Resultats globals: 14 registres trobats en 0.02 segons.
Articles, 13 registres trobats
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Articles 13 registres trobats  1 - 10següent  anar al registre:
1.
29 p, 849.9 KB Conformational conversion during controlled oligomerization into nonamylogenic protein nanoparticles / Sanchez, Julieta M. (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sánchez, Laura (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Pesarrodona Roches, Mireia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Serna, Naroa (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ; Unzueta Elorza, Ugutz (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Mangues, Ramon (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Villaverde Corrales, Antonio (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Protein materials are rapidly gaining interest in materials sciences and nanomedicine because of their intrinsic biocompatibility and full biodegradability. The controlled construction of supramolecular entities relies on the controlled oligomerization of individual polypeptides, achievable through different strategies. [...]
2018 - 10.1021/acs.biomac.8b00924
Biomacromolecules, Vol. 19, issue 9 (Sep. 2018) , p. 3788-3797  
2.
19 p, 3.1 MB Molecular context-dependent effects induced by rett syndrome-associated mutations in mecp2 / Ortega-Alarcon, D. (Institute of Biocomputation and Physics of Complex Systems (BIFI). Joint Units IQFR-CSIC-BIFI,and GBsC-CSIC-BIFI. Universidad de Zaragoza) ; Claveria-Gimeno, R. (Instituto de Investigación Sanitaria Aragón (IIS Aragón)) ; Vega, S. (Institute of Biocomputation and Physics of Complex Systems (BIFI). Joint Units IQFR-CSIC-BIFI,and GBsC-CSIC-BIFI. Universidad de Zaragoza) ; Jorge-Torres, Olga C. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Abian, O. (Departamento de Bioquímica y Biología Molecular y Celular. Universidad de Zaragoza) ; Velazquez-Campoy, A. (Fundación ARAID. Gobierno de Aragón) ; Universitat Autònoma de Barcelona
Methyl-CpG binding protein 2 (MeCP2) is a transcriptional regulator and a chromatinbinding protein involved in neuronal development and maturation. Loss-of-function mutations in MeCP2 result in Rett syndrome (RTT), a neurodevelopmental disorder that is the main cause of mental retardation in females. [...]
2020 - 10.3390/biom10111533
Biomolecules, Vol. 10 Núm. 11 (november 2020) , p. 1-18  
3.
16 p, 3.9 MB Plasticity in the Oxidative Folding Pathway of the High Affinity Nerita Versicolor Carboxypeptidase Inhibitor (NvCI) / Esperante, Sebastián (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Bronsoms i Fabrellas, Sílvia (Universitat Autònoma de Barcelona. Servei de Proteòmica i Biologia Estructural) ; Covaleda Cortés, Giovanni (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Trejo, Sebastián A. (Universitat Autònoma de Barcelona. Servei de Proteòmica i Biologia Estructural) ; Avilés, Francesc X. (Francesc Xavier) (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Nerita Versicolor carboxypeptidase inhibitor (NvCI) is the strongest inhibitor reported so far for the M14A subfamily of carboxypeptidases. It comprises 53 residues and a protein fold composed of a two-stranded antiparallel β sheet connected by three loops and stabilized by three disulfide bridges. [...]
2017 - 10.1038/s41598-017-05657-7
Scientific reports (Nature Publishing Group), Vol. 7 (2017) , art. 5457  
4.
13 p, 2.3 MB A quaternary tetramer assembly inhibits the deubiquitinating activity of USP25 / Liu, Bing (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sureda-Gómez, Marta (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Zhen, Yang (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Amador, Virginia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
USP25 deubiquitinating enzyme is a key member of the ubiquitin system, which acts as a positive regulator of the Wnt/β-catenin signaling by promoting the deubiquitination and stabilization of tankyrases. [...]
2018 - 10.1038/s41467-018-07510-5
Nature communications, Vol. 9 (2018) , art. 4973  
5.
15 p, 3.9 MB Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregationres / Sant'Anna, Ricardo (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Almedia, Maria Rosario (Instituto de Investigação e Inovação em Saúde da Universidade do Porto) ; Varejao, Nathalia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Gallego Alonso, Pablo (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Esperante, Sebastián (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ferreira, Priscilla (Instituto de Bioquímica Médica Leopoldo de Meis) ; Pereira-Henriques, Alda (Instituto de Investigação e Inovação em Saúde da Universidade do Porto) ; Palhano, Fernando L. (Instituto de Bioquímica Médica Leopoldo de Meis) ; De Carvalho, Mamede (Department Neurosciences. Hospital de Santa Maria. CHLN) ; Foguel, Debora (Instituto de Bioquímica Médica Leopoldo de Meis) ; Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Saraiva, Maria Joao (Instituto de Investigação e Inovação em Saúde da Universidade do Porto) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
More than a hundred different Transthyretin (TTR) mutations are associated with fatal systemic amyloidoses. They destabilize the protein tetrameric structure and promote the extracellular deposition of TTR as pathological amyloid fibrils. [...]
2017 - 10.1038/srep44709
Scientific reports (Nature Publishing Group), Vol. 7 (2017) , art. 44709  
6.
15 p, 1.8 MB C-mannosylation supports folding and enhances stability of thrombospondin repeats / Shcherbakova, Aleksandra (Medizinische Hochschule Hannover. Institut für Klinische Biochemie) ; Preller, Matthias (Medizinische Hochschule Hannover. Institut für Biophysikalische Chemie) ; Taft, Manuel H. (Medizinische Hochschule Hannover. Institut für Biophysikalische Chemie) ; Pujols, Jordi (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ventura, Salvador (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Tiemann, Birgit (Medizinische Hochschule Hannover. Institut für Klinische Biochemie) ; Buettner, Falk F.R. (Medizinische Hochschule Hannover. Institut für Klinische Biochemie) ; Bakker, Hans (Medizinische Hochschule Hannover. Institut für Klinische Biochemie)
Previous studies demonstrated importance of C-mannosylation for efficient protein secretion. To study its impact on protein folding and stability, we analyzed both C-mannosylated and non-C-mannosylated thrombospondin type 1 repeats (TSRs) of netrin receptor UNC-5. [...]
2019 - 10.7554/eLife.52978
eLife, Vol. 8 (Dec. 2019) , art. e52978  
7.
8 p, 2.9 MB Aggrescan3D (A3D) 2.0 : prediction and engineering of protein solubility / Kuriata, Aleksander (Centrum Nauk Biologiczno-Chemicznych Uniwersytetu Warszawskiego) ; Iglesias, Valentin (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pujols, Jordi (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Kurcinski, Mateusz (Centrum Nauk Biologiczno-Chemicznych Uniwersytetu Warszawskiego) ; Kmiecik, Sebastian (Centrum Nauk Biologiczno-Chemicznych Uniwersytetu Warszawskiego) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Protein aggregation is a hallmark of a growing number of human disorders and constitutes a major bottleneck in the manufacturing of therapeutic proteins. Therefore, there is a strong need of in-silico methods that can anticipate the aggregative properties of protein variants linked to disease and assist the engineering of soluble protein-based drugs. [...]
2019 - 10.1093/nar/gkz321
Nucleic acids research, Vol. 47, issue W1 (July 2019) , p. W300-W307  
8.
12 p, 1.5 MB Altered characteristics of silica nanoparticles in bovine and human serum : The importance of nanomaterial characterization prior to its toxicological evaluation / Izak-Nau, Emilia (University of Salzburg. Department of Molecular Biology) ; Voetz, Matthias (Bayer Technology Services GmbH) ; Eiden, Stefanie (Bayer Technology Services GmbH) ; Duschl, Albert (University of Salzburg. Department of Molecular Biology) ; Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
Background: Many toxicological studies on silica nanoparticles (NPs) have been reported, however, the literature often shows various conclusions concerning the same material. This is mainly due to a lack of sufficient NPs characterization as synthesized as well as in operando. [...]
2013 - 10.1186/1743-8977-10-56
Particle and fibre toxicology, Vol. 10 (November 2013) , art. 56  
9.
10 p, 342.2 KB New set of 2D/3D thermodynamic indices for proteins. A formalism based on "Molten Globule" theory / Ruiz Blanco, Yasser B. (Central University of Las Villas. Unit of Computer-Aided Molecular Biosilico Discovery and Bioinformatic Research (Cuba)) ; García, Yamila (Centre d'Investigació en Nanociència i Nanotecnologia) ; Sotomayor Torres, Clivia M. (Centre d'Investigació en Nanociència i Nanotecnologia) ; Marrero Ponce, Yovani (Central University of Las Villas. Unit of Computer-Aided Molecular Biosilico Discovery and Bioinformatic Research (Cuba))
We define eight new macromolecular indices, and several related descriptors for proteins. The coarse grained methodology used for its deduction ensures its fast execution and becomes a powerful potential tool to explore large databases of protein structures. [...]
2010 - 10.1016/j.phpro.2010.10.013
Physics Procedia, Vol. 8 (March 2010) , p. 63-72  
10.
17 p, 1.6 MB Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal3 and Vhs3 / Abrie, J. Albert (Stellenbosch University. Department of Biochemistry) ; Molero Merinero, Cristina (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Ariño Carmona, Joaquín (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Strauss, Erick (Stellenbosch University. Department of Biochemistry) ; Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Saccharomyces cerevisiae Hal3 and Vhs3 are moonlighting proteins, acting both as inhibitors of the serine/threonine protein phosphatase Ppz1 and as subunits (together with Cab3) of the unique heterotrimeric phosphopantothenoylcysteine decarboxylase (PPCDC) enzyme of Hemiascomycetous yeast. [...]
2015 - 10.1038/srep15774
Scientific reports (Nature Publishing Group), Vol. 5 (October 2015) , art. 15774  

Articles : 13 registres trobats   1 - 10següent  anar al registre:
Documents de recerca 1 registres trobats  
1.
75 p, 3.3 MB Development of a new methodology to predict and engineer thermostable proteins / Robles Martín, Ana ; Guallar, Victor, dir. (Barcelona Supercomputing Center) ; Masgrau, Laura, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
Studies of protein thermostability change prediction due to single mutations has been of great interest because of its importance for industries, biotechnological and biomedical research. However, the search of a highly accurate predictor has been unsuccessful. [...]
Els estudis sobre la predicció del canvi de termoestabilitat de proteïnes a causa de mutacions individuals han estat de gran interès per la seva importància per a la indústria, la investigació biotecnològica i biomèdica. [...]

2020
Máster Universitario en Bioinformática / Bioinformatics [1112]  

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