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10 p, 701.1 KB |
Circulating non-coding RNAs in biomarker-guided cardiovascular therapy : A novel tool for personalized medicine?
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Gonzalo Calvo, David de (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Vea, Ángela (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Bär, C. (Hannover Medical School) ;
Fiedler, J. (Hannover Medical School) ;
Couch, L.S. (Imperial College London) ;
Brotons, Carlos (Institut d'Investigació Biomèdica Sant Pau) ;
Llorente-Cortes, Vicenta (Institut d'Investigació Biomèdica Sant Pau) ;
Thum, T. (Hannover Medical School) ;
Universitat Autònoma de Barcelona
Current clinical guidelines emphasize the unmet need for technological innovations to guide physician decision-making and to transit from conventional care to personalized cardiovascular medicine. Biomarker-guided cardiovascular therapy represents an interesting approach to inform tailored treatment selection and monitor ongoing efficacy. [...]
2019 -  10.1093/eurheartj/ehy234
European heart journal, Vol. 40 Núm. 20 (january 2019) , p. 1643-1650
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8 p, 359.6 KB |
A pharmacogenetic intervention for the improvement of the safety profile of antipsychotic treatments
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Arranz, María Jesús (Fundació Docència i Investigació Mútua Terrassa) ;
Gonzalez-Rodriguez, Alex (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Perez-Blanco, Josefina (Institut d'Investigació Biomèdica Sant Pau) ;
Penadés, Rafael (Hospital Clínic i Provincial de Barcelona) ;
Gutierrez, Blanca (Universidad de Granada) ;
Ibañez, Laura (Fundació Docència i Recerca Mútua Terrassa) ;
Arias, Barbara (Universitat de Barcelona. Institut de Biomedicina) ;
Brunet, Mercè (Hospital Clínic i Provincial de Barcelona) ;
Cervilla, Jorge (Universidad de Granada) ;
Salazar, Juliana (Institut d'Investigació Biomèdica Sant Pau) ;
Catalan, Rosa (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona
Antipsychotic drugs fail to achieve adequate response in 30-50% of treated patients and about 50% of them develop severe and lasting side effects. Treatment failure results in poorer prognosis with devastating repercussions for the patients, carers and broader society. [...]
2019 - 10.1038/s41398-019-0511-9
Translational psychiatry, Vol. 9 Núm. 1 (january 2019) , p. 177
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3.
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12 p, 1.3 MB |
Genome-wide association study of Alzheimer's disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset
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Hong, S. (University of Lübeck) ;
Prokopenko, D. (Massachusetts General Hospital) ;
Dobricic, V. (University of Lübeck) ;
Kilpert, F. (University of Lübeck) ;
Bos, I. (Vrije Universiteit Amsterdam) ;
Vos, S.J.B. (Maastricht University) ;
Tijms, Betty M (Vrije Universiteit Amsterdam) ;
Andreasson, Ulf (Sahlgrenska University Hospital (Suècia)) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Vandenberghe, R. (University Hospitals Leuven (Bèlgica)) ;
Cleynen, I. (KU Leuven) ;
Gabel, Silvy (KU Leuven) ;
Schaeverbeke, J. (KU Leuven) ;
Scheltens, Philip (Vrije Universiteit Amsterdam) ;
Teunissen, C.E. (Vrije Universiteit) ;
Niemantsverdriet, E. (University of Antwerp) ;
Engelborghs, Sebastiaan (UZ Brussel and Vrije Universiteit Brussel (VUB)) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Blin, Olivier (Aix-Marseille Université) ;
Richardson, J.C. (GlaxoSmithKline R&D) ;
Bordet, Régis (University of Lille) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Rami Gonzalez, Lorena (Hospital Clínic i Provincial de Barcelona) ;
Kettunen, P. (University of Oxford) ;
Wallin, Anders (University of Gothenburg) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, J. (Lausanne University Hospital) ;
Peyratout, G. (Lausanne University Hospital) ;
Martinez-Lage, P. (CITA-Alzheimer Foundation) ;
Tainta, M. (CITA-Alzheimer Foundation) ;
Dobson, R.J.B. (University College London) ;
Legido-Quigley, Cristina (King's College London) ;
Sleegers, K. (University of Antwerp) ;
Van Broeckhoven, C. (University of Antwerp) ;
ten Kate, M. (Amsterdam Neuroscience) ;
Barkhof, Frederik (University College London) ;
Zetterberg, H. (UK Dementia Research Institute) ;
Lovestone, S. (University of Oxford) ;
Streffer, J. (UCB Biopharma SPRL) ;
Wittig, M. (Christian-Albrechts-University of Kiel) ;
Franke, Andre (Christian-Albrechts-University of Kiel) ;
Tanzi, R.E. (Massachusetts General Hospital) ;
Visser, Pieter Jelle (Vrije Universiteit Amsterdam) ;
Bertram, Lars (University of Oslo) ;
Universitat Autònoma de Barcelona
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and the most common form of dementia in the elderly. Susceptibility to AD is considerably determined by genetic factors which hitherto were primarily identified using case-control designs. [...]
2020 - 10.1038/s41398-020-01074-z
Translational psychiatry, Vol. 10 Núm. 1 (december 2020) , p. 403
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4.
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10 p, 1.8 MB |
A proposed approach to chronic airway disease (CAD) using therapeutic goals and treatable traits : A look to the future
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Pérez de Llano, Luis (University Hospital Lucus Augusti (Lugo, Galícia)) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Golpe, Rafael (University Hospital Lucus Augusti (Lugo, Galícia)) ;
Alvarez Gutiérrez, Francisco Javier (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Cisneros, Carolina (Hospital Universitario La Princesa (Madrid)) ;
Almonacid, Carlos (Hospital Universitario Ramón y Cajal (Madrid)) ;
Martínez-Moragón, Eva (Hospital Universitari Doctor Peset (València)) ;
González-Barcala, Francisco-Javier (Universidade de Santiago de Compostela) ;
Ramos-Barbón, David (Institut d'Investigació Biomèdica Sant Pau) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
López-Campos, José Luis (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
De Torres, Juan Pablo (Queen's University) ;
Casanova Macario, Ciro (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
García-Rivero, J. L. (Hospital de Laredo) ;
Rodriguez Hermosa, Juan Luis (Hospital Clínico San Carlos (Madrid)) ;
Calle Rubio, Myriam (Hospital Clínico San Carlos (Madrid)) ;
Soler-Cataluña, Juan José (Hospital Arnau de Vilanova (València)) ;
Cosio, Borja G (Clínica Quirón-Rotger) ;
Universitat Autònoma de Barcelona
Chronic airflow obstruction affects a wide range of airway diseases, the most frequent of which are asthma, COPD, and bronchiectasis; they are clearly identifiable in their extremes, but quite frequently overlap in some of their pathophysiological and clinical characteristics. [...]
2020 - 10.2147/COPD.S263430
International journal of COPD, Vol. 15 (2020) , p. 2091-2100
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22 p, 3.0 MB |
Genomic Validation of Endometrial Cancer Patient-Derived Xenograft Models as a Preclinical Tool
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Villafranca-Magdalena, Beatriz (Universitat Autònoma de Barcelona) ;
Masferrer-Ferragutcasas, Carina (Universitat Autònoma de Barcelona) ;
López-Gil, Carlos (Universitat Autònoma de Barcelona) ;
Coll de la Rubia, Eva (Universitat Autònoma de Barcelona) ;
Rebull, Marta (Universitat Autònoma de Barcelona) ;
Parra, Genis (Centre nacional d'anàlisi genòmica) ;
García, Ángel (Hospital Universitari Vall d'Hebron) ;
Reques, Armando (Hospital Universitari Vall d'Hebron) ;
Cabrera Díaz, Silvia (Vall d'Hebron Institut d'Oncologia) ;
Colás Ortega, Eva (Universitat Autònoma de Barcelona) ;
Gil-Moreno, Antonio 1965- (Vall d'Hebron Institut d'Oncologia) ;
Moiola, Cristian Pablo (Universitat Autònoma de Barcelona)
Endometrial cancer (EC) is the second most frequent gynecological cancer worldwide. Although improvements in EC classification have enabled an accurate establishment of disease prognosis, women with a high-risk or recurrent EC face a dramatic situation due to limited further treatment options. [...]
2022 - 10.3390/ijms23116266
International journal of molecular sciences, Vol. 23 (june 2022)
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7.
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13 p, 1.9 MB |
A study of differential microRNA expression profile in migraine : the microMIG exploratory study
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Gallardo, Víctor J.. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gómez-Galván, J. B. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Asskour, L. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Torres-Ferrús, Marta (Hospital Universitari Vall d'Hebron) ;
Alpuente, Alicia (Hospital Universitari Vall d'Hebron) ;
Caronna, Edoardo (Hospital Universitari Vall d'Hebron) ;
Pozo-Rosich, Patricia (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Several studies have described potential microRNA (miRNA) biomarkers associated with migraine, but studies are scarcely reproducible primarily due to the heterogeneous variability of participants. Increasing evidence shows that disease-related intrinsic factors together with lifestyle (environmental factors), influence epigenetic mechanisms and in turn, diseases. [...]
2023 - 10.1186/s10194-023-01542-z
Journal of headache and pain, Vol. 24 (february 2023)
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8.
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13 p, 1.0 MB |
Organ-on-a-chip technology : A novel approach to investigate cardiovascular diseases
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Paloschi, V. (German Center for Cardiovascular Research (DZHK). Partner Site Munich Heart Alliance) ;
Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Middelkamp, H. (BIOS/Lab on A Chip. University of Twente) ;
Vivas, Aisen (Applied Stem Cell Technologies. University of Twente) ;
Johansson, S.. (Department of Materials Science and Engineering,Science for Life Laboratory. Uppsala University) ;
Van Der Meer, A. (Applied Stem Cell Technologies. University of Twente) ;
Tenje, M. (Department of Materials Science and Engineering,Science for Life Laboratory. Uppsala University) ;
Maegdefessel, L. (Karolinska Institutet (Estocolm, Suècia). Department of Medicine)
The development of organs-on-chip (OoC) has revolutionized in vitro cell-culture experiments by allowing a better mimicry of human physiology and pathophysiology that has consequently led researchers to gain more meaningful insights into disease mechanisms. [...]
2021 - 10.1093/cvr/cvab088
Cardiovascular research, Vol. 117 Núm. 14 (january 2021) , p. 2742-2754
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9.
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22 p, 6.8 MB |
Peripheral myeloid-derived suppressor cells are good biomarkers of the efficacy of fingolimod in multiple sclerosis
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Camacho-Toledano, Celia (Hospital Nacional de Parapléjicos-SESCAM) ;
Machín-Díaz, Isabel (Hospital Nacional de Parapléjicos-SESCAM) ;
Calahorra, Leticia (Hospital Nacional de Parapléjicos-SESCAM) ;
Cabañas-Cotillas, María (Hospital Nacional de Parapléjicos-SESCAM) ;
Otaegui, David (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
Castillo-Triviño, Tamara (Hospital de Donostia (Sant Sebastià, País Basc)) ;
Villar, Luisa M (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Costa-Frossard, Lucienne (Hospital Universitario Ramón y Cajal (Madrid)) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
García-Domínguez, José Manuel (Hospital General Universitario Gregorio Marañón) ;
García-Arocha, Jennifer (Hospital Nacional de Parapléjicos-SESCAM) ;
Ortega, María Cristina (Hospital Nacional de Parapléjicos-SESCAM) ;
Clemente, Diego (Hospital Nacional de Parapléjicos-SESCAM) ;
Universitat Autònoma de Barcelona
The increasing number of treatments that are now available to manage patients with multiple sclerosis (MS) highlights the need to develop biomarkers that can be used within the framework of individualized medicine. [...]
2022 - 10.1186/s12974-022-02635-3
Journal of neuroinflammation, Vol. 19 (november 2022)
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10.
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31 p, 3.7 MB |
Metabolomics for personalized medicine : the input of analytical chemistry from biomarker discovery to point-of-care tests
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Castelli, Florence Anne (Université Paris-Saclay. Département Médicaments et Technologies pour la Santé) ;
Rosati, Giulio (Institut Català de Nanociència i Nanotecnologia) ;
Moguet, Christian (Université Paris-Saclay. Département Médicaments et Technologies pour la Santé) ;
Fuentes-Chust, Celia (Institut Català de Nanociència i Nanotecnologia) ;
Marrugo-Ramirez, Jose (Institut Català de Nanociència i Nanotecnologia) ;
Lefebvre, Thibaud (Université Paris-Saclay. Département Médicaments et Technologies pour la Santé) ;
Volland, Hervé (Université Paris-Saclay. Département Médicaments et Technologies pour la Santé) ;
Merkoçi, Arben (Institut Català de Nanociència i Nanotecnologia) ;
Simon, Stéphanie (Université Paris-Saclay. Département Médicaments et Technologies pour la Santé) ;
Fenaille, François (MetaboHUB (France)) ;
Junot, Christophe (MetaboHUB (France))
Metabolomics refers to the large-scale detection, quantification, and analysis of small molecules (metabolites) in biological media. Although metabolomics, alone or combined with other omics data, has already demonstrated its relevance for patient stratification in the frame of research projects and clinical studies, much remains to be done to move this approach to the clinical practice. [...]
2022 - 10.1007/s00216-021-03586-z
Analytical and bioanalytical chemistry, Vol. 414, Issue 2 (January 2022) , p. 759-789
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