (septiembre 2022) , p. 557-563
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19 p, 7.5 MB |
Assessing Blood-Based Biomarkers to Define a Therapeutic Window for Natalizumab
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Granell-Geli, Júlia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Izquierdo-Gracia, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sellés-Rius, Ares (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Teniente Serra, Aina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Presas-Rodríguez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mansilla Lopez, Maria Jose (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Brieva Ruiz, Luis (Hospital Universitari Arnau de Vilanova) ;
Sotoca Fernández, Javier (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Mañé-Martínez, María Alba (Hospital Universitari Joan XXIII de Tarragona) ;
Moral, Ester (Hospital de Sant Joan Despí Moisès Broggi) ;
Bragado, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Goelz, Susan (Biogen Idec) ;
Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ramo-Tello, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Natalizumab is a monoclonal antibody that binds CD49d. Although it is one of the most effective treatments for Relapsing-Remitting Multiple Sclerosis (RRMS), a dosing regimen has not been optimized for safety and efficacy in individual patients. [...]
2021 - 10.3390/jpm11121347
Journal of personalized medicine, Vol. 11 (december 2021)
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13 p, 1.1 MB |
Immunotherapy for people with clinically isolated syndrome or relapsing-remitting multiple sclerosis : treatment response by demographic, clinical, and biomarker subgroups (PROMISE)-a systematic review protocol
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Lehnert, Thomas (University Medical Center Hamburg-Eppendorf) ;
Röver, Christian (University Medical Center Göttingen) ;
Köpke, Sascha (University of Cologne) ;
Río, Jordi (Hospital Universitari Vall d'Hebron) ;
Chard, Declan (University College London Hospitals) ;
Fittipaldo, Andrea V. (Istituto Ricerche Farmacologiche "Mario Negri" IRCCS) ;
Friede, Tim (University Medical Center Göttingen) ;
Heesen, Christoph (University Medical Center Hamburg-Eppendorf) ;
Rahn, Anne C. (University of Lübeck) ;
Universitat Autònoma de Barcelona
Multiple sclerosis (MS) is an inflammatory and degenerative disease of the central nervous system with an increasing worldwide prevalence. Since 1993, more than 15 disease-modifying immunotherapies (DMTs) have been licenced and have shown moderate efficacy in clinical trials. [...]
2022 - 10.1186/s13643-022-01997-2
Systematic Reviews, Vol. 11 (july 2022)
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10 p, 1.1 MB |
Antibodies against the flotillin-1/2 complex in patients with multiple sclerosis
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Lleixà, Cinta (Institut d'Investigació Biomèdica Sant Pau) ;
Caballero-Ávila, Marta (Institut d'Investigació Biomèdica Sant Pau) ;
Pascual-Goñi, Elba (Institut d'Investigació Biomèdica Sant Pau) ;
Martín-Aguilar, Lorena (Institut d'Investigació Biomèdica Sant Pau) ;
Vidal, Nuria (Institut d'Investigació Biomèdica Sant Pau) ;
Tejada, Clara (Institut d'Investigació Biomèdica Sant Pau) ;
Valdés-Hevia, Eduardo (Institut d'Investigació Biomèdica Sant Pau) ;
Zárate, Elisa (Institut d'Investigació Biomèdica Sant Pau) ;
Vesperinas, Ana (Institut d'Investigació Biomèdica Sant Pau) ;
Collet, Roger (Institut d'Investigació Biomèdica Sant Pau) ;
Franco-Leyva, Teresa (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Martinez-Martinez, Laura (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Moga, Esther (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Cortés-Vicente, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Rojas-Garcia, Ricard (Institut d'Investigació Biomèdica Sant Pau) ;
Gómez-Ansón, Beatriz (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Gil, Anna ;
González-Mingot, Cristina ;
Brieva Ruiz, Luis ;
Martínez-Yélamos, Sergio (Hospital Universitari de Bellvitge) ;
Querol, Luis (Institut d'Investigació Biomèdica Sant Pau)
Multiple sclerosis is a tissue-specific autoimmune disease of the central nervous system in which the antigen(s) remains elusive. Antibodies targeting the flotillin-1/2 complex have been described in 1-2% of the patients in a recent study. [...]
2023 - 10.1093/braincomms/fcad109
Brain Communications, Vol. 5 (april 2023)
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