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A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity
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van der Lee, Sven J. (Vrije Universiteit Amsterdam, Amsterdam UMC. Department of Clinical Genetics) ;
Conway, Olivia J. (Mayo Clinic Florida. Department of Neuroscience) ;
Jansen, Iris E (Vrije Universiteit Amsterdam, Amsterdam UMC. Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience) ;
Carrasquillo, Minerva M. (Mayo Clinic Florida. Department of Neuroscience) ;
Kleineidam, Luca (Uniklinik Köln (Colònia, Alemanya)) ;
van den Akker, Erik (Delft University of Technology. Pattern Recognition and Bioinformatics) ;
Hernández, Isabel (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
van Eijk, Kristel R. (University Medical Center Utrecht. Department of Neurology, Brain Center Rudolf Magnus) ;
Stringa, Najada (Vrije Universiteit Amsterdam) ;
Chen, Jason A. (University of California. Interdepartmental Program in Bioinformatics) ;
Zettergren, Anna (Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg) ;
Andlauer, Till F. M. (German Competence Network Multiple Sclerosis (KKNMS)) ;
Diez-Fairen, Monica (Fundacio per la Recerca Biomedica I Social Mutua Terrassa) ;
Simon-Sanchez, Javier (University of Tübingen. Hertie Institute for Clinical Brain Research) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit). Department of Molecular Neuroscience) ;
Nygaard, Marianne (University of Southern Denmark. The Danish Aging Research Center, Epidemiology, Biostatistics and Biodemography, Department of Public Health) ;
Blauwendraat, Cornelis (National Institute of Neurological Disorders and Stroke. Neurodegenerative Diseases Research Unit) ;
Savage, Jeanne E. (Vrije Universiteit Amsterdam, Amsterdam UMC. Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience) ;
Mengel-From, Jonas (University of Southern Denmark. Epidemiology, Biostatistics and Biodemography, Department of Public Health) ;
Moreno-Grau, Sonia (Institut Català de Neurociènces Aplicades) ;
Wagner, Michael (DZNE, German Center for Neurodegenerative Diseases) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Keogh, Michael J. (University of Cambridge. Department of Clinical Neurosciences) ;
Blennow, Kaj (Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg. Department of Psychiatry and Neurochemistry) ;
Skoog, Ingmar (Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg) ;
Friese, Manuel A. (Universitätsklinikum Hamburg-Eppendorf. Institut für Neuroimmunologie und Multiple Sklerose (INIMS)) ;
Pletnikova, Olga (Johns Hopkins University Medical Center. Department of Pathology (Neuropathology)) ;
Zulaica, Miren (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
Lage, Carmen (IDIVAL) ;
De Rojas, Itziar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Riedel-Heller, Steffi (University of Leipzig. Institute of Social Medicine, Occupational Health and Public Health (ISAP)) ;
Illán-Gala, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ;
Wei, Wei (University of Cambridge. Department of Clinical Neurosciences) ;
Jeune, Bernard (University of Southern Denmark. Epidemiology, Biostatistics and Biodemography, Department of Public Health) ;
Orellana, Adelina (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Then Bergh, Florian (University of Leipzig. Department of Neurology) ;
Wang, Xue (Mayo Clinic Florida. Department of Neuroscience) ;
Hulsman, Marc (Delft University of Technology. Pattern Recognition and Bioinformatics) ;
Beker, Nina (Vrije Universiteit Amsterdam, Amsterdam UMC. Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience) ;
Tesi, Niccolo (Delft University of Technology. Pattern Recognition and Bioinformatics) ;
Morris, Christopher M. (Newcastle University. Newcastle Brain Tissue Resource, Edwardson Building, Institute of Neuroscience) ;
Indakoetxea, Begoña (Hospital Universitario de Donostia (Sant Sebastià, País Basc)) ;
Collij, Lyduine E. (Vrije Universiteit Amsterdam, Amsterdam UMC. Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience) ;
Scherer, Martin (Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center, Hamburg-Eppendorf, Germany) ;
Morenas-Rodríguez, Estrella (Institut d'Investigació Biomèdica Sant Pau) ;
Ironside, James W. (University of Edinburgh. Centre for Clinical Brain Sciences) ;
van Berckel, Bart N. M. (Vrije Universiteit Amsterdam, Amsterdam UMC. Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Wiendl, Heinz (University of Münster. Department of Neurology, Klinik für Neurologie mit Institut für Translationale Neurologie) ;
Strickland, Samantha L. (Mayo Clinic Florida. Department of Neuroscience) ;
Pastor, Pau (Fundacio per la Recerca Biomedica I Social Mutua Terrassa) ;
Rodríguez-Rodríguez, Eloy (IDIVAL) ;
Boeve, Bradley (Mayo Clinic Minnesota. Department of Neurology) ;
Petersen, Ronald C. (Mayo Clinic Minnesota. Department of Neurology) ;
Ferman, Tanis J. (Mayo Clinic Florida. Department of Psychiatry and Psychology) ;
van Gerpen, Jay A. (Mayo Clinic Florida. Department of Neurology) ;
Reinders, Marcel J. T. (Delft University of Technology. Delft Bioinformatics Lab) ;
Uitti, Ryan J. (Mayo Clinic Florida. Department of Neurology) ;
Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Maier, Wolfgang (DZNE, German Center for Neurodegenerative Diseases) ;
Dols Icardo, Oriol (Institut d'Investigació Biomèdica Sant Pau) ;
Kawalia, Amit (Uniklinik Köln (Colònia, Alemanya)) ;
Dalmasso, Maria Carolina (Fundación Instituto Leloir (Buenos Aires, Argentina)) ;
Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Zettl, Uwe K. (University of Rostock. Department of Neurology) ;
van Schoor, Natasja M. (Vrije Universiteit Amsterdam) ;
Beekman, Marian (Leiden University Medical Center. Molecular Epidemiology) ;
Allen, Mariet (Mayo Clinic Florida. Department of Neuroscience) ;
Masliah, Eliezer (National Institute on Aging (Estats Units d'Amèrica)) ;
de Munain, Adolfo López (Department of Neurology, Hospital Universitario San Sebastian, San Sebastian, Spain) ;
Pantelyat, Alexander (Johns Hopkins University Medical Center. Department of Neurology) ;
Wszolek, Zbigniew K. (Mayo Clinic Florida. Department of Neurology) ;
Ross, Owen A. (Mayo Clinic Florida. Department of Neuroscience) ;
Dickson, Dennis W. (Mayo Clinic Florida. Department of Neuroscience) ;
Graff-Radford, Neill R. (Mayo Clinic Florida. Department of Neurology) ;
Knopman, David (Mayo Clinic Minnesota. Department of Neurology) ;
Rademakers, Rosa (Mayo Clinic Florida. Department of Neuroscience) ;
Lemstra, Afina W. (Vrije Universiteit Amsterdam, Amsterdam UMC. Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience) ;
Pijnenburg, Yolande (Vrije Universiteit Amsterdam, Amsterdam UMC. Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience) ;
Scheltens, Philip (Vrije Universiteit Amsterdam, Amsterdam UMC. Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience) ;
Gasser, Thomas (University of Tuebingen. Center of Neurology, Department of Neurodegenerative diseases, Hertie-Institute for Clinical Brain Research) ;
Chinnery, Patrick F. (University of Cambridge. MRC Mitochondrial Biology Unit) ;
Hemmer, Bernhard (Munich Cluster for Systems Neurology (SyNergy)) ;
Huisman, Martijn A. (VU University. Department of Sociology) ;
Troncoso, Juan (Johns Hopkins University Medical Center. Department of Pathology (Neuropathology)) ;
Moreno, Fermin (Hospital Universitario de Donostia (Sant Sebastià, País Basc)) ;
Nohr, Ellen A. (University of Southern Denmark. Research Unit of Gynecology and Obstetrics, Department of Clinical Research) ;
Sørensen, Thorkild I. A. (Bristol University. MRC Integrative Epidemiology Unit) ;
Heutink, Peter (University of Tübingen. Hertie Institute for Clinical Brain Research) ;
Sánchez-Juan, Pascual (IDIVAL) ;
Posthuma, Danielle (Vrije Universiteit Amsterdam, Amsterdam UMC. Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience) ;
Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Christensen, Kaare (Odense University Hospital (Dinamarca)) ;
Ertekin-Taner, Nilüfer (Mayo Clinic Florida. Department of Neurology) ;
Scholz, Sonja (Johns Hopkins University Medical Center. Department of Neurology) ;
Ramirez, Alfredo (Uniklinik Köln (Colònia, Alemanya)) ;
Ruiz, Agustín (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Slagboom, Eline (Dutch Society for Research on Ageing, Leiden, The Netherlands) ;
van der Flier, Wiesje M. (Vrije Universiteit Amsterdam, Amsterdam UMC. Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience) ;
Holstege, Henne (Vrije Universiteit Amsterdam, Amsterdam UMC. Department of Clinical Genetics) ;
Universitat Autònoma de Barcelona
The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer's disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. [...]
2019 -  10.1007/s00401-019-02026-8
Acta Neuropathologica, Vol. 138 (may 2019) , p. 237-250
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