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16 p, 1.1 MB |
Characterization and Factors Associated with Poor Asthma Control in Adults with Severe Eosinophilic Asthma
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Padró-Casas, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Basagaña, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rivera-Ortún, María Luisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García-Olivé, Ignasi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pollan-Guisasola, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Teniente-Serra, Aina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez-Cáceres, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Navarro, José Tomás (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Abad Capa, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rosell, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Roger, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez-Rivera, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
A study was conducted in 98 adult patients diagnosed with severe eosinophilic asthma (73. 5% women, mean age 47. 2 years) and followed prospectively for 1 year. The aim of the study was to characterize this population and to identify factors associated with poor prognosis at 1 year of follow-up. [...]
2023 -  10.3390/jpm13071173
Journal of personalized medicine, Vol. 13 Núm. 7 (july 2023)
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2.
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13 p, 6.3 MB |
Evidence for the involvement of TRPV2 channels in the modulation of vascular tone in the mouse aorta
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Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Solé Piñol, Montserrat (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Serrano, Judith (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Taddeucci, Alice (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Perez, Belen (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Penas Pérez, Clara (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Manich, Gemma (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ;
Jimenez, Marcel (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
D'Ocon, Pilar (Universitat de València) ;
Jiménez Altayó, Francesc (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Aims: Transient receptor potential vanilloid 2 (TRPV2) channels are expressed in both smooth muscle and endothelial cells and participate in vascular mechanotransduction and sensing of high temperatures and lipids. [...]
2024 - 10.1016/j.lfs.2023.122286
Life Sciences, Vol. 336 (2024)
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3.
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6 p, 251.2 KB |
How reliably can algorithms identify eosinophilic asthma phenotypes using non-invasive biomarkers?
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Betancor, Diana (Hospital Universitario Fundación Jiménez Díaz) ;
Olaguibel, José María (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Rodrigo-Muñoz, José Manuel (Hospital Universitario Fundación Jiménez Díaz) ;
Arismendi, Ebymar (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Barranco, Pilar (Hospital Universitario La Paz (Madrid)) ;
Barroso, Blanca (Hospital Universitario Fundación Jiménez Díaz) ;
Bobolea, Irina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Cárdaba, Blanca (Hospital Universitario Fundación Jiménez Díaz) ;
Cruz, María Jesús (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Curto Sánchez, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Del Pozo, Victoria (Hospital Universitario Fundación Jiménez Díaz) ;
González-Barcala, Francisco-Javier (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Martínez Rivera, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mullol, Joaquim (Universitat de Barcelona) ;
Muñoz Gall, Xavier (Hospital Universitari Vall d'Hebron) ;
Picado, Cesar (Universitat de Barcelona) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
Quirce Gancedo, Santiago (Hospital Universitario La Paz (Madrid)) ;
Rial, Manuel Jorge (Complejo Hospitalario Universitario de A Coruña) ;
Soto-Retes, Lorena (Institut d'Investigació Biomèdica Sant Pau) ;
Valero, Antonio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Valverde-Monge, Marcela (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Sastre, Joaquin (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Asthma is a heterogeneous respiratory disease that encompasses different inflammatory and functional endophenotypes. Many non-invasive biomarkers has been investigated to its pathobiology. Heany et al proposed a clinical algorithm that classifies severe asthmatic patients into likely-eosinophilic phenotypes, based on accessible biomarkers: PBE, current treatment, FeNO, presence of nasal polyps (NP) and age of onset. [...]
2022 - 10.1002/clt2.12182
Clinical and translational allergy, Vol. 12, Issue 8 (August 2022) , art. e12182
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4.
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18 p, 2.0 MB |
Insights into the light response of skeletonema marinoi : Involvement of ovothiol
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Milito, Alfonsina (Centre de Recerca en Agrigenòmica) ;
Orefice, Ida (Stazione Zoologica Anton Dohrn. Department of Marine Biotechnology) ;
Smerilli, Arianna (Stazione Zoologica Anton Dohrn. Department of Marine Biotechnology) ;
Castellano, Immacolata (Stazione Zoologica Anton Dohrn. Department of Biology and Evolution of Marine Organisms) ;
Napolitano, Alessandra (University of Naples "Federico II". Department of Chemical Sciences) ;
Brunet, Christophe (Stazione Zoologica Anton Dohrn. Department of Marine Biotechnology) ;
Palumbo, Anna (Stazione Zoologica Anton Dohrn. Department of Biology and Evolution of Marine Organisms)
Diatoms are one of the most widespread groups of microalgae on Earth. They possess extraordinary metabolic capabilities, including a great ability to adapt to different light conditions. Recently, we have discovered that the diatom Skeletonema marinoi produces the natural antioxidant ovothiol B, until then identified only in clams. [...]
2020 - 10.3390/md18090477
Marine drugs, Vol. 18, Núm. 9 (September 2020) , art. 477
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5.
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8 p, 4.7 MB |
Nitric oxide-dependent biodegradation of graphene oxide reduces inflammation in the gastrointestinal tract
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Peng, Guotao (Karolinska Institutet (Estocolm, Suècia). Institute of Environmental Medicine) ;
Montenegro, Marcelo F. (Karolinska Institutet (Estocolm, Suècia). Department of Physiology and Pharmacology) ;
Ntola, Chifundo N. M. (University of Manchester. National Graphene Institute) ;
Vranic, Sandra (University of Manchester. National Graphene Institute) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ;
Vogt, Carmen (Kungl. Tekniska högskolan (Estocolm (Suècia)) ;
Toprak, Muhammet S. (Kungl. Tekniska högskolan (Estocolm (Suècia)) ;
Duan, Tianbo (Uppsala University. Department of Engineering Sciences) ;
Leifer, Klaus (Uppsala University. Department of Engineering Sciences) ;
Bräutigam, Lars (Karolinska Institutet (Estocolm, Suècia)) ;
Lundberg, Jon O. (Karolinska Institutet (Estocolm, Suècia). Department of Physiology and Pharmacology) ;
Fadeel, Bengt (Karolinska Institutet (Estocolm, Suècia). Institute of Environmental Medicine)
Understanding the biological fate of graphene-based materials such as graphene oxide (GO) is crucial to assess adverse effects following intentional or inadvertent exposure. Here we provide first evidence of biodegradation of GO in the gastrointestinal tract using zebrafish as a model. [...]
2020 - 10.1039/d0nr03675g
Nanoscale, Vol. 12, Issue 32 (August 2020) , p. 16730-16737
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6.
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14 p, 1.6 MB |
Implications of Iron Deficiency in STEMI Patients and in a Murine Model of Myocardial Infarction
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Inserte, Javier (Universitat Autònoma de Barcelona) ;
Barrabés, José A.. (Universitat Autònoma de Barcelona) ;
Aluja, David (Universitat Autònoma de Barcelona) ;
Otaegui, Imanol (Universitat Autònoma de Barcelona) ;
Bañeras, Jordi (Universitat Autònoma de Barcelona) ;
Castellote, Laura (Hospital Universitari Vall d'Hebron) ;
Sánchez, Ana (Universitat Autònoma de Barcelona) ;
Rodriguez-Palomares, Jose F (Universitat Autònoma de Barcelona) ;
Pineda, Víctor (Institut de Diagnòstic per la Imatge, Barcelona, Spain) ;
Miró-Casas, Elisabet (Universitat Autònoma de Barcelona) ;
Milà, Laia (Universitat Autònoma de Barcelona) ;
Lidón, Rosa-Maria (Universitat Autònoma de Barcelona) ;
Sambola, Antonia (Universitat Autònoma de Barcelona) ;
Valente, Filipa (Universitat Autònoma de Barcelona) ;
Rafecas, Agnès (Universitat Autònoma de Barcelona) ;
Ruiz-Meana, Marisol (Universitat Autònoma de Barcelona) ;
Rodríguez-Sinovas, Antonio (Universitat Autònoma de Barcelona) ;
Benito, Begoña (Universitat Autònoma de Barcelona) ;
Buera Surribas, Irene (Universitat Autònoma de Barcelona) ;
Delgado-Tomás, Sara (Universitat Autònoma de Barcelona) ;
Beneitez Pastor, David (Vall d'Hebron Institut d'Oncologia) ;
Ferreira-Gonzalez, Ignacio (Universitat Autònoma de Barcelona)
In patients with a first anterior ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention, iron deficiency (ID) was associated with larger infarcts, more extensive microvascular obstruction, and higher frequency of adverse left ventricular remodeling as assessed by cardiac magnetic resonance imaging. [...]
2021 - 10.1016/j.jacbts.2021.05.004
JACC: Basic to Translational Science, Vol. 6 (july 2021) , p. 567-580
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9.
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14 p, 1.9 MB |
The effects of cobalt protoporphyrin IX and tricarbonyldichlororuthenium (II) dimer treatments and its interaction with nitric oxide in the locus coeruleus of mice with peripheral inflammation
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Moreno, Patricia (Institut d'Investigació Biomèdica Sant Pau) ;
Cazuza, R. A. (Department of Psychology. University of São Paulo) ;
Gomes-Mendes, J. (Department of Psychology. University of São Paulo) ;
Díaz, A. F. (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Polo, S. (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Leánez, Sergi (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Leite-Panissi, C. R. A. (Department of Psychology. University of São Paulo) ;
Pol, Olga. (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Universitat Autònoma de Barcelona
Heme oxygenase 1 (HO-1) and carbon monoxide were shown to normalize oxidative stress and inflammatory reactions induced by neuropathic pain in the central nervous system, but their effects in the locus coeruleus (LC) of animals with peripheral inflammation and their interaction with nitric oxide are unknown. [...]
2019 - 10.3390/ijms20092211
International journal of molecular sciences, Vol. 20, Issue 9 (January 2019) , p. 2211
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10.
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10 p, 849.1 KB |
Proximal pulmonary arterial wall disease in patients with persistent pulmonary hypertension after successful left-sided valve replacement according to the hemodynamic phenotype
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Domingo Ribas, Enric (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Grignola, Juan C. (Universidad de la República (Montevideo, Uruguai)) ;
Trujillo, Pedro (Universidad de la República (Montevideo, Uruguai)) ;
Aguilar Torres, Río (Hospital Universitario de la Princesa (Madrid)) ;
Roman, Antonio (Hospital Universitari Vall d'Hebron)
Regression of pulmonary hypertension (PH) is often incomplete after successful left-sided valve replacement (LSVR). Proximal pulmonary arterial (PPA) wall disease can be involved in patients with persistent-PH after LSVR, affecting the right ventricular to pulmonary arterial (RV-PA) coupling. [...]
2018 - 10.1177/2045894018816972
Pulmonary Circulation, Vol. 9 (december 2018)
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