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20 p, 3.4 MB |
Analgesic and antidepressant effects of oltipraz on neuropathic pain in mice by modulating microglial activation
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Felipe Díaz, Andrés (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Polo, Sara (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Gallardo, Núria (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Leánez, Sergi (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Pol, Olga (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Nerve injury provokes microglial activation, contributing to the sensory and emotional disorders associated with neuropathic pain that do not completely resolve with treatment. In C57BL/6J mice with neuropathic pain induced by chronic constriction of the sciatic nerve (CCI), we evaluated the effects of oltipraz, an antioxidant and anticancer compound, on (1) allodynia and hyperalgesia, (2) microglial activation and pain signaling pathways, (3) oxidative stress, and (4) depressive-like behaviors. [...]
2019 -  10.3390/jcm8060890
Journal of clinical medicine, Vol. 8 (2019) , p. 1-20
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17 p, 1000.0 KB |
The Induction of heme oxygenase 1 decreases painful diabetic neuropathy and enhances the antinociceptive effects of morphine in diabetic mice
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Castany, Sílvia (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Carcolé, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Leanez Morilla, Sergi (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Pol, Olga (Universitat Autònoma de Barcelona. Institut de Neurociències)
Painful diabetic neuropathy is a common complication of diabetes mellitus which is poorly controlled by conventional analgesics. This study investigates if treatment with an heme oxygenase 1 (HO-1) inducer, cobalt protoporphyrin IX (CoPP), could modulate the allodynia and hyperalgesia induced by diabetes and enhanced the antinociceptive effects of morphine. [...]
2016 - 10.1371/journal.pone.0146427
PloS one, Vol. 11, Issue 1 (2016) , p. e0146427
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7 p, 169.3 KB |
Características del dolor neuropático crónico y su relación con el bienestar psicológico en pacientes con lesión medular
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Soler Fernández, Mª Dolores (Institut Germans Trias i Pujol. Institut Guttmann) ;
Saurí Ruiz, Joan (Institut Germans Trias i Pujol. Institut Guttmann) ;
Curcoll Gallemí, María Luisa (Institut Germans Trias i Pujol. Institut Guttmann) ;
Benito Penalva, Jesús (Institut Germans Trias i Pujol. Institut Guttmann) ;
Opisso, Eloy (Institut Germans Trias i Pujol. Institut Guttmann) ;
Chamarro Lusar, Andrés (Universitat Ramon Llull) ;
Vidal Samsó, Joan (Institut Germans Trias i Pujol. Institut Guttmann)
Objetivos. Determinar la prevalencia del dolor neuropático (DN) en una muestra de pacientes con lesión medular (LM), examinar la relación entre las características clínicas, demográficas y psicológicas con la prevalencia del DN después de una LM y a su vez con los diferentes tipos de DN, y estudiar el valor predictivo de los factores más significativos. [...]
AIMS. To determine the prevalence of neuropathic pain (NP) in a sample of patients with spinal cord injury (SCI), to examine the relation between clinical, demographic and psychological characteristics with the prevalence of NP after SCI and the different types of NP, and to study predictive factors. [...]
2007
Revista de neurología, Vol. 44, Núm. 1 (2007) , p. 3-9
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16 p, 1.6 MB |
Role of JNK isoforms in the development of neuropathic pain following sciatic nerve transection in the mouse
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Manassero, Giusi (University of Turin. Department of Neuroscience (Torí, Itàlia)) ;
Repetto, Ivan E. (Neuroscience Institute of the Cavalieri-Ottolenghi Foundation (Torí, Itàlia)) ;
Cobianchi, Stefano (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Valsecchi, Valeria (University of Turin. Department of Neuroscience (Torí, Itàlia)) ;
Bonny, Christophe (CHUV-University Hospital. Division of Medical Genetics (Lausanne, Suïssa)) ;
Rossi, Ferdinando (University of Turin. Department of Neuroscience (Torí, Itàlia)) ;
Vercelli, Alessandro (University of Turin. Department of Neuroscience (Torí, Itàlia))
Background: Current tools for analgesia are often only partially successful, thus investigations of new targets for pain therapy stimulate great interest. Consequent to peripheral nerve injury, c-Jun N-terminal kinase (JNK) activity in cells of the dorsal root ganglia (DRGs) and spinal cord is involved in triggering neuropathic pain. [...]
2012 - 10.1186/1744-8069-8-39
Molecular pain, Vol. 8, N. 39 (May 2012) , p. 1-16
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8 p, 314.2 KB |
The spinal cord expression of neuronal and inducible nitric oxide synthases and their contribution in the maintenance of neuropathic pain in mice
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Hervera Abad, Arnau (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Negrete, Roger (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Leánez, Sergi (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Martín-Campos, Jesús Martín (Hospital de la Sta Creu i Sant Pau (Barcelona, Catalunya). Grup de Bioquímica) ;
Pol, Olga (Universitat Autònoma de Barcelona. Institut de Neurociències)
Background: Nitric oxide generated by neuronal (NOS1), inducible (NOS2) or endothelial (NOS3) nitric oxide synthases contributes to pain processing, but the exact role of NOS1 and NOS2 in the maintenance of chronic peripheral neuropathic pain as well as the possible compensatory changes in their expression in the spinal cord of wild type (WT) and NOS knockout (KO) mice at 21 days after total sciatic nerve ligation remains unknown. [...]
2010 - 10.1371/journal.pone.0014321
PloS one, Vol. 5, Issue 12 (December 2010) , p. e14321
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