Home > Search Results: Protein misfolding
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Results overview: Found 8 records in 0.02 seconds.
Articles, 6 records found
Research literature, 2 records found
Articles 6 records found  
1.
12 p, 2.5 MB The intrinsic chaperone network of Arabidopsis stem cells confers protection against proteotoxic stress / Llamas, Ernesto (University of Cologne) ; Torres Montilla, Salvador (Centre de Recerca en Agrigenòmica) ; Lee, Hyun Ju (University of Cologne) ; Barja, Maria Victoria (Centre de Recerca en Agrigenòmica) ; Schlimgen, Elena (University of Cologne) ; Dunken, Nick (University of Cologne) ; Wagle, Prerana (University of Cologne) ; Werr, Wolfgang (University of Cologne) ; Zuccaro, Alga (University of Cologne) ; Rodríguez Concepción, Manuel (Centre de Recerca en Agrigenòmica) ; Vilchez, David (University Hospital Cologne)
The biological purpose of plant stem cells is to maintain themselves while providing new pools of differentiated cells that form organs and rejuvenate or replace damaged tissues. Protein homeostasis or proteostasis is required for cell function and viability. [...]
2021 - 10.1111/acel.13446
Aging Cell, Vol. 20, Issue 8 (July 2021) , art. e13446  
Detailed record - Creative Commons
2.
10 p, 1.4 MB Aged Cattle Brain Displays Alzheimer's Disease-Like Pathology and Promotes Brain Amyloidosis in a Transgenic Animal Model / Moreno-Gonzalez, Ines (Universidad Bernardo O'Higgins. Centro Integrativo de Biologia y Quimica Aplicada) ; Edwards, George (University of Texas. Mitchell Center for Alzheimer's Disease and Related Brain Disorders) ; Morales, Rodrigo (Universidad Bernardo O'Higgins. Centro Integrativo de Biologia y Quimica Aplicada) ; Duran-Aniotz, Claudia (Universidad Adolfo Ibañez. Latin American Institute for Brain Health) ; Escobedo, Gabriel (University of Texas. Mitchell Center for Alzheimer's Disease and Related Brain Disorders) ; Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Marquez, Mercedes (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Soto, Claudio (University of Texas. Mitchell Center for Alzheimer's Disease and Related Brain Disorders)
Alzheimer's disease (AD) is one of the leading causes of dementia in late life. Although the cause of AD neurodegenerative changes is not fully understood, extensive evidence suggests that the misfolding, aggregation and cerebral accumulation of amyloid beta (Aβ) and tau proteins are hallmark events. [...]
2022 - 10.3389/fnagi.2021.815361
Frontiers in aging neuroscience, Vol. 13 (january 2022)  
Detailed record - Creative Commons
3.
8 p, 1.3 MB Amyloid fibril formation by bovine cytochrome c / Sánchez de Groot, Natalia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Bovine heart cytochrome c is an all-α globular protein containing a covalently bound heme group. Prolonged incubation at 75°C in mild alkaline solution damages the prosthetic group and results in permanent unfolding of the polypeptide chain. [...]
2005 - 10.1155/2005/104348
Spectroscopy, Vol. 19 (2005) , p. 199-205  
Detailed record - Creative Commons
4.
10 p, 1.2 MB A single cysteine post-translational oxidation suffices to compromise globular proteins kinetic stability and promote amyloid formation / Marinelli, Patrizia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Navarro, Susanna (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Graña Montes, Ricardo (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Bañó-Polo, Manuel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Fernández Gallegos, María Rosario (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Papaleo, Elena (Kræftens Bekæmpelse) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Oxidatively modified forms of proteins accumulate during aging. Oxidized protein conformers might act as intermediates in the formation of amyloids in age-related disorders. However, it is not known whether this amyloidogenic conversion requires an extensive protein oxidative damage or it can be promoted just by a discrete, localized post-translational modification of certain residues. [...]
2017 - 10.1016/j.redox.2017.10.022
Redox biology, Vol. 14 (April 2018) , p. 566-575  
Detailed record - Creative Commons
5.
9 p, 626.3 KB Proteome response at the edge of protein aggregation / Sánchez de Groot, Natalia (MRC Laboratory of Molecular Biology) ; Gomes, Ricardo A. (Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier) ; Villar Pique, Anna (University Medical Centre Göottingen. Department of Neurodegeneration and Restorative Research) ; Babu, Madam M (MRC Laboratory of Molecular Biology) ; Varela Coelho, Ana (Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Proteins adopt defined structures and are crucial to most cellular functions. Their misfolding and aggregation is associated with numerous degenerative human disorders such as type II diabetes, Huntington's or Alzheimer's diseases. [...]
2015 - 10.1098/rsob.140221
Open biology, Vol. 5, issue 2 (Feb. 2015) , art. 140221  
Detailed record - Creative Commons
6.
14 p, 3.1 MB The importance of a gatekeeper residue on the aggregation of transthyretin / Sant'Anna, Ricardo (Instituto de Bioquímica Médica Leopoldo de Meis) ; Braga, Carolina (Instituto de Bioquímica Médica Leopoldo de Meis) ; Varejão, Nathalia (Instituto de Bioquímica Médica Leopoldo de Meis) ; Pimenta, Karinne M. (Instituto de Bioquímica Médica Leopoldo de Meis) ; Graña Montes, Ricardo (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Alves, Aline (Instituto de Bioquímica Médica Leopoldo de Meis) ; Cortines, Juliana (Instituto de Microbiologia Professor Paulo de Goés) ; Cordeiro, Yraima (Universidade Federal do Rio de Janeiro. Faculdade de Farmácia) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Foguel, Debora (From the Instituto de Bioquímica Médica Leopoldo de Meis, Programa de Biologia Estrutural)
Background: Proteins have adopted negative design to diminish aggregation. Results: The replacement of Lys-35 by Leu increases the amyloidogenicity of the 26-57 segment of TTR as well as the entire protein. [...]
2014 - 10.1074/jbc.M114.563981
Journal of biological chemistry, Vol. 289, no. 41 (Oct. 2014) , p. 28324-28337  
Detailed record - Creative Commons

Research literature 2 records found  
1.
1 p, 10.8 MB Deciphering hIAPP : a novel way to cure diabetes / Ruiz López, Iñigo ; Pallarès i Goitiz, Irantzu, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
Human islet amyloid polypeptide (hIAPP) is produced by pancreatic β-cells and is involved in type-II diabetes mellitus (T2DM) pathogenesis. In T2DM, the loss of pancreatic β-cell mass is accompanied by the accumulation of amyloid deposits of hIAPP. [...]
2019-05-29
Grau en Biotecnologia [815]  
Detailed record - Creative Commons
2.
199 p, 6.0 MB Characterization of intracellular protein aggregates / Villar i Piqué, Anna ; Ventura, Salvador, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
Durant les últimes dècades, l'agregació de proteïnes ha esdevingut un tema d'investigació molt dinàmic que s'estén transversalment per diferents camps de recerca, incloent la bioquímica, la biotecnologia, la biomedicina i la nanotecnologia. [...]
During the last decades, protein aggregation has become a dynamic research topic extending across distinct investigation fields, including biochemistry, biotechnology, biomedicine and nanotechnology. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2013  
Detailed record -

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