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9 p, 1.3 MB |
Development and evaluation of a search filter to identify prognostic factor studies in Ovid MEDLINE
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Stallings, Elena (CIBER Epidemiología Y Salud Pública (CIBERESP)) ;
Gaetano-Gil, Andrea (Instituto Ramón Y Cajal de Investigación Sanitaria) ;
Alvarez-Diaz, Noelia (Hospital Universitario Ramón Y Cajal (IRYCIS)) ;
Solà, Ivan (Institut d'Investigació Biomèdica Sant Pau) ;
López-Alcalde, Jesús (University Hospital Zurich and University of Zurich) ;
Molano, Daniel (Hospital de San José) ;
Zamora, Javier (University of Birmingham) ;
Universitat Autònoma de Barcelona
Systematic reviews (SRs) are valuable resources as they address specific clinical questions by summarizing all existing relevant studies. However, finding all information to include in systematic reviews can be challenging. [...]
2022 -  10.1186/s12874-022-01595-9
BMC Medical Research Methodology, Vol. 22 Núm. 1 (december 2022) , p. 107
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13 p, 1.6 MB |
Mutational Profile Enables the Identification of a High-Risk Subgroup in Myelodysplastic Syndromes with Isolated Trisomy 8
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Toribio-Castelló, Sofía (CIBERONC. Research Group CB16/12/00233) ;
Castaño-Díez, Sandra (Hospital Clínic i Provincial de Barcelona) ;
Villaverde-Ramiro, Ángela (Universidad de Salamanca) ;
Such, Esperanza (Hospital Universitari i Politècnic La Fe (València)) ;
Arnan, Montserrat (Hospital Duran i Reynals (Hospitalet del Llobregat)) ;
Sole, F (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Díaz-Beyá, Marina (Hospital Clínic i Provincial de Barcelona) ;
Díez-Campelo, María (CIBERONC. Research Group CB16/12/00233) ;
del Rey, Mónivs (Hospital Universitario de Salamanca) ;
González, Teresa (Hospital Universitario de Salamanca) ;
Hernández-Rivas, Jesús María (CIBERONC. Research Group CB16/12/00233)
Trisomy 8 (+8) is the most frequent trisomy in myelodysplastic syndromes (MDS) and is associated with clinical heterogeneity and intermediate cytogenetic risk when found in isolation. The presence of gene mutations in this group of patients and the prognostic significance has not been extensively analyzed. [...]
2023 - 10.3390/cancers15153822
Cancers, Vol. 15 Núm. 15 (august 2023) , p. 3822
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14 p, 1.1 MB |
Long-Term Studies Assessing Outcomes of Ibrutinib Therapy in Patients With Del(11q) Chronic Lymphocytic Leukemia
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Kipps, Thomas J. (UC San Diego Moores Cancer Center) ;
Fraser, Graeme (McMaster University (Canadà)) ;
Coutre, Steven E (Stanford University School of Medicine) ;
Brown, Jennifer R. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Barrientos, Jacqueline C. (Northwell Health Cancer Institute) ;
Barr, Paul M. (University of Rochester) ;
Byrd, John C. (The Ohio State University Comprehensive Cancer Center) ;
O'Brien, Susan M. (University of California) ;
Dilhuydy, Marie-Sarah (Hôpital Haut-Lévêque) ;
Hillmen, Peter (University of Leeds) ;
Jaeger, Ulrich (Medical University of Vienna) ;
Moreno, Carol (Institut d'Investigació Biomèdica Sant Pau) ;
Cramer, Paula (University of Cologne) ;
Stilgenbauer, Stephan (University of Ulm) ;
Chanan-Khan, Asher A. (Mayo Clinic Cancer Center) ;
Mahler, Michelle (Janssen Research and Development) ;
Salman, Mariya (Janssen Research and Development) ;
Eckert, Karl (Pharmacyclics LLC. an AbbVie Company) ;
Solman, Isabelle G. (Pharmacyclics LLC. an AbbVie Company) ;
Balasubramanian, Sriram (Janssen Research and Development) ;
Cheng, Mei (Pharmacyclics LLC. an AbbVie Company) ;
Londhe, Anil (Janssen Research and Development) ;
Ninomoto, Joi (Pharmacyclics LLC. an AbbVie Company) ;
Howes, Angela (Janssen Research and Development) ;
James, Danelle F. (Pharmacyclics LLC. an AbbVie Company) ;
Hallek, Michael (University of Cologne) ;
Universitat Autònoma de Barcelona
Certain genomic features, such as del(11q), expression of unmutated immunoglobulin heavy-chain variable region (IGHV) gene, or complex karyotype, predict poorer outcomes to chemotherapy in patients with chronic lymphocytic leukemia (CLL). [...]
2019 - 10.1016/j.clml.2019.07.004
Clinical Lymphoma, Myeloma & Leukemia, Vol. 19 Núm. 11 (november 2019) , p. 715-722.e6
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15 p, 1.9 MB |
In silico Approach for Validating and Unveiling New Applications for Prognostic Biomarkers of Endometrial Cancer
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Coll de la Rubia, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinez-Garcia, Elena (Luxembourg Institute of Health) ;
Dittmar, Gunnar (Luxembourg Institute of Health) ;
Nazarov, Petr V. (Luxembourg Institute of Health) ;
Bebia, Vicente (Hospital Universitari Vall d'Hebron) ;
Cabrera Díaz, Silvia (Hospital Universitari Vall d'Hebron) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Endometrial cancer (EC) mortality is directly associated with the presence of poor prognostic factors. Molecular prognostic factors have been identified, but none are used in clinical practice due to lack of validation studies. [...]
2021 - 10.3390/cancers13205052
Cancers, Vol. 13 (october 2021)
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13 p, 1.6 MB |
Refining Kidney Survival in 383 Genetically Characterized Patients With Nephronophthisis
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König, Jens Christian (Department of General Pediatrics, University Children's Hospital Münster) ;
Karsay, Rebeka (Department of General Pediatrics, University Children's Hospital Münster) ;
Gerß, Joachim (Institute of Biostatistics and Clinical Research, University of Münster) ;
Schlingmann, Karl-Peter (Department of General Pediatrics, University Children's Hospital Münster) ;
Dahmer-Heath, Mareike (Department of General Pediatrics, University Children's Hospital Münster) ;
Telgmann, Anna-Katharina (Department of General Pediatrics, University Children's Hospital Münster) ;
Kollmann, Sabine (Department of General Pediatrics, University Children's Hospital Münster) ;
Ariceta Iraola, Gema (Hospital Universitari Vall d'Hebron) ;
Gillion, Valentine (Division of Nephrology, Saint-Luc Academic Hospital, Université Catholique Louvain) ;
Bockenhauer, Detlef (Great Ormond Street Hospital for Children (Londres)) ;
Bertholet-Thomas, Aurélia (Centre de Référence des Maladies Rénales Rares-Néphrogones-Hôpital Femme Mère Enfant, Hospices Civils de Lyon-Filière ORKiD) ;
Mastrangelo, Antonio (Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico) ;
Boyer, Olivia (Hôpital Necker-Enfants Malades, Université de Paris) ;
Lilien, Marc (Department of Pediatric Nephrology, University Medical Center Utrecht) ;
Decramer, Stéphane (Université Toulouse III Paul-Sabatier) ;
Schanstra, Joost. P. (Université Toulouse III Paul-Sabatier) ;
Pohl, Martin (Department of Pediatrics, University Hospital Freiburg) ;
Schild, Raphael (University Medical Center Hamburg-Eppendorf) ;
Weber, Stefanie (University Children's Hospital) ;
Hoefele, Julia (Institut für Humangenetik) ;
Drube, Jens (Departement of Pediatric Nephrology, Medical School Hannover) ;
Cetiner, Metin (Department of Pediatric Nephrology, University of Duisburg-Essen) ;
Hansen, Matthias (Clementine Kinderhospital) ;
Thumfart, Julia (Charité - Universitätsmedizin Berlin) ;
Tönshoff, Burkhard (Department of Pediatrics I, University Children's Hospital Heidelberg) ;
Habbig, Sandra (Department of Pediatric, University of Cologne) ;
Liebau, Max Christoph (University Hospital Cologne and Medical) ;
Bald, Martin (Children's Hospital (Alemanya)) ;
Bergmann, Carsten (Medizinische Genetik Mainz (Alemanya)) ;
Pennekamp, Petra (Department of General Pediatrics, University Children's Hospital Münster) ;
Konrad, Martin (Department of General Pediatrics, University Children's Hospital Münster) ;
Universitat Autònoma de Barcelona
Nephronophthisis (NPH) comprises a group of rare disorders accounting for up to 10% of end-stage kidney disease (ESKD) in children. Prediction of kidney prognosis poses a major challenge. We assessed differences in kidney survival, impact of variant type, and the association of clinical characteristics with declining kidney function. [...]
2022 - 10.1016/j.ekir.2022.05.035
Kidney International Reports, Vol. 7 (june 2022) , p. 2016-2028
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7.
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7 p, 1000.2 KB |
Spontaneous reperfusion enhances succinate concentration in peripheral blood from stemi patients but its levels does not correlate with myocardial infarct size or area at risk
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Consegal, Marta (Hospital Universitari Vall d'Hebron) ;
Barba, Ignasi (Hospital Universitari Vall d'Hebron) ;
García del Blanco, Bruno (Hospital Universitari Vall d'Hebron) ;
Otaegui, Imanol (Hospital Universitari Vall d'Hebron) ;
Rodriguez-Palomares, Jose F (Hospital Universitari Vall d'Hebron) ;
Martí Balaguer, Gerard (Hospital Universitari Vall d'Hebron) ;
Serra-Vidal, Bernat (Hospital Universitari Vall d'Hebron) ;
Bellera Gotarda, Neus (Hospital Universitari Vall d'Hebron) ;
Ojeda-Ramos, Manuel (Hospital Universitari Vall d'Hebron) ;
Valente, Filipa (Hospital Universitari Vall d'Hebron) ;
Carmona, Maria Ángeles (Hospital Universitari Vall d'Hebron) ;
Miró-Casas, Elisabet (Hospital Universitari Vall d'Hebron) ;
Sambola, Antonia (Hospital Universitari Vall d'Hebron) ;
Lidón, Rosa María (Hospital Universitari Vall d'Hebron) ;
Bañeras, Jordi (Hospital Universitari Vall d'Hebron) ;
Barrabés, José A (Hospital Universitari Vall d'Hebron) ;
Rodríguez, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Benito, Begoña (Hospital Universitari Vall d'Hebron) ;
Ruiz Meana, Marisol (Hospital Universitari Vall d'Hebron) ;
Inserte Igual, Javier (Hospital Universitari Vall d'Hebron) ;
Ferreira-Gonzalez, Ignacio (Hospital Universitari Vall d'Hebron) ;
Rodríguez-Sinovas, Antonio (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Succinate is enhanced during initial reperfusion in blood from the coronary sinus in ST-segment elevation myocardial infarction (STEMI) patients and in pigs submitted to transient coronary occlusion. [...]
2023 - 10.1038/s41598-023-34196-7
Scientific reports, Vol. 13 (april 2023)
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11 p, 548.2 KB |
Estimating the Incidence and Key Risk Factors of Cardiovascular Disease in Patients at High Risk of Imminent Fracture Using Routinely Collected Real-World Data From the
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Pineda-Moncusí, Marta (University of Oxford) ;
El-Hussein, Leena (University of Oxford) ;
Delmestri, Antonella (University of Oxford) ;
Cooper, Cyrus (University of Southampton) ;
Moayyeri, Alireza (UCB Biopharma Sprl) ;
Libanati, Cesar (UCB Biopharma Sprl) ;
Toth, Emese (UCB Biopharma Sprl) ;
Prieto-Alhambra, Daniel (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Khalid, Sara (University of Oxford) ;
Universitat Autònoma de Barcelona
The objective of this work was to estimate the incidence rate of cardiovascular disease (CVD) events (myocardial infarction, stroke, or CVD death) at 1 year among three cohorts of patients at high risk of fracture (osteoporosis, previous fracture, and anti-osteoporosis medication) and to identify the key risk factors of CVD events in these three cohorts. [...]
2022 - 10.1002/jbmr.4648
Journal of Bone and Mineral Research, Vol. 37 (september 2022) , p. 1986-1996
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16 p, 1.1 MB |
Validity of prognostic models of critical COVID-19 is variable. A systematic review with external validation
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Cárdenas-Fuentes, Gabriela (Barcelona Institute for Global Health (ISGlobal)) ;
Bosch de Basea, Magda (Barcelona Institute for Global Health (ISGlobal)) ;
Cobo, Inés (Barcelona Institute for Global Health (ISGlobal)) ;
Subirana, Isaac (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Ceresa, Mario (Universitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions) ;
Famada, Ernest (Universitat Pompeu Fabra) ;
Gimeno-Santos, Elena (Hospital Clínic i Provincial de Barcelona) ;
Delgado-Ortiz, Laura (Barcelona Institute for Global Health (ISGlobal)) ;
Faner, Rosa (Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS)) ;
Molina-Molina, María (Institut d'Investigació Biomèdica de Bellvitge) ;
Agustí, Àlvar (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Muñoz Gall, Xavier (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Sibila, Oriol (Hospital Clínic i Provincial de Barcelona) ;
Gea Guiral, Joaquim (Barcelona Respiratory Network, Barcelona, Spain) ;
Garcia-Aymerich, Judith (Barcelona Institute for Global Health (ISGlobal))
To identify prognostic models that estimate the risk of critical COVID-19 in hospitalised patients and to assess their validation properties. We conducted a systematic review in Medline (up to January 2021) of studies developing or updating a model that estimated the risk of critical COVID-19, defined as death, admission to intensive care unit (ICU), and/or use of mechanical ventilation during admission. [...]
2023 - 10.1016/j.jclinepi.2023.04.011
Journal of Clinical Epidemiology, Vol. 159, (July 2023) , p. 274-288
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13 p, 2.4 MB |
Initial clinical and treatment patterns of advanced differentiated thyroid cancer : ERUDIT study
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Vallejo Casas, Juan Antonio (Insituto Maimónides de Investigación Biomédica (Córdoba)) ;
Sambo, Marcel (Hospital General Universitario Gregorio Marañón) ;
López-López, Carlos A (Instituto de Investigación Marqués de Valdecilla) ;
Durán-Poveda, Manuel (Hospital Universitario Rey Juan Carlos (Madrid)) ;
Rodríguez-Villanueva García, Julio (EISAI Farmacéutica SA) ;
Santos, Rita Joana (Department of Endocrinology. Francisco Gentil Portuguese Institute of Oncology of Lisbon) ;
Llanos, Marta (Hospital Universitario de Canarias (La Laguna)) ;
Navarro-González, Elena (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Aller, Javier (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Pubul, Virginia (Hospital Universitario Santiago de Compostela) ;
Guadalix, Sonsoles (Hospital Universitario 12 de Octubre (Madrid)) ;
Crespo, Guillermo (Hospital Universitario de Burgos) ;
González, Cintia (Institut d'Investigació Biomèdica Sant Pau) ;
Zafón, Carles (Hospital Universitari Vall d'Hebron) ;
Navarro, Miguel (Hospital Universitario de Salamanca) ;
Santamaría-Sandi, Javier (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Segura, Ángel (Hospital Universitari i Politècnic La Fe (València)) ;
Gajate, Pablo (Hospital Universitario Ramón y Cajal (Madrid)) ;
Gómez-Balaguer, Marcelino (Hospital Universitari Doctor Peset (València)) ;
Valdivia, Javier (Hospital Universitario Virgen de las Nieves (Granada)) ;
Puig-Domingo, Manel (Institut Germans Trias i Pujol) ;
Galofré, Juan C (Hospital Universitario de Navarra) ;
Castelo, Beatriz (Hospital Universitario La Paz (Madrid)) ;
Villanueva, María José (Hospital Universitario de Vigo) ;
Argüelles, Iñaki (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Orcajo-Rincón, Lorenzo (EISAI Farmacéutica SA) ;
Universitat Autònoma de Barcelona
Background: Up to 30% of differentiated thyroid cancer (DTC) will develop advanced-stage disease (aDTC) with reduced overall survival (OS). Objective: The aim of this study is to characterize initial diagnosis of aDTC, its therapeutic management, and prognosis in Spain and Portugal. [...]
2022 - 10.1530/ETJ-21-0111
European Thyroid Journal, Vol. 11 Núm. 5 (october 2022) , p. e210111
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