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17 p, 5.1 MB |
Robust temporal map of human in vitro myelopoiesis using single-cell genomics
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Alsinet, Clara (Open Targets. Wellcome Genome Campus) ;
Primo, Maria Nascimento (Open Targets. Wellcome Genome Campus) ;
Lorenzi, Valentina (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Bello, Erica (Open Targets. Wellcome Genome Campus) ;
Kelava, Iva (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Jones, Carla P. (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Vilarrasa Blasi, Roser (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Sancho Serra, Carmen (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Knights, Andrew J. (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Park, Jong Eun (Korea Advanced Institute of Science and Technology) ;
Wyspianska, Beata S. (Immunology Research Unit. Medicines Research Centre. GlaxoSmithKline) ;
Trynka, Gosia (Open Targets. Wellcome Genome Campus) ;
Tough, David F. (Immunology Research Unit. Medicines Research Centre. GlaxoSmithKline) ;
Bassett, Andrew (Open Targets. Wellcome Genome Campus) ;
Gaffney, Daniel J. (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Álvarez-Errico, Damiana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vento Tormo, Roser (Wellcome Sanger Institute. Wellcome Genome Campus)
Myeloid cells are central to homeostasis and immunity. Characterising in vitro myelopoiesis protocols is imperative for their use in research, immunotherapies, and understanding human myelopoiesis. Here, we generate a >470K cells molecular map of human induced pluripotent stem cells (iPSC) differentiation into macrophages. [...]
2022 -  10.1038/s41467-022-30557-4
Nature communications, Vol. 13 Núm. 1 (december 2022) , p. 2885
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14 p, 1.2 MB |
Progress in cardiac research : From rebooting cardiac regeneration to a complete cell atlas of the heart
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Davidson, Sean M (Hatter Cardiovascular Institute. University College London) ;
Padró, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Bollini, S. (Department of Experimental Medicine (DIMES). University of Genova) ;
Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Duncker, D.J. (Division of Experimental Cardiology. Department of Cardiology. Erasmus University Medical Center) ;
Evans, P.C. (Department of Infection. Immunity and Cardiovascular Disease and Insigneo Institute. University of Sheffield) ;
Guzik, T. (Department of Medicine. Jagiellonian University. Collegium Medicum) ;
Hoefer, I.E. (Central Diagnostic Laboratory. University Medical Center Utrecht) ;
Waltenberger, J. (Department of Cardiovascular Medicine. Medical Faculty. University of Muenster) ;
Wojta, J. (Department of Internal Medicine Ii. Medical University of Vienna) ;
Weber, C. (Cardiovascular Research Institute Maastricht (CARIM). Department of Biochemistry. Maastricht University)
We review some of the important discoveries and advances made in basic and translational cardiac research in 2020. For example, in the field of myocardial infarction (MI), new aspects of autophagy and the importance of eosinophils were described. [...]
2021 - 10.1093/cvr/cvab200
Cardiovascular research, Vol. 117 Núm. 10 (january 2021) , p. 2161-2174
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3.
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15 p, 1.1 MB |
Adapting Cord Blood Collection and Banking Standard Operating Procedures for HLA-Homozygous Induced Pluripotent Stem Cells Production and Banking for Clinical Application
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Alvarez-Palomo, Belén (Banc de Sang i Teixits) ;
Vives Armengol, Joaquim (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Casaroli-Marano, Ricardo Pedro (Institut d'Investigació Biomèdica Sant Pau) ;
G. Gómez, Susana (Banc de Sang i Teixits) ;
Rodriguez Gómez, Luciano (Banc de Sang i Teixits) ;
Edel, Michael J.. (Centre d'Oftalmologia Barraquer (Barcelona, Catalunya)) ;
Querol, Sergi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
In this article, we will discuss the main aspects to be considered to define standard operation procedures (SOPs) for the creation of an induced pluripotent stem cell (iPSC) bank using cord blood (CB)-or similar cell type-bank guidelines for clinical aims. [...]
2019 - 10.3390/jcm8040476
Journal of clinical medicine, Vol. 8 (april 2019)
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15 p, 5.7 MB |
Cell therapy with hiPSC-derived RPE cells and RPCs prevents visual function loss in a rat model of retinal degeneration
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Salas Torras, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Duarri, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fontrodona Montals, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramírez Mora, Diana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Badia Pérez, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Isla-Magrané, Helena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ferreira-de-Souza, Barbara (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Zapata, Miguel Angel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Raya, Ángel (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
García Arumí, José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Photoreceptor loss is the principal cause of blindness in retinal degenerative diseases (RDDs). Whereas some therapies exist for early stages of RDDs, no effective treatment is currently available for later stages, and once photoreceptors are lost, the only option to rescue vision is cell transplantation. [...]
2021 - 10.1016/j.omtm.2021.02.006
Molecular Therapy. Methods & Clinical Development, Vol. 20 (february 2021) , p. 688-702
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6.
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18 p, 2.2 MB |
Aberrant epigenome in -derived dopaminergic neurons from Parkinson's disease patients
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Fernández-Santiago, Rubén (Universitat de Barcelona) ;
Carballo-Carbajal, Iria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castellano, Giancarlo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Torrent, Roger (Universitat de Barcelona. Institut de Biomedicina) ;
Richaud, Yvonne (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Sánchez-Danés, Adriana (Universitat de Barcelona. Institut de Biomedicina) ;
Vilarrasa-Blasi, Roser (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Sánchez, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mosquera, José Luis (Universitat de Barcelona) ;
Soriano, Jordi (Universitat de Barcelona) ;
López-Barneo, José (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Canals, Josep M.. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Alberch i Vié, Jordi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Raya, Ángel (Institució Catalana de Recerca i Estudis Avançats) ;
Vila Bover, Miquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Consiglio, Antonella (University of Brescia and National Institute of Neuroscience) ;
Martín-Subero, José I (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ezquerra, Mario (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Tolosa, Eduardo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Universitat Autònoma de Barcelona
The epigenomic landscape of Parkinson's disease () remains unknown. We performed a genomewide methylation and a transcriptome studies in induced pluripotent stem cell ()-derived dopaminergic neurons (n) generated by cell reprogramming of somatic skin cells from patients with monogenic 2-associated (L2) or sporadic (), and healthy subjects. [...]
2015 - 10.15252/emmm.201505439
EMBO Molecular Medicine, Vol. 7, Núm. 12 (October 2015) , p. 1529-1546
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7.
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17 p, 3.5 MB |
Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency
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Muñoz López, Álvaro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Romero Moya, Damià (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Prieto, Cristina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ramos Mejía, Verónica (Centro Pfizer - Universidad de Granada - Junta de Andalucía de Genómica e Investigación Oncológica) ;
Agraz-Doblás, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Varela, Ignacio (Instituto de Biomedicina y Biotecnología de Cantabria) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Palau de Miguel, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Carvajal Vergara, Xonia (Universidad de Navarra. Centro de Investigación Médica Aplicada) ;
Giorgetti, Alessandra (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ford, Anthony (Institute of Cancer Research (London, Gran Bretanya)) ;
Lako, Majlinda (Newcastle University. Institute of Genetic Medicine) ;
Granada, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz Xivillé, Neus (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez Perales, Sandra (Centro Nacional de Investigaciones Oncológicas) ;
Torres Ruíz, Raúl (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Stam, Ronald W. (Erasmus University Medical Center (Rotterdam, Holanda)) ;
Fuster, José Luis (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ;
Fraga, Mario F.. (Instituto Universitario de Oncología del Principado de Asturias (Oviedo)) ;
Nakanishi, Mahito (National Institute of Advanced Industrial Science and Technology (Tsukuba, Japó)) ;
Cazzaniga, Giovanni (Università degli Studi di Milano-Bicocca) ;
Bardini, Michela (Università degli Studi di Milano-Bicocca) ;
Cobo, Isabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández Bayón, Gustavo (Instituto Universitario de Oncología del Principado de Asturias (Oviedo)) ;
Fernández, Agustín F. (Instituto Universitario de Oncología del Principado de Asturias (Oviedo)) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Induced pluripotent stem cells (iPSCs) are a powerful tool for disease modeling. They are routinely generated from healthy donors and patients from multiple cell types at different developmental stages. [...]
2016 - 10.1016/j.stemcr.2016.08.013
Stem cell reports, Vol. 7 Núm. 4 (October 2016)
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8.
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20 p, 974.0 KB |
Effects of the post-spinal cord injury microenvironment on the differentiation capacity of human neural stem cells derived from induced pluripotent stem cells
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López-Serrano, Clara (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Torres Espín, Abel (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Hernández Martín, Joaquim (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Álvarez Palomo, Ana Belén (Universitat de Barcelona) ;
Requena, Jordi (Universitat de Barcelona) ;
Gasull, Xavier (Universitat de Barcelona) ;
Edel, Michael J (Universitat de Barcelona) ;
Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Spinal cord injury (SCI) causes loss of neural functions below the level of the lesion due to interruption of spinal pathways and secondary neurodegenerative processes. The transplant of neural stem cells (NSCs) is a promising approach for the repair of SCI. [...]
2016 - 10.3727/096368916X691312
Cell transplantation, Vol. 25, núm. 10 (2016) , p. 1833-1852
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