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10 p, 859.5 KB |
Predicting AT(N) pathologies in Alzheimer's disease from blood-based proteomic data using neural networks
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Zhang, Y. (University of Oxford) ;
Ghose, U. (University of Oxford) ;
Buckley, N.J. (University of Oxford) ;
Engelborghs, S. (Vrije Universiteit Brussel) ;
Sleegers, K. (University of Antwerp) ;
Frisoni, G.B. (Department of Psychiatry. University of Geneva) ;
Wallin, A. (University of Gothenburg) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, J. (University of Zürich) ;
Martinez-Lage, P. (CITA-Alzheimer Foundation) ;
Legido-Quigley, C. (Steno Diabetes Center) ;
Barkhof, F. (University College London) ;
Zetterberg, H. (Kong Kong Center for Neurodegenerative Diseases) ;
Visser, P.J. (VU University Medical Center) ;
Bertram, L. (University of Oslo) ;
Lovestone, S. (Janssen RD) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Shi, L. (University of Oxford) ;
Universitat Autònoma de Barcelona
Background and objective: Blood-based biomarkers represent a promising approach to help identify early Alzheimer's disease (AD). Previous research has applied traditional machine learning (ML) to analyze plasma omics data and search for potential biomarkers, but the most modern ML methods based on deep learning has however been scarcely explored. [...]
2022 -  10.3389/fnagi.2022.1040001
Frontiers in aging neuroscience, Vol. 14 (29 2022) , p. 1040001
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13 p, 4.5 MB |
iMAGING : a novel automated system for malaria diagnosis by using artificial intelligence tools and a universal low-cost robotized microscope
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Rubio Maturana, Carles (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
de Oliveira, Allisson Dantas (Universitat Politècnica de Catalunya) ;
Nadal, Sergi (Universitat Politècnica de Catalunya) ;
Serrat, Francesc Zarzuela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sulleiro Igual, Elena (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Ruiz, Edurne (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bilalli, Besim (Universitat Politècnica de Catalunya) ;
Veiga, Anna (Probitas Foundation) ;
Espasa, Mateu (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Abelló, Alberto (Universitat Politècnica de Catalunya) ;
Pumarola Suñé, Tomàs (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Segú, Marta (Futbol Club Barcelona Foundation) ;
López-Codina, Daniel (Universitat Politècnica de Catalunya) ;
Clols, Elisa Sayrol (Universitat Pompeu Fabra) ;
Joseph-Munné, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Malaria is one of the most prevalent infectious diseases in sub-Saharan Africa, with 247 million cases reported worldwide in 2021 according to the World Health Organization. Optical microscopy remains the gold standard technique for malaria diagnosis, however, it requires expertise, is time-consuming and difficult to reproduce. [...]
2023 - 10.3389/fmicb.2023.1240936
Frontiers in microbiology, Vol. 14 (november 2023)
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13 p, 3.5 MB |
Proteomic Analysis of Human iPSC-Derived Neural Stem Cells and Motor Neurons Identifies Proteasome Structural Alterations
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Álvarez Pérez, Iñaki (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Tirado-Herranz, Adrián (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Alvarez-Palomo, Belén (Banc de Sang i Teixits (Barcelona, Catalunya)) ;
Osete, Jordi Requena (Oslo University Hospital (Oslo, Noruega)) ;
Edel, Michael J (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques)
Background: Proteins targeted by the ubiquitin proteasome system (UPS) are identified for degradation by the proteasome, which has been implicated in the development of neurodegenerative diseases. Major histocompatibility complex (MHC) molecules present peptides broken down by the proteasome and are involved in neuronal plasticity, regulating the synapse number and axon regeneration in the central or peripheral nervous system during development and in brain diseases. [...]
2023 - 10.3390/cells12242800
Cells, Vol. 12 (december 2023)
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49 p, 626.9 KB |
La traducción automática literaria : : análisis de errores de la traducción automática y las traducciones de estudiantes del mismo texto original
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Ferragud Ferragud, Maria (Universitat Jaume I)
En aquest treball es compara la TA i les traduccions fetes per alumnes del mateix text original. L'objectiu és determinar si la TA i les traduccions de l'alumnat tenen aspectes en comú. Els resultats obtinguts mostren que, tot i que la TA comet més errors i de major gravetat que les alumnes, alguns d'aquests coincideixen.
This article compares the MT of a literary text with human translations by translation students. The main purpose of this study is to determine whether MT and translations by students have aspects in common and differ from published human translations. [...]
En este trabajo se compara la TA y las traducciones hechas por alumnas del mismo texto original. El objetivo es determinar si la TA y las traducciones del alumnado tienen aspectos en común. Los resultados obtenidos muestran que, si bien la TA comete más errores y más graves que las alumnas, algunos de ellos coinciden.
2023 - 10.5565/rev/tradumatica.334
Tradumàtica, Núm. 21 (2023) , p. 184-232 (Tradumàtica dossier)
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5.
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36 p, 1.6 MB |
Schizophrenia-like reduced sensorimotor gating in intact inbred and outbred rats is associated with decreased medial prefrontal cortex activity and volume
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Tapias-Espinosa, Carles (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Río-Álamos, Cristobal (Universidad Austral de Chile. Departamento de Psicologia) ;
Sánchez González, Ana (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Oliveras, Ignasi (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sampedro-Viana, Daniel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Castillo-Ruiz, Mª del Mar (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Cañete, Toni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Tobeña, Adolf 1950- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Prepulse inhibition (PPI) of startle response is a measure of sensorimotor gating that is impaired in schizophrenia and in many other clinical conditions. Rat models using pharmacological or surgical strategies reveal that PPI is modulated by the cortico-striatal-pallido-thalamic (CSPT) circuit. [...]
2019 - 10.1038/s41386-019-0392-x
Neuropsychopharmacology, Vol. 44 Núm. 11 (2019) , p. 1975-1984
Neuropsychopharmacology, 2019
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9 p, 1.5 MB |
Deep machine learning for meteor monitoring : Advances with transfer learning and gradient-weighted class activation mapping
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Peña-Asensio, Eloy (Universitat Autònoma de Barcelona. Departament de Química) ;
Trigo Rodríguez, Josep Maria (Institut de Ciències de l'Espai) ;
Grèbol-Tomàs, Pau (Institut de Ciències de l'Espai) ;
Regordosa-Avellana, David (Spanish Meteor Network) ;
Rimola, Albert (Universitat Autònoma de Barcelona. Departament de Química)
In recent decades, the use of optical detection systems for meteor studies has increased dramatically, resulting in huge amounts of data being analyzed. Automated meteor detection tools are essential for studying the continuous meteoroid incoming flux, recovering fresh meteorites, and achieving a better understanding of our Solar System. [...]
2023 - 10.1016/j.pss.2023.105802
Planetary and Space Science, Vol. 238 (November 2023) , art. 105802
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20 p, 1.7 MB |
Tracking Therapy Response in Glioblastoma Using 1D Convolutional Neural Networks
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Ortega-Martorell, Sandra (Liverpool John Moores University) ;
Olier, Iván (Liverpool John Moores University) ;
Hernandez, Orlando (Escuela Colombiana de Ingeniería Julio Garavito) ;
Restrepo-Galvis, Paula D. (Escuela Colombiana de Ingeniería Julio Garavito) ;
Bellfield, Ryan A. A. (Liverpool John Moores University) ;
Candiota Silveira, Ana Paula (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Glioblastoma (GB) is a malignant brain tumour with no cure, even after the best treatment. The evaluation of a therapy response is usually based on magnetic resonance imaging (MRI), but it lacks precision in early stages, and doctors must wait several weeks until they are confident information is produced, facing an uncertain time window. [...]
2023 - 10.3390/cancers15154002
Cancers, Vol. 15, Num. 15 (August 2023) , art. 4002
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11 p, 2.5 MB |
Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis
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Kandel, Prasanna (Department of Biochemistry and Molecular Biomedicine. Institute of Biomedicine. University of Barcelona) ;
Semerci, Fatih (Universitat de Barcelona. Institut de Biomedicina. Departament de Bioquímica i Biomedicina Molecular) ;
Mishra, Rachana (Jan and Dan Duncan Neurological Research Institute. Texas Children's Hospital) ;
Choi, Willian (Medical Scientist Training Program. Baylor College of Medicine) ;
Bajic, Aleksandar (Department of Molecular and Human Genetics. Baylor College of Medicine) ;
Baluya, Dodge (Department of Interventional Radiology. University of Texas MD Anderson Cancer Center) ;
Ma, Li Hua (NMR and Drug Metabolism Advanced Technology Cores. Baylor College of Medicine) ;
Chen, Kevin (Department of Biosciences. Rice University) ;
Cao, Austin C. (Department of Chemistry. Rice University) ;
Phongmekhin, Tipwarin (Department of Biosciences. Rice University) ;
Matinyan, Nick (Verna and Marrs McLean Department of Biochemistry and Molecular Biology. Baylor College of Medicine) ;
Jimenez-Panizo, Alba (Universitat de Barcelona. Institut de Biomedicina. Departament de Bioquímica i Biomedicina Molecular) ;
Chamakuri, Srinivas (Department of Pathology and Immunology. Baylor College of Medicine) ;
Raji, Idris O. (Department of Pharmacology & Chemical Biology. Baylor College of Medicine) ;
Chang, Lyra (Department of Pharmacology & Chemical Biology. Baylor College of Medicine) ;
Fuentes-Prior, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
MacKenzie, Kevin R. (Department of Molecular and Cellular Biology. Baylor College of Medicine) ;
Benn, Caroline L. (Pfizer Regenerative Medicine) ;
Estebanez-Perpiña, Eva (Department of Biochemistry and Molecular Biomedicine. Institute of Biomedicine. University of Barcelona) ;
Venken, Koen (Verna and Marrs McLean Department of Biochemistry and Molecular Biology. Baylor College of Medicine) ;
Moore, David D. (Department of Molecular and Cellular Biology. Baylor College of Medicine) ;
Young, Damian W. (Center for Drug Discovery. Baylor College of Medicine) ;
Maletic-Savatic, Mirjana (Department of Neuroscience. Baylor College of Medicine)
Neural stem cells, the source of newborn neurons in the adult hippocampus, are intimately involved in learning and memory, mood, and stress response. Despite considerable progress in understanding the biology of neural stem cells and neurogenesis, regulating the neural stem cell population precisely has remained elusive because we have lacked the specific targets to stimulate their proliferation and neurogenesis. [...]
2022 - 10.1073/pnas.2023784119
Proceedings of the National Academy of Sciences of the United States of America, Vol. 119 Núm. 13 (March 2022) , p. e2023784119
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11 p, 1.1 MB |
Machine Learning-Based Analysis in the Management of Iatrogenic Bile Duct Injury During Cholecystectomy : a Nationwide Multicenter Study
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Lopez-Lopez, Victor (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ;
Maupoey, Javier (Hospital Universitari i Politècnic La Fe (València)) ;
López-Andujar, Rafael (Hospital Universitari i Politècnic La Fe (València)) ;
Ramos, Emilio (Hospital Universitari de Bellvitge) ;
Mils, Kristel (Hospital Universitari de Bellvitge) ;
Martinez, Pedro Antonio (Universidad de Murcia) ;
Valdivieso, Andres (Hospital Universitari de Cruces) ;
Garcés-Albir, Marina (Universitat de València) ;
Sabater, Luis (Universitat de València) ;
Valladares, Luis Díez (Hospital Clínico San Carlos (Madrid)) ;
Pérez, Sergio Annese (Hospital Universitario de Morales) ;
Flores, Benito (Hospital Universitario de Morales) ;
Brusadin, Roberto (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Conesa, Asunción López (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Cayuela, Valentin (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Cortijo, Sagrario Martinez (Hospital Universitario de Alcorcon) ;
Paterna, Sandra (Hospital Universitario Miguel Servet (Saragossa)) ;
Serrablo, Alejando (Hospital Universitario Miguel Servet (Saragossa)) ;
Sánchez-Cabús, Santiago (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Gil, Antonio González (Hospital Universitario Los Arcos del Mar Menor) ;
Masía, Jose Antonio González (Hospital Universitario General) ;
Loinaz, Carmelo (Hospital Universitario 12 de Octubre (Madrid)) ;
Lucena, Jose Luis (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Pastor, Patricia (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Garcia-Zamora, Cristina (Hospital Rafael Mendez) ;
Calero, Alicia (Hospital Universitario Elche) ;
Valiente, Juan (Hospital Hellin) ;
Minguillon, Antonio (Hospital Obispo Polanco) ;
Rotellar, Fernando ;
Ramia, Jose Manuel (Hospital Universitario Dr. Balmis General) ;
Alcazar, Cándido (Hospital Universitario Dr. Balmis General) ;
Aguilo, Javier (Hospital Lluís Alcanyís) ;
Cutillas, Jose (Hospital Francesc de Borja) ;
Kuemmerli, Christoph ;
Ruiperez-Valiente, Jose A. (Universidad de Murcia) ;
Robles-Campos, Ricardo (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Universitat Autònoma de Barcelona
Iatrogenic bile duct injury (IBDI) is a challenging surgical complication. IBDI management can be guided by artificial intelligence models. Our study identified the factors associated with successful initial repair of IBDI and predicted the success of definitive repair based on patient risk levels. [...]
2022 - 10.1007/s11605-022-05398-7
Journal of Gastrointestinal Surgery, Vol. 26 (july 2022) , p. 1713-1723
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