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1.
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17 p, 3.1 MB |
Isolation and Characterization of NpCI, a New Metallocarboxypeptidase Inhibitor from the Marine Snail Nerita peloronta with Anti- Plasmodium falciparum Activity
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Cabrera-Muñoz, Aymara (Universidad de la Habana. Centro de Estudio de Proteínas) ;
Sierra-Gómez, Yusvel (Universidad de la Habana. Centro de Estudio de Proteínas) ;
Covaleda Cortés, Giovanni (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Reytor, Mey L. (Universidad de la Habana. Centro de Estudio de Proteínas) ;
González-González, Yamile (Universidad de la Habana. Centro de Estudio de Proteínas) ;
Bautista, José M. (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular) ;
Avilés, Francesc X. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Alonso del Rivero, Maday (Universidad de la Habana. Centro de Estudio de Proteínas)
Metallocarboxypeptidases are zinc-dependent peptide-hydrolysing enzymes involved in several important physiological and pathological processes. They have been a target of growing interest in the search for natural or synthetic compound binders with biomedical and drug discovery purposes, i. [...]
2023 -  10.3390/md21020094
Marine drugs, Vol. 21 (january 2023)
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2.
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13 p, 1.2 MB |
Controlled human malaria infection by intramuscular and direct venous inoculation of cryopreserved Plasmodium falciparum sporozoites in malaria-naïve volunteers : effect of injection volume and dose on infectivity rates
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Gómez-Pérez, Gloria P. (University of Amsterdam) ;
Legarda, Almudena (Institut de Salut Global de Barcelona) ;
Muñoz Gutiérrez, José (Institut de Salut Global de Barcelona) ;
Sim, B. Kim Lee (Sanaria Inc, Rockville, MD USA) ;
Ballester, Maria Rosa (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Dobaño, Carlota (Institut de Salut Global de Barcelona) ;
Moncunill, Gemma (Institut de Salut Global de Barcelona) ;
Campo, Joseph J. (Antigen Discovery, Inc, Irvine, USA) ;
Cisteró, Pau (Institut de Salut Global de Barcelona) ;
Jimenez, Alfons (Institut de Salut Global de Barcelona) ;
Barrios, Diana (Institut de Salut Global de Barcelona) ;
Mordmüller, Benjamin (Institut für Tropenmedizin, Tübingen, Germany) ;
Pardos, Josefina (Institut de Salut Global de Barcelona) ;
Navarro, Mireia (Institut de Salut Global de Barcelona) ;
Zita, Cecilia Justino (Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique) ;
Nhamuave, Carlos Arlindo (Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique) ;
García-Basteiro, Alberto L.. (Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique) ;
Sanz, Ariadna (Institut de Salut Global de Barcelona) ;
Aldea, Marta (Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique) ;
Manoj, Anita (Sanaria Inc, Rockville, USA) ;
Gunasekera, Anusha (Sanaria Inc, Rockville, USA) ;
Billingsley, Peter F. (Sanaria Inc, Rockville, USA) ;
Aponte, John J. (Institut de Salut Global de Barcelona) ;
James, Eric R. (Sanaria Inc, Rockville, MD USA) ;
Guinovart, Caterina (Institut de Salut Global de Barcelona) ;
Antonijoan Arbós, Rosa Ma. (Institut d'Investigació Biomèdica Sant Pau) ;
Kremsner, Peter G. (Institut für Tropenmedizin, Eberhard Karls Universität Tübingen and German Centre for Infection Research, 72074 Tübingen, Germany) ;
Hoffman, Stephen L. (Sanaria Inc, Rockville, USA) ;
Alonso, Pedro L.. (Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique)
Controlled human malaria infection (CHMI) by mosquito bite is a powerful tool for evaluation of vaccines and drugs against Plasmodium falciparum malaria. However, only a small number of research centres have the facilities required to perform such studies. [...]
2015 - 10.1186/s12936-015-0817-x
Malaria journal, Vol. 14 (august 2015)
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3.
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11 p, 1.2 MB |
Direct venous inoculation of Plasmodium falciparum sporozoites for controlled human malaria infection : a dose-finding trial in two centres
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Mordmüller, Benjamin (Eberhard Karls Universität Tübingen and German Center for Infection Research) ;
Supan, Christian (Eberhard Karls Universität Tübingen and German Center for Infection Research) ;
Sim, Kim Lee (Sanaria Inc, Rockville) ;
Gómez-Pérez, Gloria P. (Institut de Salut Global de Barcelona) ;
Ospina Salazar, Carmen Lucelly (Eberhard Karls Universität Tübingen and German Center for Infection Research) ;
Held, Jana (Eberhard Karls Universität Tübingen and German Center for Infection Research) ;
Bolte, Stefanie (Eberhard Karls Universität Tübingen and German Center for Infection Research) ;
Esen, Meral (Eberhard Karls Universität Tübingen and German Center for Infection Research) ;
Tschan, Serena (Eberhard Karls Universität Tübingen and German Center for Infection Research) ;
Joanny, Fanny (Eberhard Karls Universität Tübingen and German Center for Infection Research) ;
Lamsfus Calle, Carlos (Eberhard Karls Universität Tübingen and German Center for Infection Research) ;
Löhr, Sascha J. Z. (Eberhard Karls Universität Tübingen and German Center for Infection Research) ;
Lalremruata, Albert (Eberhard Karls Universität Tübingen and German Center for Infection Research) ;
Gunasekera, Anusha (Sanaria Inc, Rockville) ;
James, Eric R. (Sanaria Inc, Rockville) ;
Billingsley, Peter F. (Sanaria Inc, Rockville) ;
Richman, Adam (Sanaria Inc, Rockville) ;
Chakravarty, Sumana (Sanaria Inc, Rockville) ;
Legarda, Almudena (Institut de Salut Global de Barcelona) ;
Muñoz Gutiérrez, José (Institut de Salut Global de Barcelona) ;
Antonijoan Arbós, Rosa Ma. (Institut d'Investigació Biomèdica Sant Pau) ;
Ballester, Maria Rosa (Institut d'Investigació Biomèdica Sant Pau) ;
Hoffman, Stephen L. (Sanaria Inc, Rockville) ;
Alonso, Pedro L.. (Institut de Salut Global de Barcelona) ;
Kremsner, Peter G. (Eberhard Karls Universität Tübingen and German Center for Infection Research) ;
Universitat Autònoma de Barcelona
Controlled human malaria infection (CHMI) accelerates development of anti-malarial interventions. So far, CHMI is done by exposure of volunteers to bites of five mosquitoes carrying Plasmodium falciparum sporozoites (PfSPZ), a technique available in only a few centres worldwide. [...]
2015 - 10.1186/s12936-015-0628-0
Malaria journal, Vol. 14 (march 2015)
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4.
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9 p, 2.7 MB |
Biochemistry of malaria parasite infected red blood cells by X-ray microscopy
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Kapishnikov, Sergey (University of Copenhagen) ;
Yang, Y. (European Synchrotron Radiation Facility) ;
Cloetens, Peter (European Synchrotron Radiation Facility) ;
Pereiro, Eva (ALBA Laboratori de Llum de Sincrotró) ;
Awamu Ndonglack, Florence (Humboldt University) ;
Matuschewski, Kai (Humboldt University) ;
Als-Nielsen, Jens (University of Copenhagen) ;
Leiserowitz, Leslie (Weizmann Institute of Science (Israel))
Red blood cells infected by the malaria parasite Plasmodium falciparum are correlatively imaged by tomography using soft X-rays as well as by scanning hard nano-X-ray beam to obtain fluorescence maps of various elements such as S and Fe. [...]
2017 - 10.1038/s41598-017-00921-2
Scientific reports, Vol. 7 (April 2017) , art. 802
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5.
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26 p, 5.3 MB |
Identification of tight-binding plasmepsin II and falcipain 2 inhibitors in aqueous extracts of marine invertebrates by the combination of enzymatic and interaction-based assays
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Salas-Sarduy, Emir (Universidad de La Habana (La Havana, Cuba). Centro de Estudio de Proteínas) ;
Guerra, Yasel (Universidad de La Habana (La Havana, Cuba). Centro de Estudio de Proteínas) ;
Covaleda Cortés, Giovanni (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Avilés, Francesc X. (Francesc Xavier) (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Chávez Planes, María A. (Universidad de La Habana (La Havana, Cuba). Centro de Estudio de Proteínas)
Natural products from marine origin constitute a very promising and underexplored source of interesting compounds for modern biotechnological and pharmaceutical industries. However, their evaluation is quite challenging and requires specifically designed assays to reliably identify the compounds of interest in a highly heterogeneous and interfering context. [...]
2017 - 10.3390/md15040123
Marine drugs, Vol. 15, Issue 4 (April 2017)
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6.
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6 p, 2.1 MB |
Changes in malaria epidemiology in a rural area of Cubal, Angola
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Salvador, Fernando (PROSICS Barcelona) ;
Cossio, Yolima (Hospital Universitari Vall d'Hebron) ;
Riera, Marta (Hospital Nossa Senhora da Paz (Cubal, Angola)) ;
Sánchez-Montalvá, Adrián (PROSICS Barcelona) ;
Bocanegra García, Cristina (Hospital Nossa Senhora da Paz (Cubal, Angola)) ;
Mendioroz Peña, Jacobo (Hospital Universitari Vall d'Hebron) ;
Eugenio, Arlette N. (Hospital Nossa Senhora da Paz (Cubal, Angola)) ;
Sulleiro Igual, Elena (Hospital Universitari Vall d'Hebron) ;
Meredith, Warren (University of South Africa. College of Agriculture and Environmental Sciences) ;
López, Teresa (Hospital Nossa Senhora da Paz (Cubal, Angola)) ;
Moreno, Milagros (Hospital Nossa Senhora da Paz (Cubal, Angola)) ;
Molina Romero, Israel (PROSICS Barcelona) ;
Universitat Autònoma de Barcelona
Scarce information about malaria epidemiology in Angola has been published. The objective of this study is to describe the epidemiology of malaria at the Hospital Nossa Senhora da Paz (Cubal, Angola) and the fatality rate due to malaria (total and in children under five years) in the last five years. [...]
2015 - 10.1186/s12936-014-0540-z
Malaria journal, Vol. 14 (january 2015)
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7.
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6 p, 665.3 KB |
Development of a genetic tool for functional screening of anti-malarial bioactive extracts in metagenomic libraries
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Mongui, Álvaro (CorpoGen (Bogotá)) ;
Pérez Llanos, Francy J. (CorpoGen (Bogotá)) ;
Yamamoto, Marcio M. (Universidade de São Paulo) ;
Lozano, Marcela (CorpoGen (Bogotá)) ;
Zambrano, Maria M. (CorpoGen (Bogotá)) ;
Portillo, Patricia del (CorpoGen (Bogotá)) ;
Fernández Becerra, Carmen (Institució Catalana de Recerca i Estudis Avançats) ;
Restrepo, Silvia (Institució Catalana de Recerca i Estudis Avançats) ;
Portillo Obando, Hernando A. del (Institució Catalana de Recerca i Estudis Avançats) ;
Junca, Howard (CorpoGen (Bogotá))
BACKGROUND: The chemical treatment of Plasmodium falciparum for human infections is losing efficacy each year due to the rise of resistance. One possible strategy to find novel anti-malarial drugs is to access the largest reservoir of genomic biodiversity source on earth present in metagenomes of environmental microbial communities. [...]
2015 - 10.1186/s12936-015-0748-6
Malaria journal, Vol. 14 Núm. 233 (June 2015)
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