Resultats globals: 22 registres trobats en 0.02 segons.
Articles, 18 registres trobats
Documents de recerca, 4 registres trobats
Articles 18 registres trobats  1 - 10següent  anar al registre:
1.
12 p, 3.6 MB ZPD-2, a small compound that inhibits α-synuclein amyloid aggregation and its seeded polymerization / Peña Díaz, Samuel (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pujols, Jordi (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Conde Giménez, María (Universidad de Zaragoza. Instituto Universitario de Investigación de Biocomputación y Física de Sistemas Complejos) ; Čarija, Anita (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Dalfo, Esther (Universitat Autònoma de Medicina. Facultat de Medicina) ; García, Jesús (Institut de Recerca Biomèdica) ; Navarro Cantero, Susanna (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pinheiro, Francisca (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Santos Suárez, Jaime (Universitat Autonoma de Barcelona. Departament de Bioquimica i Biologia Molecular) ; Salvatella, Xavier (Institut de Recerca Biomèdica) ; Sancho, Javier (Universidad de Zaragoza. Instituto Universitario de Investigación de Biocomputación y Física de Sistemas Complejos) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
α-Synuclein (α-Syn) forms toxic intracellular protein inclusions and transmissible amyloid structures in Parkinson's disease (PD). Preventing α-Syn self-assembly has become one of the most promising approaches in the search for disease-modifying treatments for this neurodegenerative disorder. [...]
2019 - 10.3389/fnmol.2019.00306
Frontiers in molecular neuroscience, Vol. 12 (Dec. 2019) , art. 306  
2.
20 p, 8.4 MB New insights into the mechanisms of action of topical administration of GLP-1 in an experimental model of diabetic retinopathy / Sampedro, Joel (CIBERDEM (Instituto de Salud Carlos III)) ; Solà-Adell, Cristina (CIBERDEM (Instituto de Salud Carlos III)) ; Turch, Mireia (Vall d'Hebron Research Institute. Diabetes and Metabolism Research Unit) ; Valeri, Marta (Vall d'Hebron Research Institute. Unit of High Technology) ; Simó-Servat, Olga (Universitat Autònoma de Barcelona. Departament de Medicina) ; Lagunas, Carmen (Ferrer Advanced Biotherapeutics) ; Simó, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina) ; Hernández Pascual, Cristina (Vall d'Hebron Insitut de Recerca) ; Bogdanov, Patricia (CIBERDEM (Instituto de Salud Carlos III)) ; Ramos, Hugo (Vall d'Hebron Insitut de Recerca)
The main goals of this work were to assess whether the topical administration of glucagon-like peptide-1 (GLP-1) could revert the impairment of the neurovascular unit induced by long-term diabetes (24 weeks) in diabetic mice and to look into the underlying mechanisms. [...]
2019 - 10.3390/jcm8030339
Journal of clinical medicine, Vol. 8 (2019) , p. 1-20  
3.
15 p, 1.2 MB GRP78 at the centre of the stage in cancer and neuroprotection / Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències)
The 78-kDa glucose-regulated protein GRP78, also known as BiP and HSP5a, is a multifunctional protein with activities far beyond its well-known role in the unfolded protein response (UPR) which is activated after endoplasmic reticulum (ER) stress in the cells. [...]
2017 - 10.3389/fnins.2017.00177
Frontiers in Neuroscience, Vol. 11, (May 2017) , p. 177  
4.
15 p, 4.2 MB Effects of liposomal formulation of citicoline in experimental diabetes-induced retinal neurodegeneration / Bogdanov, Patricia (CIBERDEM (Instituto de Salud Carlos III)) ; Sampedro, Joel (CIBERDEM (Instituto de Salud Carlos III)) ; Solà-Adell, Cristina (CIBERDEM (Instituto de Salud Carlos III)) ; Simó-Servat, Olga (Universitat Autònoma de Barcelona. Departament de Medicina) ; Russo, Carla (R&D Department. Omikron Italia Srl) ; Varela-Sende, Luisa (Clinical Research Department. OPKO Health Spain S.L) ; Simó, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina) ; Hernández Pascual, Cristina (Universitat Autònoma de Barcelona. Departament de Medicina)
Diabetic retinopathy (DR) has been classically considered a microcirculatory disease of the retina. However, there is growing evidence to suggest that retinal neurodegeneration is also an early event in the pathogenesis of DR. [...]
2018 - 10.3390/ijms19082458
International journal of molecular sciences, Vol. 19 Núm. 8 (20 2018) , p. 2458  
5.
15 p, 3.4 MB Topical Administration of Bosentan Prevents Retinal Neurodegeneration in Experimental Diabetes / Bogdanov, Patricia (Vall d'Hebron Insitut de Recerca) ; Simó-Servat, Olga (Vall d'Hebron Insitut de Recerca) ; Sampedro, Joel (Vall d'Hebron Insitut de Recerca) ; Solà-Adell, Cristina (Vall d'Hebron Insitut de Recerca) ; Garcia-Ramírez, Marta (Vall d'Hebron Insitut de Recerca) ; Ramos, Hugo (Vall d'Hebron Insitut de Recerca) ; Guerrero, Marta (Universitat de Barcelona. Departament de Farmàcia i Tecnologia Farmacèutica, i Fisicoquímica) ; Suñé-Negre, Josep Maria (Universitat de Barcelona. Departament de Farmàcia i Tecnologia Farmacèutica, i Fisicoquímica) ; Ticó, Josep Ramon (Universitat de Barcelona. Departament de Farmàcia i Tecnologia Farmacèutica, i Fisicoquímica) ; Montoro, Bruno (Vall d'Hebron Insitut de Recerca) ; Durán, Vicente (Medical Mix S.L.U.) ; Arias, Luis (Hospital Universitari de Bellvitge) ; Hernández Pascual, Cristina (Vall d'Hebron Insitut de Recerca) ; Simó, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina)
Experimental evidence suggests that endothelin 1 (ET-1) is involved in the development of retinal microvascular abnormalities induced by diabetes. The effects of ET-1 are mediated by endothelin A- and B-receptors (ETA and ETB). [...]
2018 - 10.3390/ijms19113578
International journal of molecular sciences, Vol. 19 Núm. 11 (13 2018)  
6.
25 p, 2.6 MB Mitochondrial Quality Control in Neurodegenerative Diseases : Focus on Parkinson's Disease and Huntington's Disease / Franco-Iborra, Sandra (Vall d'Hebron. Institut de Recerca (VHIR)) ; Vila Bover, Miquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Perier, Celine (Vall d'Hebron. Institut de Recerca (VHIR))
In recent years, several important advances have been made in our understanding of the pathways that lead to cell dysfunction and death in Parkinson's disease (PD) and Huntington's disease (HD). Despite distinct clinical and pathological features, these two neurodegenerative diseases share critical processes, such as the presence of misfolded and/or aggregated proteins, oxidative stress, and mitochondrial anomalies. [...]
2018 - 10.3389/fnins.2018.00342
Frontiers in Neuroscience, Vol. 12 (May 2018) , art. 342  
7.
17 p, 3.6 MB Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease / Gomez-Arboledas, Angela (Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)) ; Davila, Jose C. (Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)) ; Sanchez-Mejias, Elisabeth (Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)) ; Navarro, Victoria (Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Nuñez-Diaz, Cristina (Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)) ; Sanchez-Varo, Raquel (Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)) ; Sanchez-Mico, Maria Virtudes (Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Trujillo-Estrada, Laura (Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)) ; Fernandez-Valenzuela, Juan Jose (Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)) ; Vizuete, Marisa (Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Comella, Joan X. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Galea, Elena (Universitat Autònoma de Barcelona. Institut de Neurociències. Departament de Bioquímica i de Biologia Molecular) ; Vitorica, Javier (Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla) ; Gutierrez, Antonia (Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED))
Reactive astrogliosis, a complex process characterized by cell hypertrophy and upregulation of components of intermediate filaments, is a common feature in brains of Alzheimer's patients. Reactive astrocytes are found in close association with neuritic plaques; however, the precise role of these glial cells in disease pathogenesis is unknown. [...]
2017 - 10.1002/glia.23270
Glia, Vol. 66 (november 2017) , p. 637-653  
8.
13 p, 1.6 MB Neuronal Mitophagy in Neurodegenerative Diseases / Martinez-Vicente, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Neuronal homeostasis depends on the proper functioning of different quality control systems. All intracellular components are subjected to continuous turnover through the coordinated synthesis, degradation and recycling of their constituent elements. [...]
2017 - 10.3389/fnmol.2017.00064
Frontiers in molecular neuroscience, Vol. 10 (march 2017)  
9.
19 p, 8.9 MB Tauroursodeoxycholic bile acid arrests axonal degeneration by inhibiting the unfolded protein response in X-linked adrenoleukodystrophy / Launay, Nathalie (CIBERER U759, Center for Biomedical Research on Rare Diseases, Barcelona, Spain) ; Ruiz, Montserrat (CIBERER U759, Center for Biomedical Research on Rare Diseases, Barcelona, Spain) ; Grau, Laia (CIBERER U759, Center for Biomedical Research on Rare Diseases, Barcelona, Spain) ; Ortega, Francisco J. (CIBERER U759, Center for Biomedical Research on Rare Diseases, Barcelona, Spain) ; Ilieva, Ekaterina V. (Global data, London, UK) ; Martínez, Juan José (CIBERER U759, Center for Biomedical Research on Rare Diseases, Barcelona, Spain) ; Galea, Elena (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Ferrer, Isidre (CIBERNED, Center for Biomedical Research on Neurodegenerative Diseases, Barcelona, Spain) ; Knecht, Erwin (CIBERER U721, Center for Biomedical Research on Rare Diseases, Valencia, Spain) ; Pujol, Aurora (Barcelona, Spain) ; Fourcade, Stéphane (CIBERER U759, Center for Biomedical Research on Rare Diseases, Barcelona, Spain)
The online version of this article (doi:10. 1007/s00401-016-1655-9) contains supplementary material, which is available to authorized users.
2016 - 10.1007/s00401-016-1655-9
Acta Neuropathologica, Vol. 133 (december 2016) , p. 283-301  
10.
15 p, 4.8 MB The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation / Lázaro, Diana F. (Universitätsmedizin Göttingen) ; Dias, Mariana Castro (Universitätsmedizin Göttingen) ; Carija, Anita (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Navarro, Susanna (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Madaleno, Carolina Silva (Universidade Nova de Lisboa. Centro de Estudos de Doenças Crónicas) ; Tenreiro, Sandra (Universidade Nova de Lisboa. Centro de Estudos de Doenças Crónicas) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Outeiro, Tiago F. (Max-Planck-Gesellschaft)
α-synuclein (aSyn) is associated with both sporadic and familial forms of Parkinson's disease (PD), the second most common neurodegenerative disorder after Alzheimer's disease. In particular, multiplications and point mutations in the gene encoding for aSyn cause familial forms of PD. [...]
2016 - 10.1186/s40478-016-0402-8
Acta neuropathologica communications, Vol. 4 (2016) , art. 128  

Articles : 18 registres trobats   1 - 10següent  anar al registre:
Documents de recerca 4 registres trobats  
1.
1 p, 356.7 KB Alterations of astrocytic glutamate regulation in Alzheimer disease / Burgaya Julià, Mar ; Masgrau Juanola, Roser, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2016
Grau en Bioquímica [814]  
2.
188 p, 4.5 MB The role of the PDK1/PKB kinases in regulating neuronal survival and differentiation: characterization of the PDK1 K465E knock-in mice / Zurashvili, Tinatin ; Bayascas Ramírez, José Ramón, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
Neuronal cell death programmes are counteracted by survival signals during development in order to maintain the tissue homeostasis. Neuronal differentiation is a mechanism generating functionally integrated neuronal cells from their progenitors. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2015  
3.
1 p, 1.5 MB Astrocytes, the new trending topic in aging and neurodegeneration / Valls de Lacalle, Laura ; Masgrau Juanola, Roser, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2014
Grau en Bioquímica [814]  
4.
1 p, 588.4 KB Baker's yeast to study Parkinson's disease / Torrents Agut, Ester ; Fernández Gallegos, Ma. Rosario, (María Rosario), dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2014
Grau en Biotecnologia [815]  

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