|
1.
|
|
31 p, 986.9 KB |
Engineering aldo-keto reductase 1B10 to mimic the distinct 1B15 topology and specificity towards inhibitors and substrates, including retinoids and steroids
/
Giménez-Dejoz, Joan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Weber, Susanne (Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum München) ;
Fernández-Pardo, Álvaro (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Möller, Gabriele (Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum München) ;
Adamski, Jerzy (Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum München) ;
Porté, Sergio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Parés i Casasampera, Xavier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Farrés, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The aldo-keto reductase (AKR)superfamily comprises NAD(P)H-dependent enzymes that catalyze the reduction of a variety of carbonyl compounds. AKRs are classified in families and subfamilies. Humans exhibit three members of the AKR1B subfamily: AKR1B1 (aldose reductase, participates in diabetes complications), AKR1B10 (overexpressed in several cancer types), and the recently described AKR1B15. [...]
2019 -  10.1016/j.cbi.2019.04.030
Chemico-Biological Interactions, Vol. 307 (2019) , p. 186-194
|
|
|
2.
|
|
12 p, 3.0 MB |
Epitope characterization of a monoclonal antibody that selectively recognizes allotypes
/
Falco, Michela (IRCCS Istituto Giannina Gaslini) ;
Meazza, Raffaella (IRCCS Ospedale Policlinico San Martino) ;
Alicata, Claudia (IRCCS Ospedale Pediatrico Bambino Gesù) ;
Canevali, Paolo (IRCCS Ospedale Policlinico San Martino) ;
Muntasell i Castellví, Aura 1972- (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Bottino, Cristina (DIMES, University of Genoa) ;
Moretta, Lorenzo (IRCCS Ospedale Pediatrico Bambino Gesù) ;
Pende, Daniela (IRCCS Ospedale Policlinico San Martino) ;
Lopez-Botet, Miguel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Killer immunoglobulin-like receptor (KIR) genes code for a family of inhibitory and activating receptors, finely tuning NK cell function. Numerous studies reported the relevance of KIR allelic polymorphism on KIR expression, ligand affinity, and strength in signal transduction. [...]
2022 - 10.1111/tan.14630
Hla, Vol. 100 (june 2022) , p. 107-118
|
|
|
3.
|
|
11 p, 4.1 MB |
The evolution of hematopoietic cells under cancer therapy
/
Pich, Oriol (Institut de Recerca Biomèdica) ;
Cortes-Bullich, A. (Institut d'Investigació Biomèdica Sant Pau) ;
Muiños, Ferran (Institut de Recerca Biomèdica) ;
Pratcorona, Marta (Institut d'Investigació Biomèdica Sant Pau) ;
Gonzalez-Perez, A. (Universitat Pompeu Fabra) ;
Lopez-Bigas, N. (Institució Catalana de Recerca i Estudis Avançats)
Chemotherapies may increase mutagenesis of healthy cells and change the selective pressures in tissues, thus influencing their evolution. However, their contributions to the mutation burden and clonal expansions of healthy somatic tissues are not clear. [...]
2021 - 10.1038/s41467-021-24858-3
Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 4803
|
|
|
4.
|
|
16 p, 586.7 KB |
Quantifying In-Host Quasispecies Evolution
/
Gregori i Font, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ibañez-Lligoña, Marta (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Quer, Josep 1963- (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
What takes decades, centuries or millennia to happen with a natural ecosystem, it takes only days, weeks or months with a replicating viral quasispecies in a host, especially when under treatment. Some methods to quantify the evolution of a quasispecies are introduced and discussed, along with simple simulated examples to help in the interpretation and understanding of the results. [...]
2023 - 10.3390/ijms24021301
International journal of molecular sciences, Vol. 24 (january 2023)
|
|
|
5.
|
|
|
6.
|
|
12 p, 2.9 MB |
An In Silico Methodology That Facilitates Decision Making in the Engineering of Nanoscale Protein Materials
/
Parladé Molist, Eloi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Voltà-Durán, Eric (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Cano-Garrido, Olivia (Universitat Autònoma de Barcelona. Nanoligent S.L) ;
Sanchez, Julieta M. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ;
López-Laguna, Hèctor (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Serna, Naroa (Universitat Autònoma de Barcelona. Nanoligent S.L) ;
Cano, Montserrat (Universitat Autònoma de Barcelona. Nanoligent S.L) ;
Rodríguez-Mariscal, Manuel (Universitat Autònoma de Barcelona. Nanoligent S.L) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Under the need for new functional and biocompatible materials for biomedical applications, protein engineering allows the design of assemblable polypeptides, which, as convenient building blocks of supramolecular complexes, can be produced in recombinant cells by simple and scalable methodologies. [...]
2022 - 10.3390/ijms23094958
International journal of molecular sciences, Vol. 23, Issue 9 (May 2022) , art. 4958
|
|
|
7.
|
|
|
8.
|
|
|
9.
|
|
4 p, 1.7 MB |
Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB Receptor
/
Morales, Paula (Spanish Research Council) ;
Navarro Brugal, Gemma (Universitat de Barcelona) ;
Gómez-Autet, Marc (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Redondo, Laura (Spanish Research Council) ;
Fernández-Ruiz, Javier (Universidad Complutense de Madrid) ;
Pérez-Benito, Laura (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Cordomí Montoya, Arnau (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Pardo Carrasco, Leonardo (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Franco, Rafael (Universitat de Barcelona) ;
Jagerovic, Nadine (Spanish Research Council)
Single chemical entities with potential to simultaneously interact with two binding sites are emerging strategies in medicinal chemistry. We have designed, synthesized and functionally characterized the first bitopic ligands for the CB receptor. [...]
2020 - 10.1002/chem.202003389
Chemistry, Vol. 26 (november 2020) , p. 15839-15842
|
|
|
10.
|
|
guest ::
email alert
or subscribe to the 
RSS feed.
