Results overview: Found 15 records in 0.02 seconds.
Articles, 15 records found
Articles 15 records found  1 - 10next  jump to record:
1.
12 p, 1.5 MB Altered characteristics of silica nanoparticles in bovine and human serum : The importance of nanomaterial characterization prior to its toxicological evaluation / Izak-Nau, Emilia (University of Salzburg. Department of Molecular Biology) ; Voetz, Matthias (Bayer Technology Services GmbH) ; Eiden, Stefanie (Bayer Technology Services GmbH) ; Duschl, Albert (University of Salzburg. Department of Molecular Biology) ; Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
Background: Many toxicological studies on silica nanoparticles (NPs) have been reported, however, the literature often shows various conclusions concerning the same material. This is mainly due to a lack of sufficient NPs characterization as synthesized as well as in operando. [...]
2013 - 10.1186/1743-8977-10-56
Particle and fibre toxicology, Vol. 10 (November 2013) , art. 56  
2.
8 p, 985.7 KB Analysis of alternative splicing events for cancer diagnosis using a multiplexing nanophotonic biosensor / Sánchez Huertas, César (Institut Català de Nanociència i Nanotecnologia) ; Domínguez Zotes, Santos (Institut Català de Nanociència i Nanotecnologia) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Personalized medicine is a promising tool not only for prevention, screening and development of more efficient treatment strategies, but also for diminishing the side effects caused by current therapies. [...]
2017 - 10.1038/srep41368
Scientific reports, Vol. 7 (January 2017) , art. 41368  
3.
20 p, 1.9 MB Chitosan functionalisation of gold nanoparticles encourages particle uptake and induces cytotoxicity and pro-inflammatory conditions in phagocytic cells, as well as enhancing particle interactions with serum components / Boyles, Matthew S. P. (Paris-Lodron-Universität Salzburg. Department of Molecular Biology) ; Kristl, Theresa (Paris-Lodron-Universität Salzburg. Department of Molecular Biology) ; Andosch, Ancuela (Paris-Lodron-Universität Salzburg. Department of Cell Biology) ; Zimmermann, Mirjam (Paris-Lodron-Universität Salzburg. Department of Molecular Biology) ; Tran Thi Thanh, Ngoc (Institut Català de Nanotecnologia) ; Casals Mercadal, Eudald (Institut Català de Nanotecnologia) ; Himly, Martin (Paris-Lodron-Universität Salzburg. Department of Molecular Biology) ; Puntes, Víctor (Institut Catala de Recerca i Estudis Avancats) ; Huber, Christian G. (Paris-Lodron-Universität Salzburg. Department of Molecular Biology) ; Lütz-Meindl, Ursula (Paris-Lodron-Universität Salzburg. Department of Cell Biology) ; Duschl, Albert (Paris-Lodron-Universität Salzburg. Department of Molecular Biology)
Gold nanoparticles (AuNPs) are a popular choice for use in medical and biomedical research applications. With suitable functionalisation AuNPs can be applied in drug delivery systems, or can aid in disease diagnosis. [...]
2015 - 10.1186/s12951-015-0146-9
Journal of nanobiotechnology, Vol. 13, Issue 84 (november 2015)  
4.
10 p, 370.7 KB Functional recruitment for drug delivery through protein-based nanotechnologies / Vázquez Gómez, Esther, dir. (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Mangues, Ramon (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
2016 - 10.2217/nnm-2016-0090
Nanomedicine, Vol. 11 Núm 11 (Juny 2016) , p. 1333-1336  
5.
35 p, 1.1 MB Conformational and functional variants of CD44-targeted protein nanoparticles bio-produced in bacteria. / Pesarrodona Roches, Mireia (Universitat Autònoma de Barcelona. Department de Genètica i de Microbiologia) ; Fernández, Yolanda (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ; Foradada, Laia (Hospital Vall d'Hebron. CIBBIM-Nanomedicine) ; Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ; Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Unzueta Elorza, Ugutz (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Xu, Zhikun (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ; Roldán, Mónica (Universitat Autònoma de Barcelona. Servei de Microscòpia) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Schwartz, Simó (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ; Rinas, Ursula (Leibniz University of Hannover. Technical Chemistry & Life Science) ; Daura i Ribera, Xavier (Institució Catalana de Recerca i Estudis Avançats) ; Abasolo, Ibane (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ; Vázquez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Biofabrication is attracting interest as a means to produce nanostructured functional materials because of its operational versatility and full scalability. Materials based on proteins are especially appealing, as the structure and functionality of proteins can be adapted by genetic engineering. [...]
2016
Biofabrication, Vol. 8 Núm 2 (Abril 2016) , p. 25001  
6.
34 p, 1.0 MB Rational engineering of single-chain polypeptides into protein-only, BBB-targeted nanoparticles / Serna Romero, Naroa (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Céspedes, María Virtudes (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Bellaterra)) ; Saccardo, Paolo (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Xu, Zhikun (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Unzueta Elorza, Ugutz (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Álamo, Patricia (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Bellaterra)) ; Pesarrodona Roches, Mireia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ; Roldán, Mónica (Universitat Autònoma de Barcelona. Servei de Microscòpia) ; Mangues, Ramón (Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina) ; Vázquez Gómez, Esther (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
A single chain polypeptide containing the low density lipoprotein receptor (LDLR) ligand Seq-1 with blood-brain barrier (BBB) crossing activity has been successfully modified by conventional genetic engineering to self-assemble into stable protein-only nanoparticles of 30 nm. [...]
2016 - 10.1016/j.nano.2016.01.004
Nanomedicine, Vol. 12 Núm. 5 (Juliol 2016) , p. 1241-1251
6 documents
7.
38 p, 1.1 MB BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS / Peluffo, Hugo (Institut Pasteur de Montevideo. Neuroinflammation Gene Therapy Laboratory) ; Unzueta Elorza, Ugutz (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Negro, Luciana (Institut Pasteur de Montevideo. Neuroinflammation Gene Therapy Laboratory,) ; Xu, Zhikun (CIBER en Bioingeniería, Biomateriales y Nanomedicina) ; Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The increasing incidence of diseases affecting the central nervous system (CNS) demands the urgent development of efficient drugs. While many of these medicines are already available, the Blood Brain Barrier and to a lesser extent, the Blood Spinal Cord Barrier pose physical and biological limitations to their diffusion to reach target tissues. [...]
2015 - 10.1016/j.biotechadv.2015.02.004
Biotechnology advances, Vol. 33 Núm. 2(Març-Abril 2015) , p. 277-287
5 documents
8.
19 p, 142.0 KB Towards Protein-Based Viral Mimetics for Cancer Therapies / Unzueta Elorza, Ugutz (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Céspedes, María Virtudes (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Bellaterra)) ; Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Mangues, Ramon (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Bellaterra)) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
High resistance and recurrence rates, along with elevated drug clearance, compel the use of maximum tolerated drug doses in cancer therapy, resulting in high-grade toxicities and limited clinical applicability. [...]
2015 - 10.1016/j.tibtech.2015.02.007
Trends in biotechnology, Vol. 33, Issue 5 (Maig 2015) , p. 253-258
3 documents
9.
56 p, 354.6 KB Engineering protein self-assembling in protein-based nanomedicines for drug delivery and gene therapy / Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Rodríguez-Carmona, Escarlata (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; García Fruitós, Elena (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Vázquez, Esther (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Lack of targeting and improper biodistribution are major flaws in current drug-based therapies that prevent reaching high local concentrations of the therapeutic agent. Such weaknesses impose the administration of high drug doses, resulting in undesired side effects, limited efficacy and enhanced production costs. [...]
2015 - 10.3109/07388551.2013.833163
Critical reviews in biotechnology, Vol. 35 (2015)
6 documents
10.
20 p, 248.7 KB A novel bio-functional material based on mammalian cell aggresomes / Rodríguez-Carmona, Escarlata (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Mendoza, Rosa (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ruiz Cánovas, Eugènia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Abasolo, Ibane (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ; Schwartz Jr, Simó (CIBER de Bioingeniería, Biomateriales y Nanomedicina (Barcelona)) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Aggresomes are protein aggregates found in mammalian cells when the intracellular protein degradation machinery is over-titered. Despite that they abound in cells producing recombinant proteins of biomedical and biotechnological interest, the physiological roles of these protein clusters and the functional status of the embedded proteins remain basically unexplored. [...]
2015 - 10.1007/s00253-015-6684-0
Applied microbiology and biotechnology, Vol. 99 Issue 17, p. 7079–7088 (Setembre 2015)
8 documents

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