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1.
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14 p, 1.6 MB |
Toxicological Profiling and Long-Term Effects of Bare, PEGylated- and Galacto-Oligosaccharide-Functionalized Mesoporous Silica Nanoparticles
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Barguilla, Irene (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Candela-Noguera, Vicente (Universitat Politècnica de València) ;
Oliver, Patrick (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Annangi, Balasubramanyam (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Díez, Paula (Universitat Politècnica de València) ;
Aznar, Elena (Universitat Politècnica de València) ;
Martínez-Máñez, Ramón (Universitat Politècnica de València) ;
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Hernández, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Marcos Martínez, Maria Dolores (Universitat Politècnica de València)
Mesoporous silica nanoparticles (MSNs) are amongst the most used nanoparticles in biomedicine. However, the potentially toxic effects of MSNs have not yet been fully evaluated, being a controversial matter in research. [...]
2023 -  10.3390/ijms242216158
International journal of molecular sciences, Vol. 24, Issue 22 (November 2023) , art. 16158
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2.
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19 p, 2.2 MB |
Mutational Status of SMAD4 and FBXW7 Affects Clinical Outcome in TP53 -Mutated Metastatic Colorectal Cancer
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Lahoz, Sara (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rodríguez, Adela (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Fernández-Barat, Laia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Gorría, Teresa (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Moreno, Reinaldo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Esposito, Francis (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Oliveres, Helena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Albiol, Santiago (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Saurí, Tamara (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pesantez, David (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Riu-Viladoms, G (Hospital Clínic i Provincial de Barcelona) ;
Cuatrecasas, Miriam (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Jares, Pedro (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pedrosa, Leire (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pineda, Estela (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Castells, Antoni (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Prat, Aleix (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Maurel, Joan (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Camps, Jordi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
The mutational status of certain genes can be useful to advance therapeutic decision making and clinical management of cancer patients. In metastatic colorectal cancer, current clinicopathological factors employed in clinical practice have low or modest individual effect on survival, leading to a poor ability to discriminate patients at high risk. [...]
2022 - 10.3390/cancers14235921
Cancers, Vol. 14, Num. 23 (November 2022) , art. 5921
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3.
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14 p, 3.9 MB |
Copy-number intratumor heterogeneity increases the risk of relapse in chemotherapy-naive stage colon cancer
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Lahoz, Sara (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Archilla, Ivan (Universitat de Barcelona) ;
Asensio, Elena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Hernández-Illán, Eva (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ferrer Menduiña, Queralt (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
López-Prades, Sandra (Universitat de Barcelona) ;
Nadeu, Ferran (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Del Rey Azpiri, Javier (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Sanz-Pamplona, Rebeca (Institut d'Investigació Biomèdica de Bellvitge) ;
Lozano, Juan José (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Castells, Antoni (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Cuatrecasas, Miriam (Universitat de Barcelona) ;
Camps, Jordi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Optimal selection of high-risk patients with stage II colon cancer is crucial to ensure clinical benefit of adjuvant chemotherapy. Here, we investigated the prognostic value of genomic intratumor heterogeneity and aneuploidy for disease recurrence. [...]
2022 - 10.1002/path.5870
The Journal of Pathology, Vol. 257, Num. 1 (April 2022) , p. 68-81
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4.
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17 p, 9.6 MB |
Gene dysregulation in acute HIV-1 infection - early transcriptomic analysis reveals the crucial biological functions affected
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Parker, Erica (University of Western Australia) ;
Judge, Melinda A. (University of Western Australia) ;
Pastor Palomo, Lucía (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fuente-Soro, Laura (Hospital Clínic i Provincial de Barcelona) ;
Jairoce, Chenjerai (Centro de Investigação em Saúde da Manhiça (CISM)) ;
Carter, Kim W. (Telethon Kids Institute) ;
Anderson, Denise (Telethon Kids Institute) ;
Mandomando, Inácio (Centro de Investigação em Saúde da Manhiça (CISM)) ;
Clifford, Holly D. (Telethon Kids Institute) ;
Naniche, Denise (Hospital Clínic i Provincial de Barcelona) ;
Le Souëf, Peter Neils (Telethon Kids Institute) ;
Universitat Autònoma de Barcelona
Transcriptomic analyses from early human immunodeficiency virus (HIV) infection have the potential to reveal how HIV causes widespread and lasting damage to biological functions, especially in the immune system. [...]
2023 - 10.3389/fcimb.2023.1074847
Frontiers in cellular and infection microbiology, Vol. 13 (april 2023)
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5.
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12 p, 3.2 MB |
Global analysis of the association between pig muscle fatty acid composition and gene expression using RNA-Seq
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Valdés-Hernández, Jesús (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Ramayo-Caldas, Yuliaxis (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Passols, Magí (Centre de Recerca en Agrigenòmica) ;
Sebastià, Cristina (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Criado Mesas, Lourdes (Centre de Recerca en Agrigenòmica) ;
Crespo-Piazuelo, Daniel (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Esteve-Codina, Anna (Barcelona Institute of Science and Technology (BIST)) ;
Castelló Farré, Anna (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Sánchez Bonastre, Armando (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Folch, Josep M. (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Fatty acids (FAs) play an essential role as mediators of cell signaling and signal transduction, affecting metabolic homeostasis and determining meat quality in pigs. However, FAs are transformed by the action of several genes, such as those encoding desaturases and elongases of FAs in lipogenic tissues. [...]
2023 - 10.1038/s41598-022-27016-x
Scientific reports, Vol. 13 (january 2023)
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6.
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14 p, 1.9 MB |
Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma
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Frontzek, Fabian (University Hospital of Münster (Alemanya)) ;
Staiger, Annette M. (Robert Bosch Hospital) ;
Zapukhlyak, Myroslav (University Hospital of Münster (Alemanya)) ;
Xu, Wendan (University Hospital of Münster (Alemanya)) ;
Bonzheim, Irina (University Hospital of Tübingen (Alemanya)) ;
Borgmann, Vanessa (University Hospital of Tübingen (Alemanya)) ;
Sander, Philip (University Hospital of Tübingen (Alemanya)) ;
Baptista, Maria Joao (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Heming, Jan-Niklas (University Hospital of Münster (Alemanya)) ;
Berning, Philipp (University Hospital of Münster (Alemanya)) ;
Wullenkord, Ramona (University Hospital of Münster (Alemanya)) ;
Erdmann, Tabea (University Hospital of Münster (Alemanya)) ;
Lutz, Mathias (University Hospital of Münster (Alemanya)) ;
Veratti, Pia (University Hospital Freiburg) ;
Ehrenfeld, Sophia (University of Freiburg) ;
Wienand, Kirsty (University Medical Center Göttingen) ;
Horn, Heike (Robert Bosch Hospital) ;
Goodlad, John R. (Queen Elizabeth University Hospital) ;
Wilson, Matthew R. (Beatson West of Scotland Cancer Centre (Glasgow, Regne Unit)) ;
Anagnostopoulos, Ioannis (Charité - Universitätsmedizin Berlin) ;
Lamping, Mario (Charité - Universitätsmedizin Berlin) ;
González Barca, Eva (Universitat de Barcelona) ;
Climent, Fina (Institut d'Investigació Biomèdica de Bellvitge) ;
Salar, Antonio (Hospital del Mar (Barcelona, Catalunya)) ;
Castellvi, Josep (Hospital Universitari Vall d'Hebron) ;
Abrisqueta, Pau (Hospital Universitari Vall d'Hebron) ;
Menarguez, Javier (Hospital General Universitario Gregorio Marañón) ;
Aldámiz-Echevarría, T (Hospital General Universitario Gregorio Marañón) ;
Richter, Julia (Christian-Albrechts-University) ;
Klapper, Wolfram (Christian-Albrechts-University) ;
Tzankov, Alexander (University Hospital Basel (Basilea, Suïssa)) ;
Dirnhofer, Stefan (University Hospital Basel (Basilea, Suïssa)) ;
Rosenwald, Andreas (University of Würzburg) ;
Mate Sanz, Jose Luís (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tapia, Gustavo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lenz, Peter (Department of Physics. University of Marburg) ;
Miething, C. (German Cancer Research Center) ;
Hartmann, Wolfgang (University Hospital of Münster (Alemanya)) ;
Chapuy, Björn (University Medical Center Göttingen) ;
Fend, Falko (University Hospital of Tübingen (Alemanya)) ;
Ott, Gustav (Department of Clinical Pathology. Robert Bosch Hospital) ;
Navarro, José-Tomás (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Grau, Michael (University Hospital of Münster (Alemanya)) ;
Lenz, Georg (University Hospital of Münster (Alemanya)) ;
Universitat Autònoma de Barcelona
Plasmablastic lymphoma (PBL) represents a rare and aggressive lymphoma subtype frequently associated with immunosuppression. Clinically, patients with PBL are characterized by poor outcome. The current understanding of the molecular pathogenesis is limited. [...]
2021 - 10.1038/s41467-021-25405-w
Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 5183
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7.
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31 p, 22.1 MB |
The molecular evolution of spermatogenesis across mammals
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Murat, Florent (Heidelberg University. Center for Molecular Biology) ;
Mbengue, Noe (Heidelberg University. Center for Molecular Biology) ;
Boeg Winge, Sofia (Copenhagen University Hospital. Department of Growth and Reproduction) ;
Trefzer, Timo (University of Medicine Berlin. Berlin Institute of Health at Charité) ;
Leushkin, Evgeny (Heidelberg University. Center for Molecular Biology) ;
Sepp, Mari (Heidelberg University. Center for Molecular Biology) ;
Cardoso-Moreira, Margarida (Francis Crick Institute. Evolutionary Developmental Biology Laboratory (UK)) ;
Schmidt, Julia (Heidelberg University. Center for Molecular Biology) ;
Schneider, Celine (Heidelberg University. Center for Molecular Biology) ;
Mößinger, Katharina (Heidelberg University. Center for Molecular Biology) ;
Brüning, Thoomke (Heidelberg University. Center for Molecular Biology) ;
Lamanna, Francesco (Heidelberg University. Center for Molecular Biology) ;
Riera Belles, Meritxell (Aarhus University. Bioinformatics Research Centre) ;
Conrad, Christian (University of Medicine Berlin. Berlin Institute of Health at Charité) ;
Kondova, Ivanela (Biomedical Primate Research Center (the Netherlands)) ;
Bontrop, Ronald (Biomedical Primate Research Center (the Netherlands)) ;
Behr, Rüdiger (German Primate Center. Platform Degenerative Diseases) ;
Khaitovich, Philipp (Skolkovo Institute of Science and Technology. Center for Neurobiology and Brain Restoration (Russia)) ;
Pääbo, Svante (Max Planck Institute for Evolutionary Anthropology) ;
Marques-Bonet, Tomas 1975- (Institut Català de Paleontologia Miquel Crusafont) ;
Grutzner, Frank (University of Adelaide. The Robinson Research Institute (Australia)) ;
Almstrup, Kristian (Copenhagen University Hospital. Department of Growth and Reproduction) ;
Schierup, Mikkel Heide (Aarhus University. Bioinformatics Research Centre) ;
Kaessmann, Henrik (Heidelberg University. Center for Molecular Biology)
The testis produces gametes through spermatogenesis and evolves rapidly at both the morphological and molecular level in mammals1,2,3,4,5,6, probably owing to the evolutionary pressure on males to be reproductively successful7. [...]
2023 - 10.1038/s41586-022-05547-7
Nature, Vol. 613 (2023) , p. 308-316
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8.
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28 p, 729.1 KB |
Coupling dissolved oxygen microsensors measurements and heterogeneous respirometry for monitoring and modeling microbial activity within sulfide-oxidizing biofilms
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Guimerà Villalba, Xavier (Universitat Politècnica de Catalunya. Departament d'Enginyeria Minera, Industrial i TIC) ;
Mora Garrido, Mabel (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
López de León, Luis R. (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Gabriel, Gemma (Institut de Microelectrònica de Barcelona) ;
Dorado, Antonio David (Universitat Politècnica de Catalunya. Departament d'Enginyeria Minera, Industrial i TIC) ;
Lafuente Sancho, Francisco Javier (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Gamisans Noguera, Xavier (Universitat Politècnica de Catalunya. Departament d'Enginyeria Minera, Industrial i TIC) ;
Gabriel, David (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental)
A heterogeneous respirometer (HR) was coupled for the first time to a microelectrode monitoring system specifically designed for dissolved oxygen (DO) measuring within the biofilm. Monitoring of the oxygen concentration in the gas and liquid phases was complemented with pioneer monitoring of DO performed simultaneously and continuously at multiple biofilm depths in a linear array of eleven gold-disk electrodes of 50 µm-diameter. [...]
2020 - 10.1016/j.cej.2020.125846
Chemical engineering journal, Vol. 400 (November 2020) , art. 125846
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9.
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9 p, 1.9 MB |
A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood
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Gassó, Patricia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rodríguez, Natalia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Martínez Piñeiro, Alberto (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Mezquida, Gisela (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ribeiro-Fernández, María (Instituto de Investigación Sanitaria de Navarra) ;
González-Peñas, Javier (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Zorrilla, Iñaki (Araba Unibertsitate Ospitalea) ;
Martínez-Sadurni, L. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rodriguez-Jimenez, Roberto (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
Corripio, Iluminada (Institut d'Investigació Biomèdica Sant Pau) ;
Sarró, Salvador (FIDMAG Germanes Hospitalàries Research Foundation) ;
Ibáñez, Ángela (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Usall, Judith (Institut de Recerca Sant Joan de Déu) ;
Lobo, Antonio (Instituto de Investigación Sanitaria de Aragón) ;
Moren, C. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Cuesta, Manuel J (Instituto de Investigación Sanitaria de Navarra) ;
Parellada, M. (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
González-Pinto, A. (Araba Unibertsitate Ospitalea) ;
Berrocoso, E. (Instituto de Investigación e Innovación Biomédica de Cádiz) ;
Bernardo, Miquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Mas, S. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Alonso-Solís, Anna (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Grasa, Eva (Institut d'Investigació Biomèdica Sant Pau) ;
Bergé Baquero, Daniel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Trabsa, Amira (Institut Hospital del Mar d'Investigacions Mèdiques) ;
2EPs Group
Little is known about the pathophysiological mechanisms of relapse in first-episode schizophrenia, which limits the study of potential biomarkers. To explore relapse mechanisms and identify potential biomarkers for relapse prediction, we analyzed gene expression in peripheral blood in a cohort of first-episode schizophrenia patients with less than 5 years of evolution who had been evaluated over a 3-year follow-up period. [...]
2021 - 10.1038/s41398-021-01645-8
Translational psychiatry, Vol. 11 Núm. 1 (december 2021) , p. 539
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10.
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18 p, 1.6 MB |
Cytochrome c Deficiency Differentially Affects the In Vivo Mitochondrial Electron Partitioning and Primary Metabolism Depending on the Photoperiod
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Florez-Sarasa, Igor (Centre de Recerca en Agrigenòmica) ;
Welchen, Elina (Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral) ;
Racca, Sofia (Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral) ;
Gonzalez, Daniel H. (Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral) ;
Vallarino, José G. (Max-Planck-Institute of Molecular Plant Physiology) ;
Fernie, Alisdair (Max-Planck-Institute of Molecular Plant Physiology) ;
Ribas-Carbo, Miquel (Universitat de les Illes Balears) ;
Fernández Del-Saz, Néstor (Universidad de Concepción. Departamento de Botánica)
Plant respiration provides metabolic flexibility under changing environmental conditions by modulating the activity of the nonphosphorylating alternative pathways from the mitochondrial electron transport chain, which bypass the main energy-producing components of the cytochrome oxidase pathway (COP). [...]
2021 - 10.3390/plants10030444
Plants, Vol. 10, Issue 3 (March 2021) , art. 444
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