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12 p, 608.0 KB |
Switching from a ritonavir-boosted protease inhibitor to a dolutegravir-based regimen for maintenance of HIV viral suppression in patients with high cardiovascular risk
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Gatell, José Mª (Hospital Clínic i Provincial de Barcelona) ;
Assoumou, Lambert (UPMC Univ Paris 06) ;
Moyle, Graeme (St Chelsea and Westminster Hospital) ;
Waters, Laura (Mortimer Market Center) ;
Johnson, Margaret (Royal Free Hospital) ;
Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau) ;
Fox, Julie (Guys and St. Thomas Hospital) ;
Martinez, Esteban (Hospital Clínic i Provincial de Barcelona) ;
Stellbrink, Hans-Jürgen (ICH Study Centrum) ;
Guaraldi, Giovanni (University of Modena and Reggio Emilia) ;
Masia, Mar (Hospital General Universitario de Elche) ;
Gompels, Marl (Southmead Hospital) ;
De Wit, Stephane (Université Libre de Bruxelles) ;
Florence, Eric (Institute of Tropical Medicine) ;
Esser, Stefan (Universitatsklinikum) ;
Raffi, François (CHU de Nantes) ;
Pozniak, Anton L. (St Chelsea and Westminster Hospital) ;
Universitat Autònoma de Barcelona
To compare the efficacy, safety, and impact on lipid fractions of switching from a ritonavir-boosted protease inhibitor (PI/r) to a dolutegravir (DTG) regimen. HIV type 1-infected adults more than 50 years or with a Framingham score more than 10% were eligible if plasma HIV RNA less than 50 copies per ml for at least 24 weeks while on a PI/r regimen. [...]
2017 -  10.1097/QAD.0000000000001675
AIDS, Vol. 31 Núm. 18 (28 2017) , p. 2503-2514
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16 p, 1.4 MB |
Retinal Pigment Epithelium-Secreted VEGF-A Induces Alpha-2-Macroglobulin Expression in Endothelial Cells
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Lehmann, Guillermo L. (Regeneron Pharmaceuticals. Inc.) ;
Ginsberg, Michael (Angiocrine Bioscience. Inc.) ;
Nolan, Daniel J. (Angiocrine Bioscience. Inc.) ;
Rodríguez, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez-González, José (Institut d'Investigació Biomèdica Sant Pau) ;
Zeng, Shemin (Institute for Vision Research. Department of Ophthalmology and Visual Sciences. The University of Iowa) ;
Voigt, Andrew P. (Institute for Vision Research. Department of Ophthalmology and Visual Sciences. The University of Iowa) ;
Mullins, Robert F. (Institute for Vision Research. Department of Ophthalmology and Visual Sciences. The University of Iowa) ;
Rafii, Shahin (Ansary Stem Cell Institute. Department of Medicine. Division of Regenerative Medicine. Weill Cornell Medicine) ;
Rodriguez-Boulan, Enrique (Margaret Dyson Vision Research Institute. Department of Ophthalmology. Weill Cornell Medicine) ;
Benedicto, Ignacio (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Alpha-2-macroglobulin (A2M) is a protease inhibitor that regulates extracellular matrix (ECM) stability and turnover. Here, we show that A2M is expressed by endothelial cells (ECs) from human eye choroid. [...]
2022 - 10.3390/cells11192975
Cells, Vol. 11 Núm. 19 (october 2022) , p. 2975
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13 p, 2.0 MB |
A Multifunctional Trypsin Protease Inhibitor from Yellow Bell Pepper Seeds : Uncovering Its Dual Antifungal and Hypoglycemic Properties
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Cotabarren, Juliana (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Ozón, Brenda (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Claver, Santiago (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Geier, Florencia (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Rossotti, Martina (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Obregón, Walter David (Universidad Nacional de la Plata. Centro de Investigación de Proteínas Vegetales) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Fungal infections are a growing public health concern worldwide and the emergence of antifungal resistance has limited the number of therapeutic options. Therefore, developing novel strategies for identifying and developing new antifungal compounds is an active area of research in the pharmaceutical industry. [...]
2023 - 10.3390/pharmaceutics15030781
Pharmaceutics, Vol. 15, Issue 3 (March 2023) , art. 781
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19 p, 1.7 MB |
Prevalence, beliefs and impact of drug-drug interactions between antiretroviral therapy and illicit drugs among people living with HIV in Spain
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Castro-Granell, V. (Hospital Marina Baixa (La Vila Joiosa, Alacant)) ;
Garin, Noe (Institut d'Investigació Biomèdica Sant Pau) ;
Jaén, Ángeles (Fundació Docència i Recerca Mútua Terrassa) ;
Cenoz, Santiago (ViiV Healthcare (Tres Cantos, Madrid)) ;
Galindo, María José (Hospital Clínic Universitari (València)) ;
Fuster-RuizdeApodaca, María José (Sociedad Española Interdisciplinaria del Sida) ;
Universitat Autònoma de Barcelona
Drug use implies important challenges related to HIV management, particularly due to an increased risk of potential interactions between antiretroviral therapy (ART) and illicit drugs (pDDIs). This study analyses the prevalence and severity of pDDIs among people living with HIV (PLHIV). [...]
2021 - 10.1371/journal.pone.0260334
PloS one, Vol. 16 Núm. 11 (november 2021) , p. e0260334
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11 p, 827.1 KB |
Purification and Characterization of a Novel Thermostable Papain Inhibitor from Moringa oleifera with Antimicrobial and Anticoagulant Properties
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Cotabarren, Juliana (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Claver, Santiago (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Payrol, Juan Abreu (Escuela Latinoamericana de Medicina) ;
Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Obregón, Walter David (Universidad Nacional de La Plata. Departamento de Ciencias Biológicas) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Plant cystatins (or phytocystatins) comprise a large superfamily of natural bioactive small proteins that typically act as protein inhibitors of papain-like cysteine proteases. In this report, we present the purification and characterization of the first phytocystatin isolated from Moringa oleifera (MoPI). [...]
2021 - 10.3390/pharmaceutics13040512
Pharmaceutics, Vol. 13, Issue 4 (April 2021) , art. 512
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7 p, 214.7 KB |
Long-term effectiveness of unboosted atazanavir plus abacavir/lamivudine in subjects with virological suppression
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Llibre, Josep M. (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Cozzi-Lepri, Alessandro (University College London, UK) ;
Pedersen, Court (Odense University Hospital (Dinamarca)) ;
Ristola, Matti (Helsinki University Hospital (Finlàndia)) ;
Losso, Marcelo (Hospital General de Agudos JM Ramos Mejía, Buenos Aires, Argentina) ;
Mocroft, Amanda (University College London, UK) ;
Mitsura, Viktar (Gomel State Medical University, Belarus) ;
Falconer, Karolin (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Maltez, Fernando (Curry Cabral Hospital, Lisboa, Portugal) ;
Beniowski, Marek (Specialistic Hospital, Chorzów, Poland) ;
Vullo, Vincenzo (Policlinico Umberto 1, Rome, Italy) ;
Hassoun, Gamal (Rambam-Health Care Campus, Haifa, Israel) ;
Kuzovatova, Elena (Nizhny Novgorod Scientific and Research Institute of Epidemiology and Microbiology named after Academician I.N. Blokhina, Russia) ;
Szlavik, János (St László Hospital (Hongria)) ;
Kuznetsova, Anastasiia (Kharkov State Medical University, Ukraine) ;
Stellbrink, Hans-Jürgen (ICH Study Center, Hamburg, Germany) ;
Duvivier, Claudine (APHP-Hôpital Necker-Enfants Malades, Paris, France) ;
Edwards, Simon (Mortimer Market Centre, UK) ;
Laut, Kamilla (Centre for Health & University of Copenhagen, Denmark) ;
Paredes, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Effectiveness data of an unboosted atazanavir (ATV) with abacavir/lamivudine (ABC/3TC) switch strategy in clinical routine are scant. We evaluated treatment outcomes of ATV + ABC/3TC in pretreated subjects in the EuroSIDA cohort when started with undetectable plasma HIV-1 viral load (pVL), performing a time to loss of virological response (TLOVR <50 copies/mL) and a snapshot analysis at 48, 96, and 144 weeks. [...]
2016 - 10.1097/MD.0000000000005020
Medicine, Vol. 95, Num. 40 (october 2016)
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5 p, 205.2 KB |
Impact of protease inhibitors on the evolution of urinary markers
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Bonjoch, Anna (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Puig, Jordi (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Juega-Mariño, Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Echeverría, Patricia (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Clotet Sala, Bonaventura (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Romero, Ramón (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bonet Sol, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Negredo Puigmal, Eugènia (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida)
Kidney injury (defined as the presence of albuminuria, proteinuria, glycosuria [without hyperglycemia], hematuria, and/or renal hypophosphatemia) is an emerging problem in human immunodeficiency virus (HIV)-infected patients, although few data are available on the role of protease inhibitors (PIs) in this condition. [...]
2016 - 10.1097/MD.0000000000004507
Medicine, Vol. 95 (august 2016)
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49 p, 1.2 MB |
Protease activities triggered by Ralstonia solanacearum infection in susceptible and tolerant tomato lines
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Planas-Marquès, Marc (Centre de Recerca en Agrigenòmica) ;
Bernardo-Faura, Martí (Centre de Recerca en Agrigenòmica) ;
Paulus, Judith Katharina (University of Oxford. Department of Plant Sciences. Plant Chemetics Laboratory (UK)) ;
Kaschani, Farnusch (Universität Duisburg-Essen. Chemische Biologie, Zentrum für Medizinische Biotechnologie (Germany)) ;
Kaiser, Markus (Universität Duisburg-Essen. Chemische Biologie, Zentrum für Medizinische Biotechnologie (Germany)) ;
Valls, Marc (Centre de Recerca en Agrigenòmica) ;
van der Hoorn, Renier (University of Oxford. Department of Plant Sciences. Plant Chemetics Laboratory (UK)) ;
Sánchez Coll, Núria (Centre de Recerca en Agrigenòmica)
Activity-based protein profiling (ABPP) is a powerful proteomic technique to display protein activities in a proteome. It is based on the use of small molecular probes that react with the active site of proteins in an activity-dependent manner. [...]
2018 - 10.1074/mcp.RA117.000052
Molecular & Cellular Proteomics, Vol. 17, Issue 6 (March 2018) , p. 1112-1125
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