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Resultados globales: 10 registros encontrados en 0.02 segundos.
Artículos, Encontrados 8 registros
Documentos de investigación, Encontrados 2 registros
Artículos Encontrados 8 registros  
1.
21 p, 4.8 MB Different Structures-Similar Effect : Do Substituted 5-(4-Methoxyphenyl)-1 H -indoles and 5-(4-Methoxyphenyl)-1 H -imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15? / Zhuravlev, Alexander (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Cruz Saez, Alejandro (Universitat Autònoma de Barcelona. Departament de Química) ; Aksenov, Vladislav (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry) ; Golovanov, Alexey (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Kuhn, Hartmut (Charite-University Medicine Berlin. Department of Biochemistry) ; González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ivanov, Igor (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies)
Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer and inflammation models. The pathophysiological role of linoleic acid- and arachidonic acid-derived ALOX15 metabolites rendered this enzyme a target for pharmacological research. [...]
2023 - 10.3390/molecules28145418
Molecules, Vol. 28, Issue 14 (July 2023) , art. 5418  
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2.
29 p, 3.4 MB N-Substituted 5-(1H-Indol-2-yl)-2-methoxyanilines Are Allosteric Inhibitors of the Linoleate Oxygenase Activity of Selected Mammalian ALOX15 Orthologs : Mechanism of Action / Golovanov, Alexey (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Zhuravlev, Alexander (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Cruz, Alejandro (Universitat Autònoma de Barcelona. Departament de Química) ; Aksenov, Vladislav (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Shafiullina, Rania (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Kakularam, Kumar R. (University Medicine Berlin. Department of Biochemistry, Charité) ; Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Kuhn, Hartmut (University Medicine Berlin. Department of Biochemistry, Charité) ; González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ivanov, Igor (Russian Technological University. Lomonosov Institute of Fine Chemical Technologies)
Here, we describe the first systematic study on the mechanism of substrate-selective inhibition of mammalian ALOX15 orthologs. For this purpose, we prepared a series of N-substituted 5-(1H-indol-2-yl)anilines and found that (N-(5-(1H-indol-2-yl)-2-methoxyphenyl)sulfamoyl)carbamates and their monofluorinated analogues are potent and selective inhibitors of the linoleate oxygenase activity of rabbit and human ALOX15. [...]
2022 - 10.1021/acs.jmedchem.1c01563
Journal of Medicinal Chemistry, Vol. 65, Issue 3 (February 2022) , p. 1979-1995  
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3.
18 p, 31.6 MB Conformational Heterogeneity and Cooperative Effects of Mammalian ALOX15 / Ivanov, Igor (MIREA-Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Cruz Saez, Alejandro (Universitat Autònoma de Barcelona. Departament de Química) ; Zhuravlev, Alexander (MIREA-Russian Technological University. Lomonosov Institute of Fine Chemical Technologies) ; Di Venere, Almerinda (University of Tor Vergata. Department of Experimental Medicine) ; Nicolai, Eleonora (University of Tor Vergata. Department of Experimental Medicine) ; Stehling, Sabine (Charite-University Medicine Berlin. Institute of Biochemistry) ; Osca Lluch, José María (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; González-Lafont, Àngels (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Kuhn, Hartmut (Charite-University Medicine Berlin. Institute of Biochemistry)
Arachidonic acid lipoxygenases (ALOXs) have been suggested to function as monomeric enzymes, but more recent data on rabbit ALOX15 indicated that there is a dynamic monomer-dimer equilibrium in aqueous solution. [...]
2021 - 10.3390/ijms22063285
International journal of molecular sciences, Vol. 22, Issue 6 (March 2021) , art. 3285  
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4.
27 p, 2.3 MB Structural and biophysical insights into the function of the intrinsically disordered Myc oncoprotein / Beaulieu, Marie-Eve (Peptomyc S.L.) ; Castillo, Francisco (Peptomyc S.L.) ; Soucek, Laura (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Myc is a transcription factor driving growth and proliferation of cells and involved in the majority of human tumors. Despite a huge body of literature on this critical oncogene, our understanding of the exact molecular determinants and mechanisms that underlie its function is still surprisingly limited. [...]
2020 - 10.3390/cells9041038
Cells, Vol. 9, Issue 4 (April 2020) , art. 1038  
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5.
15 p, 2.9 MB Cryptic amyloidogenic regions in intrinsically disordered proteins : Function and disease association / Santos, Jaime (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Iglesias, Valentin (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
The amyloid conformation is considered a fundamental state of proteins and the propensity to populate it a generic property of polypeptides. Multiple proteome-wide analyses addressed the presence of amyloidogenic regions in proteins, nurturing our understanding of their nature and biological implications. [...]
2021 - 10.1016/j.csbj.2021.07.019
Computational and Structural Biotechnology Journal, Vol. 19 (July 2021) , p. 4192-4206  
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6.
15 p, 1.7 MB Structural and computational characterization of disease-related mutations involved in protein-protein interfaces / Navío, D. (Barcelona Supercomputing Center) ; Rosell, M. (Barcelona Supercomputing Center) ; Aguirre, Josu (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; de la Cruz, Xavier (Institució Catalana de Recerca i Estudis Avançats) ; Fernández-Recio, Juan (Universidad de La Rioja. Instituto de Ciencias de la Vid y del Vino)
One of the known potential effects of disease-causing amino acid substitutions in proteins is to modulate protein-protein interactions (PPIs). To interpret such variants at the molecular level and to obtain useful information for prediction purposes, it is important to determine whether they are located at protein-protein interfaces, which are composed of two main regions, core and rim, with different evolutionary conservation and physicochemical properties. [...]
2019 - 10.3390/ijms20071583
International journal of molecular sciences, Vol. 20 Núm. 7 (january 2019) , p. 1583  
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7.
9 p, 632.8 KB Human Albumin Impairs Amyloid β-peptide Fibrillation Through its C-terminus : From docking Modeling to Protection Against Neurotoxicity in Alzheimer's disease / Picón-Pagès, Pol (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ; Bonet, Jaume (Universitat Pompeu Fabra. Grup de Recerca en Bioinformàtica Estructural) ; García-García, Javier (Universitat Pompeu Fabra. Grup de Recerca en Bioinformàtica Estructural) ; Garcia-Buendia, Joan (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ; Gutiérrez, Daniela (Pontificia Universidad Católica de Chile. Departamento de Biología Celular y Molecular) ; Valle García, Javier (Universitat Pompeu Fabra. Grup de Recerca en Proteòmica i Química de Proteïnes) ; Gómez-Casuso, Carmen E. S. (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ; Sidelkivska, Valeriya (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ; Alvarez, Alejandra (Pontificia Universidad Católica de Chile. Departamento de Biología Celular y Molecular) ; Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Suades, Albert (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Fernàndez-Busquets, Xavier (Barcelona Institute for Global Health (ISGlobal)) ; Andreu Martínez, David (Universitat Pompeu Fabra. Grup de Recerca en Proteòmica i Química de Proteïnes) ; Vicente, Rubén (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ; Oliva Miguel, Baldomero (Universitat Pompeu Fabra. Grup de Recerca en Bioinformàtica Estructural) ; Muñoz, Francisco J. (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular)
Alzheimer's disease (AD) is a neurodegenerative process characterized by the accumulation of extracellular deposits of amyloid β-peptide (Aβ), which induces neuronal death. Monomeric Aβ is not toxic but tends to aggregate into β-sheets that are neurotoxic. [...]
2019 - 10.1016/j.csbj.2019.06.017
Computational and Structural Biotechnology Journal, Vol. 17 (2019) , p. 963-971  
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8.
11 p, 2.2 MB The membrane proximal domain of TRPV1 and TRPV2 channels mediates protein-protein interactions and lipid binding in vitro / Doñate-Macian, Pablo (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Álvarez Marimon, Elena (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Sepulcre, Francesc (Universitat Politècnica de Catalunya. Departament d'Enginyeria Agroalimentària i Biotecnologia) ; Vázquez Ibar, José Luis (Institut des Sciences du Vivant Frédéric-JOLIOT. CEA-Saclay) ; Perálvarez Marín, Alex (Universitat de Barcelona. Institut de Neurociències)
Constitutive or regulated membrane protein trafficking is a key cell biology process. Transient receptor potential channels are somatosensory proteins in charge of detecting several physical and chemical stimuli, thus requiring fine vesicular trafficking. [...]
2019 - 10.3390/ijms20030682
International journal of molecular sciences, Vol. 20, Issue 3 (February 2019) , art. 682  
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Documentos de investigación Encontrados 2 registros  
1.
100 p, 3.3 MB Prediction of host-pathogen protein-protein interactions : an integrative model / Macho Rendón, Javier ; Torrent Burgas, Marc, dir. ; Daura i Ribera, Xavier, dir.
L'ús descontrolat d'antibiòtics contra bacteris patògens ha accelerant l'aparició de bacteris resistents a múltiples fàrmacs en les darreres dècades i s'està convertint en un greu problema de salut pública a nivell mundial. [...]
El uso descontrolado de antibióticos contra bacterias patógenas está acelerando la aparición de bacterias resistentes a múltiples fármacos y se está convirtiendo en un grave problema en materia de salud pública mundial. [...]
The use and misuse of antibiotics against pathogenic bacteria is accelerating the appearance of multi-drug resistant bacteria and it is becoming a serious concern in public health worldwide. In order to fight antibacterial resistance, it is crucial to get a better understanding of the mechanisms underlying infection, which occur to a great extent due to the interaction between host and pathogen proteins. [...]
Universitat Autònoma de Barcelona. Programa de Doctorat en Bioinformàtica.
2021  
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2.
1 p, 14.3 MB Computational-aided drug discovery in protein-protein interactions : defining a simple protocol and testing it in Notch signaling / Montava Garriga, Lambert ; Maréchal, Jean-Didier, dir. (Universitat Autònoma de Barcelona. Departament de Química) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2015
Grau en Biotecnologia [815]  
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