Results overview: Found 2 records in 0.04 seconds.
Articles, 2 records found
Articles 2 records found  
1.
15 p, 3.4 MB Detoxifying Escherichia coli for endotoxin-free production of recombinant proteins / Mamat, Uwe (Forschungszentrum Borstel) ; Wilke, Kathleen (Forschungszentrum Borstel) ; Bramhill, David (Research Corporation Technologies (Tucson)) ; Schromm, Andra Beate (Forschungszentrum Borstel) ; Lindner, Buko (Forschungszentrum Borstel) ; Kohl, Thomas Andreas (Forschungszentrum Borstel) ; Corchero Nieto, José Luis (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Schaffer, Lana (Scripps Research Institute) ; Head, Steven Robert (Scripps Research Institute) ; Souvignier, Chad (Research Corporation Technologies (Tucson)) ; Meredith, Timothy Charles (Pennsylvania State University. Department of Biochemistry and Molecular Biology) ; Woodard, Ronald Wesley (Bramhill Biological Consulting)
Background: lipopolysaccharide (LPS), also referred to as endotoxin, is the major constituent of the outer leaflet of the outer membrane of virtually all Gram-negative bacteria. The lipid A moiety, which anchors the LPS molecule to the outer membrane, acts as a potent agonist for Toll-like receptor 4/myeloid differentiation factor 2-mediated pro-inflammatory activity in mammals and, thus, represents the endotoxic principle of LPS. [...]
2015 - 10.1186/s12934-015-0241-5
Microbial cell factories, Vol. 14, Issue 57 (2015)  
2.
7 p, 774.5 KB Expanding the recombinant protein quality in Lactococcus lactis / Cano Garrido, Olivia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Rueda, Fabián L. (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Sànchez-García, Laura (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Ruiz-Ávila, Luis (Spherium Biomed S.L.) ; Bosser, Ramon (Spherium Biomed S.L.) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; García Fruitós, Elena (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Background: Escherichia coli has been a main host for the production of recombinant proteins of biomedical interest, but conformational stress responses impose severe bottlenecks that impair the production of soluble, proteolytically stable versions of many protein species. [...]
2014 - 10.1186/s12934-014-0167-3
Microbial cell factories, Vol. 13 (2014) , p. 167  

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